The Evolutionary History of The Orexin/Allatotropin GPCR Family : From Placozoa and Cnidaria to Vertebrata

Autores
Alzugaray, María Eugenia; Bruno, María Cecilia; Villalobos Sambucaro, María José; Ronderos, Jorge Rafael
Año de publicación
2019
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Peptidic messengers constitute a highly diversifed group of intercellular messengers widely distributed in nature that regulate a great number of physiological processes in Metazoa. Being crucial for life, it seem that they have appeared in the ancestral group from which Metazoa evolved, and were highly conserved along the evolutionary process. Peptides act mainly through G-protein coupled receptors (GPCRs), a family of transmembrane molecules. GPCRs are also widely distributed in nature being present in metazoan, but also in Choanofagellata and Fungi. Among GPCRs, the Allatotropin/Orexin (AT/Ox) family is particularly characterized by the presence of the DRW motif in the second intracellular loop (IC Loop 2), and seems to be present in Cnidaria, Placozoa and in Bilateria, suggesting that it was present in the common ancestor of Metazoa. Looking for the evolutionary history of this GPCRs we searched for corresponding sequences in public databases. Our results suggest that AT/Ox receptors were highly conserved along evolutionary process, and that they are characterized by the presence of the E/DRWYAI motif at the IC Loop 2. Phylogenetic analyses show that AT/Ox family of receptors refects evolutionary relationships that agree with current phylogenetic understanding in Actinopterygii and Sauropsida, including also the largely discussed position of Testudines.
Facultad de Ciencias Naturales y Museo
Materia
Ciencias Naturales
Intercellular messengers
Allatotropin/Orexin
GPCR family
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/107737
Acceder
id SEDICI_7b41d6514836fbeaaf817d6393b18f2a
oai_identifier_str oai:sedici.unlp.edu.ar:10915/107737
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling The Evolutionary History of The Orexin/Allatotropin GPCR Family : From Placozoa and Cnidaria to VertebrataAlzugaray, María EugeniaBruno, María CeciliaVillalobos Sambucaro, María JoséRonderos, Jorge RafaelCiencias NaturalesIntercellular messengersAllatotropin/OrexinGPCR familyPeptidic messengers constitute a highly diversifed group of intercellular messengers widely distributed in nature that regulate a great number of physiological processes in Metazoa. Being crucial for life, it seem that they have appeared in the ancestral group from which Metazoa evolved, and were highly conserved along the evolutionary process. Peptides act mainly through G-protein coupled receptors (GPCRs), a family of transmembrane molecules. GPCRs are also widely distributed in nature being present in metazoan, but also in Choanofagellata and Fungi. Among GPCRs, the Allatotropin/Orexin (AT/Ox) family is particularly characterized by the presence of the DRW motif in the second intracellular loop (IC Loop 2), and seems to be present in Cnidaria, Placozoa and in Bilateria, suggesting that it was present in the common ancestor of Metazoa. Looking for the evolutionary history of this GPCRs we searched for corresponding sequences in public databases. Our results suggest that AT/Ox receptors were highly conserved along evolutionary process, and that they are characterized by the presence of the E/DRWYAI motif at the IC Loop 2. Phylogenetic analyses show that AT/Ox family of receptors refects evolutionary relationships that agree with current phylogenetic understanding in Actinopterygii and Sauropsida, including also the largely discussed position of Testudines.Facultad de Ciencias Naturales y Museo2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/107737spainfo:eu-repo/semantics/altIdentifier/url/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6629687&blobtype=pdfinfo:eu-repo/semantics/altIdentifier/issn/2045-2322info:eu-repo/semantics/altIdentifier/pmid/31308431info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-019-46712-9info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-22T17:04:43Zoai:sedici.unlp.edu.ar:10915/107737Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-22 17:04:43.529SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv The Evolutionary History of The Orexin/Allatotropin GPCR Family : From Placozoa and Cnidaria to Vertebrata
title The Evolutionary History of The Orexin/Allatotropin GPCR Family : From Placozoa and Cnidaria to Vertebrata
spellingShingle The Evolutionary History of The Orexin/Allatotropin GPCR Family : From Placozoa and Cnidaria to Vertebrata
