Importance of foot and mouth disease vaccine purity in interpreting serological surveys

Autores
Smitsaart, E.; Espinosa, A. M.; Maradei, E. D.; Cosentino, B.; Guinzburg, M.; Maddoni, G.; Cadennazzi, G.; Bottini, R.; Filippi, J.; Bergmann, Ingrid Evelyn
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this study was to determine whether the degree of purity achieved in conventional vaccines against the foot and mouth disease virus in Argentina interferes with the interpretation of seroepidemiological surveys for confirming the absence of viral activity, which are performed to support the recognition of free zones practising vaccination. The evaluation of 168 vaccine series due to be marketed in Argentina (2006–2012) and subjected to official control testing in cattle, as well as repeated vaccination of cattle and other species using vaccines with high antigen concentrations, demonstrated that they did not induce antibodies to non-structural proteins (NSPs). The results show clearly that vaccines with satisfactory potency do not induce a response to NSPs, even by forcing the immune response through more concentrated doses with multiple valences and revaccination protocols at shorter intervals than in vaccination campaigns. These results confirm that the vaccines used in routine vaccination programmes have a degree of antigen purification consistent with the needs observed on the basis of sampling for serological surveillance. Moreover, serological surveys conducted in 2006–2011 by Argentina’s official Veterinary Services – the National Health and Agrifood Quality Service (SENASA) – on more than 23,000 sera per year from cattle included in the vaccination programme, in order to confirm the absence of virus circulation, revealed an average 0.05% of reactive results, consistent with the specificity of the tests. In conclusion, the vaccines produced by conventional methods and with proven potency that are available in Argentina are sufficiently purified to ensure that they do not interfere with the interpretation of sampling for serological surveillance performed to support the recognition of FMD-free zones practising vaccination.
Fil: Smitsaart, E.. Biogénesis Bagó; Argentina
Fil: Espinosa, A. M.. Biogénesis Bagó; Argentina
Fil: Maradei, E. D.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Cosentino, B.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Guinzburg, M.. Biogénesis Bagó; Argentina
Fil: Maddoni, G.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Cadennazzi, G.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Bottini, R.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Filippi, J.. Biogénesis Bagó; Argentina
Fil: Bergmann, Ingrid Evelyn. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología ; Argentina
Materia
Foot-And-Mouth Disease
Herd Immunity
Serosurveys
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/40342
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/40342
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Importance of foot and mouth disease vaccine purity in interpreting serological surveysSmitsaart, E.Espinosa, A. M.Maradei, E. D.Cosentino, B.Guinzburg, M.Maddoni, G.Cadennazzi, G.Bottini, R.Filippi, J.Bergmann, Ingrid EvelynFoot-And-Mouth DiseaseHerd ImmunitySerosurveysThe aim of this study was to determine whether the degree of purity achieved in conventional vaccines against the foot and mouth disease virus in Argentina interferes with the interpretation of seroepidemiological surveys for confirming the absence of viral activity, which are performed to support the recognition of free zones practising vaccination. The evaluation of 168 vaccine series due to be marketed in Argentina (2006–2012) and subjected to official control testing in cattle, as well as repeated vaccination of cattle and other species using vaccines with high antigen concentrations, demonstrated that they did not induce antibodies to non-structural proteins (NSPs). The results show clearly that vaccines with satisfactory potency do not induce a response to NSPs, even by forcing the immune response through more concentrated doses with multiple valences and revaccination protocols at shorter intervals than in vaccination campaigns. These results confirm that the vaccines used in routine vaccination programmes have a degree of antigen purification consistent with the needs observed on the basis of sampling for serological surveillance. Moreover, serological surveys conducted in 2006–2011 by Argentina’s official Veterinary Services – the National Health and Agrifood Quality Service (SENASA) – on more than 23,000 sera per year from cattle included in the vaccination programme, in order to confirm the absence of virus circulation, revealed an average 0.05% of reactive results, consistent with the specificity of the tests. In conclusion, the vaccines produced by conventional methods and with proven potency that are available in Argentina are sufficiently purified to ensure that they do not interfere with the interpretation of sampling for serological surveillance performed to support the recognition of FMD-free zones practising vaccination.Fil: Smitsaart, E.. Biogénesis Bagó; ArgentinaFil: Espinosa, A. M.. Biogénesis Bagó; ArgentinaFil: Maradei, E. D.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; ArgentinaFil: Cosentino, B.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; ArgentinaFil: Guinzburg, M.. Biogénesis Bagó; ArgentinaFil: Maddoni, G.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; ArgentinaFil: Cadennazzi, G.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; ArgentinaFil: Bottini, R.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; ArgentinaFil: Filippi, J.. Biogénesis Bagó; ArgentinaFil: Bergmann, Ingrid Evelyn. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología ; ArgentinaOffice Int Epizooties2015-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/40342Smitsaart, E.; Espinosa, A. M.; Maradei, E. D.; Cosentino, B.; Guinzburg, M.; et al.; Importance of foot and mouth disease vaccine purity in interpreting serological surveys; Office Int Epizooties; Revue Scientifique Et Technique de L'office International Des Epizooties; 34; 3; 12-2015; 755-7660253-1933CONICET DigitalCONICETenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:50:04Zoai:ri.conicet.gov.ar:11336/40342instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:50:04.309CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Importance of foot and mouth disease vaccine purity in interpreting serological surveys
title Importance of foot and mouth disease vaccine purity in interpreting serological surveys
spellingShingle Importance of foot and mouth disease vaccine purity in interpreting serological surveys
Smitsaart, E.
