The Evolutionary History of The Orexin/Allatotropin GPCR Family: From Placozoa and Cnidaria to Vertebrata

Autores
Alzugaray, Maria Eugenia; Bruno, María Cecilia; Villalobos Sambucaro, María José; Ronderos, Jorge Rafael
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Peptidic messengers constitute a highly diversified group of intercellular messengers widely distributedin nature that regulate a great number of physiological processes in Metazoa. Being crucial for life, itseem that they have appeared in the ancestral group from which Metazoa evolved, and were highlyconserved along the evolutionary process. Peptides act mainly through G-protein coupled receptors(GPCRs), a family of transmembrane molecules. GPCRs are also widely distributed in nature beingpresent in metazoan, but also in Choanoflagellata and Fungi. Among GPCRs, the Allatotropin/Orexin(AT/Ox) family is particularly characterized by the presence of the DRW motif in the second intracellularloop (IC Loop 2), and seems to be present in Cnidaria, Placozoa and in Bilateria, suggesting that it waspresent in the common ancestor of Metazoa. Looking for the evolutionary history of this GPCRs wesearched for corresponding sequences in public databases. Our results suggest that AT/Ox receptorswere highly conserved along evolutionary process, and that they are characterized by the presenceof the E/DRWYAI motif at the IC Loop 2. Phylogenetic analyses show that AT/Ox family of receptorsreflects evolutionary relationships that agree with current phylogenetic understanding in Actinopterygiiand Sauropsida, including also the largely discussed position of Testudines
Fil: Alzugaray, Maria Eugenia. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Cátedra de Histología y Embriología Animal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Bruno, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Cátedra de Histología y Embriología Animal; Argentina
Fil: Villalobos Sambucaro, María José. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Cátedra de Histología y Embriología Animal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Ronderos, Jorge Rafael. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Cátedra de Histología y Embriología Animal; Argentina
Materia
Allatotropin
Orexin
Evolution
GPCR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/103354
Acceder
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network_name_str CONICET Digital (CONICET)
spelling The Evolutionary History of The Orexin/Allatotropin GPCR Family: From Placozoa and Cnidaria to VertebrataAlzugaray, Maria EugeniaBruno, María CeciliaVillalobos Sambucaro, María JoséRonderos, Jorge RafaelAllatotropinOrexinEvolutionGPCRhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Peptidic messengers constitute a highly diversified group of intercellular messengers widely distributedin nature that regulate a great number of physiological processes in Metazoa. Being crucial for life, itseem that they have appeared in the ancestral group from which Metazoa evolved, and were highlyconserved along the evolutionary process. Peptides act mainly through G-protein coupled receptors(GPCRs), a family of transmembrane molecules. GPCRs are also widely distributed in nature beingpresent in metazoan, but also in Choanoflagellata and Fungi. Among GPCRs, the Allatotropin/Orexin(AT/Ox) family is particularly characterized by the presence of the DRW motif in the second intracellularloop (IC Loop 2), and seems to be present in Cnidaria, Placozoa and in Bilateria, suggesting that it waspresent in the common ancestor of Metazoa. Looking for the evolutionary history of this GPCRs wesearched for corresponding sequences in public databases. Our results suggest that AT/Ox receptorswere highly conserved along evolutionary process, and that they are characterized by the presenceof the E/DRWYAI motif at the IC Loop 2. Phylogenetic analyses show that AT/Ox family of receptorsreflects evolutionary relationships that agree with current phylogenetic understanding in Actinopterygiiand Sauropsida, including also the largely discussed position of TestudinesFil: Alzugaray, Maria Eugenia. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Cátedra de Histología y Embriología Animal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Bruno, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Cátedra de Histología y Embriología Animal; ArgentinaFil: Villalobos Sambucaro, María José. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Cátedra de Histología y Embriología Animal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Ronderos, Jorge Rafael. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Cátedra de Histología y Embriología Animal; ArgentinaNature Research2019-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/103354Alzugaray, Maria Eugenia; Bruno, María Cecilia; Villalobos Sambucaro, María José; Ronderos, Jorge Rafael; The Evolutionary History of The Orexin/Allatotropin GPCR Family: From Placozoa and Cnidaria to Vertebrata; Nature Research; Scientific Reports; 9; 7-2019; 1-112045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-019-46712-9info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-019-46712-9info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:57:46Zoai:ri.conicet.gov.ar:11336/103354instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:57:46.355CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Evolutionary History of The Orexin/Allatotropin GPCR Family: From Placozoa and Cnidaria to Vertebrata
title The Evolutionary History of The Orexin/Allatotropin GPCR Family: From Placozoa and Cnidaria to Vertebrata
