4D Multimodal Nanomedicines Made of Nonequilibrium Au–Fe Alloy Nanoparticles

Autores
Torresan, Veronica; Forrer, Daniel; Guadagnini, Andrea; Badocco, Denis; Pastore, Paolo; Casarin, Maurizio; Selloni, Annabella; Coral, Diego Fernando; Ceolin, Marcelo Raul; Fernández van Raap, Marcela Beatriz; Busato, Alice; Marzola, Pasquina; Spinelli, Antonello E.; Amendola, Vincenzo
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Several examples of nanosized therapeutic and imaging agents have been proposed to date, yet for most of them there is a low chance of clinical translation due to long-term in vivo retention and toxicity risks. The realization of nano-agents that can be removed from the body after use remains thus a great challenge. Here, we demonstrate that non-equilibrium gold-iron alloys behave as shape-morphing nanocrystals with the properties of self-degradable multifunctional nanomedicines. DFT calculations combined with mixing enthalpy-weighted alloying simulations predict that Au-Fe solid solutions can exhibit self-degradation in aqueous environment if the Fe content exceeds a threshold that depends upon element topology in the nanocrystals. Exploiting a laser-assisted synthesis route, we experimentally confirm that non-equilibrium Au-Fe nanoalloys have a 4D behavior, that is the ability to change shape, size and structure over time, becoming ultrasmall Au-rich nanocrystals. In vivo tests show the potential of these transformable Au-Fe nanoalloys as efficient multimodal contrast agents for magnetic resonance imaging and computed x-ray absorption tomography and further demonstrate their self-degradation over time, with a significant reduction of long-term accumulation in the body, when compared to benchmark gold or iron oxide contrast agents. Hence, Au-Fe alloy nanoparticles exhibiting 4D behavior can respond to the need for safe and degradable inorganic multifunctional nanomedicines required in clinical translation.
Fil: Torresan, Veronica. Università di Padova; Italia
Fil: Forrer, Daniel. Università di Padova; Italia
Fil: Guadagnini, Andrea. Università di Padova; Italia
Fil: Badocco, Denis. Università di Padova; Italia
Fil: Pastore, Paolo. Università di Padova; Italia
Fil: Casarin, Maurizio. Università di Padova; Italia
Fil: Selloni, Annabella. University of Princeton; Estados Unidos
Fil: Coral, Diego Fernando. Universidad del Cauca; Colombia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Ceolin, Marcelo Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Fernández van Raap, Marcela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Busato, Alice. Universita di Verona; Italia
Fil: Marzola, Pasquina. Universita di Verona; Italia
Fil: Spinelli, Antonello E.. No especifíca;
Fil: Amendola, Vincenzo. Università di Padova; Italia
Materia
AuFe NANOPARTICLES
NANOMEDICINES
COMPUTED X-RAY TOMOGRAPHY
MRI
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/238981
Acceder
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network_name_str CONICET Digital (CONICET)
spelling 4D Multimodal Nanomedicines Made of Nonequilibrium Au–Fe Alloy NanoparticlesTorresan, VeronicaForrer, DanielGuadagnini, AndreaBadocco, DenisPastore, PaoloCasarin, MaurizioSelloni, AnnabellaCoral, Diego FernandoCeolin, Marcelo RaulFernández van Raap, Marcela BeatrizBusato, AliceMarzola, PasquinaSpinelli, Antonello E.Amendola, VincenzoAuFe NANOPARTICLESNANOMEDICINESCOMPUTED X-RAY TOMOGRAPHYMRIhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Several examples of nanosized therapeutic and imaging agents have been proposed to date, yet for most of them there is a low chance of clinical translation due to long-term in vivo retention and toxicity risks. The realization of nano-agents that can be removed from the body after use remains thus a great challenge. Here, we demonstrate that non-equilibrium gold-iron alloys behave as shape-morphing nanocrystals with the properties of self-degradable multifunctional nanomedicines. DFT calculations combined with mixing enthalpy-weighted alloying simulations predict that Au-Fe solid solutions can exhibit