Outbreak of swine influenza in Argentina reveals a non-contemporary human H3N2 virus highly transmissible among pigs

Autores
Cappuccio, Javier A.; Pena, Lindomar; Dibárbora, Marina; Rimondi, Agustina; Piñeyro Piñeiro, Pablo Enrique; Insarralde, Lucas; Quiroga, María Alejandra; Machuca, Mariana Alejandra; Craig, Maria I.; Olivera, Valeria; Chockalingam, Ashok; Perfumo, Carlos Juan; Perez, Daniel R.; Pereda, Ariel
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Sporadic outbreaks of human H3N2 influenza A virus (IAV) infections in swine populations have been reported in Asia, Europe and North America since 1970. In South America, serological surveys in pigs indicate that IAVs of the H3 and H1 subtypes are currently in circulation; however, neither virus isolation nor characterization has been reported. In November 2008, an outbreak of respiratory disease in pigs consistent with swine influenza virus (SIV) infection was detected in Argentina. The current study describes the clinical epidemiology, pathology, and molecular and biological characteristics of the virus. Phylogenetic analysis revealed that the virus isolate shared nucleotide identities of 96-98% with H3N2 IAVs that circulated in humans from 2000 to 2003. Antigenically, sera from experimentally inoculated animals cross-reacted mainly with noncontemporary human-origin H3N2 influenza viruses. In an experimental infection in a commercial swine breed, the virus was of low virulence but was transmitted efficiently to contact pigs and caused severe disease when an infected animal acquired a secondary bacterial infection. This is the first report of a wholly human H3N2 IAV associated with clinical disease in pigs in South America. These studies highlight the importance of two-way transmission of IAVs and SIVs between pigs and humans, and call for enhanced influenza surveillance in the pig population worldwide.
Facultad de Ciencias Veterinarias
Materia
Biología
Influenzavirus A
pigs
virus H3N2 IAV
humans
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/84437
Acceder
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repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Outbreak of swine influenza in Argentina reveals a non-contemporary human H3N2 virus highly transmissible among pigsCappuccio, Javier A.Pena, LindomarDibárbora, MarinaRimondi, AgustinaPiñeyro Piñeiro, Pablo EnriqueInsarralde, LucasQuiroga, María AlejandraMachuca, Mariana AlejandraCraig, Maria I.Olivera, ValeriaChockalingam, AshokPerfumo, Carlos JuanPerez, Daniel R.Pereda, ArielBiologíaInfluenzavirus Apigsvirus H3N2 IAVhumansSporadic outbreaks of human H3N2 influenza A virus (IAV) infections in swine populations have been reported in Asia, Europe and North America since 1970. In South America, serological surveys in pigs indicate that IAVs of the H3 and H1 subtypes are currently in circulation; however, neither virus isolation nor characterization has been reported. In November 2008, an outbreak of respiratory disease in pigs consistent with swine influenza virus (SIV) infection was detected in Argentina. The current study describes the clinical epidemiology, pathology, and molecular and biological characteristics of the virus. Phylogenetic analysis revealed that the virus isolate shared nucleotide identities of 96-98% with H3N2 IAVs that circulated in humans from 2000 to 2003. Antigenically, sera from experimentally inoculated animals cross-reacted mainly with noncontemporary human-origin H3N2 influenza viruses. In an experimental infection in a commercial swine breed, the virus was of low virulence but was transmitted efficiently to contact pigs and caused severe disease when an infected animal acquired a secondary bacterial infection. This is the first report of a wholly human H3N2 IAV associated with clinical disease in pigs in South America. These studies highlight the importance of two-way transmission of IAVs and SIVs between pigs and humans, and call for enhanced influenza surveillance in the pig population worldwide.Facultad de Ciencias Veterinarias2011info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf2871-2878http://sedici.unlp.edu.ar/handle/10915/84437enginfo:eu-repo/semantics/altIdentifier/issn/0022-1317info:eu-repo/semantics/altIdentifier/doi/10.1099/vir.0.036590-0info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:16:06Zoai:sedici.unlp.edu.ar:10915/84437Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:16:06.355SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Outbreak of swine influenza in Argentina reveals a non-contemporary human H3N2 virus highly transmissible among pigs
title Outbreak of swine influenza in Argentina reveals a non-contemporary human H3N2 virus highly transmissible among pigs
spellingShingle Outbreak of swine influenza in Argentina reveals a non-contemporary human H3N2 virus highly transmissible among pigs
Cappuccio, Javier A.
