Rare detection of bordetella pertussis pertactin-deficient strains in Argentina
- Autores
- Carriquiriborde, Francisco Pablo; Regidor, Victoria; Aispuro, Pablo M.; Gabrielli, Magali; Bartel, Erika Belén; Bottero, Daniela; Hozbor, Daniela Flavia
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Pertussis resurgence had been attributed to waning vaccine immunity and Bordetella pertussis adaptation to escape vaccine-induced immunity. Circulating bacteria differ genotypically from strains used in production of pertussis vaccine. Pertactin-deficient strains are highly prevalent in countries that use acellular vaccine (aP), suggesting strong aP-imposed selection of circulating bacteria. To corroborate this hypothesis, systematic studies on pertactin prevalence of infection in countries using whole-cell vaccine are needed. We provide pertussis epidemiologic data and molecular characterization of B. pertussis isolates from Buenos Aires, Argentina, during 2000-2017. This area used primary vaccination with whole-cell vaccine. Since 2002, pertussis case incidences increased at regular 4-year outbreaks; most cases were in infants <1 year of age. Of the B. pertussis isolates analyzed, 90.6% (317/350) contained the ptxP3-ptxA1-prn2-fim3-2 allelic profile. Immunoblotting and sequencing techniques detected only the 2 pertactin-deficient isolates. The low prevalence of pertactin-deficient strains in Argentina suggests that loss of pertactin gene expression might be driven by aP vaccine.
Fil: Carriquiriborde, Francisco Pablo. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Regidor, Victoria. Universidad Nacional de La Plata; Argentina
Fil: Aispuro, Pablo M.. Universidad Nacional de La Plata; Argentina
Fil: Gabrielli, Magali. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Bartel, Erika Belén. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Bottero, Daniela. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Hozbor, Daniela Flavia. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina - Materia
-
ACELLULAR VACCINE
ARGENTINA
BACTERIA
BORDETELLA PERTUSSIS
PERTACTIN
PERTACTIN-DEFICIENT STRAINS
PERTUSSIS
PRIMARY VACCINATION SERIES
RESURGENCE
VACCINATION
VACCINES
WHOLE-CELL VACCINE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/152229
Ver los metadatos del registro completo
id |
CONICETDig_5d4616758f41330a395aa43b41153eae |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/152229 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Rare detection of bordetella pertussis pertactin-deficient strains in ArgentinaCarriquiriborde, Francisco PabloRegidor, VictoriaAispuro, Pablo M.Gabrielli, MagaliBartel, Erika BelénBottero, DanielaHozbor, Daniela FlaviaACELLULAR VACCINEARGENTINABACTERIABORDETELLA PERTUSSISPERTACTINPERTACTIN-DEFICIENT STRAINSPERTUSSISPRIMARY VACCINATION SERIESRESURGENCEVACCINATIONVACCINESWHOLE-CELL VACCINEhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Pertussis resurgence had been attributed to waning vaccine immunity and Bordetella pertussis adaptation to escape vaccine-induced immunity. Circulating bacteria differ genotypically from strains used in production of pertussis vaccine. Pertactin-deficient strains are highly prevalent in countries that use acellular vaccine (aP), suggesting strong aP-imposed selection of circulating bacteria. To corroborate this hypothesis, systematic studies on pertactin prevalence of infection in countries using whole-cell vaccine are needed. We provide pertussis epidemiologic data and molecular characterization of B. pertussis isolates from Buenos Aires, Argentina, during 2000-2017. This area used primary vaccination with whole-cell vaccine. Since 2002, pertussis case incidences increased at regular 4-year outbreaks; most cases were in infants <1 year of age. Of the B. pertussis isolates analyzed, 90.6% (317/350) contained the ptxP3-ptxA1-prn2-fim3-2 allelic profile. Immunoblotting and sequencing techniques detected only the 2 pertactin-deficient isolates. The low prevalence of pertactin-deficient strains in Argentina suggests that loss of pertactin gene expression might be driven by aP vaccine.Fil: Carriquiriborde, Francisco Pablo. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Regidor, Victoria. Universidad Nacional de La Plata; ArgentinaFil: Aispuro, Pablo M.. Universidad Nacional de La Plata; ArgentinaFil: Gabrielli, Magali. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Bartel, Erika Belén. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Bottero, Daniela. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Hozbor, Daniela Flavia. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaCenters Disease Control2019-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/152229Carriquiriborde, Francisco Pablo; Regidor, Victoria; Aispuro, Pablo M.; Gabrielli, Magali; Bartel, Erika Belén; et al.; Rare detection of bordetella pertussis pertactin-deficient strains in Argentina; Centers Disease Control; Emerging Infectious Diseases; 25; 11; 11-2019; 2048-20541080-60591080-6040CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3201/eid2511.190329info:eu-repo/semantics/altIdentifier/url/https://wwwnc.cdc.gov/eid/article/25/11/19-0329_articleinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:26:21Zoai:ri.conicet.gov.ar:11336/152229instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:26:22.118CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Rare detection of bordetella pertussis pertactin-deficient strains in Argentina |
title |
Rare detection of bordetella pertussis pertactin-deficient strains in Argentina |
spellingShingle |
Rare detection of bordetella pertussis pertactin-deficient strains in Argentina Carriquiriborde, Francisco Pablo ACELLULAR VACCINE ARGENTINA BACTERIA BORDETELLA PERTUSSIS PERTACTIN PERTACTIN-DEFICIENT STRAINS PERTUSSIS PRIMARY VACCINATION SERIES RESURGENCE VACCINATION VACCINES WHOLE-CELL VACCINE |
