Mosquitoes cloak their legs to resist insecticides

Autores
Balabanidou, Vasileia; Kefi, Mary; Aivaliotis, Michalis; Koidou, Venetia; Girotti, Juan Roberto; Mijailovsky, Sergio Javier; Patricia Juárez, M.; Papadogiorgaki, Eva; Chalepakis, George; Kampouraki, Anastasia; Nikolaou, Christoforos; Ranson, Hilary; Vontas, John
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Malaria incidence has halved since the year 2000, with 80% of the reduction attributable to the use of insecticides. However, insecticide resistance is now widespread, is rapidly increasing in spectrum and intensity across Africa, and may be contributing to the increase of malaria incidence in 2018. The role of detoxification enzymes and target site mutations has been documented in the major malaria vector Anopheles gambiae; however, the emergence of striking resistant phenotypes suggests the occurrence of additional mechanisms. By comparing legs, the most relevant insect tissue for insecticide uptake, we show that resistant mosquitoes largely remodel their leg cuticles via enhanced deposition of cuticular proteins and chitin, corroborating a leg-thickening phenotype. Moreover, we show that resistant female mosquitoes seal their leg cuticles with higher total and different relative amounts of cuticular hydrocarbons, compared with susceptible ones. The structural and functional alterations in Anopheles female mosquito legs are associated with a reduced uptake of insecticides, substantially contributing to the resistance phenotype.
Fil: Balabanidou, Vasileia. Institute of Molecular Biology And Biotechnology. Foundation For Research And Technology; Grecia
Fil: Kefi, Mary. University of Crete; Grecia. Institute Of Molecular Biology And Biotechnology, Foundation For Research And Technology; Grecia
Fil: Aivaliotis, Michalis. Institute Of Molecular Biology And Biotechnology, Foundation For Research And Technology; Grecia. Aristotle University of Thessaloniki; Grecia
Fil: Koidou, Venetia. Institute Of Molecular Biology And Biotechnology, Foundation For Research And Technology; Grecia. University of Crete; Grecia
Fil: Girotti, Juan Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina
Fil: Mijailovsky, Sergio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina
Fil: Patricia Juárez, M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina
Fil: Papadogiorgaki, Eva. University of Crete; Grecia
Fil: Chalepakis, George. University of Crete; Grecia
Fil: Kampouraki, Anastasia. Institute Of Molecular Biology And Biotechnology, Foundation For Research And Technology; Grecia. Agricultural University of Athens; Grecia
Fil: Nikolaou, Christoforos. Institute Of Molecular Biology And Biotechnology, Foundation For Research And Technology; Grecia. University of Crete; Grecia
Fil: Ranson, Hilary. Liverpool School of Tropical Medicine; Reino Unido
Fil: Vontas, John. Institute Of Molecular Biology And Biotechnology, Foundation For Research And Technology; Grecia. Agricultural University of Athens; Grecia
Materia
CUTICLE ALTERATIONS
INSECTICIDE RESISTANCE
LEGS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/123118
Acceder
id CONICETDig_e9e94738f268571ca09cbef783da6751
oai_identifier_str oai:ri.conicet.gov.ar:11336/123118
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Mosquitoes cloak their legs to resist insecticidesBalabanidou, VasileiaKefi, MaryAivaliotis, MichalisKoidou, VenetiaGirotti, Juan RobertoMijailovsky, Sergio JavierPatricia Juárez, M.Papadogiorgaki, EvaChalepakis, GeorgeKampouraki, AnastasiaNikolaou, ChristoforosRanson, HilaryVontas, JohnCUTICLE ALTERATIONSINSECTICIDE RESISTANCELEGShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Malaria incidence has halved since the year 2000, with 80% of the reduction attributable to the use of insecticides. However, insecticide resistance is now widespread, is rapidly increasing in spectrum and intensity across Africa, and may be contributing to the increase of malaria incidence in 2018. The role of detoxification enzymes and target site mutations has been documented in the major malaria vector Anopheles gambiae; however, the emergence of striking resistant phenotypes suggests the occurrence