Guidelines for Diet-Induced Models of Cardiometabolic Syndrome

Autores
Sveeggen, Timothy M.; Bagher, Pooneh; Toba, Hiroe; Lindsey, Merry L.; Ritchie, Rebecca H.; Miksztowicz, Veronica Julieta; González, Germán Esteban
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cardiometabolic syndrome (CMS) encompasses a cluster of metabolic abnormalities, including obesity, insulin resistance, dyslipidemia, and hypertension which increase the risk of cardiovascular disease and type 2 diabetes. Animal models are widely used to study CMS, with diet-induced models being the most physiologically relevant. Inconsistencies in dietary composition, feeding duration, and macronutrient content across studies hinder reproducibility and translational value. We provide standardized guidelines for the preparation and use of diets in experimental models of CMS. Advantages and limitations of different diet-induced models are compared to genetic and pharmacological approaches, emphasizing replicability to human metabolic dysregulation. Key considerations include macronutrient composition, fat source selection, feeding duration, strain susceptibility, and sex differences. Additionally, we outline essential husbandry practices, including environmental factors, bedding material, and enrichment conditions, which can affect metabolic outcomes. Standardization is crucial for enhancing experimental reproducibility and facilitating cross-study comparisons. These guidelines serve as a framework for researchers to optimize dietary interventions in CMS models, improving the predictive value of preclinical findings for translational applications to aid in the development of targeted therapeutic strategies.
Fil: Sveeggen, Timothy M.. University of Nebraska; Estados Unidos
Fil: Bagher, Pooneh. University of Nebraska; Estados Unidos
Fil: Toba, Hiroe. Kyoto Pharmaceutical University; Japón
Fil: Lindsey, Merry L.. Meharry Medical College; Estados Unidos
Fil: Ritchie, Rebecca H.. Monash University; Australia
Fil: Miksztowicz, Veronica Julieta. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: González, Germán Esteban. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Materia
nutrition,
cardiometabolic syndrome,
high fat diet
cardiorenal, bedding
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/272720
Acceder
id CONICETDig_35b09f1616c9c246ac88abeea871c463
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Guidelines for Diet-Induced Models of Cardiometabolic SyndromeSveeggen, Timothy M.Bagher, PoonehToba, HiroeLindsey, Merry L.Ritchie, Rebecca H.Miksztowicz, Veronica JulietaGonzález, Germán Estebannutrition,cardiometabolic syndrome,high fat dietcardiorenal, beddinghttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Cardiometabolic syndrome (CMS) encompasses a cluster of metabolic abnormalities, including obesity, insulin resistance, dyslipidemia, and hypertension which increase the risk of cardiovascular disease and type 2 diabetes. Animal models are widely used to study CMS, with diet-induced models being the most physiologically relevant. Inconsistencies in dietary composition, feeding duration, and macronutrient content across studies hinder reproducibility and translational value. We provide standardized guidelines for the preparation and use of diets in experimental models of CMS. Advantages and limitations of different diet-induced models are compared to genetic and pharmacological approaches, emphasizing replicability to human metabolic dysregulation. Key considerations include macronutrient composition, fat source selection, feeding duration, strain susceptibility, and sex differences. Additionally, we outline essential husbandry practices, including environmental factors, bedding material, and enrichment conditions, which can affect metabolic outcomes. Standardization is crucial for enhancing experimental reproducibility and facilitating cross-study comparisons. These guidelines serve as a framework for researchers to optimize dietary interventions in CMS models, improving the predictive value of preclinical findings for translational applications to aid in the development of targeted therapeutic strategies.Fil: Sveeggen, Timothy M.. University of Nebraska; Estados UnidosFil: Bagher, Pooneh. University of Nebraska; Estados UnidosFil: Toba, Hiroe. Kyoto Pharmaceutical University; JapónFil: Lindsey, Merry L.. Meharry Medical College; Estados UnidosFil: Ritchie, Rebecca H.. Monash University; AustraliaFil: Miksztowicz, Veronica Julieta. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaFil: González, Germán Esteban. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaAmerican Physiological Society2025-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/272720Sveeggen, Timothy M.; Bagher, Pooneh; Toba, Hiroe; Lindsey, Merry L.; Ritchie, Rebecca H.; et al.; Guidelines for Diet-Induced Models of Cardiometabolic Syndrome; American Physiological Society; American Journal of Physiology - Heart and Circulatory Physiology; 8-2025; 1-170363-6135CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.physiology.org/doi/10.1152/ajpheart.00359.2025info:eu-repo/semantics/altIdentifier/doi/10.1152/ajpheart.00359.2025info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:00:38Zoai:ri.conicet.gov.ar:11336/272720instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:00:38.585CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Guidelines for Diet-Induced Models of Cardiometabolic Syndrome
title Guidelines for Diet-Induced Models of Cardiometabolic Syndrome
spellingShingle Guidelines for Diet-Induced Models of Cardiometabolic Syndrome
Sveeggen, Timothy M.
nutrition,
cardiometabolic syndrome,
high fat diet
cardiorenal, bedding
title_short Guidelines for Diet-Induced Models of Cardiometabolic Syndrome
title_full Guidelines for Diet-Induced Models of Cardiometabolic Syndrome
title_fullStr Guidelines for Diet-Induced Models of Cardiometabolic Syndrome
title_full_unstemmed Guidelines for Diet-Induced Models of Cardiometabolic Syndrome
title_sort Guidelines for Diet-Induced Models of Cardiometabolic Syndrome
dc.creator.none.fl_str_mv Sveeggen, Timothy M.
