Data from: Mosquitoes cloak their legs to resist insecticides

Autores
Balabanidou, Vasileia; Kefi, Mary; Aivaliotis, Michalis; Koidou, Venetia; Girotti, Juan Roberto; Mijailovsky, Sergio Javier; Juárez, Marta Patricia; Papadogiorgaki, Eva; Chalepakis, George; Kampouraki, Anastasia; Nikolaou, Christoforos; Ranson, Hilary; Vontas, John
Año de publicación
2019
Idioma
español castellano
Tipo de recurso
conjunto de datos
Estado
versión publicada
Descripción
Malaria incidence has halved since the year 2000, with 80% of the reduction attributable to the use of insecticides. However, insecticide resistance is now widespread and is rapidly increasing in spectrum and intensity across Africa, and may be contributing to the increase of malaria incidence in 2018. The role of detoxification enzymes and target site mutations has been documented in the major malaria vector Anopheles gambiae, however, the emergence of striking resistant phenotypes, suggests the occurrence of additional mechanisms. By comparing legs, the most relevant insect tissue for insecticide uptake, we show that resistant mosquitoes largely remodel their leg cuticles via enhanced deposition of cuticular proteins and chitin, corroborating a leg-thickening phenotype. Moreover, we show that resistant female mosquitoes seal their leg cuticles with higher total and different relative amounts of cuticular hydrocarbons, compared to susceptible ones. The structural and functional alterations in Anopheles female mosquito legs are associated with a reduced uptake of insecticides, substantially contributing to the resistance phenotype.
Fil: Girotti, Juan Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina
Fil: Girotti, Juan Roberto. Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina
Fil: Juárez, Marta Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner";Argentina
Fil: Juárez, Marta Patricia. Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina
Fil: Mijailovsky, Sergio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina
Fil: Mijailovsky, Sergio Javier. Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina
Instituto de Investigaciones Bioquímicas de La Plata
Materia
Ciencias Médicas
insecticide resistance
cuticle alterations
legs
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/106939
Acceder
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network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Data from: Mosquitoes cloak their legs to resist insecticidesBalabanidou, VasileiaKefi, MaryAivaliotis, MichalisKoidou, VenetiaGirotti, Juan RobertoMijailovsky, Sergio JavierJuárez, Marta PatriciaPapadogiorgaki, EvaChalepakis, GeorgeKampouraki, AnastasiaNikolaou, ChristoforosRanson, HilaryVontas, JohnCiencias Médicashttps://purl.org/becyt/ford/1insecticide resistancecuticle alterationslegsMalaria incidence has halved since the year 2000, with 80% of the reduction attributable to the use of insecticides. However, insecticide resistance is now widespread and is rapidly increasing in spectrum and intensity across Africa, and may be contributing to the increase of malaria incidence in 2018. The role of detoxification enzymes and target site mutations has been documented in the major malaria vector Anopheles gambiae, however, the emergence of striking resistant phenotypes, suggests the occurrence of additional mechanisms. By comparing legs, the most relevant insect tissue for insecticide uptake, we show that resistant mosquitoes largely remodel their leg cuticles via enhanced deposition of cuticular proteins and chitin, corroborating a leg-thickening phenotype. Moreover, we show that resistant female mosquitoes seal their leg cuticles with higher total and different relative amounts of cuticular hydrocarbons, compared to susceptible ones. The structural and functional alterations in Anopheles female mosquito legs are associated with a reduced uptake of insecticides, substantially contributing to the resistance phenotype.Fil: Girotti, Juan Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; ArgentinaFil: Girotti, Juan Roberto. Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; ArgentinaFil: Juárez, Marta Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner";ArgentinaFil: Juárez, Marta Patricia. Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; ArgentinaFil: Mijailovsky, Sergio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; ArgentinaFil: Mijailovsky, Sergio Javier. Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; ArgentinaInstituto de Investigaciones Bioquímicas de La Plata2019info:eu-repo/semantics/publishedVersionConjunto de datoshttp://purl.org/coar/resource_type/c_ddb1info:ar-repo/semantics/conjuntoDeDatosinfo:eu-repo/semantics/dataSetapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheethttp://sedici.unlp.edu.ar/handle/10915/106939spainfo:eu-repo/semantics/altIdentifier/url/https://rs.figshare.com/collections/Supplementary_material_from_Mosquitoes_cloak_their_legs_to_resist_insecticides_/4566284info:eu-repo/semantics/altIdentifier/doi/10.6084/m9.figshare.c.4566284.v1info:eu-repo/semantics/reference/hdl/10915/106938info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-10T12:26:41Zoai:sedici.unlp.edu.ar:10915/106939Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-10 12:26:41.904SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Data from: Mosquitoes cloak their legs to resist insecticides
