Cytotoxicity of Copper Ions Released from Metal : Variation with the Exposure Period and Concentration Gradients

Autores
Cortizo, María Cecilia; Fernández Lorenzo de Mele, Mónica Alicia
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this work is to contribute to the elucidation of the cytotoxic process caused by the copper ions released from the biomaterials. Clonal cell lines UMR106 were used in the experiments. Copper ions were obtained from two different sources: copper salts and metal dissolution. Experiments carried out with constant ion concentrations (copper salts) were compared with those with concentrations that vary with time and location (dissolution of the metal). Present results and others previously reported could be interpreted through mathematical models that describe: (1) the variation of concentration of copper ions with time and location within a biofilm and (2) the variation of the killing rate with the concentration of the toxic ion and time. The large number of dead cells found near the copper sample with an average ion concentration below the toxic limit could be interpreted bearing in mind that these cells should be exposed to a local concentration higher than this limit. A logarithmic dependence between the number of cells and exposure time was found for nearly constant ion concentrations. Apparent discrepancies, observed when these results and those of different researchers were contrasted, could be explained considering the dissimilar experimental conditions such as the source of the ions and their local concentration at real time.
Facultad de Odontología
Materia
Odontología
biocompatibility; cytotoxicity; copper; biomaterial; released ions; exposure period
Materiales Biomédicos y Dentales
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/76476

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spelling Cytotoxicity of Copper Ions Released from Metal : Variation with the Exposure Period and Concentration GradientsCortizo, María CeciliaFernández Lorenzo de Mele, Mónica AliciaOdontologíabiocompatibility; cytotoxicity; copper; biomaterial; released ions; exposure periodMateriales Biomédicos y DentalesThe aim of this work is to contribute to the elucidation of the cytotoxic process caused by the copper ions released from the biomaterials. Clonal cell lines UMR106 were used in the experiments. Copper ions were obtained from two different sources: copper salts and metal dissolution. Experiments carried out with constant ion concentrations (copper salts) were compared with those with concentrations that vary with time and location (dissolution of the metal). Present results and others previously reported could be interpreted through mathematical models that describe: (1) the variation of concentration of copper ions with time and location within a biofilm and (2) the variation of the killing rate with the concentration of the toxic ion and time. The large number of dead cells found near the copper sample with an average ion concentration below the toxic limit could be interpreted bearing in mind that these cells should be exposed to a local concentration higher than this limit. A logarithmic dependence between the number of cells and exposure time was found for nearly constant ion concentrations. Apparent discrepancies, observed when these results and those of different researchers were contrasted, could be explained considering the dissimilar experimental conditions such as the source of the ions and their local concentration at real time.Facultad de Odontología2004info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf129-141http://sedici.unlp.edu.ar/handle/10915/76476enginfo:eu-repo/semantics/altIdentifier/issn/0163-4984info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:13:29Zoai:sedici.unlp.edu.ar:10915/76476Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:13:29.894SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Cytotoxicity of Copper Ions Released from Metal : Variation with the Exposure Period and Concentration Gradients
title Cytotoxicity of Copper Ions Released from Metal : Variation with the Exposure Period and Concentration Gradients
spellingShingle Cytotoxicity of Copper Ions Released from Metal : Variation with the Exposure Period and Concentration Gradients
Cortizo, María Cecilia
Odontología
biocompatibility; cytotoxicity; copper; biomaterial; released ions; exposure period
Materiales Biomédicos y Dentales
title_short Cytotoxicity of Copper Ions Released from Metal : Variation with the Exposure Period and Concentration Gradients
title_full Cytotoxicity of Copper Ions Released from Metal : Variation with the Exposure Period and Concentration Gradients
title_fullStr Cytotoxicity of Copper Ions Released from Metal : Variation with the Exposure Period and Concentration Gradients
title_full_unstemmed Cytotoxicity of Copper Ions Released from Metal : Variation with the Exposure Period and Concentration Gradients
title_sort Cytotoxicity of Copper Ions Released from Metal : Variation with the Exposure Period and Concentration Gradients
dc.creator.none.fl_str_mv Cortizo, María Cecilia
Fernández Lorenzo de Mele, Mónica Alicia
author Cortizo, María Cecilia
author_facet Cortizo, María Cecilia
Fernández Lorenzo de Mele, Mónica Alicia
author_role author
author2 Fernández Lorenzo de Mele, Mónica Alicia
author2_role author
dc.subject.none.fl_str_mv Odontología
biocompatibility; cytotoxicity; copper; biomaterial; released ions; exposure period
Materiales Biomédicos y Dentales
topic Odontología
biocompatibility; cytotoxicity; copper; biomaterial; released ions; exposure period
Materiales Biomédicos y Dentales
dc.description.none.fl_txt_mv The aim of this work is to contribute to the elucidation of the cytotoxic process caused by the copper ions released from the biomaterials. Clonal cell lines UMR106 were used in the experiments. Copper ions were obtained from two different sources: copper salts and metal dissolution. Experiments carried out with constant ion concentrations (copper salts) were compared with those with concentrations that vary with time and location (dissolution of the metal). Present results and others previously reported could be interpreted through mathematical models that describe: (1) the variation of concentration of copper ions with time and location within a biofilm and (2) the variation of the killing rate with the concentration of the toxic ion and time. The large number of dead cells found near the copper sample with an average ion concentration below the toxic limit could be interpreted bearing in mind that these cells should be exposed to a local concentration higher than this limit. A logarithmic dependence between the number of cells and exposure time was found for nearly constant ion concentrations. Apparent discrepancies, observed when these results and those of different researchers were contrasted, could be explained considering the dissimilar experimental conditions such as the source of the ions and their local concentration at real time.
Facultad de Odontología
description The aim of this work is to contribute to the elucidation of the cytotoxic process caused by the copper ions released from the biomaterials. Clonal cell lines UMR106 were used in the experiments. Copper ions were obtained from two different sources: copper salts and metal dissolution. Experiments carried out with constant ion concentrations (copper salts) were compared with those with concentrations that vary with time and location (dissolution of the metal). Present results and others previously reported could be interpreted through mathematical models that describe: (1) the variation of concentration of copper ions with time and location within a biofilm and (2) the variation of the killing rate with the concentration of the toxic ion and time. The large number of dead cells found near the copper sample with an average ion concentration below the toxic limit could be interpreted bearing in mind that these cells should be exposed to a local concentration higher than this limit. A logarithmic dependence between the number of cells and exposure time was found for nearly constant ion concentrations. Apparent discrepancies, observed when these results and those of different researchers were contrasted, could be explained considering the dissimilar experimental conditions such as the source of the ions and their local concentration at real time.
publishDate 2004
dc.date.none.fl_str_mv 2004
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/76476
url http://sedici.unlp.edu.ar/handle/10915/76476
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0163-4984
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
129-141
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