Biochemical properties and mechanism of action of a vanadyl(IV) – aspirin complex on bone cell lines in culture

Autores
Etcheverry, Susana B.; Williams, Patricia Ana María; Sálice, Viviana C.; Barrio, Daniel A.; Ferrer, Evelina G; Cortizo, Ana María
Año de publicación
2002
Idioma
inglés
Tipo de recurso
artículo
Estado
versión enviada
Descripción
A recently synthesized vanadyl(IV) complex with aspirin [VO(aspirin)ClH2O]2, has been thoroughly investigated by physicochemical techniques. In order to support the proposed structure, stoichiometry and the coordination sphere of the vanadium center, some studies such as elemental analysis, electronic (diffuse reflectance) and vibrational (infrared) spectroscopies, magnetic susceptibility, as well as the thermal behavior, were carried out. The bioactivity of the vanadium complex (VOAspi) was evaluated on two osteoblast-like cell lines in culture, being its cytotoxic effects stronger than the vanadyl cation as assessed by morphological changes and lipid peroxidation. These effects may be partially explained through the induction of the expression of Erks (Extracellular signal-regulated kinases) and the inhibition of the PTPases (Phosphotyrosine phosphatases) present in the cellular extracts.
Materia
Ciencias Químicas
aspirin
cytotoxicity
osteoblasts
vanadium
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
CIC Digital (CICBA)
Institución
Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
OAI Identificador
oai:digital.cic.gba.gob.ar:11746/4546
Acceder
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oai_identifier_str oai:digital.cic.gba.gob.ar:11746/4546
network_acronym_str CICBA
repository_id_str 9441
network_name_str CIC Digital (CICBA)
spelling Biochemical properties and mechanism of action of a vanadyl(IV) – aspirin complex on bone cell lines in cultureEtcheverry, Susana B.Williams, Patricia Ana MaríaSálice, Viviana C.Barrio, Daniel A.Ferrer, Evelina GCortizo, Ana MaríaCiencias QuímicasaspirincytotoxicityosteoblastsvanadiumA recently synthesized vanadyl(IV) complex with aspirin [VO(aspirin)ClH2O]2, has been thoroughly investigated by physicochemical techniques. In order to support the proposed structure, stoichiometry and the coordination sphere of the vanadium center, some studies such as elemental analysis, electronic (diffuse reflectance) and vibrational (infrared) spectroscopies, magnetic susceptibility, as well as the thermal behavior, were carried out. The bioactivity of the vanadium complex (VOAspi) was evaluated on two osteoblast-like cell lines in culture, being its cytotoxic effects stronger than the vanadyl cation as assessed by morphological changes and lipid peroxidation. These effects may be partially explained through the induction of the expression of Erks (Extracellular signal-regulated kinases) and the inhibition of the PTPases (Phosphotyrosine phosphatases) present in the cellular extracts.2002info:eu-repo/semantics/articleinfo:eu-repo/semantics/submittedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://digital.cic.gba.gob.ar/handle/11746/4546enginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/reponame:CIC Digital (CICBA)instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Airesinstacron:CICBA2025-09-04T09:43:29Zoai:digital.cic.gba.gob.ar:11746/4546Institucionalhttp://digital.cic.gba.gob.arOrganismo científico-tecnológicoNo correspondehttp://digital.cic.gba.gob.ar/oai/snrdmarisa.degiusti@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:94412025-09-04 09:43:29.846CIC Digital (CICBA) - Comisión de Investigaciones Científicas de la Provincia de Buenos Airesfalse
dc.title.none.fl_str_mv Biochemical properties and mechanism of action of a vanadyl(IV) – aspirin complex on bone cell lines in culture
title Biochemical properties and mechanism of action of a vanadyl(IV) – aspirin complex on bone cell lines in culture
spellingShingle Biochemical properties and mechanism of action of a vanadyl(IV) – aspirin complex on bone cell lines in culture
Etcheverry, Susana B.
Ciencias Químicas
aspirin
cytotoxicity
osteoblasts
vanadium
title_short Biochemical properties and mechanism of action of a vanadyl(IV) – aspirin complex on bone cell lines in culture
title_full Biochemical properties and mechanism of action of a vanadyl(IV) – aspirin complex on bone cell lines in culture
title_fullStr Biochemical properties and mechanism of action of a vanadyl(IV) – aspirin complex on bone cell lines in culture
title_full_unstemmed Biochemical properties and mechanism of action of a vanadyl(IV) – aspirin complex on bone cell lines in culture
title_sort Biochemical properties and mechanism of action of a vanadyl(IV) – aspirin complex on bone cell lines in culture
dc.creator.none.fl_str_mv Etcheverry, Susana B.
Williams, Patricia Ana María
Sálice, Viviana C.
Barrio, Daniel A.
Ferrer, Evelina G
Cortizo, Ana María
author Etcheverry, Susana B.
author_facet Etcheverry, Susana B.
Williams, Patricia Ana María
Sálice, Viviana C.
Barrio, Daniel A.
Ferrer, Evelina G
Cortizo, Ana María
author_role author
author2 Williams, Patricia Ana María
Sálice, Viviana C.
Barrio, Daniel A.
Ferrer, Evelina G
Cortizo, Ana María
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Químicas
aspirin
cytotoxicity
osteoblasts
vanadium
topic Ciencias Químicas
aspirin
cytotoxicity
osteoblasts
vanadium
dc.description.none.fl_txt_mv A recently synthesized vanadyl(IV) complex with aspirin [VO(aspirin)ClH2O]2, has been thoroughly investigated by physicochemical techniques. In order to support the proposed structure, stoichiometry and the coordination sphere of the vanadium center, some studies such as elemental analysis, electronic (diffuse reflectance) and vibrational (infrared) spectroscopies, magnetic susceptibility, as well as the thermal behavior, were carried out. The bioactivity of the vanadium complex (VOAspi) was evaluated on two osteoblast-like cell lines in culture, being its cytotoxic effects stronger than the vanadyl cation as assessed by morphological changes and lipid peroxidation. These effects may be partially explained through the induction of the expression of Erks (Extracellular signal-regulated kinases) and the inhibition of the PTPases (Phosphotyrosine phosphatases) present in the cellular extracts.
description A recently synthesized vanadyl(IV) complex with aspirin [VO(aspirin)ClH2O]2, has been thoroughly investigated by physicochemical techniques. In order to support the proposed structure, stoichiometry and the coordination sphere of the vanadium center, some studies such as elemental analysis, electronic (diffuse reflectance) and vibrational (infrared) spectroscopies, magnetic susceptibility, as well as the thermal behavior, were carried out. The bioactivity of the vanadium complex (VOAspi) was evaluated on two osteoblast-like cell lines in culture, being its cytotoxic effects stronger than the vanadyl cation as assessed by morphological changes and lipid peroxidation. These effects may be partially explained through the induction of the expression of Erks (Extracellular signal-regulated kinases) and the inhibition of the PTPases (Phosphotyrosine phosphatases) present in the cellular extracts.
publishDate 2002
dc.date.none.fl_str_mv 2002
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/submittedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv https://digital.cic.gba.gob.ar/handle/11746/4546
url https://digital.cic.gba.gob.ar/handle/11746/4546
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:CIC Digital (CICBA)
instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
instacron:CICBA
reponame_str CIC Digital (CICBA)
collection CIC Digital (CICBA)
instname_str Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
instacron_str CICBA
institution CICBA
repository.name.fl_str_mv CIC Digital (CICBA) - Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
repository.mail.fl_str_mv marisa.degiusti@sedici.unlp.edu.ar
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score 12.623145

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