self-degradation in aqueous environment if the Fe content exceeds a threshold that depends upon element topology in the nanocrystals. Exploiting a laser-assisted synthesis route, we experimentally confirm that non-equilibrium Au-Fe nanoalloys have a 4D behavior, that is the ability to change shape, size and structure over time, becoming ultrasmall Au-rich nanocrystals. In vivo tests show the potential of these transformable Au-Fe nanoalloys as efficient multimodal contrast agents for magnetic resonance imaging and computed x-ray absorption tomography and further demonstrate their self-degradation over time, with a significant reduction of long-term accumulation in the body, when compared to benchmark gold or iron oxide contrast agents. Hence, Au-Fe alloy nanoparticles exhibiting 4D behavior can respond to the need for safe and degradable inorganic multifunctional nanomedicines required in clinical translation.Fil: Torresan, Veronica. Università di Padova; ItaliaFil: Forrer, Daniel. Università di Padova; ItaliaFil: Guadagnini, Andrea. Università di Padova; ItaliaFil: Badocco, Denis. Università di Padova; ItaliaFil: Pastore, Paolo. Università di Padova; ItaliaFil: Casarin, Maurizio. Università di Padova; ItaliaFil: Selloni, Annabella. University of Princeton; Estados UnidosFil: Coral, Diego Fernando. Universidad del Cauca; Colombia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Ceolin, Marcelo Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Fernández van Raap, Marcela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Busato, Alice. Universita di Verona; ItaliaFil: Marzola, Pasquina. Universita di Verona; ItaliaFil: Spinelli, Antonello E.. No especifíca;Fil: Amendola, Vincenzo. Università di Padova; ItaliaAmerican Chemical Society2020-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/238981Torresan, Veronica; Forrer, Daniel; Guadagnini, Andrea; Badocco, Denis; Pastore, Paolo; et al.; 4D Multimodal Nanomedicines Made of Nonequilibrium Au–Fe Alloy Nanoparticles; American Chemical Society; ACS Nano; 14; 10; 9-2020; 12840-128531936-0851CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acsnano.0c03614info:eu-repo/semantics/altIdentifier/doi/10.1021/acsnano.0c03614info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:23:20Zoai:ri.conicet.gov.ar:11336/238981instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:23:21.237CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv 4D Multimodal Nanomedicines Made of Nonequilibrium Au–Fe Alloy Nanoparticles
title 4D Multimodal Nanomedicines Made of Nonequilibrium Au–Fe Alloy Nanoparticles
spellingShingle 4D Multimodal Nanomedicines Made of Nonequilibrium Au–Fe Alloy Nanoparticles
Torresan, Veronica
AuFe NANOPARTICLES
NANOMEDICINES
COMPUTED X-RAY TOMOGRAPHY
MRI
title_short 4D Multimodal Nanomedicines Made of Nonequilibrium Au–Fe Alloy Nanoparticles
title_full 4D Multimodal Nanomedicines Made of Nonequilibrium Au–Fe Alloy Nanoparticles
title_fullStr 4D Multimodal Nanomedicines Made of Nonequilibrium Au–Fe Alloy Nanoparticles
title_full_unstemmed 4D Multimodal Nanomedicines Made of Nonequilibrium Au–Fe Alloy Nanoparticles
title_sort 4D Multimodal Nanomedicines Made of Nonequilibrium Au–Fe Alloy Nanoparticles
dc.creator.none.fl_str_mv Torresan, Veronica
Forrer, Daniel
Guadagnini, Andrea
Badocco, Denis
Pastore, Paolo
Casarin, Maurizio
Selloni, Annabella
Coral, Diego Fernando
Ceolin, Marcelo Raul
Fernández van Raap, Marcela Beatriz
Busato, Alice
Marzola, Pasquina
Spinelli, Antonello E.
Amendola, Vincenzo
author Torresan, Veronica
author_facet Torresan, Veronica
Forrer, Daniel
Guadagnini, Andrea
Badocco, Denis
Pastore, Paolo
Casarin, Maurizio
Selloni, Annabella
Coral, Diego Fernando
Ceolin, Marcelo Raul
Fernández van Raap, Marcela Beatriz
Busato, Alice
Marzola, Pasquina
Spinelli, Antonello E.
Amendola, Vincenzo
author_role author
author2 Forrer, Daniel
Guadagnini, Andrea
Badocco, Denis
Pastore, Paolo
Casarin, Maurizio
Selloni, Annabella
Coral, Diego Fernando
Ceolin, Marcelo Raul
Fernández van Raap, Marcela Beatriz
Busato, Alice
Marzola, Pasquina
Spinelli, Antonello E.
