Evidence of Wild Boars as a Reservoir of Zoonotic Hepatitis E Virus Genotype 3: Implications for Public Health in Argentina
- Autores
- Williman, Macarena Marta; Colina, Santiago Emanuel; Di Cola, Guadalupe; Ozaeta, Diana Sofía; Carpinetti, Bruno Nicolás; Pisano, María Belén; Ré, Viviana Elizabeth; Serena, María Soledad; Echeverría, María Gabriela; Metz, Germán Ernesto
- Año de publicación
- 2026
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Hepatitis E virus (HEV) is a global public health concern, causing over 20 million infections annually. It is primarily transmitted via the fecal–oral route, with wild boars and domestic swine as major reservoirs involved in zoonotic transmission. Bahía de Samborombón is an important natural reserve in Argentina characterized by a high population of wild boars, located in a livestock-intensive region near major urban centers. As part of a wild boar control program, 11 sampling campaigns were carried out between 2022 and 2023. Fecal, blood, and liver samples were systematically collected from 80 captured animals for the detection and characterization of HEV through antibody and RNA testing. Serological analysis revealed a positivity rate of 42.4%, whereas RT-qPCR detected HEV RNA in 9.1% of fecal samples and 12.5% of liver samples. From the positive samples, seven viral sequences were recovered using RT-nested PCR, including six from ORF1 and one from ORF2. Phylogenetic analysis clustered these sequences within zoonotic HEV genotype 3, showing a close relationship with human sequences from Buenos Aires and neighboring provinces. This study confirms the presence of HEV in wild boars from Argentina, highlighting the circulation of genotype 3, clade abchijklmno and the associated zoonotic risk.
Centro de Microbiología Básica y Aplicada
Consejo Nacional de Investigaciones Científicas y Técnicas - Materia
-
Ciencias Veterinarias
hepatitis E
wild boar
Argentina
phylogeny
zoonosis
public health - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
.jpg)
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/191863
Ver los metadatos del registro completo
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Evidence of Wild Boars as a Reservoir of Zoonotic Hepatitis E Virus Genotype 3: Implications for Public Health in ArgentinaWilliman, Macarena MartaColina, Santiago EmanuelDi Cola, GuadalupeOzaeta, Diana SofíaCarpinetti, Bruno NicolásPisano, María BelénRé, Viviana ElizabethSerena, María SoledadEcheverría, María GabrielaMetz, Germán ErnestoCiencias Veterinariashepatitis Ewild boarArgentinaphylogenyzoonosispublic healthHepatitis E virus (HEV) is a global public health concern, causing over 20 million infections annually. It is primarily transmitted via the fecal–oral route, with wild boars and domestic swine as major reservoirs involved in zoonotic transmission. Bahía de Samborombón is an important natural reserve in Argentina characterized by a high population of wild boars, located in a livestock-intensive region near major urban centers. As part of a wild boar control program, 11 sampling campaigns were carried out between 2022 and 2023. Fecal, blood, and liver samples were systematically collected from 80 captured animals for the detection and characterization of HEV through antibody and RNA testing. Serological analysis revealed a positivity rate of 42.4%, whereas RT-qPCR detected HEV RNA in 9.1% of fecal samples and 12.5% of liver samples. From the positive samples, seven viral sequences were recovered using RT-nested PCR, including six from ORF1 and one from ORF2. Phylogenetic analysis clustered these sequences within zoonotic HEV genotype 3, showing a close relationship with human sequences from Buenos Aires and neighboring provinces. This study confirms the presence of HEV in wild boars from Argentina, highlighting the circulation of genotype 3, clade abchijklmno and the associated zoonotic risk.Centro de Microbiología Básica y AplicadaConsejo Nacional de Investigaciones Científicas y Técnicas2026-02-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/191863enginfo:eu-repo/semantics/altIdentifier/issn/2076-0817info:eu-repo/semantics/altIdentifier/doi/10.3390/pathogens15020205info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2026-03-26T09:21:42Zoai:sedici.unlp.edu.ar:10915/191863Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292026-03-26 09:21:43.054SEDICI (UNLP) - Universidad Nacional de La Platafalse |
| dc.title.none.fl_str_mv |
Evidence of Wild Boars as a Reservoir of Zoonotic Hepatitis E Virus Genotype 3: Implications for Public Health in Argentina |
| title |
Evidence of Wild Boars as a Reservoir of Zoonotic Hepatitis E Virus Genotype 3: Implications for Public Health in Argentina |
| spellingShingle |
