Magnetic field-assisted gene delivery: achievements and therapeutic potential
- Autores
- Schwerdt, José Ignacio; Goya, Gerardo F.; Calatayud, M. Pilar; Hereñú, Claudia Beatriz; Reggiani, Paula Cecilia; Goya, Rodolfo Gustavo
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The discovery in the early 2000’s that magnetic nanoparticles (MNPs) complexed to nonviral or viral vectors can, in the presence of an external magnetic field, greatly enhance gene transfer into cells has raised much interest. This technique, called magnetofection, was initially developed mainly to improve gene transfer in cell cultures, a simpler and more easily controllable scenario than in vivo models. These studies provided evidence for some unique capabilities of magnetofection. Progressively, the interest in magnetofection expanded to its application in animal models and led to the association of this technique with another technology, magnetic drug targeting (MDT). This combination offers the possibility to develop more efficient and less invasive gene therapy strategies for a number of major pathologies like cancer, neurodegeneration and myocardial infarction. The goal of MDT is to concentrate MNPs functionalized with therapeutic drugs, in target areas of the body by means of properly focused external magnetic fields. The availability of stable, nontoxic MNP-gene vector complexes now offers the opportunity to develop magnetic gene targeting (MGT), a variant of MDT in which the gene coding for a therapeutic molecule, rather than the molecule itself, is delivered to a therapeutic target area in the body. This article will first outline the principle of magnetofection, subsequently describing the properties of the magnetic fields and MNPs used in this technique. Next, it will review the results achieved by magnetofection in cell cultures. Last, the potential of MGT for implementing minimally invasive gene therapy will be discussed.
Instituto de Investigaciones Bioquímicas de La Plata - Materia
-
Bioquímica
Gene delivery
Magnetic nanoparticles
Magnetofection
Magnetic gene targeting
Minimal invasiveness- nanomedicine - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/127940
Ver los metadatos del registro completo
id |
SEDICI_b6cd199bb0bfa1c271e4f619b694c611 |
---|---|
oai_identifier_str |
oai:sedici.unlp.edu.ar:10915/127940 |
network_acronym_str |
SEDICI |
repository_id_str |
1329 |
network_name_str |
SEDICI (UNLP) |
spelling |
Magnetic field-assisted gene delivery: achievements and therapeutic potentialSchwerdt, José IgnacioGoya, Gerardo F.Calatayud, M. PilarHereñú, Claudia BeatrizReggiani, Paula CeciliaGoya, Rodolfo GustavoBioquímicaGene deliveryMagnetic nanoparticlesMagnetofectionMagnetic gene targetingMinimal invasiveness- nanomedicineThe discovery in the early 2000’s that magnetic nanoparticles (MNPs) complexed to nonviral or viral vectors can, in the presence of an external magnetic field, greatly enhance gene transfer into cells has raised much interest. This technique, called magnetofection, was initially developed mainly to improve gene transfer in cell cultures, a simpler and more easily controllable scenario than in vivo models. These studies provided evidence for some unique capabilities of magnetofection. Progressively, the interest in magnetofection expanded to its application in animal models and led to the association of this technique with another technology, magnetic drug targeting (MDT). This combination offers the possibility to develop more efficient and less invasive gene therapy strategies for a number of major pathologies like cancer, neurodegeneration and myocardial infarction. The goal of MDT is to concentrate MNPs functionalized with therapeutic drugs, in target areas of the body by means of properly focused external magnetic fields. The availability of stable, nontoxic MNP-gene vector complexes now offers the opportunity to develop magnetic gene targeting (MGT), a variant of MDT in which the gene coding for a therapeutic molecule, rather than the molecule itself, is delivered to a therapeutic target area in the body. This article will first outline the principle of magnetofection, subsequently describing the properties of the magnetic fields and MNPs used in this technique. Next, it will review the results achieved by magnetofection in cell cultures. Last, the potential of MGT for implementing minimally invasive gene therapy will be discussed.Instituto de Investigaciones Bioquímicas de La Plata2012-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf116-126http://sedici.unlp.edu.ar/handle/10915/127940enginfo:eu-repo/semantics/altIdentifier/issn/1875-5631info:eu-repo/semantics/altIdentifier/issn/1566-5232info:eu-repo/semantics/altIdentifier/pmid/22348552info:eu-repo/semantics/altIdentifier/doi/10.2174/156652312800099616info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:30:58Zoai:sedici.unlp.edu.ar:10915/127940Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:30:59.12SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Magnetic field-assisted gene delivery: achievements and therapeutic potential |
title |
Magnetic field-assisted gene delivery: achievements and therapeutic potential |
spellingShingle |
Magnetic field-assisted gene delivery: achievements and therapeutic potential Schwerdt, José Ignacio Bioquímica Gene delivery Magnetic nanoparticles Magnetofection Magnetic gene targeting Minimal invasiveness- nanomedicine |
title_short |
Magnetic field-assisted gene delivery: achievements and therapeutic potential |
title_full |