Amendola, Vincenzo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv AuFe NANOPARTICLES
NANOMEDICINES
COMPUTED X-RAY TOMOGRAPHY
MRI
topic AuFe NANOPARTICLES
NANOMEDICINES
COMPUTED X-RAY TOMOGRAPHY
MRI
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Several examples of nanosized therapeutic and imaging agents have been proposed to date, yet for most of them there is a low chance of clinical translation due to long-term in vivo retention and toxicity risks. The realization of nano-agents that can be removed from the body after use remains thus a great challenge. Here, we demonstrate that non-equilibrium gold-iron alloys behave as shape-morphing nanocrystals with the properties of self-degradable multifunctional nanomedicines. DFT calculations combined with mixing enthalpy-weighted alloying simulations predict that Au-Fe solid solutions can exhibit self-degradation in aqueous environment if the Fe content exceeds a threshold that depends upon element topology in the nanocrystals. Exploiting a laser-assisted synthesis route, we experimentally confirm that non-equilibrium Au-Fe nanoalloys have a 4D behavior, that is the ability to change shape, size and structure over time, becoming ultrasmall Au-rich nanocrystals. In vivo tests show the potential of these transformable Au-Fe nanoalloys as efficient multimodal contrast agents for magnetic resonance imaging and computed x-ray absorption tomography and further demonstrate their self-degradation over time, with a significant reduction of long-term accumulation in the body, when compared to benchmark gold or iron oxide contrast agents. Hence, Au-Fe alloy nanoparticles exhibiting 4D behavior can respond to the need for safe and degradable inorganic multifunctional nanomedicines required in clinical translation.
Fil: Torresan, Veronica. Università di Padova; Italia
Fil: Forrer, Daniel. Università di Padova; Italia
Fil: Guadagnini, Andrea. Università di Padova; Italia
Fil: Badocco, Denis. Università di Padova; Italia
Fil: Pastore, Paolo. Università di Padova; Italia
Fil: Casarin, Maurizio. Università di Padova; Italia
Fil: Selloni, Annabella. University of Princeton; Estados Unidos
Fil: Coral, Diego Fernando. Universidad del Cauca; Colombia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Ceolin, Marcelo Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Fernández van Raap, Marcela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Busato, Alice. Universita di Verona; Italia
Fil: Marzola, Pasquina. Universita di Verona; Italia
Fil: Spinelli, Antonello E.. No especifíca;
Fil: Amendola, Vincenzo. Università di Padova; Italia
description Several examples of nanosized therapeutic and imaging agents have been proposed to date, yet for most of them there is a low chance of clinical translation due to long-term in vivo retention and toxicity risks. The realization of nano-agents that can be removed from the body after use remains thus a great challenge. Here, we demonstrate that non-equilibrium gold-iron alloys behave as shape-morphing nanocrystals with the properties of self-degradable multifunctional nanomedicines. DFT calculations combined with mixing enthalpy-weighted alloying simulations predict that Au-Fe solid solutions can exhibit self-degradation in aqueous environment if the Fe content exceeds a threshold that depends upon element topology in the nanocrystals. Exploiting a laser-assisted synthesis route, we experimentally confirm that non-equilibrium Au-Fe nanoalloys have a 4D behavior, that is the ability to change shape, size and structure over time, becoming ultrasmall Au-rich nanocrystals. In vivo tests show the potential of these transformable Au-Fe nanoalloys as efficient multimodal contrast agents for magnetic resonance imaging and computed x-ray absorption tomography and further demonstrate their self-degradation over time, with a significant reduction of long-term accumulation in the body, when compared to benchmark gold or iron oxide contrast agents. Hence, Au-Fe alloy nanoparticles exhibiting 4D behavior can respond to the need for safe and degradable inorganic multifunctional nanomedicines required in clinical translation.
publishDate 2020
dc.date.none.fl_str_mv 2020-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/238981
Torresan, Veronica; Forrer, Daniel; Guadagnini, Andrea; Badocco, Denis; Pastore, Paolo; et al.; 4D Multimodal Nanomedicines Made of Nonequilibrium Au–Fe Alloy Nanoparticles; American Chemical Society; ACS Nano; 14; 10; 9-2020; 12840-12853
1936-0851
CONICET Digital
CONICET
url http://hdl.handle.net/11336/238981
identifier_str_mv Torresan, Veronica; Forrer, Daniel; Guadagnini, Andrea; Badocco, Denis; Pastore, Paolo; et al.; 4D Multimodal Nanomedicines Made of Nonequilibrium Au–Fe Alloy Nanoparticles; American Chemical Society; ACS Nano; 14; 10; 9-2020; 12840-12853
1936-0851
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acsnano.0c03614
info:eu-repo/semantics/altIdentifier/doi/10.1021/acsnano.0c03614
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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