Decrease in Cytotoxicity of Copper-Based Intrauterine Devices (IUD) Pretreated with 6-Mercaptopurine and Pterin as Biocompatible Corrosion Inhibitors

Autores
Alvarez, Florencia; Grillo, Claudia Alejandra; Schilardi, Patricia Laura; Rubert, Aldo Alberto; Benitez, Guillermo Alfredo; Lorente, Carolina; Fernandez Lorenzo, Monica Alicia
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The copper intrauterine device (IUD) based its contraceptive action on the release of cupric ions from a copper wire. Immediately after the insertion, a burst release of copper ions occurs, which may be associated to a variety of side effects. 6-Mercaptopurine (6-MP) and pterin (PT) have been proposed as corrosion inhibitors to reduce this harmful release. Pretreatments with 1x10-4 M 6-MP and 1x10-4 M PT solutions with 1h and 3h immersion times were tested. Conventional electrochemical techniques, EDX and XPS analysis, and cytotoxicity assays with HeLa cell line were employed to investigate the corrosion behavior and biocompatibility of copper with and without treatments. Results showed that copper samples treated with PT and 6-MP solutions for 3 and 1 h, respectively, are more biocompatible than those without treatment. Besides, the treatment reduces the burst release effect of copper in simulated uterine solutions during the first week after the insertion. It was concluded that PT and 6-MP treatments are promising strategies able to reduce the side effects related to the "burst release" of copper-based IUD without altering the contraceptive action.
Fil: Alvarez, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
Fil: Grillo, Claudia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
Fil: Schilardi, Patricia Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
Fil: Rubert, Aldo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
Fil: Benitez, Guillermo Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
Fil: Lorente, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
Fil: Fernandez Lorenzo, Monica Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata. Facultad de Ingenieria; Argentina
Materia
Intrauterine Device
Copper
Copper Ions
Pterin
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/5309
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/5309
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Decrease in Cytotoxicity of Copper-Based Intrauterine Devices (IUD) Pretreated with 6-Mercaptopurine and Pterin as Biocompatible Corrosion InhibitorsAlvarez, FlorenciaGrillo, Claudia AlejandraSchilardi, Patricia LauraRubert, Aldo AlbertoBenitez, Guillermo AlfredoLorente, CarolinaFernandez Lorenzo, Monica AliciaIntrauterine DeviceCopperCopper IonsPterinhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The copper intrauterine device (IUD) based its contraceptive action on the release of cupric ions from a copper wire. Immediately after the insertion, a burst release of copper ions occurs, which may be associated to a variety of side effects. 6-Mercaptopurine (6-MP) and pterin (PT) have been proposed as corrosion inhibitors to reduce this harmful release. Pretreatments with 1x10-4 M 6-MP and 1x10-4 M PT solutions with 1h and 3h immersion times were tested. Conventional electrochemical techniques, EDX and XPS analysis, and cytotoxicity assays with HeLa cell line were employed to investigate the corrosion behavior and biocompatibility of copper with and without treatments. Results showed that copper samples treated with PT and 6-MP solutions for 3 and 1 h, respectively, are more biocompatible than those without treatment. Besides, the treatment reduces the burst release effect of copper in simulated uterine solutions during the first week after the insertion. It was concluded that PT and 6-MP treatments are promising strategies able to reduce the side effects related to the "burst release" of copper-based IUD without altering the contraceptive action.Fil: Alvarez, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; ArgentinaFil: Grillo, Claudia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; ArgentinaFil: Schilardi, Patricia Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; ArgentinaFil: Rubert, Aldo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; ArgentinaFil: Benitez, Guillermo Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; ArgentinaFil: Lorente, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; ArgentinaFil: Fernandez Lorenzo, Monica Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata. Facultad de Ingenieria; ArgentinaAmerican Chemical Society2013-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/5309Alvarez, Florencia; Grillo, Claudia Alejandra; Schilardi, Patricia Laura; Rubert, Aldo Alberto; Benitez, Guillermo Alfredo; et al.; Decrease in Cytotoxicity of Copper-Based Intrauterine Devices (IUD) Pretreated with 6-Mercaptopurine and Pterin as Biocompatible Corrosion Inhibitors; American Chemical Society; Acs Applied Materials & Interfaces; 5; 2; 2-2013; 249-2551944-8244enginfo:eu-repo/semantics/altIdentifier/pmid/23252335info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/am3025307info:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1021/am3025307info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:34:55Zoai:ri.conicet.gov.ar:11336/5309instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:34:56.151CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Decrease in Cytotoxicity of Copper-Based Intrauterine Devices (IUD) Pretreated with 6-Mercaptopurine and Pterin as Biocompatible Corrosion Inhibitors
title Decrease in Cytotoxicity of Copper-Based Intrauterine Devices (IUD) Pretreated with 6-Mercaptopurine and Pterin as Biocompatible Corrosion Inhibitors
spellingShingle Decrease in Cytotoxicity of Copper-Based Intrauterine Devices (IUD) Pretreated with 6-Mercaptopurine and Pterin as Biocompatible Corrosion Inhibitors