Evidence of Wild Boars as a Reservoir of Zoonotic Hepatitis E Virus Genotype 3: Implications for Public Health in Argentina Williman, Macarena Marta Ciencias Veterinarias hepatitis E wild boar Argentina phylogeny zoonosis public health |
| title_short |
Evidence of Wild Boars as a Reservoir of Zoonotic Hepatitis E Virus Genotype 3: Implications for Public Health in Argentina |
| title_full |
Evidence of Wild Boars as a Reservoir of Zoonotic Hepatitis E Virus Genotype 3: Implications for Public Health in Argentina |
| title_fullStr |
Evidence of Wild Boars as a Reservoir of Zoonotic Hepatitis E Virus Genotype 3: Implications for Public Health in Argentina |
| title_full_unstemmed |
Evidence of Wild Boars as a Reservoir of Zoonotic Hepatitis E Virus Genotype 3: Implications for Public Health in Argentina |
| title_sort |
Evidence of Wild Boars as a Reservoir of Zoonotic Hepatitis E Virus Genotype 3: Implications for Public Health in Argentina |
| dc.creator.none.fl_str_mv |
Williman, Macarena Marta Colina, Santiago Emanuel Di Cola, Guadalupe Ozaeta, Diana Sofía Carpinetti, Bruno Nicolás Pisano, María Belén Ré, Viviana Elizabeth Serena, María Soledad Echeverría, María Gabriela Metz, Germán Ernesto |
| author |
Williman, Macarena Marta |
| author_facet |
Williman, Macarena Marta Colina, Santiago Emanuel Di Cola, Guadalupe Ozaeta, Diana Sofía Carpinetti, Bruno Nicolás Pisano, María Belén Ré, Viviana Elizabeth Serena, María Soledad Echeverría, María Gabriela Metz, Germán Ernesto |
| author_role |
author |
| author2 |
Colina, Santiago Emanuel Di Cola, Guadalupe Ozaeta, Diana Sofía Carpinetti, Bruno Nicolás Pisano, María Belén Ré, Viviana Elizabeth Serena, María Soledad Echeverría, María Gabriela Metz, Germán Ernesto |
| author2_role |
author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Ciencias Veterinarias hepatitis E wild boar Argentina phylogeny zoonosis public health |
| topic |
Ciencias Veterinarias hepatitis E wild boar Argentina phylogeny zoonosis public health |
| dc.description.none.fl_txt_mv |
Hepatitis E virus (HEV) is a global public health concern, causing over 20 million infections annually. It is primarily transmitted via the fecal–oral route, with wild boars and domestic swine as major reservoirs involved in zoonotic transmission. Bahía de Samborombón is an important natural reserve in Argentina characterized by a high population of wild boars, located in a livestock-intensive region near major urban centers. As part of a wild boar control program, 11 sampling campaigns were carried out between 2022 and 2023. Fecal, blood, and liver samples were systematically collected from 80 captured animals for the detection and characterization of HEV through antibody and RNA testing. Serological analysis revealed a positivity rate of 42.4%, whereas RT-qPCR detected HEV RNA in 9.1% of fecal samples and 12.5% of liver samples. From the positive samples, seven viral sequences were recovered using RT-nested PCR, including six from ORF1 and one from ORF2. Phylogenetic analysis clustered these sequences within zoonotic HEV genotype 3, showing a close relationship with human sequences from Buenos Aires and neighboring provinces. This study confirms the presence of HEV in wild boars from Argentina, highlighting the circulation of genotype 3, clade abchijklmno and the associated zoonotic risk. Centro de Microbiología Básica y Aplicada Consejo Nacional de Investigaciones Científicas y Técnicas |
| description |
Hepatitis E virus (HEV) is a global public health concern, causing over 20 million infections annually. It is primarily transmitted via the fecal–oral route, with wild boars and domestic swine as major reservoirs involved in zoonotic transmission. Bahía de Samborombón is an important natural reserve in Argentina characterized by a high population of wild boars, located in a livestock-intensive region near major urban centers. As part of a wild boar control program, 11 sampling campaigns were carried out between 2022 and 2023. Fecal, blood, and liver samples were systematically collected from 80 captured animals for the detection and characterization of HEV through antibody and RNA testing. Serological analysis revealed a positivity rate of 42.4%, whereas RT-qPCR detected HEV RNA in 9.1% of fecal samples and 12.5% of liver samples. From the positive samples, seven viral sequences were recovered using RT-nested PCR, including six from ORF1 and one from ORF2. Phylogenetic analysis clustered these sequences within zoonotic HEV genotype 3, showing a close relationship with human sequences from Buenos Aires and neighboring provinces. This study confirms the presence of HEV in wild boars from Argentina, highlighting the circulation of genotype 3, clade abchijklmno and the associated zoonotic risk. |
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2026 |
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2026-02-12 |
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