G4.5 Pamam Dendrimer-Risperidone: Biodistribution and Behavioral Changes in In Vivo Model

Autores
Prieto, María Jimena; del Río Zabala, Nahuel Eduardo; Marotta, Cristian Hernán; Bichara, Darío Román; Simonetta, Sergio Hernán; Chiaramoni, Nadia Silvia; Alonso, Silvia del Valle
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Dendritic polymers are considered as emerging and outstanding carriers as modern medicinal systems due to their derivatisable branched architecture and possibility to modify them in numerous ways. Here, G4.5 PAMAM dendrimers were obtained as carriers of the antipsychotic drug risperidone. Despite their extensive applicability in the pharmaceutical field, the use of dendrimers as carriers in biological systems is constrained due to their inherent associated toxicity. The biocompatibility of dendrimers and dendrimer-risperidone complexes was evaluated in vivo for biological performance. To this end, the pharmacokinetics and biodistribution after oral treatment of free risperidone and dendrimer-risperidone complexes were studied in healthy mice. Also, the behavioral changes such as locomotion, aggression, dominance in male and female mice were evaluated both after a single dose and after daily therapy for 8 days. Also, in vivo effects of risperidone and dendrimer-risperidone complexes on the locomotion of zebrafish larvae were explored. The data obtained suggest that the unmetabolized risperidone complexes increase the arrival to the brain after 90 minutes. On the other hand, behavioral studies showed an increase in the potency of the drug in animals treated with the complexes
Instituto Multidisciplinario de Biología Celular
Materia
Química
G4.5 Pamam
Locomotor
Risp
Zebrafish
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/98691
Acceder
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network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling G4.5 Pamam Dendrimer-Risperidone: Biodistribution and Behavioral Changes in In Vivo ModelPrieto, María Jimenadel Río Zabala, Nahuel EduardoMarotta, Cristian HernánBichara, Darío RománSimonetta, Sergio HernánChiaramoni, Nadia SilviaAlonso, Silvia del ValleQuímicaG4.5 PamamLocomotorRispZebrafishDendritic polymers are considered as emerging and outstanding carriers as modern medicinal systems due to their derivatisable branched architecture and possibility to modify them in numerous ways. Here, G4.5 PAMAM dendrimers were obtained as carriers of the antipsychotic drug risperidone. Despite their extensive applicability in the pharmaceutical field, the use of dendrimers as carriers in biological systems is constrained due to their inherent associated toxicity. The biocompatibility of dendrimers and dendrimer-risperidone complexes was evaluated in vivo for biological performance. To this end, the pharmacokinetics and biodistribution after oral treatment of free risperidone and dendrimer-risperidone complexes were studied in healthy mice. Also, the behavioral changes such as locomotion, aggression, dominance in male and female mice were evaluated both after a single dose and after daily therapy for 8 days. Also, in vivo effects of risperidone and dendrimer-risperidone complexes on the locomotion of zebrafish larvae were explored. The data obtained suggest that the unmetabolized risperidone complexes increase the arrival to the brain after 90 minutes. On the other hand, behavioral studies showed an increase in the potency of the drug in animals treated with the complexesInstituto Multidisciplinario de Biología Celular2013-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1000121-1000132http://sedici.unlp.edu.ar/handle/10915/98691enginfo:eu-repo/semantics/altIdentifier/url/https://ri.conicet.gov.ar/11336/24512info:eu-repo/semantics/altIdentifier/url/https://www.omicsonline.org/open-access/g-pamam-dendrimerrisperidone-biodistribution-and-behavioral-changes-in-in-vivo-model-2155-983X.1000121.php?aid=23468info:eu-repo/semantics/altIdentifier/url/https://www.longdom.org/abstract/g45-pamam-dendrimerrisperidone-biodistribution-and-behavioral-changes-in-emin-vivoem-model-20854.htmlinfo:eu-repo/semantics/altIdentifier/issn/2155-983Xinfo:eu-repo/semantics/altIdentifier/doi/10.4172/2155-983X.1000121info:eu-repo/semantics/altIdentifier/hdl/11336/24512info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-11-12T10:44:16Zoai:sedici.unlp.edu.ar:10915/98691Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-11-12 10:44:16.876SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv G4.5 Pamam Dendrimer-Risperidone: Biodistribution and Behavioral Changes in In Vivo Model
title G4.5 Pamam Dendrimer-Risperidone: Biodistribution and Behavioral Changes in In Vivo Model
spellingShingle G4.5 Pamam Dendrimer-Risperidone: Biodistribution and Behavioral Changes in In Vivo Model
Prieto, María Jimena
Química
G4.5 Pamam
Locomotor
Risp
Zebrafish
title_short G4.5 Pamam Dendrimer-Risperidone: Biodistribution and Behavioral Changes in In Vivo Model
