Protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitis

Autores
Portiansky, Enrique Leo; González, Pedro Horacio
Año de publicación
1995
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Experimental infection of mice with foot-and-mouth disease virus (FMDV) induces a necrotizing pancreatitis of the exocrinar portion of the organ. The lesions are characterized by vascular congestion, edema and interstitial polymorphonuclear leukocyte (PMN) infiltrates. When infected mice were treated with different amounts of lidocaine (a local anesthetic, chemically defined as a tertiary amide compound), reduction in intensity of the pancreatic necrosis and in the number of PMN were observed. Even though lidocaine could interfere with FMDV post-replicative cytolytic mechanisms, it appears that protection against pancreatic necrosis is by attenuation of PMN presentation in the infected tissue.
Facultad de Ciencias Veterinarias
Facultad de Ciencias Médicas
Materia
Ciencias Médicas
Veterinaria
foot-and-mouth disease
lidocaine
pancreatitis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/137861
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/137861
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitisPortiansky, Enrique LeoGonzález, Pedro HoracioCiencias MédicasVeterinariafoot-and-mouth diseaselidocainepancreatitisExperimental infection of mice with foot-and-mouth disease virus (FMDV) induces a necrotizing pancreatitis of the exocrinar portion of the organ. The lesions are characterized by vascular congestion, edema and interstitial polymorphonuclear leukocyte (PMN) infiltrates. When infected mice were treated with different amounts of lidocaine (a local anesthetic, chemically defined as a tertiary amide compound), reduction in intensity of the pancreatic necrosis and in the number of PMN were observed. Even though lidocaine could interfere with FMDV post-replicative cytolytic mechanisms, it appears that protection against pancreatic necrosis is by attenuation of PMN presentation in the infected tissue.Facultad de Ciencias VeterinariasFacultad de Ciencias Médicas1995-11-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1060-1062http://sedici.unlp.edu.ar/handle/10915/137861enginfo:eu-repo/semantics/altIdentifier/issn/0014-4754info:eu-repo/semantics/altIdentifier/issn/1420-9071info:eu-repo/semantics/altIdentifier/issn/1420-682xinfo:eu-repo/semantics/altIdentifier/doi/10.1007/bf01946916info:eu-repo/semantics/altIdentifier/pmid/7498445info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-11-26T10:09:49Zoai:sedici.unlp.edu.ar:10915/137861Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-11-26 10:09:49.976SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitis
title Protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitis
spellingShingle Protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitis
Portiansky, Enrique Leo
Ciencias Médicas
Veterinaria
foot-and-mouth disease
lidocaine
pancreatitis
title_short Protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitis
title_full Protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitis
title_fullStr Protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitis
title_full_unstemmed Protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitis
title_sort Protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitis
dc.creator.none.fl_str_mv Portiansky, Enrique Leo
González, Pedro Horacio
author Portiansky, Enrique Leo
author_facet Portiansky, Enrique Leo
González, Pedro Horacio
author_role author
author2 González, Pedro Horacio
author2_role author
dc.subject.none.fl_str_mv Ciencias Médicas
Veterinaria
foot-and-mouth disease
lidocaine
pancreatitis
topic Ciencias Médicas
Veterinaria
foot-and-mouth disease
lidocaine
pancreatitis
dc.description.none.fl_txt_mv Experimental infection of mice with foot-and-mouth disease virus (FMDV) induces a necrotizing pancreatitis of the exocrinar portion of the organ. The lesions are characterized by vascular congestion, edema and interstitial polymorphonuclear leukocyte (PMN) infiltrates. When infected mice were treated with different amounts of lidocaine (a local anesthetic, chemically defined as a tertiary amide compound), reduction in intensity of the pancreatic necrosis and in the number of PMN were observed. Even though lidocaine could interfere with FMDV post-replicative cytolytic mechanisms, it appears that protection against pancreatic necrosis is by attenuation of PMN presentation in the infected tissue.
Facultad de Ciencias Veterinarias
Facultad de Ciencias Médicas
description Experimental infection of mice with foot-and-mouth disease virus (FMDV) induces a necrotizing pancreatitis of the exocrinar portion of the organ. The lesions are characterized by vascular congestion, edema and interstitial polymorphonuclear leukocyte (PMN) infiltrates. When infected mice were treated with different amounts of lidocaine (a local anesthetic, chemically defined as a tertiary amide compound), reduction in intensity of the pancreatic necrosis and in the number of PMN were observed. Even though lidocaine could interfere with FMDV post-replicative cytolytic mechanisms, it appears that protection against pancreatic necrosis is by attenuation of PMN presentation in the infected tissue.
publishDate 1995
dc.date.none.fl_str_mv 1995-11-15
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/137861
url http://sedici.unlp.edu.ar/handle/10915/137861
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0014-4754
info:eu-repo/semantics/altIdentifier/issn/1420-9071
info:eu-repo/semantics/altIdentifier/issn/1420-682x
info:eu-repo/semantics/altIdentifier/doi/10.1007/bf01946916
info:eu-repo/semantics/altIdentifier/pmid/7498445
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
1060-1062
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.011256

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