of additional mechanisms. By comparing legs, the most relevant insect tissue for insecticide uptake, we show that resistant mosquitoes largely remodel their leg cuticles via enhanced deposition of cuticular proteins and chitin, corroborating a leg-thickening phenotype. Moreover, we show that resistant female mosquitoes seal their leg cuticles with higher total and different relative amounts of cuticular hydrocarbons, compared with susceptible ones. The structural and functional alterations in Anopheles female mosquito legs are associated with a reduced uptake of insecticides, substantially contributing to the resistance phenotype.Fil: Balabanidou, Vasileia. Institute of Molecular Biology And Biotechnology. Foundation For Research And Technology; GreciaFil: Kefi, Mary. University of Crete; Grecia. Institute Of Molecular Biology And Biotechnology, Foundation For Research And Technology; GreciaFil: Aivaliotis, Michalis. Institute Of Molecular Biology And Biotechnology, Foundation For Research And Technology; Grecia. Aristotle University of Thessaloniki; GreciaFil: Koidou, Venetia. Institute Of Molecular Biology And Biotechnology, Foundation For Research And Technology; Grecia. University of Crete; GreciaFil: Girotti, Juan Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; ArgentinaFil: Mijailovsky, Sergio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; ArgentinaFil: Patricia Juárez, M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; ArgentinaFil: Papadogiorgaki, Eva. University of Crete; GreciaFil: Chalepakis, George. University of Crete; GreciaFil: Kampouraki, Anastasia. Institute Of Molecular Biology And Biotechnology, Foundation For Research And Technology; Grecia. Agricultural University of Athens; GreciaFil: Nikolaou, Christoforos. Institute Of Molecular Biology And Biotechnology, Foundation For Research And Technology; Grecia. University of Crete; GreciaFil: Ranson, Hilary. Liverpool School of Tropical Medicine; Reino UnidoFil: Vontas, John. Institute Of Molecular Biology And Biotechnology, Foundation For Research And Technology; Grecia. Agricultural University of Athens; GreciaThe Royal Society2019-07-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/123118Balabanidou, Vasileia; Kefi, Mary; Aivaliotis, Michalis; Koidou, Venetia; Girotti, Juan Roberto; et al.; Mosquitoes cloak their legs to resist insecticides; The Royal Society; Proceedings of the Royal Society of London. Series B: Biological Sciences; 286; 1091; 17-7-2019; 1-90962-8452CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1098/rspb.2019.1091info:eu-repo/semantics/altIdentifier/url/https://royalsocietypublishing.org/doi/10.1098/rspb.2019.1091info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:52:14Zoai:ri.conicet.gov.ar:11336/123118instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:52:15.258CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mosquitoes cloak their legs to resist insecticides
title Mosquitoes cloak their legs to resist insecticides
spellingShingle Mosquitoes cloak their legs to resist insecticides
Balabanidou, Vasileia
CUTICLE ALTERATIONS
INSECTICIDE RESISTANCE
LEGS
title_short Mosquitoes cloak their legs to resist insecticides
title_full Mosquitoes cloak their legs to resist insecticides
title_fullStr Mosquitoes cloak their legs to resist insecticides
title_full_unstemmed Mosquitoes cloak their legs to resist insecticides
title_sort Mosquitoes cloak their legs to resist insecticides
dc.creator.none.fl_str_mv Balabanidou, Vasileia
Kefi, Mary
Aivaliotis, Michalis
Koidou, Venetia
Girotti, Juan Roberto
Mijailovsky, Sergio Javier
Patricia Juárez, M.
Papadogiorgaki, Eva
Chalepakis, George
Kampouraki, Anastasia
Nikolaou, Christoforos
Ranson, Hilary
Vontas, John
author Balabanidou, Vasileia
author_facet Balabanidou, Vasileia
Kefi, Mary
Aivaliotis, Michalis
Koidou, Venetia
Girotti, Juan Roberto
Mijailovsky, Sergio Javier
Patricia Juárez, M.
Papadogiorgaki, Eva
Chalepakis, George
Kampouraki, Anastasia
Nikolaou, Christoforos
Ranson, Hilary
Vontas, John
author_role author
author2 Kefi, Mary
Aivaliotis, Michalis
Koidou, Venetia
Girotti, Juan Roberto
Mijailovsky, Sergio Javier
Patricia Juárez, M.
