Effect of different carbon sources on the biosynthesis of polyunsaturated fatty acids of α-linolenic acid family in culture of minimal deviation hepatoma 7288 c cells
- Autores
- Tacconi de Alaniz, María Josefa; Brenner, Rodolfo Roberto
- Año de publicación
- 1976
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The effect of three different carbon sources on the biosynthesis of polyunsaturated fatty acids of the α-linolenic acid series was investigated in hepatoma tissue culture (HTC) cells. Alpha linolenic acid was converted to higher homologs by a desaturating route that synthetized mainly 18:4 (Δ6, 9, 12, 15), 20:4 (Δ8, 11, 14, 17) and 20:5 (Δ5, 8, 11, 14, 17) and an elongating route that produced 20:3 (Δ11, 14, 17) and 20:4 (Δ5, 11, 14, 17) acids. ‘Fasting’ decreased both biosynthetic routes whereas glucose reactivated only the elongating pathway. Lactalbumin hydrolysate enhanced significantly only the desaturating route whereas glycerol was inactive. Glucose and aminoacids increased similarly the incorporation of labeledα linolenic acid in the cells. The results are independent of hormonal effects.
Facultad de Ciencias Médicas - Materia
-
Medicina
Bioquímica
Alpha linolenic acid
hepatoma tissue culture
carbon - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
.jpg)
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/141425
Ver los metadatos del registro completo
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Effect of different carbon sources on the biosynthesis of polyunsaturated fatty acids of α-linolenic acid family in culture of minimal deviation hepatoma 7288 c cellsTacconi de Alaniz, María JosefaBrenner, Rodolfo RobertoMedicinaBioquímicaAlpha linolenic acidhepatoma tissue culturecarbonThe effect of three different carbon sources on the biosynthesis of polyunsaturated fatty acids of the α-linolenic acid series was investigated in hepatoma tissue culture (HTC) cells. Alpha linolenic acid was converted to higher homologs by a desaturating route that synthetized mainly 18:4 (Δ6, 9, 12, 15), 20:4 (Δ8, 11, 14, 17) and 20:5 (Δ5, 8, 11, 14, 17) and an elongating route that produced 20:3 (Δ11, 14, 17) and 20:4 (Δ5, 11, 14, 17) acids. ‘Fasting’ decreased both biosynthetic routes whereas glucose reactivated only the elongating pathway. Lactalbumin hydrolysate enhanced significantly only the desaturating route whereas glycerol was inactive. Glucose and aminoacids increased similarly the incorporation of labeledα linolenic acid in the cells. The results are independent of hormonal effects.Facultad de Ciencias Médicas1976-08-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf81-87http://sedici.unlp.edu.ar/handle/10915/141425enginfo:eu-repo/semantics/altIdentifier/issn/0300-8177info:eu-repo/semantics/altIdentifier/issn/1573-4919info:eu-repo/semantics/altIdentifier/doi/10.1007/bf01731553info:eu-repo/semantics/altIdentifier/pmid/183100info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:32:07Zoai:sedici.unlp.edu.ar:10915/141425Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:32:08.264SEDICI (UNLP) - Universidad Nacional de La Platafalse |
| dc.title.none.fl_str_mv |
Effect of different carbon sources on the biosynthesis of polyunsaturated fatty acids of α-linolenic acid family in culture of minimal deviation hepatoma 7288 c cells |
| title |
Effect of different carbon sources on the biosynthesis of polyunsaturated fatty acids of α-linolenic acid family in culture of minimal deviation hepatoma 7288 c cells |
| spellingShingle |
Effect of different carbon sources on the biosynthesis of polyunsaturated fatty acids of α-linolenic acid family in culture of minimal deviation hepatoma 7288 c cells Tacconi de Alaniz, María Josefa Medicina Bioquímica Alpha linolenic acid hepatoma tissue culture carbon |
| title_short |
Effect of different carbon sources on the biosynthesis of polyunsaturated fatty acids of α-linolenic acid family in culture of minimal deviation hepatoma 7288 c cells |
