Crucial role of antibodies to pertactin in <i>Bordetella pertussis</i> immunity
- Autores
- Hellwig, Sandra M. M.; Rodríguez, María Eugenia; Berbers, Guy A. M.; Winkel, Jan G. J. van de; Mooi, Frits R.
- Año de publicación
- 2003
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Pertussis, a serious infectious disease of the respiratory tract caused by Bordetella pertussis, is reemerging in vaccinated populations. Efforts to curtail this disease are hampered by limited insight into the basis of protective immunity. Opsonophagocytosis was recently found to play a central role in cellular bactericidal activity against B. pertussis. In the present study, we studied the specificity of opsonic antibodies. Anti-pertactin antibodies, but not anti-pertussis toxin, anti-fimbriae, or anti-filamentous hemagglutinin antibodies, were found to be crucial for B. pertussis phagocytosis. These data are consistent with field studies showing that levels of antibodies to pertactin correlate with protection.
Centro de Investigación y Desarrollo en Fermentaciones Industriales - Materia
-
Ciencias Exactas
Bordetella pertussis - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/83288
Ver los metadatos del registro completo
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Crucial role of antibodies to pertactin in <i>Bordetella pertussis</i> immunityHellwig, Sandra M. M.Rodríguez, María EugeniaBerbers, Guy A. M.Winkel, Jan G. J. van deMooi, Frits R.Ciencias ExactasBordetella pertussisPertussis, a serious infectious disease of the respiratory tract caused by Bordetella pertussis, is reemerging in vaccinated populations. Efforts to curtail this disease are hampered by limited insight into the basis of protective immunity. Opsonophagocytosis was recently found to play a central role in cellular bactericidal activity against B. pertussis. In the present study, we studied the specificity of opsonic antibodies. Anti-pertactin antibodies, but not anti-pertussis toxin, anti-fimbriae, or anti-filamentous hemagglutinin antibodies, were found to be crucial for B. pertussis phagocytosis. These data are consistent with field studies showing that levels of antibodies to pertactin correlate with protection.Centro de Investigación y Desarrollo en Fermentaciones Industriales2003info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf738-742http://sedici.unlp.edu.ar/handle/10915/83288enginfo:eu-repo/semantics/altIdentifier/issn/0022-1899info:eu-repo/semantics/altIdentifier/doi/10.1086/377283info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:15:50Zoai:sedici.unlp.edu.ar:10915/83288Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:15:50.813SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Crucial role of antibodies to pertactin in <i>Bordetella pertussis</i> immunity |
title |
Crucial role of antibodies to pertactin in <i>Bordetella pertussis</i> immunity |
spellingShingle |
Crucial role of antibodies to pertactin in <i>Bordetella pertussis</i> immunity Hellwig, Sandra M. M. Ciencias Exactas Bordetella pertussis |
title_short |
Crucial role of antibodies to pertactin in <i>Bordetella pertussis</i> immunity |
title_full |
Crucial role of antibodies to pertactin in <i>Bordetella pertussis</i> immunity |
title_fullStr |
Crucial role of antibodies to pertactin in <i>Bordetella pertussis</i> immunity |
title_full_unstemmed |
Crucial role of antibodies to pertactin in <i>Bordetella pertussis</i> immunity |
title_sort |
Crucial role of antibodies to pertactin in <i>Bordetella pertussis</i> immunity |
dc.creator.none.fl_str_mv |
Hellwig, Sandra M. M. Rodríguez, María Eugenia Berbers, Guy A. M. Winkel, Jan G. J. van de Mooi, Frits R. |
author |
Hellwig, Sandra M. M. |
author_facet |
Hellwig, Sandra M. M. Rodríguez, María Eugenia Berbers, Guy A. M. Winkel, Jan G. J. van de Mooi, Frits R. |
author_role |
author |
author2 |
Rodríguez, María Eugenia Berbers, Guy A. M. Winkel, Jan G. J. van de Mooi, Frits R. |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Ciencias Exactas Bordetella pertussis |
topic |
Ciencias Exactas Bordetella pertussis |
dc.description.none.fl_txt_mv |
Pertussis, a serious infectious disease of the respiratory tract caused by Bordetella pertussis, is reemerging in vaccinated populations. Efforts to curtail this disease are hampered by limited insight into the basis of protective immunity. Opsonophagocytosis was recently found to play a central role in cellular bactericidal activity against B. pertussis. In the present study, we studied the specificity of opsonic antibodies. Anti-pertactin antibodies, but not anti-pertussis toxin, anti-fimbriae, or anti-filamentous hemagglutinin antibodies, were found to be crucial for B. pertussis phagocytosis. These data are consistent with field studies showing that levels of antibodies to pertactin correlate with protection. Centro de Investigación y Desarrollo en Fermentaciones Industriales |
description |
Pertussis, a serious infectious disease of the respiratory tract caused by Bordetella pertussis, is reemerging in vaccinated populations. Efforts to curtail this disease are hampered by limited insight into the basis of protective immunity. Opsonophagocytosis was recently found to play a central role in cellular bactericidal activity against B. pertussis. In the present study, we studied the specificity of opsonic antibodies. Anti-pertactin antibodies, but not anti-pertussis toxin, anti-fimbriae, or anti-filamentous hemagglutinin antibodies, were found to be crucial for B. pertussis phagocytosis. These data are consistent with field studies showing that levels of antibodies to pertactin correlate with protection. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/83288 |
url |
http://sedici.unlp.edu.ar/handle/10915/83288 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/issn/0022-1899 info:eu-repo/semantics/altIdentifier/doi/10.1086/377283 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
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openAccess |
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http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
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application/pdf 738-742 |
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