Biochemical properties and mechanism of action of a vanadyl(IV)-aspirin complex on bone cell lines in culture

Autores
Etcheverry, Susana Beatriz; Williams, Patricia Ana María; Sálice, Viviana C.; Barrio, Daniel Alejandro; Ferrer, Evelina Gloria; Cortizo, Ana María
Año de publicación
2002
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A recently synthesized vanadyl(IV) complex with aspirin [VO(aspirin)ClH2O]2, has been thoroughly investigated by physicochemical techniques. In order to support the proposed structure, stoichiometry and the coordination sphere of the vanadium center, some studies such as elemental analysis, electronic (diffuse reflectance) and vibrational (infrared) spectroscopies, magnetic susceptibility, as well as the thermal behavior, were carried out. The bioactivity of the vanadium complex (VOAspi) was evaluated on two osteoblast-like cell lines in culture, being its cytotoxic effects stronger than the vanadyl cation as assessed by morphological changes and lipid peroxidation. These effects may be partially explained through the induction of the expression of Erks (Extracellular signal-regulated kinases) and the inhibition of the PTPases (Phosphotyrosine phosphatases) present in the cellular extracts.
Centro de Química Inorgánica
Materia
Ciencias Exactas
Química
aspirin
cytotoxicity
osteoblasts
vanadium
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/132747
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/132747
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Biochemical properties and mechanism of action of a vanadyl(IV)-aspirin complex on bone cell lines in cultureEtcheverry, Susana BeatrizWilliams, Patricia Ana MaríaSálice, Viviana C.Barrio, Daniel AlejandroFerrer, Evelina GloriaCortizo, Ana MaríaCiencias ExactasQuímicaaspirincytotoxicityosteoblastsvanadiumA recently synthesized vanadyl(IV) complex with aspirin [VO(aspirin)ClH2O]2, has been thoroughly investigated by physicochemical techniques. In order to support the proposed structure, stoichiometry and the coordination sphere of the vanadium center, some studies such as elemental analysis, electronic (diffuse reflectance) and vibrational (infrared) spectroscopies, magnetic susceptibility, as well as the thermal behavior, were carried out. The bioactivity of the vanadium complex (VOAspi) was evaluated on two osteoblast-like cell lines in culture, being its cytotoxic effects stronger than the vanadyl cation as assessed by morphological changes and lipid peroxidation. These effects may be partially explained through the induction of the expression of Erks (Extracellular signal-regulated kinases) and the inhibition of the PTPases (Phosphotyrosine phosphatases) present in the cellular extracts.Centro de Química Inorgánica2002info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf37-49http://sedici.unlp.edu.ar/handle/10915/132747spainfo:eu-repo/semantics/altIdentifier/issn/0966-0844info:eu-repo/semantics/altIdentifier/issn/1572-8773info:eu-repo/semantics/altIdentifier/doi/10.1023/a:1013183910203info:eu-repo/semantics/altIdentifier/pmid/11865824info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T11:03:49Zoai:sedici.unlp.edu.ar:10915/132747Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 11:03:49.312SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Biochemical properties and mechanism of action of a vanadyl(IV)-aspirin complex on bone cell lines in culture
title Biochemical properties and mechanism of action of a vanadyl(IV)-aspirin complex on bone cell lines in culture
spellingShingle Biochemical properties and mechanism of action of a vanadyl(IV)-aspirin complex on bone cell lines in culture
Etcheverry, Susana Beatriz
Ciencias Exactas
Química
aspirin
cytotoxicity
osteoblasts
vanadium
title_short Biochemical properties and mechanism of action of a vanadyl(IV)-aspirin complex on bone cell lines in culture
title_full Biochemical properties and mechanism of action of a vanadyl(IV)-aspirin complex on bone cell lines in culture
title_fullStr Biochemical properties and mechanism of action of a vanadyl(IV)-aspirin complex on bone cell lines in culture
title_full_unstemmed Biochemical properties and mechanism of action of a vanadyl(IV)-aspirin complex on bone cell lines in culture
title_sort Biochemical properties and mechanism of action of a vanadyl(IV)-aspirin complex on bone cell lines in culture
dc.creator.none.fl_str_mv Etcheverry, Susana Beatriz
Williams, Patricia Ana María
Sálice, Viviana C.
Barrio, Daniel Alejandro
Ferrer, Evelina Gloria
Cortizo, Ana María
author Etcheverry, Susana Beatriz
author_facet Etcheverry, Susana Beatriz
Williams, Patricia Ana María
Sálice, Viviana C.
Barrio, Daniel Alejandro
Ferrer, Evelina Gloria
Cortizo, Ana María
author_role author
author2 Williams, Patricia Ana María
Sálice, Viviana C.
Barrio, Daniel Alejandro
Ferrer, Evelina Gloria
Cortizo, Ana María
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Química
aspirin
cytotoxicity
osteoblasts
vanadium
topic Ciencias Exactas
Química
aspirin
cytotoxicity
osteoblasts
vanadium
dc.description.none.fl_txt_mv A recently synthesized vanadyl(IV) complex with aspirin [VO(aspirin)ClH2O]2, has been thoroughly investigated by physicochemical techniques. In order to support the proposed structure, stoichiometry and the coordination sphere of the vanadium center, some studies such as elemental analysis, electronic (diffuse reflectance) and vibrational (infrared) spectroscopies, magnetic susceptibility, as well as the thermal behavior, were carried out. The bioactivity of the vanadium complex (VOAspi) was evaluated on two osteoblast-like cell lines in culture, being its cytotoxic effects stronger than the vanadyl cation as assessed by morphological changes and lipid peroxidation. These effects may be partially explained through the induction of the expression of Erks (Extracellular signal-regulated kinases) and the inhibition of the PTPases (Phosphotyrosine phosphatases) present in the cellular extracts.
Centro de Química Inorgánica
description A recently synthesized vanadyl(IV) complex with aspirin [VO(aspirin)ClH2O]2, has been thoroughly investigated by physicochemical techniques. In order to support the proposed structure, stoichiometry and the coordination sphere of the vanadium center, some studies such as elemental analysis, electronic (diffuse reflectance) and vibrational (infrared) spectroscopies, magnetic susceptibility, as well as the thermal behavior, were carried out. The bioactivity of the vanadium complex (VOAspi) was evaluated on two osteoblast-like cell lines in culture, being its cytotoxic effects stronger than the vanadyl cation as assessed by morphological changes and lipid peroxidation. These effects may be partially explained through the induction of the expression of Erks (Extracellular signal-regulated kinases) and the inhibition of the PTPases (Phosphotyrosine phosphatases) present in the cellular extracts.
publishDate 2002
dc.date.none.fl_str_mv 2002
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/132747
url http://sedici.unlp.edu.ar/handle/10915/132747
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0966-0844
info:eu-repo/semantics/altIdentifier/issn/1572-8773
info:eu-repo/semantics/altIdentifier/doi/10.1023/a:1013183910203
info:eu-repo/semantics/altIdentifier/pmid/11865824
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
37-49
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.13397

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