Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia – reperfusion

Autores
Consolini, Alicia Elvira; Ragone, María Inés; Colareda, German A.; Bonazzola, Patricia
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This review describes the application of calorimetry to study cardiac energetics in physiological, pharmacological and pathophysiological conditions of a perfused heart preparation. In particular, the factors influencing the resting heat rate (Hr), such asspecies differences among rat, mouse and guinea-pig hearts, as well as the mechanismsunderlying the increased resting heat rate under a high [K+]-cardioplegia were discussed. Our results give support to a functional interaction between the sarcoplasmic reticulum and mitochondria for myocardial Ca2+ movements. Finally, it is briefly commented the application of calorimetry to study Ca2+ homeostasis during a model of stunning induced by no-flow ischemia and reperfusion in entire hearts by usingselective inhibitors of cellular Ca2+ transporters. Either in the presence or absence ofperfusion, calorimetry allows to evaluate the total muscle economy. As application, calorimetry allows to detect a cardiac dysfunction still under unaltered contractility, demonstrating that it is a very sensitive methodology for studying pathological situations and pharmacological consequences.
Fil: Consolini, Alicia Elvira. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina
Fil: Ragone, María Inés. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Colareda, German A.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina
Fil: Bonazzola, Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Materia
CALORIMETRY
CARDIAC STUNNING
SARCOPLASMIC RETICULUM
MITOCHONDRIA
CALCIUM
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/42000
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia – reperfusionConsolini, Alicia ElviraRagone, María InésColareda, German A.Bonazzola, PatriciaCALORIMETRYCARDIAC STUNNINGSARCOPLASMIC RETICULUMMITOCHONDRIACALCIUMhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3This review describes the application of calorimetry to study cardiac energetics in physiological, pharmacological and pathophysiological conditions of a perfused heart preparation. In particular, the factors influencing the resting heat rate (Hr), such asspecies differences among rat, mouse and guinea-pig hearts, as well as the mechanismsunderlying the increased resting heat rate under a high [K+]-cardioplegia were discussed. Our results give support to a functional interaction between the sarcoplasmic reticulum and mitochondria for myocardial Ca2+ movements. Finally, it is briefly commented the application of calorimetry to study Ca2+ homeostasis during a model of stunning induced by no-flow ischemia and reperfusion in entire hearts by usingselective inhibitors of cellular Ca2+ transporters. Either in the presence or absence ofperfusion, calorimetry allows to evaluate the total muscle economy. As application, calorimetry allows to detect a cardiac dysfunction still under unaltered contractility, demonstrating that it is a very sensitive methodology for studying pathological situations and pharmacological consequences.Fil: Consolini, Alicia Elvira. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; ArgentinaFil: Ragone, María Inés. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Colareda, German A.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; ArgentinaFil: Bonazzola, Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaSociedad Argentina de Fisiología2017-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/42000Consolini, Alicia Elvira; Ragone, María Inés; Colareda, German A.; Bonazzola, Patricia; Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia – reperfusion; Sociedad Argentina de Fisiología; Physiological Mini Reviews; 10; 3; 8-2017; 23-361669-5402CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://pmr.safisiol.org.ar/archive/id/95info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:23Zoai:ri.conicet.gov.ar:11336/42000instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:24.147CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia – reperfusion
title Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia – reperfusion
spellingShingle Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia – reperfusion
Consolini, Alicia Elvira
CALORIMETRY
CARDIAC STUNNING
SARCOPLASMIC RETICULUM
MITOCHONDRIA
CALCIUM
title_short Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia – reperfusion
title_full Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia – reperfusion
title_fullStr Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia – reperfusion
title_full_unstemmed Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia – reperfusion
title_sort Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia – reperfusion
dc.creator.none.fl_str_mv Consolini, Alicia Elvira
Ragone, María Inés
Colareda, German A.
Bonazzola, Patricia
author Consolini, Alicia Elvira
author_facet Consolini, Alicia Elvira
Ragone, María Inés
Colareda, German A.
Bonazzola, Patricia
author_role author
author2 Ragone, María Inés
Colareda, German A.
Bonazzola, Patricia
author2_role author
author
author
dc.subject.none.fl_str_mv CALORIMETRY
CARDIAC STUNNING
SARCOPLASMIC RETICULUM
MITOCHONDRIA
CALCIUM
topic CALORIMETRY
CARDIAC STUNNING
SARCOPLASMIC RETICULUM
MITOCHONDRIA
CALCIUM
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv This review describes the application of calorimetry to study cardiac energetics in physiological, pharmacological and pathophysiological conditions of a perfused heart preparation. In particular, the factors influencing the resting heat rate (Hr), such asspecies differences among rat, mouse and guinea-pig hearts, as well as the mechanismsunderlying the increased resting heat rate under a high [K+]-cardioplegia were discussed. Our results give support to a functional interaction between the sarcoplasmic reticulum and mitochondria for myocardial Ca2+ movements. Finally, it is briefly commented the application of calorimetry to study Ca2+ homeostasis during a model of stunning induced by no-flow ischemia and reperfusion in entire hearts by usingselective inhibitors of cellular Ca2+ transporters. Either in the presence or absence ofperfusion, calorimetry allows to evaluate the total muscle economy. As application, calorimetry allows to detect a cardiac dysfunction still under unaltered contractility, demonstrating that it is a very sensitive methodology for studying pathological situations and pharmacological consequences.
Fil: Consolini, Alicia Elvira. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina
Fil: Ragone, María Inés. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Colareda, German A.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina
Fil: Bonazzola, Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
description This review describes the application of calorimetry to study cardiac energetics in physiological, pharmacological and pathophysiological conditions of a perfused heart preparation. In particular, the factors influencing the resting heat rate (Hr), such asspecies differences among rat, mouse and guinea-pig hearts, as well as the mechanismsunderlying the increased resting heat rate under a high [K+]-cardioplegia were discussed. Our results give support to a functional interaction between the sarcoplasmic reticulum and mitochondria for myocardial Ca2+ movements. Finally, it is briefly commented the application of calorimetry to study Ca2+ homeostasis during a model of stunning induced by no-flow ischemia and reperfusion in entire hearts by usingselective inhibitors of cellular Ca2+ transporters. Either in the presence or absence ofperfusion, calorimetry allows to evaluate the total muscle economy. As application, calorimetry allows to detect a cardiac dysfunction still under unaltered contractility, demonstrating that it is a very sensitive methodology for studying pathological situations and pharmacological consequences.
publishDate 2017
dc.date.none.fl_str_mv 2017-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/42000
Consolini, Alicia Elvira; Ragone, María Inés; Colareda, German A.; Bonazzola, Patricia; Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia – reperfusion; Sociedad Argentina de Fisiología; Physiological Mini Reviews; 10; 3; 8-2017; 23-36
1669-5402
CONICET Digital
CONICET
url http://hdl.handle.net/11336/42000
identifier_str_mv Consolini, Alicia Elvira; Ragone, María Inés; Colareda, German A.; Bonazzola, Patricia; Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia – reperfusion; Sociedad Argentina de Fisiología; Physiological Mini Reviews; 10; 3; 8-2017; 23-36
1669-5402
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://pmr.safisiol.org.ar/archive/id/95
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Sociedad Argentina de Fisiología
publisher.none.fl_str_mv Sociedad Argentina de Fisiología
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270117858115584
score 13.13397

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