A new, simple and sensitive analytical method for determination of methyldopa in pharmaceutical formulations using the 2,2-diphenyil-picrylhydrazyl

Autores
Matos, Orleane R.; Silva, Francisca C. da; Silva Ribeiro, Paulo R. da
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A new, simple, precise, sensitive and low-cost spectrophotometric method for methyldopa (MTD) determination in pharmaceutical preparations is described. This method is based on the reduction reaction of the free radical, 2,2-diphenyil-picrylhydrazyl (DPPH•), by the MTD. Absorbance of the resulting product is measured at 515 nm. Beer's Law is obeyed in a concentration range of 3.36 × 10-6 a 1.34 × 10-5 mol/L methyldopa with a good correlation coefficient (r = 0.9971). No interference was observed from common excipients in formulations. The results show a simple, accurate and readily applied method to the determination of methyldopa in pharmaceutical products. The analytical results obtained for these products by the proposed method are in agreement with those of the Brazilian Pharmacopoeia procedure at 95 % confidence level.
Colegio de Farmacéuticos de la Provincia de Buenos Aires
Materia
Farmacia
Metildopa
2,2-diphenyil-picrylhydrazyl; pharmaceutical formulations
Espectrofotometría
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Licencia de distribución no exclusiva SEDICI
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/18047
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/18047
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling A new, simple and sensitive analytical method for determination of methyldopa in pharmaceutical formulations using the 2,2-diphenyil-picrylhydrazylMatos, Orleane R.Silva, Francisca C. daSilva Ribeiro, Paulo R. daFarmaciaMetildopa2,2-diphenyil-picrylhydrazyl; pharmaceutical formulationsEspectrofotometríaA new, simple, precise, sensitive and low-cost spectrophotometric method for methyldopa (MTD) determination in pharmaceutical preparations is described. This method is based on the reduction reaction of the free radical, 2,2-diphenyil-picrylhydrazyl (DPPH•), by the MTD. Absorbance of the resulting product is measured at 515 nm. Beer's Law is obeyed in a concentration range of 3.36 × 10<sup>-6</sup> a 1.34 × 10<sup>-5</sup> mol/L methyldopa with a good correlation coefficient (r = 0.9971). No interference was observed from common excipients in formulations. The results show a simple, accurate and readily applied method to the determination of methyldopa in pharmaceutical products. The analytical results obtained for these products by the proposed method are in agreement with those of the Brazilian Pharmacopoeia procedure at 95 % confidence level.Colegio de Farmacéuticos de la Provincia de Buenos Aires2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/18047enginfo:eu-repo/semantics/altIdentifier/url/http://www.latamjpharm.org/resumenes/31/2/LAJOP_31_2_1_2.pdfinfo:eu-repo/semantics/altIdentifier/issn/0326-2383info:eu-repo/semantics/openAccessLicencia de distribución no exclusiva SEDICIreponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T10:53:23Zoai:sedici.unlp.edu.ar:10915/18047Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 10:53:23.3SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv A new, simple and sensitive analytical method for determination of methyldopa in pharmaceutical formulations using the 2,2-diphenyil-picrylhydrazyl
title A new, simple and sensitive analytical method for determination of methyldopa in pharmaceutical formulations using the 2,2-diphenyil-picrylhydrazyl
spellingShingle A new, simple and sensitive analytical method for determination of methyldopa in pharmaceutical formulations using the 2,2-diphenyil-picrylhydrazyl
Matos, Orleane R.
Farmacia
Metildopa
2,2-diphenyil-picrylhydrazyl; pharmaceutical formulations
Espectrofotometría
title_short A new, simple and sensitive analytical method for determination of methyldopa in pharmaceutical formulations using the 2,2-diphenyil-picrylhydrazyl
title_full A new, simple and sensitive analytical method for determination of methyldopa in pharmaceutical formulations using the 2,2-diphenyil-picrylhydrazyl
title_fullStr A new, simple and sensitive analytical method for determination of methyldopa in pharmaceutical formulations using the 2,2-diphenyil-picrylhydrazyl
title_full_unstemmed A new, simple and sensitive analytical method for determination of methyldopa in pharmaceutical formulations using the 2,2-diphenyil-picrylhydrazyl
title_sort A new, simple and sensitive analytical method for determination of methyldopa in pharmaceutical formulations using the 2,2-diphenyil-picrylhydrazyl
dc.creator.none.fl_str_mv Matos, Orleane R.
Silva, Francisca C. da
Silva Ribeiro, Paulo R. da
author Matos, Orleane R.
author_facet Matos, Orleane R.
Silva, Francisca C. da
Silva Ribeiro, Paulo R. da
author_role author
author2 Silva, Francisca C. da
Silva Ribeiro, Paulo R. da
author2_role author
author
dc.subject.none.fl_str_mv Farmacia
Metildopa
2,2-diphenyil-picrylhydrazyl; pharmaceutical formulations
Espectrofotometría
topic Farmacia
Metildopa
2,2-diphenyil-picrylhydrazyl; pharmaceutical formulations
Espectrofotometría
dc.description.none.fl_txt_mv A new, simple, precise, sensitive and low-cost spectrophotometric method for methyldopa (MTD) determination in pharmaceutical preparations is described. This method is based on the reduction reaction of the free radical, 2,2-diphenyil-picrylhydrazyl (DPPH•), by the MTD. Absorbance of the resulting product is measured at 515 nm. Beer's Law is obeyed in a concentration range of 3.36 × 10<sup>-6</sup> a 1.34 × 10<sup>-5</sup> mol/L methyldopa with a good correlation coefficient (r = 0.9971). No interference was observed from common excipients in formulations. The results show a simple, accurate and readily applied method to the determination of methyldopa in pharmaceutical products. The analytical results obtained for these products by the proposed method are in agreement with those of the Brazilian Pharmacopoeia procedure at 95 % confidence level.
Colegio de Farmacéuticos de la Provincia de Buenos Aires
description A new, simple, precise, sensitive and low-cost spectrophotometric method for methyldopa (MTD) determination in pharmaceutical preparations is described. This method is based on the reduction reaction of the free radical, 2,2-diphenyil-picrylhydrazyl (DPPH•), by the MTD. Absorbance of the resulting product is measured at 515 nm. Beer's Law is obeyed in a concentration range of 3.36 × 10<sup>-6</sup> a 1.34 × 10<sup>-5</sup> mol/L methyldopa with a good correlation coefficient (r = 0.9971). No interference was observed from common excipients in formulations. The results show a simple, accurate and readily applied method to the determination of methyldopa in pharmaceutical products. The analytical results obtained for these products by the proposed method are in agreement with those of the Brazilian Pharmacopoeia procedure at 95 % confidence level.
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/18047
url http://sedici.unlp.edu.ar/handle/10915/18047
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.latamjpharm.org/resumenes/31/2/LAJOP_31_2_1_2.pdf
info:eu-repo/semantics/altIdentifier/issn/0326-2383
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Licencia de distribución no exclusiva SEDICI
eu_rights_str_mv openAccess
rights_invalid_str_mv Licencia de distribución no exclusiva SEDICI
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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