Papadogiorgaki, Eva
Chalepakis, George
Kampouraki, Anastasia
Nikolaou, Christoforos
Ranson, Hilary
Vontas, John
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CUTICLE ALTERATIONS
INSECTICIDE RESISTANCE
LEGS
topic CUTICLE ALTERATIONS
INSECTICIDE RESISTANCE
LEGS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Malaria incidence has halved since the year 2000, with 80% of the reduction attributable to the use of insecticides. However, insecticide resistance is now widespread, is rapidly increasing in spectrum and intensity across Africa, and may be contributing to the increase of malaria incidence in 2018. The role of detoxification enzymes and target site mutations has been documented in the major malaria vector Anopheles gambiae; however, the emergence of striking resistant phenotypes suggests the occurrence of additional mechanisms. By comparing legs, the most relevant insect tissue for insecticide uptake, we show that resistant mosquitoes largely remodel their leg cuticles via enhanced deposition of cuticular proteins and chitin, corroborating a leg-thickening phenotype. Moreover, we show that resistant female mosquitoes seal their leg cuticles with higher total and different relative amounts of cuticular hydrocarbons, compared with susceptible ones. The structural and functional alterations in Anopheles female mosquito legs are associated with a reduced uptake of insecticides, substantially contributing to the resistance phenotype.
Fil: Balabanidou, Vasileia. Institute of Molecular Biology And Biotechnology. Foundation For Research And Technology; Grecia
Fil: Kefi, Mary. University of Crete; Grecia. Institute Of Molecular Biology And Biotechnology, Foundation For Research And Technology; Grecia
Fil: Aivaliotis, Michalis. Institute Of Molecular Biology And Biotechnology, Foundation For Research And Technology; Grecia. Aristotle University of Thessaloniki; Grecia
Fil: Koidou, Venetia. Institute Of Molecular Biology And Biotechnology, Foundation For Research And Technology; Grecia. University of Crete; Grecia
Fil: Girotti, Juan Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina
Fil: Mijailovsky, Sergio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina
Fil: Patricia Juárez, M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina
Fil: Papadogiorgaki, Eva. University of Crete; Grecia
Fil: Chalepakis, George. University of Crete; Grecia
Fil: Kampouraki, Anastasia. Institute Of Molecular Biology And Biotechnology, Foundation For Research And Technology; Grecia. Agricultural University of Athens; Grecia
Fil: Nikolaou, Christoforos. Institute Of Molecular Biology And Biotechnology, Foundation For Research And Technology; Grecia. University of Crete; Grecia
Fil: Ranson, Hilary. Liverpool School of Tropical Medicine; Reino Unido
Fil: Vontas, John. Institute Of Molecular Biology And Biotechnology, Foundation For Research And Technology; Grecia. Agricultural University of Athens; Grecia
description Malaria incidence has halved since the year 2000, with 80% of the reduction attributable to the use of insecticides. However, insecticide resistance is now widespread, is rapidly increasing in spectrum and intensity across Africa, and may be contributing to the increase of malaria incidence in 2018. The role of detoxification enzymes and target site mutations has been documented in the major malaria vector Anopheles gambiae; however, the emergence of striking resistant phenotypes suggests the occurrence of additional mechanisms. By comparing legs, the most relevant insect tissue for insecticide uptake, we show that resistant mosquitoes largely remodel their leg cuticles via enhanced deposition of cuticular proteins and chitin, corroborating a leg-thickening phenotype. Moreover, we show that resistant female mosquitoes seal their leg cuticles with higher total and different relative amounts of cuticular hydrocarbons, compared with susceptible ones. The structural and functional alterations in Anopheles female mosquito legs are associated with a reduced uptake of insecticides, substantially contributing to the resistance phenotype.
publishDate 2019
dc.date.none.fl_str_mv 2019-07-17
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/123118
Balabanidou, Vasileia; Kefi, Mary; Aivaliotis, Michalis; Koidou, Venetia; Girotti, Juan Roberto; et al.; Mosquitoes cloak their legs to resist insecticides; The Royal Society; Proceedings of the Royal Society of London. Series B: Biological Sciences; 286; 1091; 17-7-2019; 1-9
0962-8452
CONICET Digital
CONICET
url http://hdl.handle.net/11336/123118
identifier_str_mv Balabanidou, Vasileia; Kefi, Mary; Aivaliotis, Michalis; Koidou, Venetia; Girotti, Juan Roberto; et al.; Mosquitoes cloak their legs to resist insecticides; The Royal Society; Proceedings of the Royal Society of London. Series B: Biological Sciences; 286; 1091; 17-7-2019; 1-9
0962-8452
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1098/rspb.2019.1091
info:eu-repo/semantics/altIdentifier/url/https://royalsocietypublishing.org/doi/10.1098/rspb.2019.1091
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv The Royal Society
publisher.none.fl_str_mv The Royal Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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