Controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluids
- Autores
- Costas, Luciana; Pera, Licia María; Gómez López, Azucena; Mechetti, Magdalena; Castro, Guillermo Raúl
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Sulfasalazine (SLZ) is a synthetic nonsteroidal anti-inflammatory drug used mainly for the treatment of an inflammatory bowel and other diseases. Two pectins with different methylation degrees were blended to synthesized gel microspheres by ionotropic gelation for SLZ encapsulation. The encapsulation efficiency was found to be around of 99% in all formulations tested. However, different SLZ release profiles related to the methylation degrees of pectin were observed. Mixture of low methylated (LM) and high methylated (HM) pectins in the presence of calcium(II) displayed the best microsphere morphologies among the formulations tested determined by optical and electronic microscopies. The percentage of drug release using a mixture of LM and HM pectins after 255 min in simulated gastric fluid (pH = 1.2), simulated intestinal fluid (pH = 6.8), and phosphate buffer (pH = 7.4) were 15.0%, 47.0%, and 52.2%, respectively.
Centro de Investigación y Desarrollo en Fermentaciones Industriales - Materia
-
Ciencias Exactas
Pectin
Hydrogel
Drug delivery
Sulfasalazine
Biopolymers
Rheological analysis
Physiological simulated fluids - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/135819
Ver los metadatos del registro completo
id |
SEDICI_a45e34419460694c884f971f6920c7c7 |
---|---|
oai_identifier_str |
oai:sedici.unlp.edu.ar:10915/135819 |
network_acronym_str |
SEDICI |
repository_id_str |
1329 |
network_name_str |
SEDICI (UNLP) |
spelling |
Controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluidsCostas, LucianaPera, Licia MaríaGómez López, AzucenaMechetti, MagdalenaCastro, Guillermo RaúlCiencias ExactasPectinHydrogelDrug deliverySulfasalazineBiopolymersRheological analysisPhysiological simulated fluidsSulfasalazine (SLZ) is a synthetic nonsteroidal anti-inflammatory drug used mainly for the treatment of an inflammatory bowel and other diseases. Two pectins with different methylation degrees were blended to synthesized gel microspheres by ionotropic gelation for SLZ encapsulation. The encapsulation efficiency was found to be around of 99% in all formulations tested. However, different SLZ release profiles related to the methylation degrees of pectin were observed. Mixture of low methylated (LM) and high methylated (HM) pectins in the presence of calcium(II) displayed the best microsphere morphologies among the formulations tested determined by optical and electronic microscopies. The percentage of drug release using a mixture of LM and HM pectins after 255 min in simulated gastric fluid (pH = 1.2), simulated intestinal fluid (pH = 6.8), and phosphate buffer (pH = 7.4) were 15.0%, 47.0%, and 52.2%, respectively.Centro de Investigación y Desarrollo en Fermentaciones Industriales2012-02-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1396-1407http://sedici.unlp.edu.ar/handle/10915/135819enginfo:eu-repo/semantics/altIdentifier/issn/1559-0291info:eu-repo/semantics/altIdentifier/issn/0273-2289info:eu-repo/semantics/altIdentifier/doi/10.1007/s12010-012-9615-xinfo:eu-repo/semantics/altIdentifier/pmid/22371067info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:31:57Zoai:sedici.unlp.edu.ar:10915/135819Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:31:58.253SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluids |
title |
Controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluids |
spellingShingle |
Controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluids Costas, Luciana Ciencias Exactas Pectin Hydrogel Drug delivery Sulfasalazine Biopolymers Rheological analysis Physiological simulated fluids |
title_short |
Controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluids |
title_full |
Controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluids |
title_fullStr |
Controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluids |
title_full_unstemmed |
Controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluids |
title_sort |
Controlled release of sulfasalazine release from "smart" pectin gel microspheres under physiological simulated fluids |
dc.creator.none.fl_str_mv |
Costas, Luciana Pera, Licia María Gómez López, Azucena Mechetti, Magdalena Castro, Guillermo Raúl |
author |
Costas, Luciana |
author_facet |
Costas, Luciana Pera, Licia María Gómez López, Azucena Mechetti, Magdalena Castro, Guillermo Raúl |
author_role |
author |
author2 |
Pera, Licia María Gómez López, Azucena Mechetti, Magdalena Castro, Guillermo Raúl |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Ciencias Exactas Pectin Hydrogel Drug delivery Sulfasalazine Biopolymers Rheological analysis Physiological simulated fluids |
topic |
Ciencias Exactas Pectin Hydrogel Drug delivery Sulfasalazine Biopolymers Rheological analysis Physiological simulated fluids |
dc.description.none.fl_txt_mv |
Sulfasalazine (SLZ) is a synthetic nonsteroidal anti-inflammatory drug used mainly for the treatment of an inflammatory bowel and other diseases. Two pectins with different methylation degrees were blended to synthesized gel microspheres by ionotropic gelation for SLZ encapsulation. The encapsulation efficiency was found to be around of 99% in all formulations tested. However, different SLZ release profiles related to the methylation degrees of pectin were observed. Mixture of low methylated (LM) and high methylated (HM) pectins in the presence of calcium(II) displayed the best microsphere morphologies among the formulations tested determined by optical and electronic microscopies. The percentage of drug release using a mixture of LM and HM pectins after 255 min in simulated gastric fluid (pH = 1.2), simulated intestinal fluid (pH = 6.8), and phosphate buffer (pH = 7.4) were 15.0%, 47.0%, and 52.2%, respectively. Centro de Investigación y Desarrollo en Fermentaciones Industriales |
description |
Sulfasalazine (SLZ) is a synthetic nonsteroidal anti-inflammatory drug used mainly for the treatment of an inflammatory bowel and other diseases. Two pectins with different methylation degrees were blended to synthesized gel microspheres by ionotropic gelation for SLZ encapsulation. The encapsulation efficiency was found to be around of 99% in all formulations tested. However, different SLZ release profiles related to the methylation degrees of pectin were observed. Mixture of low methylated (LM) and high methylated (HM) pectins in the presence of calcium(II) displayed the best microsphere morphologies among the formulations tested determined by optical and electronic microscopies. The percentage of drug release using a mixture of LM and HM pectins after 255 min in simulated gastric fluid (pH = 1.2), simulated intestinal fluid (pH = 6.8), and phosphate buffer (pH = 7.4) were 15.0%, 47.0%, and 52.2%, respectively. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-02-29 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/135819 |
url |
http://sedici.unlp.edu.ar/handle/10915/135819 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/issn/1559-0291 info:eu-repo/semantics/altIdentifier/issn/0273-2289 info:eu-repo/semantics/altIdentifier/doi/10.1007/s12010-012-9615-x info:eu-repo/semantics/altIdentifier/pmid/22371067 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
dc.format.none.fl_str_mv |
application/pdf 1396-1407 |
dc.source.none.fl_str_mv |
reponame:SEDICI (UNLP) instname:Universidad Nacional de La Plata instacron:UNLP |
reponame_str |
SEDICI (UNLP) |
collection |
SEDICI (UNLP) |
instname_str |
Universidad Nacional de La Plata |
instacron_str |
UNLP |
institution |
UNLP |
repository.name.fl_str_mv |
SEDICI (UNLP) - Universidad Nacional de La Plata |
repository.mail.fl_str_mv |
alira@sedici.unlp.edu.ar |
_version_ |
1844616199457996800 |
score |
13.070432 |