Oxidative stress in fetal programming of cardiometabolic syndrome

Autores
Chao, Yung-Mei; Chan, Julie Y.H.
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cardiometabolic syndrome (CMS) is now a disease entity recognized by the World Health Organization. Emerging evidence from both human epidemiological and animal studies indicates that adult CMS may have its origins in early life and can be programmed by intrauterine and early postnatal environments; a phenomenon known as fetal programming of adult disease. This mini-review discusses [1]how exposures to various insults from the mother during gestation and/or lactation programs the fetus that prompts the development of CMS during adulthood; [2] what are the currently known underlying mechanisms, with emphasis on the role of tissue oxidative stress; and [3] whether CMS in the offspring can be reprogrammed via targeting maternal tissue oxidative stress. Translational perspective of the research field is also discussed.
Sociedad Argentina de Fisiología
Materia
Ciencias Médicas
Fetal programming
Oxidative stress
Cardiometabolic syndrome
Reprogramming therapy
Antioxidants
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/126221
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/126221
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Oxidative stress in fetal programming of cardiometabolic syndromeChao, Yung-MeiChan, Julie Y.H.Ciencias MédicasFetal programmingOxidative stressCardiometabolic syndromeReprogramming therapyAntioxidantsCardiometabolic syndrome (CMS) is now a disease entity recognized by the World Health Organization. Emerging evidence from both human epidemiological and animal studies indicates that adult CMS may have its origins in early life and can be programmed by intrauterine and early postnatal environments; a phenomenon known as fetal programming of adult disease. This mini-review discusses [1]how exposures to various insults from the mother during gestation and/or lactation programs the fetus that prompts the development of CMS during adulthood; [2] what are the currently known underlying mechanisms, with emphasis on the role of tissue oxidative stress; and [3] whether CMS in the offspring can be reprogrammed via targeting maternal tissue oxidative stress. Translational perspective of the research field is also discussed.Sociedad Argentina de Fisiología2020-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf24-33http://sedici.unlp.edu.ar/handle/10915/126221enginfo:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/archive/id/119info:eu-repo/semantics/altIdentifier/issn/1669-5410info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T11:02:33Zoai:sedici.unlp.edu.ar:10915/126221Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 11:02:33.736SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Oxidative stress in fetal programming of cardiometabolic syndrome
title Oxidative stress in fetal programming of cardiometabolic syndrome
spellingShingle Oxidative stress in fetal programming of cardiometabolic syndrome
Chao, Yung-Mei
Ciencias Médicas
Fetal programming
Oxidative stress
Cardiometabolic syndrome
Reprogramming therapy
Antioxidants
title_short Oxidative stress in fetal programming of cardiometabolic syndrome
title_full Oxidative stress in fetal programming of cardiometabolic syndrome
title_fullStr Oxidative stress in fetal programming of cardiometabolic syndrome
title_full_unstemmed Oxidative stress in fetal programming of cardiometabolic syndrome
title_sort Oxidative stress in fetal programming of cardiometabolic syndrome
dc.creator.none.fl_str_mv Chao, Yung-Mei
Chan, Julie Y.H.
author Chao, Yung-Mei
author_facet Chao, Yung-Mei
Chan, Julie Y.H.
author_role author
author2 Chan, Julie Y.H.
author2_role author
dc.subject.none.fl_str_mv Ciencias Médicas
Fetal programming
Oxidative stress
Cardiometabolic syndrome
Reprogramming therapy
Antioxidants
topic Ciencias Médicas
Fetal programming
Oxidative stress
Cardiometabolic syndrome
Reprogramming therapy
Antioxidants
dc.description.none.fl_txt_mv Cardiometabolic syndrome (CMS) is now a disease entity recognized by the World Health Organization. Emerging evidence from both human epidemiological and animal studies indicates that adult CMS may have its origins in early life and can be programmed by intrauterine and early postnatal environments; a phenomenon known as fetal programming of adult disease. This mini-review discusses [1]how exposures to various insults from the mother during gestation and/or lactation programs the fetus that prompts the development of CMS during adulthood; [2] what are the currently known underlying mechanisms, with emphasis on the role of tissue oxidative stress; and [3] whether CMS in the offspring can be reprogrammed via targeting maternal tissue oxidative stress. Translational perspective of the research field is also discussed.
Sociedad Argentina de Fisiología
description Cardiometabolic syndrome (CMS) is now a disease entity recognized by the World Health Organization. Emerging evidence from both human epidemiological and animal studies indicates that adult CMS may have its origins in early life and can be programmed by intrauterine and early postnatal environments; a phenomenon known as fetal programming of adult disease. This mini-review discusses [1]how exposures to various insults from the mother during gestation and/or lactation programs the fetus that prompts the development of CMS during adulthood; [2] what are the currently known underlying mechanisms, with emphasis on the role of tissue oxidative stress; and [3] whether CMS in the offspring can be reprogrammed via targeting maternal tissue oxidative stress. Translational perspective of the research field is also discussed.
publishDate 2020
dc.date.none.fl_str_mv 2020-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/126221
url http://sedici.unlp.edu.ar/handle/10915/126221
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/archive/id/119
info:eu-repo/semantics/altIdentifier/issn/1669-5410
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
24-33
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.13397

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