4D Multimodal Nanomedicines Made of Nonequilibrium Au-Fe Alloy Nanoparticles
- Autores
- Torresan, Veronica; Forrer, Daniel; Guadagnini, Andrea; Badocco, Denis; Pastore, Paolo; Casarin, Maurizio; Selloni, Annabella; Coral, D. F.; Ceolín, Marcelo Raúl; Fernández van Raap, Marcela Beatriz; Busato, Alice; Marzola, Pasquina; Spinelli, Antonello E.; Amendola, Vincenzo
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Several examples of nanosized therapeutic and imaging agents have been proposed to date, yet for most of them there is a low chance of clinical translation due to long-term in vivo retention and toxicity risks. The realization of nanoagents that can be removed from the body after use remains thus a great challenge. Here, we demonstrate that nonequilibrium gold–iron alloys behave as shape-morphing nanocrystals with the properties of self-degradable multifunctional nanomedicines. DFT calculations combined with mixing enthalpy-weighted alloying simulations predict that Au–Fe solid solutions can exhibit self-degradation in an aqueous environment if the Fe content exceeds a threshold that depends upon element topology in the nanocrystals. Exploiting a laser-assisted synthesis route, we experimentally confirm that nonequilibrium Au–Fe nanoalloys have a 4D behavior, that is, the ability to change shape, size, and structure over time, becoming ultrasmall Au-rich nanocrystals. In vivo tests show the potential of these transformable Au–Fe nanoalloys as efficient multimodal contrast agents for magnetic resonance imaging and computed X-ray absorption tomography and further demonstrate their self-degradation over time, with a significant reduction of long-term accumulation in the body, when compared to benchmark gold or iron oxide contrast agents. Hence, Au–Fe alloy nanoparticles exhibiting 4D behavior can respond to the need for safe and degradable inorganic multifunctional nanomedicines required in clinical translation.
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
Instituto de Física La Plata - Materia
-
Física
Química
Au nanoparticles
Fe nanoparticles
alloys
nanomedicine
degradable materials
CT
MRI - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/139039
Ver los metadatos del registro completo
id |
SEDICI_3705636e0739432c399e2d0d125ec7f7 |
---|---|
oai_identifier_str |
oai:sedici.unlp.edu.ar:10915/139039 |
network_acronym_str |
SEDICI |
repository_id_str |
1329 |
network_name_str |
SEDICI (UNLP) |
spelling |
4D Multimodal Nanomedicines Made of Nonequilibrium Au-Fe Alloy NanoparticlesTorresan, VeronicaForrer, DanielGuadagnini, AndreaBadocco, DenisPastore, PaoloCasarin, MaurizioSelloni, AnnabellaCoral, D. F.Ceolín, Marcelo RaúlFernández van Raap, Marcela BeatrizBusato, AliceMarzola, PasquinaSpinelli, Antonello E.Amendola, VincenzoFísicaQuímicaAu nanoparticlesFe nanoparticlesalloysnanomedicinedegradable materialsCTMRISeveral examples of nanosized therapeutic and imaging agents have been proposed to date, yet for most of them there is a low chance of clinical translation due to long-term in vivo retention and toxicity risks. The realization of nanoagents that can be removed from the body after use remains thus a great challenge. Here, we demonstrate that nonequilibrium gold–iron alloys behave as shape-morphing nanocrystals with the properties of self-degradable multifunctional nanomedicines. DFT calculations combined with mixing enthalpy-weighted alloying simulations predict that Au–Fe solid solutions can exhibit self-degradation in an aqueous environment if the Fe content exceeds a threshold that depends upon element topology in the nanocrystals. Exploiting a laser-assisted synthesis route, we experimentally confirm that nonequilibrium Au–Fe nanoalloys have a 4D behavior, that is, the ability to change shape, size, and structure over time, becoming ultrasmall Au-rich nanocrystals. In vivo tests show the potential of these transformable Au–Fe nanoalloys as efficient multimodal contrast agents for magnetic resonance imaging and computed X-ray absorption tomography and further demonstrate their self-degradation over time, with a significant reduction of long-term accumulation in the body, when compared to benchmark gold or iron oxide contrast agents. Hence, Au–Fe alloy nanoparticles exhibiting 4D behavior can respond to the need for safe and degradable inorganic multifunctional nanomedicines required in clinical translation.Instituto de Investigaciones Fisicoquímicas Teóricas y AplicadasInstituto de Física La Plata2020-09-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf12840-12853http://sedici.unlp.edu.ar/handle/10915/139039enginfo:eu-repo/semantics/altIdentifier/issn/1936-086Xinfo:eu-repo/semantics/altIdentifier/issn/1936-0851info:eu-repo/semantics/altIdentifier/doi/10.1021/acsnano.0c03614info:eu-repo/semantics/altIdentifier/pmid/32877170info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:31:52Zoai:sedici.unlp.edu.ar:10915/139039Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:31:52.467SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
4D Multimodal Nanomedicines Made of Nonequilibrium Au-Fe Alloy Nanoparticles |
title |
4D Multimodal Nanomedicines Made of Nonequilibrium Au-Fe Alloy Nanoparticles |
spellingShingle |
4D Multimodal Nanomedicines Made of Nonequilibrium Au-Fe Alloy Nanoparticles Torresan, Veronica Física Química Au nanoparticles Fe nanoparticles alloys nanomedicine degradable materials CT MRI |
title_short |
4D Multimodal Nanomedicines Made of Nonequilibrium Au-Fe Alloy Nanoparticles |
title_full |
4D Multimodal Nanomedicines Made of Nonequilibrium Au-Fe Alloy Nanoparticles |
