Evaluation of pharmaceutical bioequivalence and anthelmintic afficacy for different albendazole generic formulations in parasitized sheep

Autores
Suarez, Gonzalo; Alvarez, Luis Ignacio; Castells, Daniel; Faggiolino, Pietro; Correa, Oscar; Lanusse, Carlos Edmundo
Año de publicación
2008
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Albendazole (ABZ) is a broad-spectrum anthelmintic drug widely used in human and veterinary medicine. The aim of this work was to evaluate the bioequivalence and anthelmintic efficacy of four different generic formulations of ABZ in sheep parasitized with resistant nematodes. Fifty parasitized lambs were divided into five groups (n=10): Untreated control and treated groups A (reference), B, C and D. Treated animals received different ABZ formulations (5 mg/kg). Plasma samples were collected over 3 days post-treatment and drug concentrations measured by HPLC. The efficacy of the different treatments was estimated by the faecal egg counts reduction test (FECRT). No bioequivalence was observed between the reference and either B or D generic formulations. The FECRT ranged between 36 and 59%. The study demonstrated a lack of bioequivalence for some of the generic ABZ formulations under study, which are commercially available for use in sheep.
Fil: Suarez, Gonzalo. Universidad de la Republica. Facultad de Veterinaria.; Uruguay
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Castells, Daniel. Universidad de la Republica. Facultad de Veterinaria.; Uruguay
Fil: Faggiolino, Pietro. Universidad de la Republica. Facultad de Veterinaria.; Uruguay
Fil: Correa, Oscar. Universidad de la Republica. Facultad de Veterinaria.; Uruguay
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
XL Reunión Anual de la Sociedad Argentina de Farmacología Experimental
Tandil
Argentina
Sociedad Argentina de Farmacología Experimental
Materia
Pharmaceutical
Bioequivalence
Anthelmintic
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/268503
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Evaluation of pharmaceutical bioequivalence and anthelmintic afficacy for different albendazole generic formulations in parasitized sheepSuarez, GonzaloAlvarez, Luis IgnacioCastells, DanielFaggiolino, PietroCorrea, OscarLanusse, Carlos EdmundoPharmaceuticalBioequivalenceAnthelmintichttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Albendazole (ABZ) is a broad-spectrum anthelmintic drug widely used in human and veterinary medicine. The aim of this work was to evaluate the bioequivalence and anthelmintic efficacy of four different generic formulations of ABZ in sheep parasitized with resistant nematodes. Fifty parasitized lambs were divided into five groups (n=10): Untreated control and treated groups A (reference), B, C and D. Treated animals received different ABZ formulations (5 mg/kg). Plasma samples were collected over 3 days post-treatment and drug concentrations measured by HPLC. The efficacy of the different treatments was estimated by the faecal egg counts reduction test (FECRT). No bioequivalence was observed between the reference and either B or D generic formulations. The FECRT ranged between 36 and 59%. The study demonstrated a lack of bioequivalence for some of the generic ABZ formulations under study, which are commercially available for use in sheep.Fil: Suarez, Gonzalo. Universidad de la Republica. Facultad de Veterinaria.; UruguayFil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Castells, Daniel. Universidad de la Republica. Facultad de Veterinaria.; UruguayFil: Faggiolino, Pietro. Universidad de la Republica. Facultad de Veterinaria.; UruguayFil: Correa, Oscar. Universidad de la Republica. Facultad de Veterinaria.; UruguayFil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaXL Reunión Anual de la Sociedad Argentina de Farmacología ExperimentalTandilArgentinaSociedad Argentina de Farmacología ExperimentalSociedad Argentina de Farmacología Experimental2008info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/268503Evaluation of pharmaceutical bioequivalence and anthelmintic afficacy for different albendazole generic formulations in parasitized sheep; XL Reunión Anual de la Sociedad Argentina de Farmacología Experimental; Tandil; Argentina; 2008; 25-25CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://aafeargentina.org/congresos-aafe/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:39:54Zoai:ri.conicet.gov.ar:11336/268503instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:39:54.804CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Evaluation of pharmaceutical bioequivalence and anthelmintic afficacy for different albendazole generic formulations in parasitized sheep
title Evaluation of pharmaceutical bioequivalence and anthelmintic afficacy for different albendazole generic formulations in parasitized sheep
spellingShingle Evaluation of pharmaceutical bioequivalence and anthelmintic afficacy for different albendazole generic formulations in parasitized sheep