title_short |
Rare detection of bordetella pertussis pertactin-deficient strains in Argentina |
title_full |
Rare detection of bordetella pertussis pertactin-deficient strains in Argentina |
title_fullStr |
Rare detection of bordetella pertussis pertactin-deficient strains in Argentina |
title_full_unstemmed |
Rare detection of bordetella pertussis pertactin-deficient strains in Argentina |
title_sort |
Rare detection of bordetella pertussis pertactin-deficient strains in Argentina |
dc.creator.none.fl_str_mv |
Carriquiriborde, Francisco Pablo Regidor, Victoria Aispuro, Pablo M. Gabrielli, Magali Bartel, Erika Belén Bottero, Daniela Hozbor, Daniela Flavia |
author |
Carriquiriborde, Francisco Pablo |
author_facet |
Carriquiriborde, Francisco Pablo Regidor, Victoria Aispuro, Pablo M. Gabrielli, Magali Bartel, Erika Belén Bottero, Daniela Hozbor, Daniela Flavia |
author_role |
author |
author2 |
Regidor, Victoria Aispuro, Pablo M. Gabrielli, Magali Bartel, Erika Belén Bottero, Daniela Hozbor, Daniela Flavia |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
ACELLULAR VACCINE ARGENTINA BACTERIA BORDETELLA PERTUSSIS PERTACTIN PERTACTIN-DEFICIENT STRAINS PERTUSSIS PRIMARY VACCINATION SERIES RESURGENCE VACCINATION VACCINES WHOLE-CELL VACCINE |
topic |
ACELLULAR VACCINE ARGENTINA BACTERIA BORDETELLA PERTUSSIS PERTACTIN PERTACTIN-DEFICIENT STRAINS PERTUSSIS PRIMARY VACCINATION SERIES RESURGENCE VACCINATION VACCINES WHOLE-CELL VACCINE |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Pertussis resurgence had been attributed to waning vaccine immunity and Bordetella pertussis adaptation to escape vaccine-induced immunity. Circulating bacteria differ genotypically from strains used in production of pertussis vaccine. Pertactin-deficient strains are highly prevalent in countries that use acellular vaccine (aP), suggesting strong aP-imposed selection of circulating bacteria. To corroborate this hypothesis, systematic studies on pertactin prevalence of infection in countries using whole-cell vaccine are needed. We provide pertussis epidemiologic data and molecular characterization of B. pertussis isolates from Buenos Aires, Argentina, during 2000-2017. This area used primary vaccination with whole-cell vaccine. Since 2002, pertussis case incidences increased at regular 4-year outbreaks; most cases were in infants <1 year of age. Of the B. pertussis isolates analyzed, 90.6% (317/350) contained the ptxP3-ptxA1-prn2-fim3-2 allelic profile. Immunoblotting and sequencing techniques detected only the 2 pertactin-deficient isolates. The low prevalence of pertactin-deficient strains in Argentina suggests that loss of pertactin gene expression might be driven by aP vaccine. Fil: Carriquiriborde, Francisco Pablo. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina Fil: Regidor, Victoria. Universidad Nacional de La Plata; Argentina Fil: Aispuro, Pablo M.. Universidad Nacional de La Plata; Argentina Fil: Gabrielli, Magali. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina Fil: Bartel, Erika Belén. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina Fil: Bottero, Daniela. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina Fil: Hozbor, Daniela Flavia. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina |
description |
Pertussis resurgence had been attributed to waning vaccine immunity and Bordetella pertussis adaptation to escape vaccine-induced immunity. Circulating bacteria differ genotypically from strains used in production of pertussis vaccine. Pertactin-deficient strains are highly prevalent in countries that use acellular vaccine (aP), suggesting strong aP-imposed selection of circulating bacteria. To corroborate this hypothesis, systematic studies on pertactin prevalence of infection in countries using whole-cell vaccine are needed. We provide pertussis epidemiologic data and molecular characterization of B. pertussis isolates from Buenos Aires, Argentina, during 2000-2017. This area used primary vaccination with whole-cell vaccine. Since 2002, pertussis case incidences increased at regular 4-year outbreaks; most cases were in infants <1 year of age. Of the B. pertussis isolates analyzed, 90.6% (317/350) contained the ptxP3-ptxA1-prn2-fim3-2 allelic profile. Immunoblotting and sequencing techniques detected only the 2 pertactin-deficient isolates. The low prevalence of pertactin-deficient strains in Argentina suggests that loss of pertactin gene expression might be driven by aP vaccine. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-11 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/152229 Carriquiriborde, Francisco Pablo; Regidor, Victoria; Aispuro, Pablo M.; Gabrielli, Magali; Bartel, Erika Belén; et al.; Rare detection of bordetella pertussis pertactin-deficient strains in Argentina; Centers Disease Control; Emerging Infectious Diseases; 25; 11; 11-2019; 2048-2054 1080-6059 1080-6040 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/152229 |
identifier_str_mv |
Carriquiriborde, Francisco Pablo; Regidor, Victoria; Aispuro, Pablo M.; Gabrielli, Magali; Bartel, Erika Belén; et al.; Rare detection of bordetella pertussis pertactin-deficient strains in Argentina; Centers Disease Control; Emerging Infectious Diseases; 25; 11; 11-2019; 2048-2054 1080-6059 1080-6040 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.3201/eid2511.190329 info:eu-repo/semantics/altIdentifier/url/https://wwwnc.cdc.gov/eid/article/25/11/19-0329_article |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Centers Disease Control |
publisher.none.fl_str_mv |
Centers Disease Control |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844614265009340416 |
score |
13.070432 |