Vaccination in Pregnancy against Pertussis: A Consensus Statement on Behalf of the Global Pertussis Initiative

Autores
Abu Raya, Bahaa; Forsyth, Kevin; Halperin, Scott A.; Maertens, Kirsten; Jones, Christine E.; Heininger, Ulrich; Hozbor, Daniela Flavia; Heinz Wirsing von König, Carl; Chitkara, Amar J.; Muloiwa, Rudzani; Tan, Tina Q.
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Vaccination against pertussis in pregnancy is safe for pregnant women and newborns. Vaccination against pertussis during the second or early third trimester of pregnancy is highly protective against pertussis in young infants. Vaccination early in the third trimester versus vaccination late in the third trimester is associated with higher newborn anti-B. pertussis antibody levels. Infants whose mothers were vaccinated in pregnancy have less boosting of anti-B. pertussis antibody concentrations after their own vaccination, but this is not clinically significant. More immunogenicity and vaccine effectiveness studies are needed in countries using whole-cell pertussis vaccines. Vaccination in pregnancy induces anti-B. pertussis antibodies in breast milk. COVID-19 mitigation strategies have resulted in a significant decrease in B. pertussis circulation, which could negatively affect population immunity against B. pertussis. Highlights: Infants are at high risk for severe morbidity and mortality from pertussis disease during early infancy. Vaccination against pertussis in pregnancy has emerged as the ideal strategy to protect infants during these early, vulnerable, first months of life. On 30 November and 1 December 2021, the Global Pertussis Initiative held a meeting that aimed to discuss and review the most up-to-date scientific literature supporting vaccination against pertussis in pregnancy and outstanding scientific questions. Herein, we review the current and historically published literature and summarize the findings as consensus statements on vaccination against pertussis in pregnancy on behalf of the Global Pertussis Initiative.
Fil: Abu Raya, Bahaa. University of British Columbia; Canadá
Fil: Forsyth, Kevin. Flinders University.; Australia
Fil: Halperin, Scott A.. Dalhousie University Halifax; Canadá
Fil: Maertens, Kirsten. Universiteit Antwerp; Bélgica
Fil: Jones, Christine E.. University of Southampton; Reino Unido
Fil: Heininger, Ulrich. University of Basel Children’s Hospital; Suiza
Fil: Hozbor, Daniela Flavia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; Argentina
Fil: Heinz Wirsing von König, Carl. No especifíca;
Fil: Chitkara, Amar J.. Max Super Speciality Hospital; India
Fil: Muloiwa, Rudzani. University of Cape Town; Sudáfrica
Fil: Tan, Tina Q.. Northwestern University; Estados Unidos
Materia
GLOBAL PERTUSSIS INITIATIVE
IMMUNITY
PERTUSSIS
PREGNANCY
PROTECTION
VACCINATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/214363
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/214363
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Vaccination in Pregnancy against Pertussis: A Consensus Statement on Behalf of the Global Pertussis InitiativeAbu Raya, BahaaForsyth, KevinHalperin, Scott A.Maertens, KirstenJones, Christine E.Heininger, UlrichHozbor, Daniela FlaviaHeinz Wirsing von König, CarlChitkara, Amar J.Muloiwa, RudzaniTan, Tina Q.GLOBAL PERTUSSIS INITIATIVEIMMUNITYPERTUSSISPREGNANCYPROTECTIONVACCINATIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Vaccination against pertussis in pregnancy is safe for pregnant women and newborns. Vaccination against pertussis during the second or early third trimester of pregnancy is highly protective against pertussis in young infants. Vaccination early in the third trimester versus vaccination late in the third trimester is associated with higher newborn anti-B. pertussis antibody levels. Infants whose mothers were vaccinated in pregnancy have less boosting of anti-B. pertussis antibody concentrations after their own vaccination, but this is not clinically significant. More immunogenicity and vaccine effectiveness studies are needed in countries