Alzugaray, María Eugenia
Ciencias Naturales
Intercellular messengers
Allatotropin/Orexin
GPCR family
title_short The Evolutionary History of The Orexin/Allatotropin GPCR Family : From Placozoa and Cnidaria to Vertebrata
title_full The Evolutionary History of The Orexin/Allatotropin GPCR Family : From Placozoa and Cnidaria to Vertebrata
title_fullStr The Evolutionary History of The Orexin/Allatotropin GPCR Family : From Placozoa and Cnidaria to Vertebrata
title_full_unstemmed The Evolutionary History of The Orexin/Allatotropin GPCR Family : From Placozoa and Cnidaria to Vertebrata
title_sort The Evolutionary History of The Orexin/Allatotropin GPCR Family : From Placozoa and Cnidaria to Vertebrata
dc.creator.none.fl_str_mv Alzugaray, María Eugenia
Bruno, María Cecilia
Villalobos Sambucaro, María José
Ronderos, Jorge Rafael
author Alzugaray, María Eugenia
author_facet Alzugaray, María Eugenia
Bruno, María Cecilia
Villalobos Sambucaro, María José
Ronderos, Jorge Rafael
author_role author
author2 Bruno, María Cecilia
Villalobos Sambucaro, María José
Ronderos, Jorge Rafael
author2_role author
author
author
dc.subject.none.fl_str_mv Ciencias Naturales
Intercellular messengers
Allatotropin/Orexin
GPCR family
topic Ciencias Naturales
Intercellular messengers
Allatotropin/Orexin
GPCR family
dc.description.none.fl_txt_mv Peptidic messengers constitute a highly diversifed group of intercellular messengers widely distributed in nature that regulate a great number of physiological processes in Metazoa. Being crucial for life, it seem that they have appeared in the ancestral group from which Metazoa evolved, and were highly conserved along the evolutionary process. Peptides act mainly through G-protein coupled receptors (GPCRs), a family of transmembrane molecules. GPCRs are also widely distributed in nature being present in metazoan, but also in Choanofagellata and Fungi. Among GPCRs, the Allatotropin/Orexin (AT/Ox) family is particularly characterized by the presence of the DRW motif in the second intracellular loop (IC Loop 2), and seems to be present in Cnidaria, Placozoa and in Bilateria, suggesting that it was present in the common ancestor of Metazoa. Looking for the evolutionary history of this GPCRs we searched for corresponding sequences in public databases. Our results suggest that AT/Ox receptors were highly conserved along evolutionary process, and that they are characterized by the presence of the E/DRWYAI motif at the IC Loop 2. Phylogenetic analyses show that AT/Ox family of receptors refects evolutionary relationships that agree with current phylogenetic understanding in Actinopterygii and Sauropsida, including also the largely discussed position of Testudines.
Facultad de Ciencias Naturales y Museo
description Peptidic messengers constitute a highly diversifed group of intercellular messengers widely distributed in nature that regulate a great number of physiological processes in Metazoa. Being crucial for life, it seem that they have appeared in the ancestral group from which Metazoa evolved, and were highly conserved along the evolutionary process. Peptides act mainly through G-protein coupled receptors (GPCRs), a family of transmembrane molecules. GPCRs are also widely distributed in nature being present in metazoan, but also in Choanofagellata and Fungi. Among GPCRs, the Allatotropin/Orexin (AT/Ox) family is particularly characterized by the presence of the DRW motif in the second intracellular loop (IC Loop 2), and seems to be present in Cnidaria, Placozoa and in Bilateria, suggesting that it was present in the common ancestor of Metazoa. Looking for the evolutionary history of this GPCRs we searched for corresponding sequences in public databases. Our results suggest that AT/Ox receptors were highly conserved along evolutionary process, and that they are characterized by the presence of the E/DRWYAI motif at the IC Loop 2. Phylogenetic analyses show that AT/Ox family of receptors refects evolutionary relationships that agree with current phylogenetic understanding in Actinopterygii and Sauropsida, including also the largely discussed position of Testudines.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/107737
url http://sedici.unlp.edu.ar/handle/10915/107737
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6629687&blobtype=pdf
info:eu-repo/semantics/altIdentifier/issn/2045-2322
info:eu-repo/semantics/altIdentifier/pmid/31308431
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-019-46712-9
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
_version_ 1846783324097347584
score 12.982451

Publicaciones similares