Foot-And-Mouth Disease
Herd Immunity
Serosurveys
title_short Importance of foot and mouth disease vaccine purity in interpreting serological surveys
title_full Importance of foot and mouth disease vaccine purity in interpreting serological surveys
title_fullStr Importance of foot and mouth disease vaccine purity in interpreting serological surveys
title_full_unstemmed Importance of foot and mouth disease vaccine purity in interpreting serological surveys
title_sort Importance of foot and mouth disease vaccine purity in interpreting serological surveys
dc.creator.none.fl_str_mv Smitsaart, E.
Espinosa, A. M.
Maradei, E. D.
Cosentino, B.
Guinzburg, M.
Maddoni, G.
Cadennazzi, G.
Bottini, R.
Filippi, J.
Bergmann, Ingrid Evelyn
author Smitsaart, E.
author_facet Smitsaart, E.
Espinosa, A. M.
Maradei, E. D.
Cosentino, B.
Guinzburg, M.
Maddoni, G.
Cadennazzi, G.
Bottini, R.
Filippi, J.
Bergmann, Ingrid Evelyn
author_role author
author2 Espinosa, A. M.
Maradei, E. D.
Cosentino, B.
Guinzburg, M.
Maddoni, G.
Cadennazzi, G.
Bottini, R.
Filippi, J.
Bergmann, Ingrid Evelyn
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Foot-And-Mouth Disease
Herd Immunity
Serosurveys
topic Foot-And-Mouth Disease
Herd Immunity
Serosurveys
dc.description.none.fl_txt_mv The aim of this study was to determine whether the degree of purity achieved in conventional vaccines against the foot and mouth disease virus in Argentina interferes with the interpretation of seroepidemiological surveys for confirming the absence of viral activity, which are performed to support the recognition of free zones practising vaccination. The evaluation of 168 vaccine series due to be marketed in Argentina (2006–2012) and subjected to official control testing in cattle, as well as repeated vaccination of cattle and other species using vaccines with high antigen concentrations, demonstrated that they did not induce antibodies to non-structural proteins (NSPs). The results show clearly that vaccines with satisfactory potency do not induce a response to NSPs, even by forcing the immune response through more concentrated doses with multiple valences and revaccination protocols at shorter intervals than in vaccination campaigns. These results confirm that the vaccines used in routine vaccination programmes have a degree of antigen purification consistent with the needs observed on the basis of sampling for serological surveillance. Moreover, serological surveys conducted in 2006–2011 by Argentina’s official Veterinary Services – the National Health and Agrifood Quality Service (SENASA) – on more than 23,000 sera per year from cattle included in the vaccination programme, in order to confirm the absence of virus circulation, revealed an average 0.05% of reactive results, consistent with the specificity of the tests. In conclusion, the vaccines produced by conventional methods and with proven potency that are available in Argentina are sufficiently purified to ensure that they do not interfere with the interpretation of sampling for serological surveillance performed to support the recognition of FMD-free zones practising vaccination.
Fil: Smitsaart, E.. Biogénesis Bagó; Argentina
Fil: Espinosa, A. M.. Biogénesis Bagó; Argentina
Fil: Maradei, E. D.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Cosentino, B.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Guinzburg, M.. Biogénesis Bagó; Argentina
Fil: Maddoni, G.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Cadennazzi, G.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Bottini, R.. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Filippi, J.. Biogénesis Bagó; Argentina
Fil: Bergmann, Ingrid Evelyn. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología ; Argentina
description The aim of this study was to determine whether the degree of purity achieved in conventional vaccines against the foot and mouth disease virus in Argentina interferes with the interpretation of seroepidemiological surveys for confirming the absence of viral activity, which are performed to support the recognition of free zones practising vaccination. The evaluation of 168 vaccine series due to be marketed in Argentina (2006–2012) and subjected to official control testing in cattle, as well as repeated vaccination of cattle and other species using vaccines with high antigen concentrations, demonstrated that they did not induce antibodies to non-structural proteins (NSPs). The results show clearly that vaccines with satisfactory potency do not induce a response to NSPs, even by forcing the immune response through more concentrated doses with multiple valences and revaccination protocols at shorter intervals than in vaccination campaigns. These results confirm that the vaccines used in routine vaccination programmes have a degree of antigen purification consistent with the needs observed on the basis of sampling for serological surveillance. Moreover, serological surveys conducted in 2006–2011 by Argentina’s official Veterinary Services – the National Health and Agrifood Quality Service (SENASA) – on more than 23,000 sera per year from cattle included in the vaccination programme, in order to confirm the absence of virus circulation, revealed an average 0.05% of reactive results, consistent with the specificity of the tests. In conclusion, the vaccines produced by conventional methods and with proven potency that are available in Argentina are sufficiently purified to ensure that they do not interfere with the interpretation of sampling for serological surveillance performed to support the recognition of FMD-free zones practising vaccination.
publishDate 2015
dc.date.none.fl_str_mv 2015-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/40342
Smitsaart, E.; Espinosa, A. M.; Maradei, E. D.; Cosentino, B.; Guinzburg, M.; et al.; Importance of foot and mouth disease vaccine purity in interpreting serological surveys; Office Int Epizooties; Revue Scientifique Et Technique de L'office International Des Epizooties; 34; 3; 12-2015; 755-766
0253-1933
CONICET Digital
CONICET
url http://hdl.handle.net/11336/40342
identifier_str_mv Smitsaart, E.; Espinosa, A. M.; Maradei, E. D.; Cosentino, B.; Guinzburg, M.; et al.; Importance of foot and mouth disease vaccine purity in interpreting serological surveys; Office Int Epizooties; Revue Scientifique Et Technique de L'office International Des Epizooties; 34; 3; 12-2015; 755-766
0253-1933
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Office Int Epizooties
publisher.none.fl_str_mv Office Int Epizooties
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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