using whole-cell pertussis vaccines. Vaccination in pregnancy induces anti-B. pertussis antibodies in breast milk. COVID-19 mitigation strategies have resulted in a significant decrease in B. pertussis circulation, which could negatively affect population immunity against B. pertussis. Highlights: Infants are at high risk for severe morbidity and mortality from pertussis disease during early infancy. Vaccination against pertussis in pregnancy has emerged as the ideal strategy to protect infants during these early, vulnerable, first months of life. On 30 November and 1 December 2021, the Global Pertussis Initiative held a meeting that aimed to discuss and review the most up-to-date scientific literature supporting vaccination against pertussis in pregnancy and outstanding scientific questions. Herein, we review the current and historically published literature and summarize the findings as consensus statements on vaccination against pertussis in pregnancy on behalf of the Global Pertussis Initiative.Fil: Abu Raya, Bahaa. University of British Columbia; CanadáFil: Forsyth, Kevin. Flinders University.; AustraliaFil: Halperin, Scott A.. Dalhousie University Halifax; CanadáFil: Maertens, Kirsten. Universiteit Antwerp; BélgicaFil: Jones, Christine E.. University of Southampton; Reino UnidoFil: Heininger, Ulrich. University of Basel Children’s Hospital; SuizaFil: Hozbor, Daniela Flavia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; ArgentinaFil: Heinz Wirsing von König, Carl. No especifíca;Fil: Chitkara, Amar J.. Max Super Speciality Hospital; IndiaFil: Muloiwa, Rudzani. University of Cape Town; SudáfricaFil: Tan, Tina Q.. Northwestern University; Estados UnidosMDPI2022-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/214363Abu Raya, Bahaa; Forsyth, Kevin; Halperin, Scott A.; Maertens, Kirsten; Jones, Christine E.; et al.; Vaccination in Pregnancy against Pertussis: A Consensus Statement on Behalf of the Global Pertussis Initiative; MDPI; Vaccines; 10; 12; 12-2022; 1-162076-393XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/vaccines10121990info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:39:35Zoai:ri.conicet.gov.ar:11336/214363instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:39:36.158CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Vaccination in Pregnancy against Pertussis: A Consensus Statement on Behalf of the Global Pertussis Initiative
title Vaccination in Pregnancy against Pertussis: A Consensus Statement on Behalf of the Global Pertussis Initiative
spellingShingle Vaccination in Pregnancy against Pertussis: A Consensus Statement on Behalf of the Global Pertussis Initiative
Abu Raya, Bahaa
GLOBAL PERTUSSIS INITIATIVE
IMMUNITY
PERTUSSIS
PREGNANCY
PROTECTION
VACCINATION
title_short Vaccination in Pregnancy against Pertussis: A Consensus Statement on Behalf of the Global Pertussis Initiative
title_full Vaccination in Pregnancy against Pertussis: A Consensus Statement on Behalf of the Global Pertussis Initiative
title_fullStr Vaccination in Pregnancy against Pertussis: A Consensus Statement on Behalf of the Global Pertussis Initiative
title_full_unstemmed Vaccination in Pregnancy against Pertussis: A Consensus Statement on Behalf of the Global Pertussis Initiative
title_sort Vaccination in Pregnancy against Pertussis: A Consensus Statement on Behalf of the Global Pertussis Initiative
dc.creator.none.fl_str_mv Abu Raya, Bahaa
Forsyth, Kevin
Halperin, Scott A.
Maertens, Kirsten
Jones, Christine E.
Heininger, Ulrich
Hozbor, Daniela Flavia
Heinz Wirsing von König, Carl
Chitkara, Amar J.
Muloiwa, Rudzani
Tan, Tina Q.
author Abu Raya, Bahaa
author_facet Abu Raya, Bahaa
Forsyth, Kevin
Halperin, Scott A.
Maertens, Kirsten
Jones, Christine E.
Heininger, Ulrich
Hozbor, Daniela Flavia
Heinz Wirsing von König, Carl
Chitkara, Amar J.
Muloiwa, Rudzani
Tan, Tina Q.
author_role author
author2 Forsyth, Kevin
Halperin, Scott A.
Maertens, Kirsten
Jones, Christine E.
Heininger, Ulrich
Hozbor, Daniela Flavia
Heinz Wirsing von König, Carl
Chitkara, Amar J.
Muloiwa, Rudzani
Tan, Tina Q.