Magnetic field-assisted gene delivery: achievements and therapeutic potential |
title_fullStr |
Magnetic field-assisted gene delivery: achievements and therapeutic potential |
title_full_unstemmed |
Magnetic field-assisted gene delivery: achievements and therapeutic potential |
title_sort |
Magnetic field-assisted gene delivery: achievements and therapeutic potential |
dc.creator.none.fl_str_mv |
Schwerdt, José Ignacio Goya, Gerardo F. Calatayud, M. Pilar Hereñú, Claudia Beatriz Reggiani, Paula Cecilia Goya, Rodolfo Gustavo |
author |
Schwerdt, José Ignacio |
author_facet |
Schwerdt, José Ignacio Goya, Gerardo F. Calatayud, M. Pilar Hereñú, Claudia Beatriz Reggiani, Paula Cecilia Goya, Rodolfo Gustavo |
author_role |
author |
author2 |
Goya, Gerardo F. Calatayud, M. Pilar Hereñú, Claudia Beatriz Reggiani, Paula Cecilia Goya, Rodolfo Gustavo |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Bioquímica Gene delivery Magnetic nanoparticles Magnetofection Magnetic gene targeting Minimal invasiveness- nanomedicine |
topic |
Bioquímica Gene delivery Magnetic nanoparticles Magnetofection Magnetic gene targeting Minimal invasiveness- nanomedicine |
dc.description.none.fl_txt_mv |
The discovery in the early 2000’s that magnetic nanoparticles (MNPs) complexed to nonviral or viral vectors can, in the presence of an external magnetic field, greatly enhance gene transfer into cells has raised much interest. This technique, called magnetofection, was initially developed mainly to improve gene transfer in cell cultures, a simpler and more easily controllable scenario than in vivo models. These studies provided evidence for some unique capabilities of magnetofection. Progressively, the interest in magnetofection expanded to its application in animal models and led to the association of this technique with another technology, magnetic drug targeting (MDT). This combination offers the possibility to develop more efficient and less invasive gene therapy strategies for a number of major pathologies like cancer, neurodegeneration and myocardial infarction. The goal of MDT is to concentrate MNPs functionalized with therapeutic drugs, in target areas of the body by means of properly focused external magnetic fields. The availability of stable, nontoxic MNP-gene vector complexes now offers the opportunity to develop magnetic gene targeting (MGT), a variant of MDT in which the gene coding for a therapeutic molecule, rather than the molecule itself, is delivered to a therapeutic target area in the body. This article will first outline the principle of magnetofection, subsequently describing the properties of the magnetic fields and MNPs used in this technique. Next, it will review the results achieved by magnetofection in cell cultures. Last, the potential of MGT for implementing minimally invasive gene therapy will be discussed. Instituto de Investigaciones Bioquímicas de La Plata |
description |
The discovery in the early 2000’s that magnetic nanoparticles (MNPs) complexed to nonviral or viral vectors can, in the presence of an external magnetic field, greatly enhance gene transfer into cells has raised much interest. This technique, called magnetofection, was initially developed mainly to improve gene transfer in cell cultures, a simpler and more easily controllable scenario than in vivo models. These studies provided evidence for some unique capabilities of magnetofection. Progressively, the interest in magnetofection expanded to its application in animal models and led to the association of this technique with another technology, magnetic drug targeting (MDT). This combination offers the possibility to develop more efficient and less invasive gene therapy strategies for a number of major pathologies like cancer, neurodegeneration and myocardial infarction. The goal of MDT is to concentrate MNPs functionalized with therapeutic drugs, in target areas of the body by means of properly focused external magnetic fields. The availability of stable, nontoxic MNP-gene vector complexes now offers the opportunity to develop magnetic gene targeting (MGT), a variant of MDT in which the gene coding for a therapeutic molecule, rather than the molecule itself, is delivered to a therapeutic target area in the body. This article will first outline the principle of magnetofection, subsequently describing the properties of the magnetic fields and MNPs used in this technique. Next, it will review the results achieved by magnetofection in cell cultures. Last, the potential of MGT for implementing minimally invasive gene therapy will be discussed. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-04-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/127940 |
url |
http://sedici.unlp.edu.ar/handle/10915/127940 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/issn/1875-5631 info:eu-repo/semantics/altIdentifier/issn/1566-5232 info:eu-repo/semantics/altIdentifier/pmid/22348552 info:eu-repo/semantics/altIdentifier/doi/10.2174/156652312800099616 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
dc.format.none.fl_str_mv |
application/pdf 116-126 |
dc.source.none.fl_str_mv |
reponame:SEDICI (UNLP) instname:Universidad Nacional de La Plata instacron:UNLP |
reponame_str |
SEDICI (UNLP) |
collection |
SEDICI (UNLP) |
instname_str |
Universidad Nacional de La Plata |
instacron_str |
UNLP |
institution |
UNLP |
repository.name.fl_str_mv |
SEDICI (UNLP) - Universidad Nacional de La Plata |
repository.mail.fl_str_mv |
alira@sedici.unlp.edu.ar |
_version_ |
1844616190087921664 |
score |
13.070432 |