title Data from: Mosquitoes cloak their legs to resist insecticides
spellingShingle Data from: Mosquitoes cloak their legs to resist insecticides
Balabanidou, Vasileia
Ciencias Médicas
insecticide resistance
cuticle alterations
legs
title_short Data from: Mosquitoes cloak their legs to resist insecticides
title_full Data from: Mosquitoes cloak their legs to resist insecticides
title_fullStr Data from: Mosquitoes cloak their legs to resist insecticides
title_full_unstemmed Data from: Mosquitoes cloak their legs to resist insecticides
title_sort Data from: Mosquitoes cloak their legs to resist insecticides
dc.creator.none.fl_str_mv Balabanidou, Vasileia
Kefi, Mary
Aivaliotis, Michalis
Koidou, Venetia
Girotti, Juan Roberto
Mijailovsky, Sergio Javier
Juárez, Marta Patricia
Papadogiorgaki, Eva
Chalepakis, George
Kampouraki, Anastasia
Nikolaou, Christoforos
Ranson, Hilary
Vontas, John
author Balabanidou, Vasileia
author_facet Balabanidou, Vasileia
Kefi, Mary
Aivaliotis, Michalis
Koidou, Venetia
Girotti, Juan Roberto
Mijailovsky, Sergio Javier
Juárez, Marta Patricia
Papadogiorgaki, Eva
Chalepakis, George
Kampouraki, Anastasia
Nikolaou, Christoforos
Ranson, Hilary
Vontas, John
author_role author
author2 Kefi, Mary
Aivaliotis, Michalis
Koidou, Venetia
Girotti, Juan Roberto
Mijailovsky, Sergio Javier
Juárez, Marta Patricia
Papadogiorgaki, Eva
Chalepakis, George
Kampouraki, Anastasia
Nikolaou, Christoforos
Ranson, Hilary
Vontas, John
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Médicas
insecticide resistance
cuticle alterations
legs
topic Ciencias Médicas
insecticide resistance
cuticle alterations
legs
purl_subject.fl_str_mv https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Malaria incidence has halved since the year 2000, with 80% of the reduction attributable to the use of insecticides. However, insecticide resistance is now widespread and is rapidly increasing in spectrum and intensity across Africa, and may be contributing to the increase of malaria incidence in 2018. The role of detoxification enzymes and target site mutations has been documented in the major malaria vector Anopheles gambiae, however, the emergence of striking resistant phenotypes, suggests the occurrence of additional mechanisms. By comparing legs, the most relevant insect tissue for insecticide uptake, we show that resistant mosquitoes largely remodel their leg cuticles via enhanced deposition of cuticular proteins and chitin, corroborating a leg-thickening phenotype. Moreover, we show that resistant female mosquitoes seal their leg cuticles with higher total and different relative amounts of cuticular hydrocarbons, compared to susceptible ones. The structural and functional alterations in Anopheles female mosquito legs are associated with a reduced uptake of insecticides, substantially contributing to the resistance phenotype.
Fil: Girotti, Juan Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina
Fil: Girotti, Juan Roberto. Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina
Fil: Juárez, Marta Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner";Argentina
Fil: Juárez, Marta Patricia. Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina
Fil: Mijailovsky, Sergio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina
Fil: Mijailovsky, Sergio Javier. Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina
Instituto de Investigaciones Bioquímicas de La Plata
description Malaria incidence has halved since the year 2000, with 80% of the reduction attributable to the use of insecticides. However, insecticide resistance is now widespread and is rapidly increasing in spectrum and intensity across Africa, and may be contributing to the increase of malaria incidence in 2018. The role of detoxification enzymes and target site mutations has been documented in the major malaria vector Anopheles gambiae, however, the emergence of striking resistant phenotypes, suggests the occurrence of additional mechanisms. By comparing legs, the most relevant insect tissue for insecticide uptake, we show that resistant mosquitoes largely remodel their leg cuticles via enhanced deposition of cuticular proteins and chitin, corroborating a leg-thickening phenotype. Moreover, we show that resistant female mosquitoes seal their leg cuticles with higher total and different relative amounts of cuticular hydrocarbons, compared to susceptible ones. The structural and functional alterations in Anopheles female mosquito legs are associated with a reduced uptake of insecticides, substantially contributing to the resistance phenotype.
publishDate 2019
dc.date.none.fl_str_mv 2019
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