Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative

Autores
Feng, Ye; Chiu, Cheng-Hsun; Heininger, Ulrich; Hozbor, Daniela Flavia; Tan, Tina Q.; Wirsing von König, Carl-Heinz
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Whooping cough, or pertussis, is a highly communicable infectious disease caused by the bacterium Bordetella pertussis. Vaccination once reduced the incidence of the disease, but a global resurgence of the infection happened during the past two decades, likely due to the waning immunity of vaccination. Macrolides such as erythromycin and azithromycin are the drugs of primary choice for treatment. In this personal view, we call for attention to macrolide-resistant B. pertussis (MRBP), which has emerged and prevailed in mainland China for years and are exclusively mediated by mutations in the 23S rRNA gene. Whether the prevalence of MRBP in China results from overuse of azithromycin in clinical medicine remains unknown. The incidence of MRBP is low in other countries, but this could be a technical illusion since China employs culture as the mainstream diagnostic method whereas nucleic-acid amplification test being widely used in other countries fail to test antimicrobial susceptibility. Given the increasingly frequent global travel that facilitates microbial transmission worldwide, there is a pressing need to perform international surveillance on MRBP to prevent the potential circulation of the organism. Finding alternative agents that possess good activity against B. pertussis is also urgently required.
Instituto de Biotecnologia y Biologia Molecular
Materia
Biología
Pertussis
Macrolide
Resistance
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-nd/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/128427

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spelling Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiativeFeng, YeChiu, Cheng-HsunHeininger, UlrichHozbor, Daniela FlaviaTan, Tina Q.Wirsing von König, Carl-HeinzBiologíaPertussisMacrolideResistanceWhooping cough, or pertussis, is a highly communicable infectious disease caused by the bacterium Bordetella pertussis. Vaccination once reduced the incidence of the disease, but a global resurgence of the infection happened during the past two decades, likely due to the waning immunity of vaccination. Macrolides such as erythromycin and azithromycin are the drugs of primary choice for treatment. In this personal view, we call for attention to macrolide-resistant B. pertussis (MRBP), which has emerged and prevailed in mainland China for years and are exclusively mediated by mutations in the 23S rRNA gene. Whether the prevalence of MRBP in China results from overuse of azithromycin in clinical medicine remains unknown. The incidence of MRBP is low in other countries, but this could be a technical illusion since China employs culture as the mainstream diagnostic method whereas nucleic-acid amplification test being widely used in other countries fail to test antimicrobial susceptibility. Given the increasingly frequent global travel that facilitates microbial transmission worldwide, there is a pressing need to perform international surveillance on MRBP to prevent the potential circulation of the organism. Finding alternative agents that possess good activity against B. pertussis is also urgently required.Instituto de Biotecnologia y Biologia Molecular2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/128427enginfo:eu-repo/semantics/altIdentifier/issn/2666-6065info:eu-repo/semantics/altIdentifier/doi/10.1016/j.lanwpc.2021.100098info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:30:57Zoai:sedici.unlp.edu.ar:10915/128427Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:30:57.943SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative
title Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative
spellingShingle Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative
Feng, Ye
Biología
Pertussis
Macrolide
Resistance
title_short Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative
title_full Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative
title_fullStr Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative
title_full_unstemmed Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative
title_sort Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative
dc.creator.none.fl_str_mv Feng, Ye
Chiu, Cheng-Hsun
Heininger, Ulrich
Hozbor, Daniela Flavia
Tan, Tina Q.
Wirsing von König, Carl-Heinz
author Feng, Ye
author_facet Feng, Ye
Chiu, Cheng-Hsun
Heininger, Ulrich
Hozbor, Daniela Flavia
Tan, Tina Q.
Wirsing von König, Carl-Heinz
author_role author
author2 Chiu, Cheng-Hsun
Heininger, Ulrich
Hozbor, Daniela Flavia
Tan, Tina Q.
Wirsing von König, Carl-Heinz
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Biología
Pertussis
Macrolide
Resistance
topic Biología
Pertussis
Macrolide
Resistance
dc.description.none.fl_txt_mv Whooping cough, or pertussis, is a highly communicable infectious disease caused by the bacterium Bordetella pertussis. Vaccination once reduced the incidence of the disease, but a global resurgence of the infection happened during the past two decades, likely due to the waning immunity of vaccination. Macrolides such as erythromycin and azithromycin are the drugs of primary choice for treatment. In this personal view, we call for attention to macrolide-resistant B. pertussis (MRBP), which has emerged and prevailed in mainland China for years and are exclusively mediated by mutations in the 23S rRNA gene. Whether the prevalence of MRBP in China results from overuse of azithromycin in clinical medicine remains unknown. The incidence of MRBP is low in other countries, but this could be a technical illusion since China employs culture as the mainstream diagnostic method whereas nucleic-acid amplification test being widely used in other countries fail to test antimicrobial susceptibility. Given the increasingly frequent global travel that facilitates microbial transmission worldwide, there is a pressing need to perform international surveillance on MRBP to prevent the potential circulation of the organism. Finding alternative agents that possess good activity against B. pertussis is also urgently required.
Instituto de Biotecnologia y Biologia Molecular
description Whooping cough, or pertussis, is a highly communicable infectious disease caused by the bacterium Bordetella pertussis. Vaccination once reduced the incidence of the disease, but a global resurgence of the infection happened during the past two decades, likely due to the waning immunity of vaccination. Macrolides such as erythromycin and azithromycin are the drugs of primary choice for treatment. In this personal view, we call for attention to macrolide-resistant B. pertussis (MRBP), which has emerged and prevailed in mainland China for years and are exclusively mediated by mutations in the 23S rRNA gene. Whether the prevalence of MRBP in China results from overuse of azithromycin in clinical medicine remains unknown. The incidence of MRBP is low in other countries, but this could be a technical illusion since China employs culture as the mainstream diagnostic method whereas nucleic-acid amplification test being widely used in other countries fail to test antimicrobial susceptibility. Given the increasingly frequent global travel that facilitates microbial transmission worldwide, there is a pressing need to perform international surveillance on MRBP to prevent the potential circulation of the organism. Finding alternative agents that possess good activity against B. pertussis is also urgently required.
publishDate 2021
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
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