Bagher, Pooneh
Toba, Hiroe
Lindsey, Merry L.
Ritchie, Rebecca H.
Miksztowicz, Veronica Julieta
González, Germán Esteban
author Sveeggen, Timothy M.
author_facet Sveeggen, Timothy M.
Bagher, Pooneh
Toba, Hiroe
Lindsey, Merry L.
Ritchie, Rebecca H.
Miksztowicz, Veronica Julieta
González, Germán Esteban
author_role author
author2 Bagher, Pooneh
Toba, Hiroe
Lindsey, Merry L.
Ritchie, Rebecca H.
Miksztowicz, Veronica Julieta
González, Germán Esteban
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv nutrition,
cardiometabolic syndrome,
high fat diet
cardiorenal, bedding
topic nutrition,
cardiometabolic syndrome,
high fat diet
cardiorenal, bedding
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Cardiometabolic syndrome (CMS) encompasses a cluster of metabolic abnormalities, including obesity, insulin resistance, dyslipidemia, and hypertension which increase the risk of cardiovascular disease and type 2 diabetes. Animal models are widely used to study CMS, with diet-induced models being the most physiologically relevant. Inconsistencies in dietary composition, feeding duration, and macronutrient content across studies hinder reproducibility and translational value. We provide standardized guidelines for the preparation and use of diets in experimental models of CMS. Advantages and limitations of different diet-induced models are compared to genetic and pharmacological approaches, emphasizing replicability to human metabolic dysregulation. Key considerations include macronutrient composition, fat source selection, feeding duration, strain susceptibility, and sex differences. Additionally, we outline essential husbandry practices, including environmental factors, bedding material, and enrichment conditions, which can affect metabolic outcomes. Standardization is crucial for enhancing experimental reproducibility and facilitating cross-study comparisons. These guidelines serve as a framework for researchers to optimize dietary interventions in CMS models, improving the predictive value of preclinical findings for translational applications to aid in the development of targeted therapeutic strategies.
Fil: Sveeggen, Timothy M.. University of Nebraska; Estados Unidos
Fil: Bagher, Pooneh. University of Nebraska; Estados Unidos
Fil: Toba, Hiroe. Kyoto Pharmaceutical University; Japón
Fil: Lindsey, Merry L.. Meharry Medical College; Estados Unidos
Fil: Ritchie, Rebecca H.. Monash University; Australia
Fil: Miksztowicz, Veronica Julieta. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: González, Germán Esteban. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
description Cardiometabolic syndrome (CMS) encompasses a cluster of metabolic abnormalities, including obesity, insulin resistance, dyslipidemia, and hypertension which increase the risk of cardiovascular disease and type 2 diabetes. Animal models are widely used to study CMS, with diet-induced models being the most physiologically relevant. Inconsistencies in dietary composition, feeding duration, and macronutrient content across studies hinder reproducibility and translational value. We provide standardized guidelines for the preparation and use of diets in experimental models of CMS. Advantages and limitations of different diet-induced models are compared to genetic and pharmacological approaches, emphasizing replicability to human metabolic dysregulation. Key considerations include macronutrient composition, fat source selection, feeding duration, strain susceptibility, and sex differences. Additionally, we outline essential husbandry practices, including environmental factors, bedding material, and enrichment conditions, which can affect metabolic outcomes. Standardization is crucial for enhancing experimental reproducibility and facilitating cross-study comparisons. These guidelines serve as a framework for researchers to optimize dietary interventions in CMS models, improving the predictive value of preclinical findings for translational applications to aid in the development of targeted therapeutic strategies.
publishDate 2025
dc.date.none.fl_str_mv 2025-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/272720
Sveeggen, Timothy M.; Bagher, Pooneh; Toba, Hiroe; Lindsey, Merry L.; Ritchie, Rebecca H.; et al.; Guidelines for Diet-Induced Models of Cardiometabolic Syndrome; American Physiological Society; American Journal of Physiology - Heart and Circulatory Physiology; 8-2025; 1-17
0363-6135
CONICET Digital
CONICET
url http://hdl.handle.net/11336/272720
identifier_str_mv Sveeggen, Timothy M.; Bagher, Pooneh; Toba, Hiroe; Lindsey, Merry L.; Ritchie, Rebecca H.; et al.; Guidelines for Diet-Induced Models of Cardiometabolic Syndrome; American Physiological Society; American Journal of Physiology - Heart and Circulatory Physiology; 8-2025; 1-17
0363-6135
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.physiology.org/doi/10.1152/ajpheart.00359.2025
info:eu-repo/semantics/altIdentifier/doi/10.1152/ajpheart.00359.2025
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Physiological Society
publisher.none.fl_str_mv American Physiological Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083145698377728
score 13.22299

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