title_fullStr |
4D Multimodal Nanomedicines Made of Nonequilibrium Au-Fe Alloy Nanoparticles |
title_full_unstemmed |
4D Multimodal Nanomedicines Made of Nonequilibrium Au-Fe Alloy Nanoparticles |
title_sort |
4D Multimodal Nanomedicines Made of Nonequilibrium Au-Fe Alloy Nanoparticles |
dc.creator.none.fl_str_mv |
Torresan, Veronica Forrer, Daniel Guadagnini, Andrea Badocco, Denis Pastore, Paolo Casarin, Maurizio Selloni, Annabella Coral, D. F. Ceolín, Marcelo Raúl Fernández van Raap, Marcela Beatriz Busato, Alice Marzola, Pasquina Spinelli, Antonello E. Amendola, Vincenzo |
author |
Torresan, Veronica |
author_facet |
Torresan, Veronica Forrer, Daniel Guadagnini, Andrea Badocco, Denis Pastore, Paolo Casarin, Maurizio Selloni, Annabella Coral, D. F. Ceolín, Marcelo Raúl Fernández van Raap, Marcela Beatriz Busato, Alice Marzola, Pasquina Spinelli, Antonello E. Amendola, Vincenzo |
author_role |
author |
author2 |
Forrer, Daniel Guadagnini, Andrea Badocco, Denis Pastore, Paolo Casarin, Maurizio Selloni, Annabella Coral, D. F. Ceolín, Marcelo Raúl Fernández van Raap, Marcela Beatriz Busato, Alice Marzola, Pasquina Spinelli, Antonello E. Amendola, Vincenzo |
author2_role |
author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Física Química Au nanoparticles Fe nanoparticles alloys nanomedicine degradable materials CT MRI |
topic |
Física Química Au nanoparticles Fe nanoparticles alloys nanomedicine degradable materials CT MRI |
dc.description.none.fl_txt_mv |
Several examples of nanosized therapeutic and imaging agents have been proposed to date, yet for most of them there is a low chance of clinical translation due to long-term in vivo retention and toxicity risks. The realization of nanoagents that can be removed from the body after use remains thus a great challenge. Here, we demonstrate that nonequilibrium gold–iron alloys behave as shape-morphing nanocrystals with the properties of self-degradable multifunctional nanomedicines. DFT calculations combined with mixing enthalpy-weighted alloying simulations predict that Au–Fe solid solutions can exhibit self-degradation in an aqueous environment if the Fe content exceeds a threshold that depends upon element topology in the nanocrystals. Exploiting a laser-assisted synthesis route, we experimentally confirm that nonequilibrium Au–Fe nanoalloys have a 4D behavior, that is, the ability to change shape, size, and structure over time, becoming ultrasmall Au-rich nanocrystals. In vivo tests show the potential of these transformable Au–Fe nanoalloys as efficient multimodal contrast agents for magnetic resonance imaging and computed X-ray absorption tomography and further demonstrate their self-degradation over time, with a significant reduction of long-term accumulation in the body, when compared to benchmark gold or iron oxide contrast agents. Hence, Au–Fe alloy nanoparticles exhibiting 4D behavior can respond to the need for safe and degradable inorganic multifunctional nanomedicines required in clinical translation. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas Instituto de Física La Plata |
description |
Several examples of nanosized therapeutic and imaging agents have been proposed to date, yet for most of them there is a low chance of clinical translation due to long-term in vivo retention and toxicity risks. The realization of nanoagents that can be removed from the body after use remains thus a great challenge. Here, we demonstrate that nonequilibrium gold–iron alloys behave as shape-morphing nanocrystals with the properties of self-degradable multifunctional nanomedicines. DFT calculations combined with mixing enthalpy-weighted alloying simulations predict that Au–Fe solid solutions can exhibit self-degradation in an aqueous environment if the Fe content exceeds a threshold that depends upon element topology in the nanocrystals. Exploiting a laser-assisted synthesis route, we experimentally confirm that nonequilibrium Au–Fe nanoalloys have a 4D behavior, that is, the ability to change shape, size, and structure over time, becoming ultrasmall Au-rich nanocrystals. In vivo tests show the potential of these transformable Au–Fe nanoalloys as efficient multimodal contrast agents for magnetic resonance imaging and computed X-ray absorption tomography and further demonstrate their self-degradation over time, with a significant reduction of long-term accumulation in the body, when compared to benchmark gold or iron oxide contrast agents. Hence, Au–Fe alloy nanoparticles exhibiting 4D behavior can respond to the need for safe and degradable inorganic multifunctional nanomedicines required in clinical translation. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-09-15 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/139039 |
url |
http://sedici.unlp.edu.ar/handle/10915/139039 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/issn/1936-086X info:eu-repo/semantics/altIdentifier/issn/1936-0851 info:eu-repo/semantics/altIdentifier/doi/10.1021/acsnano.0c03614 info:eu-repo/semantics/altIdentifier/pmid/32877170 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
dc.format.none.fl_str_mv |
application/pdf 12840-12853 |
dc.source.none.fl_str_mv |
reponame:SEDICI (UNLP) instname:Universidad Nacional de La Plata instacron:UNLP |
reponame_str |
SEDICI (UNLP) |
collection |
SEDICI (UNLP) |
instname_str |
Universidad Nacional de La Plata |
instacron_str |
UNLP |
institution |
UNLP |
repository.name.fl_str_mv |
SEDICI (UNLP) - Universidad Nacional de La Plata |
repository.mail.fl_str_mv |
alira@sedici.unlp.edu.ar |
_version_ |
1844616198328680448 |
score |
13.070432 |