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv GLOBAL PERTUSSIS INITIATIVE
IMMUNITY
PERTUSSIS
PREGNANCY
PROTECTION
VACCINATION
topic GLOBAL PERTUSSIS INITIATIVE
IMMUNITY
PERTUSSIS
PREGNANCY
PROTECTION
VACCINATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Vaccination against pertussis in pregnancy is safe for pregnant women and newborns. Vaccination against pertussis during the second or early third trimester of pregnancy is highly protective against pertussis in young infants. Vaccination early in the third trimester versus vaccination late in the third trimester is associated with higher newborn anti-B. pertussis antibody levels. Infants whose mothers were vaccinated in pregnancy have less boosting of anti-B. pertussis antibody concentrations after their own vaccination, but this is not clinically significant. More immunogenicity and vaccine effectiveness studies are needed in countries using whole-cell pertussis vaccines. Vaccination in pregnancy induces anti-B. pertussis antibodies in breast milk. COVID-19 mitigation strategies have resulted in a significant decrease in B. pertussis circulation, which could negatively affect population immunity against B. pertussis. Highlights: Infants are at high risk for severe morbidity and mortality from pertussis disease during early infancy. Vaccination against pertussis in pregnancy has emerged as the ideal strategy to protect infants during these early, vulnerable, first months of life. On 30 November and 1 December 2021, the Global Pertussis Initiative held a meeting that aimed to discuss and review the most up-to-date scientific literature supporting vaccination against pertussis in pregnancy and outstanding scientific questions. Herein, we review the current and historically published literature and summarize the findings as consensus statements on vaccination against pertussis in pregnancy on behalf of the Global Pertussis Initiative.
Fil: Abu Raya, Bahaa. University of British Columbia; Canadá
Fil: Forsyth, Kevin. Flinders University.; Australia
Fil: Halperin, Scott A.. Dalhousie University Halifax; Canadá
Fil: Maertens, Kirsten. Universiteit Antwerp; Bélgica
Fil: Jones, Christine E.. University of Southampton; Reino Unido
Fil: Heininger, Ulrich. University of Basel Children’s Hospital; Suiza
Fil: Hozbor, Daniela Flavia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; Argentina
Fil: Heinz Wirsing von König, Carl. No especifíca;
Fil: Chitkara, Amar J.. Max Super Speciality Hospital; India
Fil: Muloiwa, Rudzani. University of Cape Town; Sudáfrica
Fil: Tan, Tina Q.. Northwestern University; Estados Unidos
description Vaccination against pertussis in pregnancy is safe for pregnant women and newborns. Vaccination against pertussis during the second or early third trimester of pregnancy is highly protective against pertussis in young infants. Vaccination early in the third trimester versus vaccination late in the third trimester is associated with higher newborn anti-B. pertussis antibody levels. Infants whose mothers were vaccinated in pregnancy have less boosting of anti-B. pertussis antibody concentrations after their own vaccination, but this is not clinically significant. More immunogenicity and vaccine effectiveness studies are needed in countries using whole-cell pertussis vaccines. Vaccination in pregnancy induces anti-B. pertussis antibodies in breast milk. COVID-19 mitigation strategies have resulted in a significant decrease in B. pertussis circulation, which could negatively affect population immunity against B. pertussis. Highlights: Infants are at high risk for severe morbidity and mortality from pertussis disease during early infancy. Vaccination against pertussis in pregnancy has emerged as the ideal strategy to protect infants during these early, vulnerable, first months of life. On 30 November and 1 December 2021, the Global Pertussis Initiative held a meeting that aimed to discuss and review the most up-to-date scientific literature supporting vaccination against pertussis in pregnancy and outstanding scientific questions. Herein, we review the current and historically published literature and summarize the findings as consensus statements on vaccination against pertussis in pregnancy on behalf of the Global Pertussis Initiative.
publishDate 2022
dc.date.none.fl_str_mv 2022-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/214363
Abu Raya, Bahaa; Forsyth, Kevin; Halperin, Scott A.; Maertens, Kirsten; Jones, Christine E.; et al.; Vaccination in Pregnancy against Pertussis: A Consensus Statement on Behalf of the Global Pertussis Initiative; MDPI; Vaccines; 10; 12; 12-2022; 1-16
2076-393X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/214363
identifier_str_mv Abu Raya, Bahaa; Forsyth, Kevin; Halperin, Scott A.; Maertens, Kirsten; Jones, Christine E.; et al.; Vaccination in Pregnancy against Pertussis: A Consensus Statement on Behalf of the Global Pertussis Initiative; MDPI; Vaccines; 10; 12; 12-2022; 1-16
2076-393X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/vaccines10121990
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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