Multi-target drug with potential applications: violacein in the spotlight

Autores
Durán, Nelson; Nakazato, Gerson; Durán, Marcela; Rivero Berti, Ignacio; Castro, Guillermo Raúl; Stanisic, Danijela; Brocchi, Marcelo; Fávaro, Wagner José; Ferreira-Halder, Carmen Veríssima; Justo, Giselle Z.; Tasic, Ljubica
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of the current review is to address updated research on a natural pigment called violacein, with emphasis on its production, biological activity and applications. New information about violacein’s action mechanisms as antitumor agent and about its synergistic action in drug delivery systems has brought new alternatives for anticancer therapy. Thus, violacein is introduced as reliable drug capable of overcoming at least three cancer hallmarks, namely: proliferative signaling, cell death resistance and metastasis. In addition, antimicrobial effects on several microorganisms affecting humans and other animals turn violacein into an attractive drug to combat resistant pathogens. Emphasis is given to effects of violacein combined with different agents, such as antibiotics, anticancer agents and nanoparticles. Although violacein is well-known for many decades, it remains an attractive compound. Thus, research groups have been making continuous effort to help improving its production in recent years, which can surely enable its pharmaceutical and chemical application as multi-task compound, even in the cosmetics and food industries.
Centro de Investigación y Desarrollo en Fermentaciones Industriales
Materia
Ciencias Exactas
Bioquímica
Biological activities
Chromobacterium violaceum
Genome
Production
Violacein
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/141055
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/141055
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Multi-target drug with potential applications: violacein in the spotlightDurán, NelsonNakazato, GersonDurán, MarcelaRivero Berti, IgnacioCastro, Guillermo RaúlStanisic, DanijelaBrocchi, MarceloFávaro, Wagner JoséFerreira-Halder, Carmen VeríssimaJusto, Giselle Z.Tasic, LjubicaCiencias ExactasBioquímicaBiological activitiesChromobacterium violaceumGenomeProductionViolaceinThe aim of the current review is to address updated research on a natural pigment called violacein, with emphasis on its production, biological activity and applications. New information about violacein’s action mechanisms as antitumor agent and about its synergistic action in drug delivery systems has brought new alternatives for anticancer therapy. Thus, violacein is introduced as reliable drug capable of overcoming at least three cancer hallmarks, namely: proliferative signaling, cell death resistance and metastasis. In addition, antimicrobial effects on several microorganisms affecting humans and other animals turn violacein into an attractive drug to combat resistant pathogens. Emphasis is given to effects of violacein combined with different agents, such as antibiotics, anticancer agents and nanoparticles. Although violacein is well-known for many decades, it remains an attractive compound. Thus, research groups have been making continuous effort to help improving its production in recent years, which can surely enable its pharmaceutical and chemical application as multi-task compound, even in the cosmetics and food industries.Centro de Investigación y Desarrollo en Fermentaciones Industriales2021-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/141055enginfo:eu-repo/semantics/altIdentifier/issn/1573-0972info:eu-repo/semantics/altIdentifier/issn/0959-3993info:eu-repo/semantics/altIdentifier/doi/10.1007/s11274-021-03120-4info:eu-repo/semantics/altIdentifier/pmid/34398340info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:32:32Zoai:sedici.unlp.edu.ar:10915/141055Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:32:33.185SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Multi-target drug with potential applications: violacein in the spotlight
title Multi-target drug with potential applications: violacein in the spotlight
spellingShingle Multi-target drug with potential applications: violacein in the spotlight
Durán, Nelson
Ciencias Exactas
Bioquímica
Biological activities
Chromobacterium violaceum
Genome
Production
Violacein
title_short Multi-target drug with potential applications: violacein in the spotlight
title_full Multi-target drug with potential applications: violacein in the spotlight
title_fullStr Multi-target drug with potential applications: violacein in the spotlight
title_full_unstemmed Multi-target drug with potential applications: violacein in the spotlight
title_sort Multi-target drug with potential applications: violacein in the spotlight
dc.creator.none.fl_str_mv Durán, Nelson
Nakazato, Gerson
Durán, Marcela
Rivero Berti, Ignacio
Castro, Guillermo Raúl
Stanisic, Danijela
Brocchi, Marcelo
Fávaro, Wagner José
Ferreira-Halder, Carmen Veríssima
Justo, Giselle Z.
Tasic, Ljubica
author Durán, Nelson
author_facet Durán, Nelson
Nakazato, Gerson
Durán, Marcela
Rivero Berti, Ignacio
Castro, Guillermo Raúl
Stanisic, Danijela
Brocchi, Marcelo
Fávaro, Wagner José
Ferreira-Halder, Carmen Veríssima
Justo, Giselle Z.
Tasic, Ljubica
author_role author
author2 Nakazato, Gerson
Durán, Marcela
Rivero Berti, Ignacio
Castro, Guillermo Raúl
Stanisic, Danijela
Brocchi, Marcelo
Fávaro, Wagner José
Ferreira-Halder, Carmen Veríssima
Justo, Giselle Z.
Tasic, Ljubica
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Bioquímica
Biological activities
Chromobacterium violaceum
Genome
Production
Violacein
topic Ciencias Exactas
Bioquímica
Biological activities
Chromobacterium violaceum
Genome
Production
Violacein
dc.description.none.fl_txt_mv The aim of the current review is to address updated research on a natural pigment called violacein, with emphasis on its production, biological activity and applications. New information about violacein’s action mechanisms as antitumor agent and about its synergistic action in drug delivery systems has brought new alternatives for anticancer therapy. Thus, violacein is introduced as reliable drug capable of overcoming at least three cancer hallmarks, namely: proliferative signaling, cell death resistance and metastasis. In addition, antimicrobial effects on several microorganisms affecting humans and other animals turn violacein into an attractive drug to combat resistant pathogens. Emphasis is given to effects of violacein combined with different agents, such as antibiotics, anticancer agents and nanoparticles. Although violacein is well-known for many decades, it remains an attractive compound. Thus, research groups have been making continuous effort to help improving its production in recent years, which can surely enable its pharmaceutical and chemical application as multi-task compound, even in the cosmetics and food industries.
Centro de Investigación y Desarrollo en Fermentaciones Industriales
description The aim of the current review is to address updated research on a natural pigment called violacein, with emphasis on its production, biological activity and applications. New information about violacein’s action mechanisms as antitumor agent and about its synergistic action in drug delivery systems has brought new alternatives for anticancer therapy. Thus, violacein is introduced as reliable drug capable of overcoming at least three cancer hallmarks, namely: proliferative signaling, cell death resistance and metastasis. In addition, antimicrobial effects on several microorganisms affecting humans and other animals turn violacein into an attractive drug to combat resistant pathogens. Emphasis is given to effects of violacein combined with different agents, such as antibiotics, anticancer agents and nanoparticles. Although violacein is well-known for many decades, it remains an attractive compound. Thus, research groups have been making continuous effort to help improving its production in recent years, which can surely enable its pharmaceutical and chemical application as multi-task compound, even in the cosmetics and food industries.
publishDate 2021
dc.date.none.fl_str_mv 2021-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/141055
url http://sedici.unlp.edu.ar/handle/10915/141055
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1573-0972
info:eu-repo/semantics/altIdentifier/issn/0959-3993
info:eu-repo/semantics/altIdentifier/doi/10.1007/s11274-021-03120-4
info:eu-repo/semantics/altIdentifier/pmid/34398340
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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