How Can Network-Pharmacology Contribute to Antiepileptic Drug Development?

Autores
Di Ianni, Mauricio Emiliano; Talevi, Alan
Año de publicación
2014
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Network-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant magic bullet paradigm which proposed the search of exquisitely selective drugs. What is more, drug targets are often involved in multiple diseases and frequently present co-expression patterns. Therefore, useful therapeutic information can be drawn from network representations of drug targets. Here, we discuss potential applications of drug-target networks in the field of antiepileptic drug development.
Facultad de Ciencias Exactas
Materia
Ciencias Exactas
Química
Biología
Drug-protein networks
Network analysis
Epilepsy
Drug repositioning
Drug repurposing
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/102558
Acceder
id SEDICI_fad9bf38fb29d71817f5b1d34f80a349
oai_identifier_str oai:sedici.unlp.edu.ar:10915/102558
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling How Can Network-Pharmacology Contribute to Antiepileptic Drug Development?Di Ianni, Mauricio EmilianoTalevi, AlanCiencias ExactasQuímicaBiologíaDrug-protein networksNetwork analysisEpilepsyDrug repositioningDrug repurposingNetwork-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant <i>magic bullet</i> paradigm which proposed the search of exquisitely selective drugs. What is more, drug targets are often involved in multiple diseases and frequently present co-expression patterns. Therefore, useful therapeutic information can be drawn from network representations of drug targets. Here, we discuss potential applications of drug-target networks in the field of antiepileptic drug development.Facultad de Ciencias Exactas2014-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf21-28http://sedici.unlp.edu.ar/handle/10915/102558spainfo:eu-repo/semantics/altIdentifier/url/https://ri.conicet.gov.ar/11336/31186info:eu-repo/semantics/altIdentifier/url/https://www.smartscitech.com/index.php/MCE/article/view/922info:eu-repo/semantics/altIdentifier/issn/2330-3883info:eu-repo/semantics/altIdentifier/hdl/11336/31186info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T10:52:16Zoai:sedici.unlp.edu.ar:10915/102558Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 10:52:16.341SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv How Can Network-Pharmacology Contribute to Antiepileptic Drug Development?
title How Can Network-Pharmacology Contribute to Antiepileptic Drug Development?
spellingShingle How Can Network-Pharmacology Contribute to Antiepileptic Drug Development?
Di Ianni, Mauricio Emiliano
Ciencias Exactas
Química
Biología
Drug-protein networks
Network analysis
Epilepsy
Drug repositioning
Drug repurposing
title_short How Can Network-Pharmacology Contribute to Antiepileptic Drug Development?
title_full How Can Network-Pharmacology Contribute to Antiepileptic Drug Development?
title_fullStr How Can Network-Pharmacology Contribute to Antiepileptic Drug Development?
title_full_unstemmed How Can Network-Pharmacology Contribute to Antiepileptic Drug Development?
title_sort How Can Network-Pharmacology Contribute to Antiepileptic Drug Development?
dc.creator.none.fl_str_mv Di Ianni, Mauricio Emiliano
Talevi, Alan
author Di Ianni, Mauricio Emiliano
author_facet Di Ianni, Mauricio Emiliano
Talevi, Alan
author_role author
author2 Talevi, Alan
author2_role author
dc.subject.none.fl_str_mv Ciencias Exactas
Química
Biología
Drug-protein networks
Network analysis
Epilepsy
Drug repositioning
Drug repurposing
topic Ciencias Exactas
Química
Biología
Drug-protein networks
Network analysis
Epilepsy
Drug repositioning
Drug repurposing
dc.description.none.fl_txt_mv Network-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant <i>magic bullet</i> paradigm which proposed the search of exquisitely selective drugs. What is more, drug targets are often involved in multiple diseases and frequently present co-expression patterns. Therefore, useful therapeutic information can be drawn from network representations of drug targets. Here, we discuss potential applications of drug-target networks in the field of antiepileptic drug development.
Facultad de Ciencias Exactas
description Network-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant <i>magic bullet</i> paradigm which proposed the search of exquisitely selective drugs. What is more, drug targets are often involved in multiple diseases and frequently present co-expression patterns. Therefore, useful therapeutic information can be drawn from network representations of drug targets. Here, we discuss potential applications of drug-target networks in the field of antiepileptic drug development.
publishDate 2014
dc.date.none.fl_str_mv 2014-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/102558
url http://sedici.unlp.edu.ar/handle/10915/102558
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://ri.conicet.gov.ar/11336/31186
info:eu-repo/semantics/altIdentifier/url/https://www.smartscitech.com/index.php/MCE/article/view/922
info:eu-repo/semantics/altIdentifier/issn/2330-3883
info:eu-repo/semantics/altIdentifier/hdl/11336/31186
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
21-28
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
_version_ 1842260404243267584
score 13.13397

Publicaciones similares