Multi-target drug with potential applications: violacein in the spotlight

Autores
Durán, Nelson; Nakazato, Gerson; Durán, Marcela; Rivero Berti, Ignacio; Castro, Guillermo Raul; Stanisic, Danijela; Brocchi, Marcelo; Fávaro, Wagner J.; Ferreira Halder, Carmen V.; Justo, Giselle Z.; Tasic, Ljubica
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of the current review is to address updated research on a natural pigment called violacein, with emphasis on its production, biological activity and applications. New information about violacein’s action mechanisms as antitumor agent and about its synergistic action in drug delivery systems has brought new alternatives for anticancer therapy. Thus, violacein is introduced as reliable drug capable of overcoming at least three cancer hallmarks, namely: proliferative signaling, cell death resistance and metastasis. In addition, antimicrobial effects on several microorganisms affecting humans and other animals turn violacein into an attractive drug to combat resistant pathogens. Emphasis is given to effects of violacein combined with different agents, such as antibiotics, anticancer agents and nanoparticles. Although violacein is well-known for many decades, it remains an attractive compound. Thus, research groups have been making continuous effort to help improving its production in recent years, which can surely enable its pharmaceutical and chemical application as multi-task compound, even in the cosmetics and food industries.
Fil: Durán, Nelson. Universidade Estadual de Campinas; Brasil
Fil: Nakazato, Gerson. Universidade Estadual de Londrina; Brasil
Fil: Durán, Marcela. Universidade Estadual de Campinas; Brasil
Fil: Rivero Berti, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina
Fil: Castro, Guillermo Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina
Fil: Stanisic, Danijela. Universidade Estadual de Campinas; Brasil
Fil: Brocchi, Marcelo. Universidade Estadual de Campinas; Brasil
Fil: Fávaro, Wagner J.. Universidade Estadual de Campinas; Brasil
Fil: Ferreira Halder, Carmen V.. Universidade Estadual de Campinas; Brasil
Fil: Justo, Giselle Z.. Universidade Federal de Sao Paulo.; Brasil
Fil: Tasic, Ljubica. Universidade Estadual de Campinas; Brasil
Materia
BIOLOGICAL ACTIVITIES
CHROMOBACTERIUM VIOLACEUM
GENOME
PRODUCTION
VIOLACEIN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/181058
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/181058
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Multi-target drug with potential applications: violacein in the spotlightDurán, NelsonNakazato, GersonDurán, MarcelaRivero Berti, IgnacioCastro, Guillermo RaulStanisic, DanijelaBrocchi, MarceloFávaro, Wagner J.Ferreira Halder, Carmen V.Justo, Giselle Z.Tasic, LjubicaBIOLOGICAL ACTIVITIESCHROMOBACTERIUM VIOLACEUMGENOMEPRODUCTIONVIOLACEINhttps://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2The aim of the current review is to address updated research on a natural pigment called violacein, with emphasis on its production, biological activity and applications. New information about violacein’s action mechanisms as antitumor agent and about its synergistic action in drug delivery systems has brought new alternatives for anticancer therapy. Thus, violacein is introduced as reliable drug capable of overcoming at least three cancer hallmarks, namely: proliferative signaling, cell death resistance and metastasis. In addition, antimicrobial effects on several microorganisms affecting humans and other animals turn violacein into an attractive drug to combat resistant pathogens. Emphasis is given to effects of violacein combined with different agents, such as antibiotics, anticancer agents and nanoparticles. Although violacein is well-known for many decades, it remains an attractive compound. Thus, research groups have been making continuous effort to help improving its production in recent years, which can surely enable its pharmaceutical and chemical application as multi-task compound, even in the cosmetics and food industries.Fil: Durán, Nelson. Universidade Estadual de Campinas; BrasilFil: Nakazato, Gerson. Universidade Estadual de Londrina; BrasilFil: Durán, Marcela. Universidade Estadual de Campinas; BrasilFil: Rivero Berti, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; ArgentinaFil: Castro, Guillermo Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; ArgentinaFil: Stanisic, Danijela. Universidade Estadual de Campinas; BrasilFil: Brocchi, Marcelo. Universidade Estadual de Campinas; BrasilFil: Fávaro, Wagner J.. Universidade Estadual de Campinas; BrasilFil: Ferreira Halder, Carmen V.. Universidade Estadual de Campinas; BrasilFil: Justo, Giselle Z.. Universidade Federal de Sao Paulo.; BrasilFil: Tasic, Ljubica. Universidade Estadual de Campinas; BrasilSpringer2021-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/181058Durán, Nelson; Nakazato, Gerson; Durán, Marcela; Rivero Berti, Ignacio; Castro, Guillermo Raul; et al.; Multi-target drug with potential applications: violacein in the spotlight; Springer; World Journal of Microbiology; 37; 9; 8-2021; 151-1710959-3993CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/10.1007/s11274-021-03120-4info:eu-repo/semantics/altIdentifier/doi/10.1007/s11274-021-03120-4info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:35:46Zoai:ri.conicet.gov.ar:11336/181058instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:35:47.226CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Multi-target drug with potential applications: violacein in the spotlight
title Multi-target drug with potential applications: violacein in the spotlight
spellingShingle Multi-target drug with potential applications: violacein in the spotlight
Durán, Nelson
BIOLOGICAL ACTIVITIES
CHROMOBACTERIUM VIOLACEUM
GENOME
PRODUCTION
VIOLACEIN
title_short Multi-target drug with potential applications: violacein in the spotlight
title_full Multi-target drug with potential applications: violacein in the spotlight
title_fullStr Multi-target drug with potential applications: violacein in the spotlight
title_full_unstemmed Multi-target drug with potential applications: violacein in the spotlight
title_sort Multi-target drug with potential applications: violacein in the spotlight
dc.creator.none.fl_str_mv Durán, Nelson
Nakazato, Gerson
Durán, Marcela
Rivero Berti, Ignacio
Castro, Guillermo Raul
Stanisic, Danijela
Brocchi, Marcelo
Fávaro, Wagner J.
