Nanomotion Detection-Based Rapid Antibiotic Susceptibility Testing

Autores
Kasas, Sandor; Malovichko, Anton; Villalba, Maria Ines; Vela, María Elena; Yantorno, Osvaldo Miguel; Willaert, Ronnie
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Rapid antibiotic susceptibility testing (AST) could play a major role in fighting multidrug-resistant bacteria. Recently, it was discovered that all living organisms oscillate in the range of nanometers and that these oscillations, referred to as nanomotion, stop as soon the organism dies. This finding led to the development of rapid AST techniques based on the monitoring of these oscillations upon exposure to antibiotics. In this review, we explain the working principle of this novel technique, compare the method with current ASTs, explore its application and give some advice about its implementation. As an illustrative example, we present the application of the technique to the slowly growing and pathogenic Bordetella pertussis bacteria.
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
Materia
Ciencias Exactas
Física
Química
B. pertussis
atomic force microscopy (AFM)
nanomotion
rapid antibiotic susceptibility testing (AST)
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/123601
Acceder
id SEDICI_4110984d9a63917ea7c84a02380226c3
oai_identifier_str oai:sedici.unlp.edu.ar:10915/123601
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Nanomotion Detection-Based Rapid Antibiotic Susceptibility TestingKasas, SandorMalovichko, AntonVillalba, Maria InesVela, María ElenaYantorno, Osvaldo MiguelWillaert, RonnieCiencias ExactasFísicaQuímicaB. pertussisatomic force microscopy (AFM)nanomotionrapid antibiotic susceptibility testing (AST)Rapid antibiotic susceptibility testing (AST) could play a major role in fighting multidrug-resistant bacteria. Recently, it was discovered that all living organisms oscillate in the range of nanometers and that these oscillations, referred to as nanomotion, stop as soon the organism dies. This finding led to the development of rapid AST techniques based on the monitoring of these oscillations upon exposure to antibiotics. In this review, we explain the working principle of this novel technique, compare the method with current ASTs, explore its application and give some advice about its implementation. As an illustrative example, we present the application of the technique to the slowly growing and pathogenic Bordetella pertussis bacteria.Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas2021-03-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/123601enginfo:eu-repo/semantics/altIdentifier/issn/2079-6382info:eu-repo/semantics/altIdentifier/pmid/33801939info:eu-repo/semantics/altIdentifier/doi/10.3390/antibiotics10030287info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-17T10:12:14Zoai:sedici.unlp.edu.ar:10915/123601Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-17 10:12:14.767SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Nanomotion Detection-Based Rapid Antibiotic Susceptibility Testing
title Nanomotion Detection-Based Rapid Antibiotic Susceptibility Testing
spellingShingle Nanomotion Detection-Based Rapid Antibiotic Susceptibility Testing
Kasas, Sandor
Ciencias Exactas
Física
Química
B. pertussis
atomic force microscopy (AFM)
nanomotion
rapid antibiotic susceptibility testing (AST)
title_short Nanomotion Detection-Based Rapid Antibiotic Susceptibility Testing
title_full Nanomotion Detection-Based Rapid Antibiotic Susceptibility Testing
title_fullStr Nanomotion Detection-Based Rapid Antibiotic Susceptibility Testing
title_full_unstemmed Nanomotion Detection-Based Rapid Antibiotic Susceptibility Testing
title_sort Nanomotion Detection-Based Rapid Antibiotic Susceptibility Testing
dc.creator.none.fl_str_mv Kasas, Sandor
Malovichko, Anton
Villalba, Maria Ines
Vela, María Elena
Yantorno, Osvaldo Miguel
Willaert, Ronnie
author Kasas, Sandor
author_facet Kasas, Sandor
Malovichko, Anton
Villalba, Maria Ines
Vela, María Elena
Yantorno, Osvaldo Miguel
Willaert, Ronnie
author_role author
author2 Malovichko, Anton
Villalba, Maria Ines
Vela, María Elena
Yantorno, Osvaldo Miguel
Willaert, Ronnie
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Física
Química
B. pertussis
atomic force microscopy (AFM)
nanomotion
rapid antibiotic susceptibility testing (AST)
topic Ciencias Exactas
Física
Química
B. pertussis
atomic force microscopy (AFM)
nanomotion
rapid antibiotic susceptibility testing (AST)
dc.description.none.fl_txt_mv Rapid antibiotic susceptibility testing (AST) could play a major role in fighting multidrug-resistant bacteria. Recently, it was discovered that all living organisms oscillate in the range of nanometers and that these oscillations, referred to as nanomotion, stop as soon the organism dies. This finding led to the development of rapid AST techniques based on the monitoring of these oscillations upon exposure to antibiotics. In this review, we explain the working principle of this novel technique, compare the method with current ASTs, explore its application and give some advice about its implementation. As an illustrative example, we present the application of the technique to the slowly growing and pathogenic Bordetella pertussis bacteria.
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
description Rapid antibiotic susceptibility testing (AST) could play a major role in fighting multidrug-resistant bacteria. Recently, it was discovered that all living organisms oscillate in the range of nanometers and that these oscillations, referred to as nanomotion, stop as soon the organism dies. This finding led to the development of rapid AST techniques based on the monitoring of these oscillations upon exposure to antibiotics. In this review, we explain the working principle of this novel technique, compare the method with current ASTs, explore its application and give some advice about its implementation. As an illustrative example, we present the application of the technique to the slowly growing and pathogenic Bordetella pertussis bacteria.
publishDate 2021
dc.date.none.fl_str_mv 2021-03-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/123601
url http://sedici.unlp.edu.ar/handle/10915/123601
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/2079-6382
info:eu-repo/semantics/altIdentifier/pmid/33801939
info:eu-repo/semantics/altIdentifier/doi/10.3390/antibiotics10030287
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.001348

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