Suarez, Gonzalo
Pharmaceutical
Bioequivalence
Anthelmintic
title_short Evaluation of pharmaceutical bioequivalence and anthelmintic afficacy for different albendazole generic formulations in parasitized sheep
title_full Evaluation of pharmaceutical bioequivalence and anthelmintic afficacy for different albendazole generic formulations in parasitized sheep
title_fullStr Evaluation of pharmaceutical bioequivalence and anthelmintic afficacy for different albendazole generic formulations in parasitized sheep
title_full_unstemmed Evaluation of pharmaceutical bioequivalence and anthelmintic afficacy for different albendazole generic formulations in parasitized sheep
title_sort Evaluation of pharmaceutical bioequivalence and anthelmintic afficacy for different albendazole generic formulations in parasitized sheep
dc.creator.none.fl_str_mv Suarez, Gonzalo
Alvarez, Luis Ignacio
Castells, Daniel
Faggiolino, Pietro
Correa, Oscar
Lanusse, Carlos Edmundo
author Suarez, Gonzalo
author_facet Suarez, Gonzalo
Alvarez, Luis Ignacio
Castells, Daniel
Faggiolino, Pietro
Correa, Oscar
Lanusse, Carlos Edmundo
author_role author
author2 Alvarez, Luis Ignacio
Castells, Daniel
Faggiolino, Pietro
Correa, Oscar
Lanusse, Carlos Edmundo
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Pharmaceutical
Bioequivalence
Anthelmintic
topic Pharmaceutical
Bioequivalence
Anthelmintic
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Albendazole (ABZ) is a broad-spectrum anthelmintic drug widely used in human and veterinary medicine. The aim of this work was to evaluate the bioequivalence and anthelmintic efficacy of four different generic formulations of ABZ in sheep parasitized with resistant nematodes. Fifty parasitized lambs were divided into five groups (n=10): Untreated control and treated groups A (reference), B, C and D. Treated animals received different ABZ formulations (5 mg/kg). Plasma samples were collected over 3 days post-treatment and drug concentrations measured by HPLC. The efficacy of the different treatments was estimated by the faecal egg counts reduction test (FECRT). No bioequivalence was observed between the reference and either B or D generic formulations. The FECRT ranged between 36 and 59%. The study demonstrated a lack of bioequivalence for some of the generic ABZ formulations under study, which are commercially available for use in sheep.
Fil: Suarez, Gonzalo. Universidad de la Republica. Facultad de Veterinaria.; Uruguay
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Castells, Daniel. Universidad de la Republica. Facultad de Veterinaria.; Uruguay
Fil: Faggiolino, Pietro. Universidad de la Republica. Facultad de Veterinaria.; Uruguay
Fil: Correa, Oscar. Universidad de la Republica. Facultad de Veterinaria.; Uruguay
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
XL Reunión Anual de la Sociedad Argentina de Farmacología Experimental
Tandil
Argentina
Sociedad Argentina de Farmacología Experimental
description Albendazole (ABZ) is a broad-spectrum anthelmintic drug widely used in human and veterinary medicine. The aim of this work was to evaluate the bioequivalence and anthelmintic efficacy of four different generic formulations of ABZ in sheep parasitized with resistant nematodes. Fifty parasitized lambs were divided into five groups (n=10): Untreated control and treated groups A (reference), B, C and D. Treated animals received different ABZ formulations (5 mg/kg). Plasma samples were collected over 3 days post-treatment and drug concentrations measured by HPLC. The efficacy of the different treatments was estimated by the faecal egg counts reduction test (FECRT). No bioequivalence was observed between the reference and either B or D generic formulations. The FECRT ranged between 36 and 59%. The study demonstrated a lack of bioequivalence for some of the generic ABZ formulations under study, which are commercially available for use in sheep.
publishDate 2008
dc.date.none.fl_str_mv 2008
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/268503
Evaluation of pharmaceutical bioequivalence and anthelmintic afficacy for different albendazole generic formulations in parasitized sheep; XL Reunión Anual de la Sociedad Argentina de Farmacología Experimental; Tandil; Argentina; 2008; 25-25
CONICET Digital
CONICET
url http://hdl.handle.net/11336/268503
identifier_str_mv Evaluation of pharmaceutical bioequivalence and anthelmintic afficacy for different albendazole generic formulations in parasitized sheep; XL Reunión Anual de la Sociedad Argentina de Farmacología Experimental; Tandil; Argentina; 2008; 25-25
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://aafeargentina.org/congresos-aafe/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
application/pdf
dc.publisher.none.fl_str_mv Sociedad Argentina de Farmacología Experimental
publisher.none.fl_str_mv Sociedad Argentina de Farmacología Experimental
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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