Triterpenic Acids and Flavonoids from Satureja parvifolia: Evaluation of their Antiprotozoal Activity

Autores
van Baren, Catalina; Martino, Virginia S.; Di Leo Lira, Paola; Anao, Ivie; Houghton, Peter; Debenedetti, Silvia Laura; Croft, Simon
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Bioassay-guided fractionation of a Satureja parvifolia MeOH extract led to the isolation of eriodictyol, luteolin and ursolic and oleanolic acids as its active components against Plasmodium falciparum K1. This is the first time these compounds are reported as constituents of S. parvifolia. Ursolic acid showed an IC50 of 4.9,Mg/ml, luteolin 6.4,μg/ml, oleanolic acid 9.3,μg/ml and eriodictyol 17.2,μg/ml. Antiplasmodial activity of eriodictyol and luteolin is reported here for the first time. Besides, the four compounds showed activity against P falciparum 3D7 strain and Trypanosoma brucei rhodesiense. Eriodictyol showed moderate activity on all the parasites but was the most selective compound as a result of its rather low cytotoxicity (IC50 174.2,μg/ml) on the mammalian KB cell line.
Facultad de Ciencias Exactas
Materia
Farmacia
Antiprotozoal Compounds
Satureja parvifolia
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/83257
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/83257
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Triterpenic Acids and Flavonoids from Satureja parvifolia: Evaluation of their Antiprotozoal Activityvan Baren, CatalinaMartino, Virginia S.Di Leo Lira, PaolaAnao, IvieHoughton, PeterDebenedetti, Silvia LauraCroft, SimonFarmaciaAntiprotozoal CompoundsSatureja parvifoliaBioassay-guided fractionation of a Satureja parvifolia MeOH extract led to the isolation of eriodictyol, luteolin and ursolic and oleanolic acids as its active components against Plasmodium falciparum K1. This is the first time these compounds are reported as constituents of S. parvifolia. Ursolic acid showed an IC50 of 4.9,Mg/ml, luteolin 6.4,μg/ml, oleanolic acid 9.3,μg/ml and eriodictyol 17.2,μg/ml. Antiplasmodial activity of eriodictyol and luteolin is reported here for the first time. Besides, the four compounds showed activity against P falciparum 3D7 strain and Trypanosoma brucei rhodesiense. Eriodictyol showed moderate activity on all the parasites but was the most selective compound as a result of its rather low cytotoxicity (IC50 174.2,μg/ml) on the mammalian KB cell line.Facultad de Ciencias Exactas2006info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf189-192http://sedici.unlp.edu.ar/handle/10915/83257enginfo:eu-repo/semantics/altIdentifier/issn/0939-5075info:eu-repo/semantics/altIdentifier/doi/10.1515/znc-2006-3-406info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:15:46Zoai:sedici.unlp.edu.ar:10915/83257Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:15:46.838SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Triterpenic Acids and Flavonoids from Satureja parvifolia: Evaluation of their Antiprotozoal Activity
title Triterpenic Acids and Flavonoids from Satureja parvifolia: Evaluation of their Antiprotozoal Activity
spellingShingle Triterpenic Acids and Flavonoids from Satureja parvifolia: Evaluation of their Antiprotozoal Activity
van Baren, Catalina
Farmacia
Antiprotozoal Compounds
Satureja parvifolia
title_short Triterpenic Acids and Flavonoids from Satureja parvifolia: Evaluation of their Antiprotozoal Activity
title_full Triterpenic Acids and Flavonoids from Satureja parvifolia: Evaluation of their Antiprotozoal Activity
title_fullStr Triterpenic Acids and Flavonoids from Satureja parvifolia: Evaluation of their Antiprotozoal Activity
title_full_unstemmed Triterpenic Acids and Flavonoids from Satureja parvifolia: Evaluation of their Antiprotozoal Activity
title_sort Triterpenic Acids and Flavonoids from Satureja parvifolia: Evaluation of their Antiprotozoal Activity
dc.creator.none.fl_str_mv van Baren, Catalina
Martino, Virginia S.
Di Leo Lira, Paola
Anao, Ivie
Houghton, Peter
Debenedetti, Silvia Laura
Croft, Simon
author van Baren, Catalina
author_facet van Baren, Catalina
Martino, Virginia S.
Di Leo Lira, Paola
Anao, Ivie
Houghton, Peter
Debenedetti, Silvia Laura
Croft, Simon
author_role author
author2 Martino, Virginia S.
Di Leo Lira, Paola
Anao, Ivie
Houghton, Peter
Debenedetti, Silvia Laura
Croft, Simon
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Farmacia
Antiprotozoal Compounds
Satureja parvifolia
topic Farmacia
Antiprotozoal Compounds
Satureja parvifolia
dc.description.none.fl_txt_mv Bioassay-guided fractionation of a Satureja parvifolia MeOH extract led to the isolation of eriodictyol, luteolin and ursolic and oleanolic acids as its active components against Plasmodium falciparum K1. This is the first time these compounds are reported as constituents of S. parvifolia. Ursolic acid showed an IC50 of 4.9,Mg/ml, luteolin 6.4,μg/ml, oleanolic acid 9.3,μg/ml and eriodictyol 17.2,μg/ml. Antiplasmodial activity of eriodictyol and luteolin is reported here for the first time. Besides, the four compounds showed activity against P falciparum 3D7 strain and Trypanosoma brucei rhodesiense. Eriodictyol showed moderate activity on all the parasites but was the most selective compound as a result of its rather low cytotoxicity (IC50 174.2,μg/ml) on the mammalian KB cell line.
Facultad de Ciencias Exactas
description Bioassay-guided fractionation of a Satureja parvifolia MeOH extract led to the isolation of eriodictyol, luteolin and ursolic and oleanolic acids as its active components against Plasmodium falciparum K1. This is the first time these compounds are reported as constituents of S. parvifolia. Ursolic acid showed an IC50 of 4.9,Mg/ml, luteolin 6.4,μg/ml, oleanolic acid 9.3,μg/ml and eriodictyol 17.2,μg/ml. Antiplasmodial activity of eriodictyol and luteolin is reported here for the first time. Besides, the four compounds showed activity against P falciparum 3D7 strain and Trypanosoma brucei rhodesiense. Eriodictyol showed moderate activity on all the parasites but was the most selective compound as a result of its rather low cytotoxicity (IC50 174.2,μg/ml) on the mammalian KB cell line.
publishDate 2006
dc.date.none.fl_str_mv 2006
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/83257
url http://sedici.unlp.edu.ar/handle/10915/83257
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0939-5075
info:eu-repo/semantics/altIdentifier/doi/10.1515/znc-2006-3-406
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
189-192
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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