| title_full |
Effect of different carbon sources on the biosynthesis of polyunsaturated fatty acids of α-linolenic acid family in culture of minimal deviation hepatoma 7288 c cells |
| title_fullStr |
Effect of different carbon sources on the biosynthesis of polyunsaturated fatty acids of α-linolenic acid family in culture of minimal deviation hepatoma 7288 c cells |
| title_full_unstemmed |
Effect of different carbon sources on the biosynthesis of polyunsaturated fatty acids of α-linolenic acid family in culture of minimal deviation hepatoma 7288 c cells |
| title_sort |
Effect of different carbon sources on the biosynthesis of polyunsaturated fatty acids of α-linolenic acid family in culture of minimal deviation hepatoma 7288 c cells |
| dc.creator.none.fl_str_mv |
Tacconi de Alaniz, María Josefa Brenner, Rodolfo Roberto |
| author |
Tacconi de Alaniz, María Josefa |
| author_facet |
Tacconi de Alaniz, María Josefa Brenner, Rodolfo Roberto |
| author_role |
author |
| author2 |
Brenner, Rodolfo Roberto |
| author2_role |
author |
| dc.subject.none.fl_str_mv |
Medicina Bioquímica Alpha linolenic acid hepatoma tissue culture carbon |
| topic |
Medicina Bioquímica Alpha linolenic acid hepatoma tissue culture carbon |
| dc.description.none.fl_txt_mv |
The effect of three different carbon sources on the biosynthesis of polyunsaturated fatty acids of the α-linolenic acid series was investigated in hepatoma tissue culture (HTC) cells. Alpha linolenic acid was converted to higher homologs by a desaturating route that synthetized mainly 18:4 (Δ6, 9, 12, 15), 20:4 (Δ8, 11, 14, 17) and 20:5 (Δ5, 8, 11, 14, 17) and an elongating route that produced 20:3 (Δ11, 14, 17) and 20:4 (Δ5, 11, 14, 17) acids. ‘Fasting’ decreased both biosynthetic routes whereas glucose reactivated only the elongating pathway. Lactalbumin hydrolysate enhanced significantly only the desaturating route whereas glycerol was inactive. Glucose and aminoacids increased similarly the incorporation of labeledα linolenic acid in the cells. The results are independent of hormonal effects. Facultad de Ciencias Médicas |
| description |
The effect of three different carbon sources on the biosynthesis of polyunsaturated fatty acids of the α-linolenic acid series was investigated in hepatoma tissue culture (HTC) cells. Alpha linolenic acid was converted to higher homologs by a desaturating route that synthetized mainly 18:4 (Δ6, 9, 12, 15), 20:4 (Δ8, 11, 14, 17) and 20:5 (Δ5, 8, 11, 14, 17) and an elongating route that produced 20:3 (Δ11, 14, 17) and 20:4 (Δ5, 11, 14, 17) acids. ‘Fasting’ decreased both biosynthetic routes whereas glucose reactivated only the elongating pathway. Lactalbumin hydrolysate enhanced significantly only the desaturating route whereas glycerol was inactive. Glucose and aminoacids increased similarly the incorporation of labeledα linolenic acid in the cells. The results are independent of hormonal effects. |
| publishDate |
1976 |
| dc.date.none.fl_str_mv |
1976-08-30 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/141425 |
| url |
http://sedici.unlp.edu.ar/handle/10915/141425 |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/issn/0300-8177 info:eu-repo/semantics/altIdentifier/issn/1573-4919 info:eu-repo/semantics/altIdentifier/doi/10.1007/bf01731553 info:eu-repo/semantics/altIdentifier/pmid/183100 |
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info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
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openAccess |
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http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
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application/pdf 81-87 |
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SEDICI (UNLP) - Universidad Nacional de La Plata |
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