Controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluids

Autores
Costas, Luciana; Pera, Licia María; Gómez López, Azucena; Mechetti, Magdalena; Castro, Guillermo Raúl
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Sulfasalazine (SLZ) is a synthetic nonsteroidal anti-inflammatory drug used mainly for the treatment of an inflammatory bowel and other diseases. Two pectins with different methylation degrees were blended to synthesized gel microspheres by ionotropic gelation for SLZ encapsulation. The encapsulation efficiency was found to be around of 99% in all formulations tested. However, different SLZ release profiles related to the methylation degrees of pectin were observed. Mixture of low methylated (LM) and high methylated (HM) pectins in the presence of calcium(II) displayed the best microsphere morphologies among the formulations tested determined by optical and electronic microscopies. The percentage of drug release using a mixture of LM and HM pectins after 255 min in simulated gastric fluid (pH = 1.2), simulated intestinal fluid (pH = 6.8), and phosphate buffer (pH = 7.4) were 15.0%, 47.0%, and 52.2%, respectively.
Centro de Investigación y Desarrollo en Fermentaciones Industriales
Materia
Ciencias Exactas
Pectin
Hydrogel
Drug delivery
Sulfasalazine
Biopolymers
Rheological analysis
Physiological simulated fluids
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/135819
Acceder
id SEDICI_a45e34419460694c884f971f6920c7c7
oai_identifier_str oai:sedici.unlp.edu.ar:10915/135819
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluidsCostas, LucianaPera, Licia MaríaGómez López, AzucenaMechetti, MagdalenaCastro, Guillermo RaúlCiencias ExactasPectinHydrogelDrug deliverySulfasalazineBiopolymersRheological analysisPhysiological simulated fluidsSulfasalazine (SLZ) is a synthetic nonsteroidal anti-inflammatory drug used mainly for the treatment of an inflammatory bowel and other diseases. Two pectins with different methylation degrees were blended to synthesized gel microspheres by ionotropic gelation for SLZ encapsulation. The encapsulation efficiency was found to be around of 99% in all formulations tested. However, different SLZ release profiles related to the methylation degrees of pectin were observed. Mixture of low methylated (LM) and high methylated (HM) pectins in the presence of calcium(II) displayed the best microsphere morphologies among the formulations tested determined by optical and electronic microscopies. The percentage of drug release using a mixture of LM and HM pectins after 255 min in simulated gastric fluid (pH = 1.2), simulated intestinal fluid (pH = 6.8), and phosphate buffer (pH = 7.4) were 15.0%, 47.0%, and 52.2%, respectively.Centro de Investigación y Desarrollo en Fermentaciones Industriales2012-02-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1396-1407http://sedici.unlp.edu.ar/handle/10915/135819enginfo:eu-repo/semantics/altIdentifier/issn/1559-0291info:eu-repo/semantics/altIdentifier/issn/0273-2289info:eu-repo/semantics/altIdentifier/doi/10.1007/s12010-012-9615-xinfo:eu-repo/semantics/altIdentifier/pmid/22371067info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-22T17:12:52Zoai:sedici.unlp.edu.ar:10915/135819Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-22 17:12:52.69SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluids
title Controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluids
spellingShingle Controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluids
Costas, Luciana
Ciencias Exactas
Pectin
Hydrogel
Drug delivery
Sulfasalazine
Biopolymers
Rheological analysis
Physiological simulated fluids
title_short Controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluids
title_full Controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluids
title_fullStr Controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluids
title_full_unstemmed Controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluids
title_sort Controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluids
dc.creator.none.fl_str_mv Costas, Luciana
Pera, Licia María
Gómez López, Azucena
Mechetti, Magdalena
Castro, Guillermo Raúl
author Costas, Luciana
author_facet Costas, Luciana
Pera, Licia María
Gómez López, Azucena
Mechetti, Magdalena
Castro, Guillermo Raúl
author_role author
author2 Pera, Licia María
Gómez López, Azucena
Mechetti, Magdalena
Castro, Guillermo Raúl
author2_role author
author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Pectin
Hydrogel
Drug delivery
Sulfasalazine
Biopolymers
Rheological analysis
Physiological simulated fluids
topic Ciencias Exactas
Pectin
Hydrogel
Drug delivery
Sulfasalazine
Biopolymers
Rheological analysis
Physiological simulated fluids
dc.description.none.fl_txt_mv Sulfasalazine (SLZ) is a synthetic nonsteroidal anti-inflammatory drug used mainly for the treatment of an inflammatory bowel and other diseases. Two pectins with different methylation degrees were blended to synthesized gel microspheres by ionotropic gelation for SLZ encapsulation. The encapsulation efficiency was found to be around of 99% in all formulations tested. However, different SLZ release profiles related to the methylation degrees of pectin were observed. Mixture of low methylated (LM) and high methylated (HM) pectins in the presence of calcium(II) displayed the best microsphere morphologies among the formulations tested determined by optical and electronic microscopies. The percentage of drug release using a mixture of LM and HM pectins after 255 min in simulated gastric fluid (pH = 1.2), simulated intestinal fluid (pH = 6.8), and phosphate buffer (pH = 7.4) were 15.0%, 47.0%, and 52.2%, respectively.
Centro de Investigación y Desarrollo en Fermentaciones Industriales
description Sulfasalazine (SLZ) is a synthetic nonsteroidal anti-inflammatory drug used mainly for the treatment of an inflammatory bowel and other diseases. Two pectins with different methylation degrees were blended to synthesized gel microspheres by ionotropic gelation for SLZ encapsulation. The encapsulation efficiency was found to be around of 99% in all formulations tested. However, different SLZ release profiles related to the methylation degrees of pectin were observed. Mixture of low methylated (LM) and high methylated (HM) pectins in the presence of calcium(II) displayed the best microsphere morphologies among the formulations tested determined by optical and electronic microscopies. The percentage of drug release using a mixture of LM and HM pectins after 255 min in simulated gastric fluid (pH = 1.2), simulated intestinal fluid (pH = 6.8), and phosphate buffer (pH = 7.4) were 15.0%, 47.0%, and 52.2%, respectively.
publishDate 2012
dc.date.none.fl_str_mv 2012-02-29
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/135819
url http://sedici.unlp.edu.ar/handle/10915/135819
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1559-0291
info:eu-repo/semantics/altIdentifier/issn/0273-2289
info:eu-repo/semantics/altIdentifier/doi/10.1007/s12010-012-9615-x
info:eu-repo/semantics/altIdentifier/pmid/22371067
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
1396-1407
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 12.982451

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