Crucial role of antibodies to pertactin in <i>Bordetella pertussis</i> immunity

Autores
Hellwig, Sandra M. M.; Rodríguez, María Eugenia; Berbers, Guy A. M.; Winkel, Jan G. J. van de; Mooi, Frits R.
Año de publicación
2003
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Pertussis, a serious infectious disease of the respiratory tract caused by Bordetella pertussis, is reemerging in vaccinated populations. Efforts to curtail this disease are hampered by limited insight into the basis of protective immunity. Opsonophagocytosis was recently found to play a central role in cellular bactericidal activity against B. pertussis. In the present study, we studied the specificity of opsonic antibodies. Anti-pertactin antibodies, but not anti-pertussis toxin, anti-fimbriae, or anti-filamentous hemagglutinin antibodies, were found to be crucial for B. pertussis phagocytosis. These data are consistent with field studies showing that levels of antibodies to pertactin correlate with protection.
Centro de Investigación y Desarrollo en Fermentaciones Industriales
Materia
Ciencias Exactas
Bordetella pertussis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/83288
Acceder
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network_name_str SEDICI (UNLP)
spelling Crucial role of antibodies to pertactin in <i>Bordetella pertussis</i> immunityHellwig, Sandra M. M.Rodríguez, María EugeniaBerbers, Guy A. M.Winkel, Jan G. J. van deMooi, Frits R.Ciencias ExactasBordetella pertussisPertussis, a serious infectious disease of the respiratory tract caused by Bordetella pertussis, is reemerging in vaccinated populations. Efforts to curtail this disease are hampered by limited insight into the basis of protective immunity. Opsonophagocytosis was recently found to play a central role in cellular bactericidal activity against B. pertussis. In the present study, we studied the specificity of opsonic antibodies. Anti-pertactin antibodies, but not anti-pertussis toxin, anti-fimbriae, or anti-filamentous hemagglutinin antibodies, were found to be crucial for B. pertussis phagocytosis. These data are consistent with field studies showing that levels of antibodies to pertactin correlate with protection.Centro de Investigación y Desarrollo en Fermentaciones Industriales2003info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf738-742http://sedici.unlp.edu.ar/handle/10915/83288enginfo:eu-repo/semantics/altIdentifier/issn/0022-1899info:eu-repo/semantics/altIdentifier/doi/10.1086/377283info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-22T16:56:38Zoai:sedici.unlp.edu.ar:10915/83288Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-22 16:56:38.386SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Crucial role of antibodies to pertactin in <i>Bordetella pertussis</i> immunity
title Crucial role of antibodies to pertactin in <i>Bordetella pertussis</i> immunity
spellingShingle Crucial role of antibodies to pertactin in <i>Bordetella pertussis</i> immunity
Hellwig, Sandra M. M.
Ciencias Exactas
Bordetella pertussis
title_short Crucial role of antibodies to pertactin in <i>Bordetella pertussis</i> immunity
title_full Crucial role of antibodies to pertactin in <i>Bordetella pertussis</i> immunity
title_fullStr Crucial role of antibodies to pertactin in <i>Bordetella pertussis</i> immunity
title_full_unstemmed Crucial role of antibodies to pertactin in <i>Bordetella pertussis</i> immunity
title_sort Crucial role of antibodies to pertactin in <i>Bordetella pertussis</i> immunity
dc.creator.none.fl_str_mv Hellwig, Sandra M. M.
Rodríguez, María Eugenia
Berbers, Guy A. M.
Winkel, Jan G. J. van de
Mooi, Frits R.
author Hellwig, Sandra M. M.
author_facet Hellwig, Sandra M. M.
Rodríguez, María Eugenia
Berbers, Guy A. M.
Winkel, Jan G. J. van de
Mooi, Frits R.
author_role author
author2 Rodríguez, María Eugenia
Berbers, Guy A. M.
Winkel, Jan G. J. van de
Mooi, Frits R.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Bordetella pertussis
topic Ciencias Exactas
Bordetella pertussis
dc.description.none.fl_txt_mv Pertussis, a serious infectious disease of the respiratory tract caused by Bordetella pertussis, is reemerging in vaccinated populations. Efforts to curtail this disease are hampered by limited insight into the basis of protective immunity. Opsonophagocytosis was recently found to play a central role in cellular bactericidal activity against B. pertussis. In the present study, we studied the specificity of opsonic antibodies. Anti-pertactin antibodies, but not anti-pertussis toxin, anti-fimbriae, or anti-filamentous hemagglutinin antibodies, were found to be crucial for B. pertussis phagocytosis. These data are consistent with field studies showing that levels of antibodies to pertactin correlate with protection.
Centro de Investigación y Desarrollo en Fermentaciones Industriales
description Pertussis, a serious infectious disease of the respiratory tract caused by Bordetella pertussis, is reemerging in vaccinated populations. Efforts to curtail this disease are hampered by limited insight into the basis of protective immunity. Opsonophagocytosis was recently found to play a central role in cellular bactericidal activity against B. pertussis. In the present study, we studied the specificity of opsonic antibodies. Anti-pertactin antibodies, but not anti-pertussis toxin, anti-fimbriae, or anti-filamentous hemagglutinin antibodies, were found to be crucial for B. pertussis phagocytosis. These data are consistent with field studies showing that levels of antibodies to pertactin correlate with protection.
publishDate 2003
dc.date.none.fl_str_mv 2003
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/83288
url http://sedici.unlp.edu.ar/handle/10915/83288
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0022-1899
info:eu-repo/semantics/altIdentifier/doi/10.1086/377283
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
738-742
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
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reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
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repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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