Biología
Influenzavirus A
pigs
virus H3N2 IAV
humans
title_short Outbreak of swine influenza in Argentina reveals a non-contemporary human H3N2 virus highly transmissible among pigs
title_full Outbreak of swine influenza in Argentina reveals a non-contemporary human H3N2 virus highly transmissible among pigs
title_fullStr Outbreak of swine influenza in Argentina reveals a non-contemporary human H3N2 virus highly transmissible among pigs
title_full_unstemmed Outbreak of swine influenza in Argentina reveals a non-contemporary human H3N2 virus highly transmissible among pigs
title_sort Outbreak of swine influenza in Argentina reveals a non-contemporary human H3N2 virus highly transmissible among pigs
dc.creator.none.fl_str_mv Cappuccio, Javier A.
Pena, Lindomar
Dibárbora, Marina
Rimondi, Agustina
Piñeyro Piñeiro, Pablo Enrique
Insarralde, Lucas
Quiroga, María Alejandra
Machuca, Mariana Alejandra
Craig, Maria I.
Olivera, Valeria
Chockalingam, Ashok
Perfumo, Carlos Juan
Perez, Daniel R.
Pereda, Ariel
author Cappuccio, Javier A.
author_facet Cappuccio, Javier A.
Pena, Lindomar
Dibárbora, Marina
Rimondi, Agustina
Piñeyro Piñeiro, Pablo Enrique
Insarralde, Lucas
Quiroga, María Alejandra
Machuca, Mariana Alejandra
Craig, Maria I.
Olivera, Valeria
Chockalingam, Ashok
Perfumo, Carlos Juan
Perez, Daniel R.
Pereda, Ariel
author_role author
author2 Pena, Lindomar
Dibárbora, Marina
Rimondi, Agustina
Piñeyro Piñeiro, Pablo Enrique
Insarralde, Lucas
Quiroga, María Alejandra
Machuca, Mariana Alejandra
Craig, Maria I.
Olivera, Valeria
Chockalingam, Ashok
Perfumo, Carlos Juan
Perez, Daniel R.
Pereda, Ariel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Biología
Influenzavirus A
pigs
virus H3N2 IAV
humans
topic Biología
Influenzavirus A
pigs
virus H3N2 IAV
humans
dc.description.none.fl_txt_mv Sporadic outbreaks of human H3N2 influenza A virus (IAV) infections in swine populations have been reported in Asia, Europe and North America since 1970. In South America, serological surveys in pigs indicate that IAVs of the H3 and H1 subtypes are currently in circulation; however, neither virus isolation nor characterization has been reported. In November 2008, an outbreak of respiratory disease in pigs consistent with swine influenza virus (SIV) infection was detected in Argentina. The current study describes the clinical epidemiology, pathology, and molecular and biological characteristics of the virus. Phylogenetic analysis revealed that the virus isolate shared nucleotide identities of 96-98% with H3N2 IAVs that circulated in humans from 2000 to 2003. Antigenically, sera from experimentally inoculated animals cross-reacted mainly with noncontemporary human-origin H3N2 influenza viruses. In an experimental infection in a commercial swine breed, the virus was of low virulence but was transmitted efficiently to contact pigs and caused severe disease when an infected animal acquired a secondary bacterial infection. This is the first report of a wholly human H3N2 IAV associated with clinical disease in pigs in South America. These studies highlight the importance of two-way transmission of IAVs and SIVs between pigs and humans, and call for enhanced influenza surveillance in the pig population worldwide.
Facultad de Ciencias Veterinarias
description Sporadic outbreaks of human H3N2 influenza A virus (IAV) infections in swine populations have been reported in Asia, Europe and North America since 1970. In South America, serological surveys in pigs indicate that IAVs of the H3 and H1 subtypes are currently in circulation; however, neither virus isolation nor characterization has been reported. In November 2008, an outbreak of respiratory disease in pigs consistent with swine influenza virus (SIV) infection was detected in Argentina. The current study describes the clinical epidemiology, pathology, and molecular and biological characteristics of the virus. Phylogenetic analysis revealed that the virus isolate shared nucleotide identities of 96-98% with H3N2 IAVs that circulated in humans from 2000 to 2003. Antigenically, sera from experimentally inoculated animals cross-reacted mainly with noncontemporary human-origin H3N2 influenza viruses. In an experimental infection in a commercial swine breed, the virus was of low virulence but was transmitted efficiently to contact pigs and caused severe disease when an infected animal acquired a secondary bacterial infection. This is the first report of a wholly human H3N2 IAV associated with clinical disease in pigs in South America. These studies highlight the importance of two-way transmission of IAVs and SIVs between pigs and humans, and call for enhanced influenza surveillance in the pig population worldwide.
publishDate 2011
dc.date.none.fl_str_mv 2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/84437
url http://sedici.unlp.edu.ar/handle/10915/84437
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0022-1317
info:eu-repo/semantics/altIdentifier/doi/10.1099/vir.0.036590-0
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
2871-2878
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
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repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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