Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative

Autores
Feng, Ye; Chiu, Cheng Hsun; Heininger, Ulrich; Hozbor, Daniela Flavia; Tan, Tina Quanbee; von König, Carl Heinz Wirsing
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Whooping cough, or pertussis, is a highly communicable infectious disease caused by the bacterium Bordetella pertussis. Vaccination once reduced the incidence of the disease, but a global resurgence of the infection happened during the past two decades, likely due to the waning immunity of vaccination. Macrolides such as erythromycin and azithromycin are the drugs of primary choice for treatment. In this personal view, we call for attention to macrolide-resistant B. pertussis (MRBP), which has emerged and prevailed in mainland China for years and are exclusively mediated by mutations in the 23S rRNA gene. Whether the prevalence of MRBP in China results from overuse of azithromycin in clinical medicine remains unknown. The incidence of MRBP is low in other countries, but this could be a technical illusion since China employs culture as the mainstream diagnostic method whereas nucleic-acid amplification test being widely used in other countries fail to test antimicrobial susceptibility. Given the increasingly frequent global travel that facilitates microbial transmission worldwide, there is a pressing need to perform international surveillance on MRBP to prevent the potential circulation of the organism. Finding alternative agents that possess good activity against B. pertussis is also urgently required.
Fil: Feng, Ye. Zhejiang University School of Medicine; China
Fil: Chiu, Cheng Hsun. Chang Gung University College of Medicine; China. Chang Gung Memorial Hospital; China
Fil: Heininger, Ulrich. Universidad de Basilea; Suiza
Fil: Hozbor, Daniela Flavia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; Argentina
Fil: Tan, Tina Quanbee. Northwestern University; Estados Unidos
Fil: von König, Carl Heinz Wirsing. Krefeld; Alemania
Materia
MACROLIDE
PERTUSSIS
RESISTANCE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/180997
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiativeFeng, YeChiu, Cheng HsunHeininger, UlrichHozbor, Daniela FlaviaTan, Tina Quanbeevon König, Carl Heinz WirsingMACROLIDEPERTUSSISRESISTANCEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Whooping cough, or pertussis, is a highly communicable infectious disease caused by the bacterium Bordetella pertussis. Vaccination once reduced the incidence of the disease, but a global resurgence of the infection happened during the past two decades, likely due to the waning immunity of vaccination. Macrolides such as erythromycin and azithromycin are the drugs of primary choice for treatment. In this personal view, we call for attention to macrolide-resistant B. pertussis (MRBP), which has emerged and prevailed in mainland China for years and are exclusively mediated by mutations in the 23S rRNA gene. Whether the prevalence of MRBP in China results from overuse of azithromycin in clinical medicine remains unknown. The incidence of MRBP is low in other countries, but this could be a technical illusion since China employs culture as the mainstream diagnostic method whereas nucleic-acid amplification test being widely used in other countries fail to test antimicrobial susceptibility. Given the increasingly frequent global travel that facilitates microbial transmission worldwide, there is a pressing need to perform international surveillance on MRBP to prevent the potential circulation of the organism. Finding alternative agents that possess good activity against B. pertussis is also urgently required.Fil: Feng, Ye. Zhejiang University School of Medicine; ChinaFil: Chiu, Cheng Hsun. Chang Gung University College of Medicine; China. Chang Gung Memorial Hospital; ChinaFil: Heininger, Ulrich. Universidad de Basilea; SuizaFil: Hozbor, Daniela Flavia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; ArgentinaFil: Tan, Tina Quanbee. Northwestern University; Estados UnidosFil: von König, Carl Heinz Wirsing. Krefeld; AlemaniaElsevier2021-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/180997Feng, Ye; Chiu, Cheng Hsun; Heininger, Ulrich; Hozbor, Daniela Flavia; Tan, Tina Quanbee; et al.; Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative; Elsevier; The Lancet Regional Health - Western Pacific; 8; 3-2021; 1-42666-6065CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S2666606521000079info:eu-repo/semantics/altIdentifier/doi/10.1016/j.lanwpc.2021.100098info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:31:56Zoai:ri.conicet.gov.ar:11336/180997instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:31:57.131CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative
title Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative
spellingShingle Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative
Feng, Ye
MACROLIDE
PERTUSSIS
RESISTANCE
title_short Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative
title_full Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative
title_fullStr Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative
title_full_unstemmed Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative
title_sort Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative
dc.creator.none.fl_str_mv Feng, Ye
Chiu, Cheng Hsun
Heininger, Ulrich
Hozbor, Daniela Flavia
Tan, Tina Quanbee
von König, Carl Heinz Wirsing
author Feng, Ye
author_facet Feng, Ye
Chiu, Cheng Hsun
Heininger, Ulrich
Hozbor, Daniela Flavia
Tan, Tina Quanbee
von König, Carl Heinz Wirsing
author_role author
author2 Chiu, Cheng Hsun
Heininger, Ulrich
Hozbor, Daniela Flavia
Tan, Tina Quanbee
von König, Carl Heinz Wirsing
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv MACROLIDE
PERTUSSIS
RESISTANCE
topic MACROLIDE
PERTUSSIS
RESISTANCE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Whooping cough, or pertussis, is a highly communicable infectious disease caused by the bacterium Bordetella pertussis. Vaccination once reduced the incidence of the disease, but a global resurgence of the infection happened during the past two decades, likely due to the waning immunity of vaccination. Macrolides such as erythromycin and azithromycin are the drugs of primary choice for treatment. In this personal view, we call for attention to macrolide-resistant B. pertussis (MRBP), which has emerged and prevailed in mainland China for years and are exclusively mediated by mutations in the 23S rRNA gene. Whether the prevalence of MRBP in China results from overuse of azithromycin in clinical medicine remains unknown. The incidence of MRBP is low in other countries, but this could be a technical illusion since China employs culture as the mainstream diagnostic method whereas nucleic-acid amplification test being widely used in other countries fail to test antimicrobial susceptibility. Given the increasingly frequent global travel that facilitates microbial transmission worldwide, there is a pressing need to perform international surveillance on MRBP to prevent the potential circulation of the organism. Finding alternative agents that possess good activity against B. pertussis is also urgently required.
Fil: Feng, Ye. Zhejiang University School of Medicine; China
Fil: Chiu, Cheng Hsun. Chang Gung University College of Medicine; China. Chang Gung Memorial Hospital; China
Fil: Heininger, Ulrich. Universidad de Basilea; Suiza
Fil: Hozbor, Daniela Flavia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; Argentina
Fil: Tan, Tina Quanbee. Northwestern University; Estados Unidos
Fil: von König, Carl Heinz Wirsing. Krefeld; Alemania
description Whooping cough, or pertussis, is a highly communicable infectious disease caused by the bacterium Bordetella pertussis. Vaccination once reduced the incidence of the disease, but a global resurgence of the infection happened during the past two decades, likely due to the waning immunity of vaccination. Macrolides such as erythromycin and azithromycin are the drugs of primary choice for treatment. In this personal view, we call for attention to macrolide-resistant B. pertussis (MRBP), which has emerged and prevailed in mainland China for years and are exclusively mediated by mutations in the 23S rRNA gene. Whether the prevalence of MRBP in China results from overuse of azithromycin in clinical medicine remains unknown. The incidence of MRBP is low in other countries, but this could be a technical illusion since China employs culture as the mainstream diagnostic method whereas nucleic-acid amplification test being widely used in other countries fail to test antimicrobial susceptibility. Given the increasingly frequent global travel that facilitates microbial transmission worldwide, there is a pressing need to perform international surveillance on MRBP to prevent the potential circulation of the organism. Finding alternative agents that possess good activity against B. pertussis is also urgently required.
publishDate 2021
dc.date.none.fl_str_mv 2021-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/180997
Feng, Ye; Chiu, Cheng Hsun; Heininger, Ulrich; Hozbor, Daniela Flavia; Tan, Tina Quanbee; et al.; Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative; Elsevier; The Lancet Regional Health - Western Pacific; 8; 3-2021; 1-4
2666-6065
CONICET Digital
CONICET
url http://hdl.handle.net/11336/180997
identifier_str_mv Feng, Ye; Chiu, Cheng Hsun; Heininger, Ulrich; Hozbor, Daniela Flavia; Tan, Tina Quanbee; et al.; Emerging macrolide resistance in Bordetella pertussis in mainland China: findings and warning from the global pertussis initiative; Elsevier; The Lancet Regional Health - Western Pacific; 8; 3-2021; 1-4
2666-6065
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S2666606521000079
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.lanwpc.2021.100098
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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