HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in Argentina

Autores
Moavro, Damián Ezequiel; Andrini, Laura Beatriz; Iribarne, Ailén; Colaci, Pablo Francisco; García, Marcela Nilda
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Transitional carcinoma (TC) is the most common neoplasm of the bladder (80%). The immune checkpoint (IC) Human leukocyte antigen G (HLA‐G) expression has been demonstrated within numerous types of cancer and correlates with the degree of malignancy. This study aims for HLA‐G expression in the bladder TC in a public hospital in Argentina linking its malignancy grade with the survival of the patients. We study thirty TC samples, in which we determine the invasion level and the HLA‐G expression by immunohistochemistry. From all analyzed cases, 23 correspond to high‐grade TC, of whom 91% presented HLA‐G immunostaining and 83% compromised the muscularis propria layer of the bladder. Four patients in this group have not exceeded 5 years of survival. This data confirms that HLA‐G expression in the bladder TC is associated with greater aggressiveness. Therefore, adding this immunostaining to the immunohistochemical panel used in the routine diagnosis of this neoplasm would be very useful.
Facultad de Ciencias Médicas
Materia
Ciencias Médicas
Transitional bladder carcinoma
Human leukocyte antigen G
Immunohistochemistry
Prognostic factor
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/162467

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network_name_str SEDICI (UNLP)
spelling HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in ArgentinaMoavro, Damián EzequielAndrini, Laura BeatrizIribarne, AilénColaci, Pablo FranciscoGarcía, Marcela NildaCiencias MédicasTransitional bladder carcinomaHuman leukocyte antigen GImmunohistochemistryPrognostic factorTransitional carcinoma (TC) is the most common neoplasm of the bladder (80%). The immune checkpoint (IC) Human leukocyte antigen G (HLA‐G) expression has been demonstrated within numerous types of cancer and correlates with the degree of malignancy. This study aims for HLA‐G expression in the bladder TC in a public hospital in Argentina linking its malignancy grade with the survival of the patients. We study thirty TC samples, in which we determine the invasion level and the HLA‐G expression by immunohistochemistry. From all analyzed cases, 23 correspond to high‐grade TC, of whom 91% presented HLA‐G immunostaining and 83% compromised the muscularis propria layer of the bladder. Four patients in this group have not exceeded 5 years of survival. This data confirms that HLA‐G expression in the bladder TC is associated with greater aggressiveness. Therefore, adding this immunostaining to the immunohistochemical panel used in the routine diagnosis of this neoplasm would be very useful.Facultad de Ciencias Médicas2023-04-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf423-427http://sedici.unlp.edu.ar/handle/10915/162467enginfo:eu-repo/semantics/altIdentifier/issn/0198-8859info:eu-repo/semantics/altIdentifier/doi/10.1016/j.humimm.2023.03.008info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:42:40Zoai:sedici.unlp.edu.ar:10915/162467Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:42:41.198SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in Argentina
title HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in Argentina
spellingShingle HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in Argentina
Moavro, Damián Ezequiel
Ciencias Médicas
Transitional bladder carcinoma
Human leukocyte antigen G
Immunohistochemistry
Prognostic factor
title_short HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in Argentina
title_full HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in Argentina
title_fullStr HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in Argentina
title_full_unstemmed HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in Argentina
title_sort HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in Argentina
dc.creator.none.fl_str_mv Moavro, Damián Ezequiel
Andrini, Laura Beatriz
Iribarne, Ailén
Colaci, Pablo Francisco
García, Marcela Nilda
author Moavro, Damián Ezequiel
author_facet Moavro, Damián Ezequiel
Andrini, Laura Beatriz
Iribarne, Ailén
Colaci, Pablo Francisco
García, Marcela Nilda
author_role author
author2 Andrini, Laura Beatriz
Iribarne, Ailén
Colaci, Pablo Francisco
García, Marcela Nilda
author2_role author
author
author
author
dc.subject.none.fl_str_mv Ciencias Médicas
Transitional bladder carcinoma
Human leukocyte antigen G
Immunohistochemistry
Prognostic factor
topic Ciencias Médicas
Transitional bladder carcinoma
Human leukocyte antigen G
Immunohistochemistry
Prognostic factor
dc.description.none.fl_txt_mv Transitional carcinoma (TC) is the most common neoplasm of the bladder (80%). The immune checkpoint (IC) Human leukocyte antigen G (HLA‐G) expression has been demonstrated within numerous types of cancer and correlates with the degree of malignancy. This study aims for HLA‐G expression in the bladder TC in a public hospital in Argentina linking its malignancy grade with the survival of the patients. We study thirty TC samples, in which we determine the invasion level and the HLA‐G expression by immunohistochemistry. From all analyzed cases, 23 correspond to high‐grade TC, of whom 91% presented HLA‐G immunostaining and 83% compromised the muscularis propria layer of the bladder. Four patients in this group have not exceeded 5 years of survival. This data confirms that HLA‐G expression in the bladder TC is associated with greater aggressiveness. Therefore, adding this immunostaining to the immunohistochemical panel used in the routine diagnosis of this neoplasm would be very useful.
Facultad de Ciencias Médicas
description Transitional carcinoma (TC) is the most common neoplasm of the bladder (80%). The immune checkpoint (IC) Human leukocyte antigen G (HLA‐G) expression has been demonstrated within numerous types of cancer and correlates with the degree of malignancy. This study aims for HLA‐G expression in the bladder TC in a public hospital in Argentina linking its malignancy grade with the survival of the patients. We study thirty TC samples, in which we determine the invasion level and the HLA‐G expression by immunohistochemistry. From all analyzed cases, 23 correspond to high‐grade TC, of whom 91% presented HLA‐G immunostaining and 83% compromised the muscularis propria layer of the bladder. Four patients in this group have not exceeded 5 years of survival. This data confirms that HLA‐G expression in the bladder TC is associated with greater aggressiveness. Therefore, adding this immunostaining to the immunohistochemical panel used in the routine diagnosis of this neoplasm would be very useful.
publishDate 2023
dc.date.none.fl_str_mv 2023-04-15
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/162467
url http://sedici.unlp.edu.ar/handle/10915/162467
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0198-8859
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.humimm.2023.03.008
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
423-427
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
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institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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