spellingShingle The Evolutionary History of The Orexin/Allatotropin GPCR Family: From Placozoa and Cnidaria to Vertebrata
Alzugaray, Maria Eugenia
Allatotropin
Orexin
Evolution
GPCR
title_short The Evolutionary History of The Orexin/Allatotropin GPCR Family: From Placozoa and Cnidaria to Vertebrata
title_full The Evolutionary History of The Orexin/Allatotropin GPCR Family: From Placozoa and Cnidaria to Vertebrata
title_fullStr The Evolutionary History of The Orexin/Allatotropin GPCR Family: From Placozoa and Cnidaria to Vertebrata
title_full_unstemmed The Evolutionary History of The Orexin/Allatotropin GPCR Family: From Placozoa and Cnidaria to Vertebrata
title_sort The Evolutionary History of The Orexin/Allatotropin GPCR Family: From Placozoa and Cnidaria to Vertebrata
dc.creator.none.fl_str_mv Alzugaray, Maria Eugenia
Bruno, María Cecilia
Villalobos Sambucaro, María José
Ronderos, Jorge Rafael
author Alzugaray, Maria Eugenia
author_facet Alzugaray, Maria Eugenia
Bruno, María Cecilia
Villalobos Sambucaro, María José
Ronderos, Jorge Rafael
author_role author
author2 Bruno, María Cecilia
Villalobos Sambucaro, María José
Ronderos, Jorge Rafael
author2_role author
author
author
dc.subject.none.fl_str_mv Allatotropin
Orexin
Evolution
GPCR
topic Allatotropin
Orexin
Evolution
GPCR
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Peptidic messengers constitute a highly diversified group of intercellular messengers widely distributedin nature that regulate a great number of physiological processes in Metazoa. Being crucial for life, itseem that they have appeared in the ancestral group from which Metazoa evolved, and were highlyconserved along the evolutionary process. Peptides act mainly through G-protein coupled receptors(GPCRs), a family of transmembrane molecules. GPCRs are also widely distributed in nature beingpresent in metazoan, but also in Choanoflagellata and Fungi. Among GPCRs, the Allatotropin/Orexin(AT/Ox) family is particularly characterized by the presence of the DRW motif in the second intracellularloop (IC Loop 2), and seems to be present in Cnidaria, Placozoa and in Bilateria, suggesting that it waspresent in the common ancestor of Metazoa. Looking for the evolutionary history of this GPCRs wesearched for corresponding sequences in public databases. Our results suggest that AT/Ox receptorswere highly conserved along evolutionary process, and that they are characterized by the presenceof the E/DRWYAI motif at the IC Loop 2. Phylogenetic analyses show that AT/Ox family of receptorsreflects evolutionary relationships that agree with current phylogenetic understanding in Actinopterygiiand Sauropsida, including also the largely discussed position of Testudines
Fil: Alzugaray, Maria Eugenia. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Cátedra de Histología y Embriología Animal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Bruno, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Cátedra de Histología y Embriología Animal; Argentina
Fil: Villalobos Sambucaro, María José. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Cátedra de Histología y Embriología Animal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Ronderos, Jorge Rafael. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Cátedra de Histología y Embriología Animal; Argentina
description Peptidic messengers constitute a highly diversified group of intercellular messengers widely distributedin nature that regulate a great number of physiological processes in Metazoa. Being crucial for life, itseem that they have appeared in the ancestral group from which Metazoa evolved, and were highlyconserved along the evolutionary process. Peptides act mainly through G-protein coupled receptors(GPCRs), a family of transmembrane molecules. GPCRs are also widely distributed in nature beingpresent in metazoan, but also in Choanoflagellata and Fungi. Among GPCRs, the Allatotropin/Orexin(AT/Ox) family is particularly characterized by the presence of the DRW motif in the second intracellularloop (IC Loop 2), and seems to be present in Cnidaria, Placozoa and in Bilateria, suggesting that it waspresent in the common ancestor of Metazoa. Looking for the evolutionary history of this GPCRs wesearched for corresponding sequences in public databases. Our results suggest that AT/Ox receptorswere highly conserved along evolutionary process, and that they are characterized by the presenceof the E/DRWYAI motif at the IC Loop 2. Phylogenetic analyses show that AT/Ox family of receptorsreflects evolutionary relationships that agree with current phylogenetic understanding in Actinopterygiiand Sauropsida, including also the largely discussed position of Testudines
publishDate 2019
dc.date.none.fl_str_mv 2019-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/103354
Alzugaray, Maria Eugenia; Bruno, María Cecilia; Villalobos Sambucaro, María José; Ronderos, Jorge Rafael; The Evolutionary History of The Orexin/Allatotropin GPCR Family: From Placozoa and Cnidaria to Vertebrata; Nature Research; Scientific Reports; 9; 7-2019; 1-11
2045-2322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/103354
identifier_str_mv Alzugaray, Maria Eugenia; Bruno, María Cecilia; Villalobos Sambucaro, María José; Ronderos, Jorge Rafael; The Evolutionary History of The Orexin/Allatotropin GPCR Family: From Placozoa and Cnidaria to Vertebrata; Nature Research; Scientific Reports; 9; 7-2019; 1-11
2045-2322
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-019-46712-9
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-019-46712-9
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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