title_full G4.5 Pamam Dendrimer-Risperidone: Biodistribution and Behavioral Changes in In Vivo Model
title_fullStr G4.5 Pamam Dendrimer-Risperidone: Biodistribution and Behavioral Changes in In Vivo Model
title_full_unstemmed G4.5 Pamam Dendrimer-Risperidone: Biodistribution and Behavioral Changes in In Vivo Model
title_sort G4.5 Pamam Dendrimer-Risperidone: Biodistribution and Behavioral Changes in In Vivo Model
dc.creator.none.fl_str_mv Prieto, María Jimena
del Río Zabala, Nahuel Eduardo
Marotta, Cristian Hernán
Bichara, Darío Román
Simonetta, Sergio Hernán
Chiaramoni, Nadia Silvia
Alonso, Silvia del Valle
author Prieto, María Jimena
author_facet Prieto, María Jimena
del Río Zabala, Nahuel Eduardo
Marotta, Cristian Hernán
Bichara, Darío Román
Simonetta, Sergio Hernán
Chiaramoni, Nadia Silvia
Alonso, Silvia del Valle
author_role author
author2 del Río Zabala, Nahuel Eduardo
Marotta, Cristian Hernán
Bichara, Darío Román
Simonetta, Sergio Hernán
Chiaramoni, Nadia Silvia
Alonso, Silvia del Valle
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Química
G4.5 Pamam
Locomotor
Risp
Zebrafish
topic Química
G4.5 Pamam
Locomotor
Risp
Zebrafish
dc.description.none.fl_txt_mv Dendritic polymers are considered as emerging and outstanding carriers as modern medicinal systems due to their derivatisable branched architecture and possibility to modify them in numerous ways. Here, G4.5 PAMAM dendrimers were obtained as carriers of the antipsychotic drug risperidone. Despite their extensive applicability in the pharmaceutical field, the use of dendrimers as carriers in biological systems is constrained due to their inherent associated toxicity. The biocompatibility of dendrimers and dendrimer-risperidone complexes was evaluated in vivo for biological performance. To this end, the pharmacokinetics and biodistribution after oral treatment of free risperidone and dendrimer-risperidone complexes were studied in healthy mice. Also, the behavioral changes such as locomotion, aggression, dominance in male and female mice were evaluated both after a single dose and after daily therapy for 8 days. Also, in vivo effects of risperidone and dendrimer-risperidone complexes on the locomotion of zebrafish larvae were explored. The data obtained suggest that the unmetabolized risperidone complexes increase the arrival to the brain after 90 minutes. On the other hand, behavioral studies showed an increase in the potency of the drug in animals treated with the complexes
Instituto Multidisciplinario de Biología Celular
description Dendritic polymers are considered as emerging and outstanding carriers as modern medicinal systems due to their derivatisable branched architecture and possibility to modify them in numerous ways. Here, G4.5 PAMAM dendrimers were obtained as carriers of the antipsychotic drug risperidone. Despite their extensive applicability in the pharmaceutical field, the use of dendrimers as carriers in biological systems is constrained due to their inherent associated toxicity. The biocompatibility of dendrimers and dendrimer-risperidone complexes was evaluated in vivo for biological performance. To this end, the pharmacokinetics and biodistribution after oral treatment of free risperidone and dendrimer-risperidone complexes were studied in healthy mice. Also, the behavioral changes such as locomotion, aggression, dominance in male and female mice were evaluated both after a single dose and after daily therapy for 8 days. Also, in vivo effects of risperidone and dendrimer-risperidone complexes on the locomotion of zebrafish larvae were explored. The data obtained suggest that the unmetabolized risperidone complexes increase the arrival to the brain after 90 minutes. On the other hand, behavioral studies showed an increase in the potency of the drug in animals treated with the complexes
publishDate 2013
dc.date.none.fl_str_mv 2013-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/98691
url http://sedici.unlp.edu.ar/handle/10915/98691
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://ri.conicet.gov.ar/11336/24512
info:eu-repo/semantics/altIdentifier/url/https://www.omicsonline.org/open-access/g-pamam-dendrimerrisperidone-biodistribution-and-behavioral-changes-in-in-vivo-model-2155-983X.1000121.php?aid=23468
info:eu-repo/semantics/altIdentifier/url/https://www.longdom.org/abstract/g45-pamam-dendrimerrisperidone-biodistribution-and-behavioral-changes-in-emin-vivoem-model-20854.html
info:eu-repo/semantics/altIdentifier/issn/2155-983X
info:eu-repo/semantics/altIdentifier/doi/10.4172/2155-983X.1000121
info:eu-repo/semantics/altIdentifier/hdl/11336/24512
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
1000121-1000132
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
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repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
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