Rare detection of bordetella pertussis pertactin-deficient strains in Argentina

Autores
Carriquiriborde, Francisco Pablo; Regidor, Victoria; Aispuro, Pablo M.; Gabrielli, Magali; Bartel, Erika Belén; Bottero, Daniela; Hozbor, Daniela Flavia
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Pertussis resurgence had been attributed to waning vaccine immunity and Bordetella pertussis adaptation to escape vaccine-induced immunity. Circulating bacteria differ genotypically from strains used in production of pertussis vaccine. Pertactin-deficient strains are highly prevalent in countries that use acellular vaccine (aP), suggesting strong aP-imposed selection of circulating bacteria. To corroborate this hypothesis, systematic studies on pertactin prevalence of infection in countries using whole-cell vaccine are needed. We provide pertussis epidemiologic data and molecular characterization of B. pertussis isolates from Buenos Aires, Argentina, during 2000-2017. This area used primary vaccination with whole-cell vaccine. Since 2002, pertussis case incidences increased at regular 4-year outbreaks; most cases were in infants <1 year of age. Of the B. pertussis isolates analyzed, 90.6% (317/350) contained the ptxP3-ptxA1-prn2-fim3-2 allelic profile. Immunoblotting and sequencing techniques detected only the 2 pertactin-deficient isolates. The low prevalence of pertactin-deficient strains in Argentina suggests that loss of pertactin gene expression might be driven by aP vaccine.
Fil: Carriquiriborde, Francisco Pablo. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Regidor, Victoria. Universidad Nacional de La Plata; Argentina
Fil: Aispuro, Pablo M.. Universidad Nacional de La Plata; Argentina
Fil: Gabrielli, Magali. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Bartel, Erika Belén. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Bottero, Daniela. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Hozbor, Daniela Flavia. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Materia
ACELLULAR VACCINE
ARGENTINA
BACTERIA
BORDETELLA PERTUSSIS
PERTACTIN
PERTACTIN-DEFICIENT STRAINS
PERTUSSIS
PRIMARY VACCINATION SERIES
RESURGENCE
VACCINATION
VACCINES
WHOLE-CELL VACCINE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/152229

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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Rare detection of bordetella pertussis pertactin-deficient strains in ArgentinaCarriquiriborde, Francisco PabloRegidor, VictoriaAispuro, Pablo M.Gabrielli, MagaliBartel, Erika BelénBottero, DanielaHozbor, Daniela FlaviaACELLULAR VACCINEARGENTINABACTERIABORDETELLA PERTUSSISPERTACTINPERTACTIN-DEFICIENT STRAINSPERTUSSISPRIMARY VACCINATION SERIESRESURGENCEVACCINATIONVACCINESWHOLE-CELL VACCINEhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Pertussis resurgence had been attributed to waning vaccine immunity and Bordetella pertussis adaptation to escape vaccine-induced immunity. Circulating bacteria differ genotypically from strains used in production of pertussis vaccine. Pertactin-deficient strains are highly prevalent in countries that use acellular vaccine (aP), suggesting strong aP-imposed selection of circulating bacteria. To corroborate this hypothesis, systematic studies on pertactin prevalence of infection in countries using whole-cell vaccine are needed. We provide pertussis epidemiologic data and molecular characterization of B. pertussis isolates from Buenos Aires, Argentina, during 2000-2017. This area used primary vaccination with whole-cell vaccine. Since 2002, pertussis case incidences increased at regular 4-year outbreaks; most cases were in infants <1 year of age. Of the B. pertussis isolates analyzed, 90.6% (317/350) contained the ptxP3-ptxA1-prn2-fim3-2 allelic profile. Immunoblotting and sequencing techniques detected only the 2 pertactin-deficient isolates. The low prevalence of pertactin-deficient strains in Argentina suggests that loss of pertactin gene expression might be driven by aP vaccine.Fil: Carriquiriborde, Francisco Pablo. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Regidor, Victoria. Universidad Nacional de La Plata; ArgentinaFil: Aispuro, Pablo M.. Universidad Nacional de La Plata; ArgentinaFil: Gabrielli, Magali. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Bartel, Erika Belén. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Bottero, Daniela. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Hozbor, Daniela Flavia. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaCenters Disease Control2019-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/152229Carriquiriborde, Francisco Pablo; Regidor, Victoria; Aispuro, Pablo M.; Gabrielli, Magali; Bartel, Erika Belén; et al.; Rare detection of bordetella pertussis pertactin-deficient strains in Argentina; Centers Disease Control; Emerging Infectious Diseases; 25; 11; 11-2019; 2048-20541080-60591080-6040CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3201/eid2511.190329info:eu-repo/semantics/altIdentifier/url/https://wwwnc.cdc.gov/eid/article/25/11/19-0329_articleinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:26:21Zoai:ri.conicet.gov.ar:11336/152229instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:26:22.118CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Rare detection of bordetella pertussis pertactin-deficient strains in Argentina
title Rare detection of bordetella pertussis pertactin-deficient strains in Argentina
spellingShingle Rare detection of bordetella pertussis pertactin-deficient strains in Argentina
Carriquiriborde, Francisco Pablo
ACELLULAR VACCINE
ARGENTINA
BACTERIA
BORDETELLA PERTUSSIS
PERTACTIN
PERTACTIN-DEFICIENT STRAINS
PERTUSSIS
PRIMARY VACCINATION SERIES
RESURGENCE
VACCINATION
VACCINES
WHOLE-CELL VACCINE
title_short Rare detection of bordetella pertussis pertactin-deficient strains in Argentina
title_full Rare detection of bordetella pertussis pertactin-deficient strains in Argentina
title_fullStr Rare detection of bordetella pertussis pertactin-deficient strains in Argentina
title_full_unstemmed Rare detection of bordetella pertussis pertactin-deficient strains in Argentina
title_sort Rare detection of bordetella pertussis pertactin-deficient strains in Argentina
dc.creator.none.fl_str_mv Carriquiriborde, Francisco Pablo
Regidor, Victoria
Aispuro, Pablo M.