Alvarez, Florencia
Intrauterine Device
Copper
Copper Ions
Pterin
title_short Decrease in Cytotoxicity of Copper-Based Intrauterine Devices (IUD) Pretreated with 6-Mercaptopurine and Pterin as Biocompatible Corrosion Inhibitors
title_full Decrease in Cytotoxicity of Copper-Based Intrauterine Devices (IUD) Pretreated with 6-Mercaptopurine and Pterin as Biocompatible Corrosion Inhibitors
title_fullStr Decrease in Cytotoxicity of Copper-Based Intrauterine Devices (IUD) Pretreated with 6-Mercaptopurine and Pterin as Biocompatible Corrosion Inhibitors
title_full_unstemmed Decrease in Cytotoxicity of Copper-Based Intrauterine Devices (IUD) Pretreated with 6-Mercaptopurine and Pterin as Biocompatible Corrosion Inhibitors
title_sort Decrease in Cytotoxicity of Copper-Based Intrauterine Devices (IUD) Pretreated with 6-Mercaptopurine and Pterin as Biocompatible Corrosion Inhibitors
dc.creator.none.fl_str_mv Alvarez, Florencia
Grillo, Claudia Alejandra
Schilardi, Patricia Laura
Rubert, Aldo Alberto
Benitez, Guillermo Alfredo
Lorente, Carolina
Fernandez Lorenzo, Monica Alicia
author Alvarez, Florencia
author_facet Alvarez, Florencia
Grillo, Claudia Alejandra
Schilardi, Patricia Laura
Rubert, Aldo Alberto
Benitez, Guillermo Alfredo
Lorente, Carolina
Fernandez Lorenzo, Monica Alicia
author_role author
author2 Grillo, Claudia Alejandra
Schilardi, Patricia Laura
Rubert, Aldo Alberto
Benitez, Guillermo Alfredo
Lorente, Carolina
Fernandez Lorenzo, Monica Alicia
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Intrauterine Device
Copper
Copper Ions
Pterin
topic Intrauterine Device
Copper
Copper Ions
Pterin
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The copper intrauterine device (IUD) based its contraceptive action on the release of cupric ions from a copper wire. Immediately after the insertion, a burst release of copper ions occurs, which may be associated to a variety of side effects. 6-Mercaptopurine (6-MP) and pterin (PT) have been proposed as corrosion inhibitors to reduce this harmful release. Pretreatments with 1x10-4 M 6-MP and 1x10-4 M PT solutions with 1h and 3h immersion times were tested. Conventional electrochemical techniques, EDX and XPS analysis, and cytotoxicity assays with HeLa cell line were employed to investigate the corrosion behavior and biocompatibility of copper with and without treatments. Results showed that copper samples treated with PT and 6-MP solutions for 3 and 1 h, respectively, are more biocompatible than those without treatment. Besides, the treatment reduces the burst release effect of copper in simulated uterine solutions during the first week after the insertion. It was concluded that PT and 6-MP treatments are promising strategies able to reduce the side effects related to the "burst release" of copper-based IUD without altering the contraceptive action.
Fil: Alvarez, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
Fil: Grillo, Claudia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
Fil: Schilardi, Patricia Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
Fil: Rubert, Aldo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
Fil: Benitez, Guillermo Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
Fil: Lorente, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
Fil: Fernandez Lorenzo, Monica Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata. Facultad de Ingenieria; Argentina
description The copper intrauterine device (IUD) based its contraceptive action on the release of cupric ions from a copper wire. Immediately after the insertion, a burst release of copper ions occurs, which may be associated to a variety of side effects. 6-Mercaptopurine (6-MP) and pterin (PT) have been proposed as corrosion inhibitors to reduce this harmful release. Pretreatments with 1x10-4 M 6-MP and 1x10-4 M PT solutions with 1h and 3h immersion times were tested. Conventional electrochemical techniques, EDX and XPS analysis, and cytotoxicity assays with HeLa cell line were employed to investigate the corrosion behavior and biocompatibility of copper with and without treatments. Results showed that copper samples treated with PT and 6-MP solutions for 3 and 1 h, respectively, are more biocompatible than those without treatment. Besides, the treatment reduces the burst release effect of copper in simulated uterine solutions during the first week after the insertion. It was concluded that PT and 6-MP treatments are promising strategies able to reduce the side effects related to the "burst release" of copper-based IUD without altering the contraceptive action.
publishDate 2013
dc.date.none.fl_str_mv 2013-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/5309
Alvarez, Florencia; Grillo, Claudia Alejandra; Schilardi, Patricia Laura; Rubert, Aldo Alberto; Benitez, Guillermo Alfredo; et al.; Decrease in Cytotoxicity of Copper-Based Intrauterine Devices (IUD) Pretreated with 6-Mercaptopurine and Pterin as Biocompatible Corrosion Inhibitors; American Chemical Society; Acs Applied Materials & Interfaces; 5; 2; 2-2013; 249-255
1944-8244
url http://hdl.handle.net/11336/5309
identifier_str_mv Alvarez, Florencia; Grillo, Claudia Alejandra; Schilardi, Patricia Laura; Rubert, Aldo Alberto; Benitez, Guillermo Alfredo; et al.; Decrease in Cytotoxicity of Copper-Based Intrauterine Devices (IUD) Pretreated with 6-Mercaptopurine and Pterin as Biocompatible Corrosion Inhibitors; American Chemical Society; Acs Applied Materials & Interfaces; 5; 2; 2-2013; 249-255
1944-8244
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/pmid/23252335
info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/am3025307
info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.1021/am3025307
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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