Ferreira Halder, Carmen V.
Justo, Giselle Z.
Tasic, Ljubica
author Durán, Nelson
author_facet Durán, Nelson
Nakazato, Gerson
Durán, Marcela
Rivero Berti, Ignacio
Castro, Guillermo Raul
Stanisic, Danijela
Brocchi, Marcelo
Fávaro, Wagner J.
Ferreira Halder, Carmen V.
Justo, Giselle Z.
Tasic, Ljubica
author_role author
author2 Nakazato, Gerson
Durán, Marcela
Rivero Berti, Ignacio
Castro, Guillermo Raul
Stanisic, Danijela
Brocchi, Marcelo
Fávaro, Wagner J.
Ferreira Halder, Carmen V.
Justo, Giselle Z.
Tasic, Ljubica
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BIOLOGICAL ACTIVITIES
CHROMOBACTERIUM VIOLACEUM
GENOME
PRODUCTION
VIOLACEIN
topic BIOLOGICAL ACTIVITIES
CHROMOBACTERIUM VIOLACEUM
GENOME
PRODUCTION
VIOLACEIN
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The aim of the current review is to address updated research on a natural pigment called violacein, with emphasis on its production, biological activity and applications. New information about violacein’s action mechanisms as antitumor agent and about its synergistic action in drug delivery systems has brought new alternatives for anticancer therapy. Thus, violacein is introduced as reliable drug capable of overcoming at least three cancer hallmarks, namely: proliferative signaling, cell death resistance and metastasis. In addition, antimicrobial effects on several microorganisms affecting humans and other animals turn violacein into an attractive drug to combat resistant pathogens. Emphasis is given to effects of violacein combined with different agents, such as antibiotics, anticancer agents and nanoparticles. Although violacein is well-known for many decades, it remains an attractive compound. Thus, research groups have been making continuous effort to help improving its production in recent years, which can surely enable its pharmaceutical and chemical application as multi-task compound, even in the cosmetics and food industries.
Fil: Durán, Nelson. Universidade Estadual de Campinas; Brasil
Fil: Nakazato, Gerson. Universidade Estadual de Londrina; Brasil
Fil: Durán, Marcela. Universidade Estadual de Campinas; Brasil
Fil: Rivero Berti, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina
Fil: Castro, Guillermo Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina
Fil: Stanisic, Danijela. Universidade Estadual de Campinas; Brasil
Fil: Brocchi, Marcelo. Universidade Estadual de Campinas; Brasil
Fil: Fávaro, Wagner J.. Universidade Estadual de Campinas; Brasil
Fil: Ferreira Halder, Carmen V.. Universidade Estadual de Campinas; Brasil
Fil: Justo, Giselle Z.. Universidade Federal de Sao Paulo.; Brasil
Fil: Tasic, Ljubica. Universidade Estadual de Campinas; Brasil
description The aim of the current review is to address updated research on a natural pigment called violacein, with emphasis on its production, biological activity and applications. New information about violacein’s action mechanisms as antitumor agent and about its synergistic action in drug delivery systems has brought new alternatives for anticancer therapy. Thus, violacein is introduced as reliable drug capable of overcoming at least three cancer hallmarks, namely: proliferative signaling, cell death resistance and metastasis. In addition, antimicrobial effects on several microorganisms affecting humans and other animals turn violacein into an attractive drug to combat resistant pathogens. Emphasis is given to effects of violacein combined with different agents, such as antibiotics, anticancer agents and nanoparticles. Although violacein is well-known for many decades, it remains an attractive compound. Thus, research groups have been making continuous effort to help improving its production in recent years, which can surely enable its pharmaceutical and chemical application as multi-task compound, even in the cosmetics and food industries.
publishDate 2021
dc.date.none.fl_str_mv 2021-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/181058
Durán, Nelson; Nakazato, Gerson; Durán, Marcela; Rivero Berti, Ignacio; Castro, Guillermo Raul; et al.; Multi-target drug with potential applications: violacein in the spotlight; Springer; World Journal of Microbiology; 37; 9; 8-2021; 151-171
0959-3993
CONICET Digital
CONICET
url http://hdl.handle.net/11336/181058
identifier_str_mv Durán, Nelson; Nakazato, Gerson; Durán, Marcela; Rivero Berti, Ignacio; Castro, Guillermo Raul; et al.; Multi-target drug with potential applications: violacein in the spotlight; Springer; World Journal of Microbiology; 37; 9; 8-2021; 151-171
0959-3993
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/10.1007/s11274-021-03120-4
info:eu-repo/semantics/altIdentifier/doi/10.1007/s11274-021-03120-4
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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