Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia-reperfusion

Autores
Consolini, Alicia Elvira; Ragone, María Inés; Colareda, Germán Andrés; Bonazzola, Patricia
Año de publicación
2017
Idioma
inglés
Tipo de recurso
reseña artículo
Estado
versión publicada
Descripción
This review describes the application of calorimetry to study cardiac energetics in physiological, pharmacological and pathophysiological conditions of a perfused heart preparation. In particular, the factors influencing the resting heat rate (Hr), such asspecies differences among rat, mouse and guinea-pig hearts, as well as the mechanismsunderlying the increased resting heat rate under a high [K+]-cardioplegia were discussed. Our results give support to a functional interaction between the sarcoplasmic reticulum and mitochondria for myocardial Ca2+ movements. Finally, it is briefly commented the application of calorimetry to study Ca2+ homeostasis during a model of stunning induced by no-flow ischemia and reperfusion in entire hearts by usingselective inhibitors of cellular Ca2+ transporters. Either in the presence or absence ofperfusion, calorimetry allows to evaluate the total muscle economy. As application, calorimetry allows to detect a cardiac dysfunction still under unaltered contractility, demonstrating that it is a very sensitive methodology for studying pathological situations and pharmacological consequences.
Facultad de Ciencias Exactas
Materia
Ciencias Médicas
Calorimetry
Cardiac stunning
Sarcoplasmic reticulum
Mitochondria
Calcium
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/101003
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/101003
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia-reperfusionConsolini, Alicia ElviraRagone, María InésColareda, Germán AndrésBonazzola, PatriciaCiencias MédicasCalorimetryCardiac stunningSarcoplasmic reticulumMitochondriaCalciumThis review describes the application of calorimetry to study cardiac energetics in physiological, pharmacological and pathophysiological conditions of a perfused heart preparation. In particular, the factors influencing the resting heat rate (Hr), such asspecies differences among rat, mouse and guinea-pig hearts, as well as the mechanismsunderlying the increased resting heat rate under a high [K+]-cardioplegia were discussed. Our results give support to a functional interaction between the sarcoplasmic reticulum and mitochondria for myocardial Ca2+ movements. Finally, it is briefly commented the application of calorimetry to study Ca2+ homeostasis during a model of stunning induced by no-flow ischemia and reperfusion in entire hearts by usingselective inhibitors of cellular Ca2+ transporters. Either in the presence or absence ofperfusion, calorimetry allows to evaluate the total muscle economy. As application, calorimetry allows to detect a cardiac dysfunction still under unaltered contractility, demonstrating that it is a very sensitive methodology for studying pathological situations and pharmacological consequences.Facultad de Ciencias Exactas2017-08info:eu-repo/semantics/reviewinfo:eu-repo/semantics/publishedVersionRevisionhttp://purl.org/coar/resource_type/c_dcae04bcinfo:ar-repo/semantics/resenaArticuloapplication/pdf23-36http://sedici.unlp.edu.ar/handle/10915/101003enginfo:eu-repo/semantics/altIdentifier/url/https://ri.conicet.gov.ar/11336/42000info:eu-repo/semantics/altIdentifier/url/http://pmr.safisiol.org.ar/archive/id/95info:eu-repo/semantics/altIdentifier/issn/1669-5402info:eu-repo/semantics/altIdentifier/hdl/11336/42000info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T10:53:20Zoai:sedici.unlp.edu.ar:10915/101003Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 10:53:20.61SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia-reperfusion
title Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia-reperfusion
spellingShingle Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia-reperfusion
Consolini, Alicia Elvira
Ciencias Médicas
Calorimetry
Cardiac stunning
Sarcoplasmic reticulum
Mitochondria
Calcium
title_short Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia-reperfusion
title_full Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia-reperfusion
title_fullStr Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia-reperfusion
title_full_unstemmed Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia-reperfusion
title_sort Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia-reperfusion
dc.creator.none.fl_str_mv Consolini, Alicia Elvira
Ragone, María Inés
Colareda, Germán Andrés
Bonazzola, Patricia
author Consolini, Alicia Elvira
author_facet Consolini, Alicia Elvira
Ragone, María Inés
Colareda, Germán Andrés
Bonazzola, Patricia
author_role author
author2 Ragone, María Inés
Colareda, Germán Andrés
Bonazzola, Patricia
author2_role author
author
author
dc.subject.none.fl_str_mv Ciencias Médicas
Calorimetry
Cardiac stunning
Sarcoplasmic reticulum
Mitochondria
Calcium
topic Ciencias Médicas
Calorimetry
Cardiac stunning
Sarcoplasmic reticulum
Mitochondria
Calcium
dc.description.none.fl_txt_mv This review describes the application of calorimetry to study cardiac energetics in physiological, pharmacological and pathophysiological conditions of a perfused heart preparation. In particular, the factors influencing the resting heat rate (Hr), such asspecies differences among rat, mouse and guinea-pig hearts, as well as the mechanismsunderlying the increased resting heat rate under a high [K+]-cardioplegia were discussed. Our results give support to a functional interaction between the sarcoplasmic reticulum and mitochondria for myocardial Ca2+ movements. Finally, it is briefly commented the application of calorimetry to study Ca2+ homeostasis during a model of stunning induced by no-flow ischemia and reperfusion in entire hearts by usingselective inhibitors of cellular Ca2+ transporters. Either in the presence or absence ofperfusion, calorimetry allows to evaluate the total muscle economy. As application, calorimetry allows to detect a cardiac dysfunction still under unaltered contractility, demonstrating that it is a very sensitive methodology for studying pathological situations and pharmacological consequences.
Facultad de Ciencias Exactas
description This review describes the application of calorimetry to study cardiac energetics in physiological, pharmacological and pathophysiological conditions of a perfused heart preparation. In particular, the factors influencing the resting heat rate (Hr), such asspecies differences among rat, mouse and guinea-pig hearts, as well as the mechanismsunderlying the increased resting heat rate under a high [K+]-cardioplegia were discussed. Our results give support to a functional interaction between the sarcoplasmic reticulum and mitochondria for myocardial Ca2+ movements. Finally, it is briefly commented the application of calorimetry to study Ca2+ homeostasis during a model of stunning induced by no-flow ischemia and reperfusion in entire hearts by usingselective inhibitors of cellular Ca2+ transporters. Either in the presence or absence ofperfusion, calorimetry allows to evaluate the total muscle economy. As application, calorimetry allows to detect a cardiac dysfunction still under unaltered contractility, demonstrating that it is a very sensitive methodology for studying pathological situations and pharmacological consequences.
publishDate 2017
dc.date.none.fl_str_mv 2017-08
dc.type.none.fl_str_mv info:eu-repo/semantics/review
info:eu-repo/semantics/publishedVersion
Revision
http://purl.org/coar/resource_type/c_dcae04bc
info:ar-repo/semantics/resenaArticulo
format review
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/101003
url http://sedici.unlp.edu.ar/handle/10915/101003
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://ri.conicet.gov.ar/11336/42000
info:eu-repo/semantics/altIdentifier/url/http://pmr.safisiol.org.ar/archive/id/95
info:eu-repo/semantics/altIdentifier/issn/1669-5402
info:eu-repo/semantics/altIdentifier/hdl/11336/42000
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
23-36
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.13397

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