Gabrielli, Magali
Bartel, Erika Belén
Bottero, Daniela
Hozbor, Daniela Flavia
author Carriquiriborde, Francisco Pablo
author_facet Carriquiriborde, Francisco Pablo
Regidor, Victoria
Aispuro, Pablo M.
Gabrielli, Magali
Bartel, Erika Belén
Bottero, Daniela
Hozbor, Daniela Flavia
author_role author
author2 Regidor, Victoria
Aispuro, Pablo M.
Gabrielli, Magali
Bartel, Erika Belén
Bottero, Daniela
Hozbor, Daniela Flavia
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ACELLULAR VACCINE
ARGENTINA
BACTERIA
BORDETELLA PERTUSSIS
PERTACTIN
PERTACTIN-DEFICIENT STRAINS
PERTUSSIS
PRIMARY VACCINATION SERIES
RESURGENCE
VACCINATION
VACCINES
WHOLE-CELL VACCINE
topic ACELLULAR VACCINE
ARGENTINA
BACTERIA
BORDETELLA PERTUSSIS
PERTACTIN
PERTACTIN-DEFICIENT STRAINS
PERTUSSIS
PRIMARY VACCINATION SERIES
RESURGENCE
VACCINATION
VACCINES
WHOLE-CELL VACCINE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Pertussis resurgence had been attributed to waning vaccine immunity and Bordetella pertussis adaptation to escape vaccine-induced immunity. Circulating bacteria differ genotypically from strains used in production of pertussis vaccine. Pertactin-deficient strains are highly prevalent in countries that use acellular vaccine (aP), suggesting strong aP-imposed selection of circulating bacteria. To corroborate this hypothesis, systematic studies on pertactin prevalence of infection in countries using whole-cell vaccine are needed. We provide pertussis epidemiologic data and molecular characterization of B. pertussis isolates from Buenos Aires, Argentina, during 2000-2017. This area used primary vaccination with whole-cell vaccine. Since 2002, pertussis case incidences increased at regular 4-year outbreaks; most cases were in infants <1 year of age. Of the B. pertussis isolates analyzed, 90.6% (317/350) contained the ptxP3-ptxA1-prn2-fim3-2 allelic profile. Immunoblotting and sequencing techniques detected only the 2 pertactin-deficient isolates. The low prevalence of pertactin-deficient strains in Argentina suggests that loss of pertactin gene expression might be driven by aP vaccine.
Fil: Carriquiriborde, Francisco Pablo. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Regidor, Victoria. Universidad Nacional de La Plata; Argentina
Fil: Aispuro, Pablo M.. Universidad Nacional de La Plata; Argentina
Fil: Gabrielli, Magali. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Bartel, Erika Belén. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Bottero, Daniela. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Hozbor, Daniela Flavia. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
description Pertussis resurgence had been attributed to waning vaccine immunity and Bordetella pertussis adaptation to escape vaccine-induced immunity. Circulating bacteria differ genotypically from strains used in production of pertussis vaccine. Pertactin-deficient strains are highly prevalent in countries that use acellular vaccine (aP), suggesting strong aP-imposed selection of circulating bacteria. To corroborate this hypothesis, systematic studies on pertactin prevalence of infection in countries using whole-cell vaccine are needed. We provide pertussis epidemiologic data and molecular characterization of B. pertussis isolates from Buenos Aires, Argentina, during 2000-2017. This area used primary vaccination with whole-cell vaccine. Since 2002, pertussis case incidences increased at regular 4-year outbreaks; most cases were in infants <1 year of age. Of the B. pertussis isolates analyzed, 90.6% (317/350) contained the ptxP3-ptxA1-prn2-fim3-2 allelic profile. Immunoblotting and sequencing techniques detected only the 2 pertactin-deficient isolates. The low prevalence of pertactin-deficient strains in Argentina suggests that loss of pertactin gene expression might be driven by aP vaccine.
publishDate 2019
dc.date.none.fl_str_mv 2019-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/152229
Carriquiriborde, Francisco Pablo; Regidor, Victoria; Aispuro, Pablo M.; Gabrielli, Magali; Bartel, Erika Belén; et al.; Rare detection of bordetella pertussis pertactin-deficient strains in Argentina; Centers Disease Control; Emerging Infectious Diseases; 25; 11; 11-2019; 2048-2054
1080-6059
1080-6040
CONICET Digital
CONICET
url http://hdl.handle.net/11336/152229
identifier_str_mv Carriquiriborde, Francisco Pablo; Regidor, Victoria; Aispuro, Pablo M.; Gabrielli, Magali; Bartel, Erika Belén; et al.; Rare detection of bordetella pertussis pertactin-deficient strains in Argentina; Centers Disease Control; Emerging Infectious Diseases; 25; 11; 11-2019; 2048-2054
1080-6059
1080-6040
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3201/eid2511.190329
info:eu-repo/semantics/altIdentifier/url/https://wwwnc.cdc.gov/eid/article/25/11/19-0329_article
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Centers Disease Control
publisher.none.fl_str_mv Centers Disease Control
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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