HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in Argentina
- Autores
- Moavro, Damián Ezequiel; Andrini, Laura Beatriz; Iribarne, Ailén; Colaci, Pablo Francisco; García, Marcela Nilda
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Transitional carcinoma (TC) is the most common neoplasm of the bladder (80%). The immune checkpoint (IC) Human leukocyte antigen G (HLA‐G) expression has been demonstrated within numerous types of cancer and correlates with the degree of malignancy. This study aims for HLA‐G expression in the bladder TC in a public hospital in Argentina linking its malignancy grade with the survival of the patients. We study thirty TC samples, in which we determine the invasion level and the HLA‐G expression by immunohistochemistry. From all analyzed cases, 23 correspond to high‐grade TC, of whom 91% presented HLA‐G immunostaining and 83% compromised the muscularis propria layer of the bladder. Four patients in this group have not exceeded 5 years of survival. This data confirms that HLA‐G expression in the bladder TC is associated with greater aggressiveness. Therefore, adding this immunostaining to the immunohistochemical panel used in the routine diagnosis of this neoplasm would be very useful.
Facultad de Ciencias Médicas - Materia
-
Ciencias Médicas
Transitional bladder carcinoma
Human leukocyte antigen G
Immunohistochemistry
Prognostic factor - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/162467
Ver los metadatos del registro completo
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HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in ArgentinaMoavro, Damián EzequielAndrini, Laura BeatrizIribarne, AilénColaci, Pablo FranciscoGarcía, Marcela NildaCiencias MédicasTransitional bladder carcinomaHuman leukocyte antigen GImmunohistochemistryPrognostic factorTransitional carcinoma (TC) is the most common neoplasm of the bladder (80%). The immune checkpoint (IC) Human leukocyte antigen G (HLA‐G) expression has been demonstrated within numerous types of cancer and correlates with the degree of malignancy. This study aims for HLA‐G expression in the bladder TC in a public hospital in Argentina linking its malignancy grade with the survival of the patients. We study thirty TC samples, in which we determine the invasion level and the HLA‐G expression by immunohistochemistry. From all analyzed cases, 23 correspond to high‐grade TC, of whom 91% presented HLA‐G immunostaining and 83% compromised the muscularis propria layer of the bladder. Four patients in this group have not exceeded 5 years of survival. This data confirms that HLA‐G expression in the bladder TC is associated with greater aggressiveness. Therefore, adding this immunostaining to the immunohistochemical panel used in the routine diagnosis of this neoplasm would be very useful.Facultad de Ciencias Médicas2023-04-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf423-427http://sedici.unlp.edu.ar/handle/10915/162467enginfo:eu-repo/semantics/altIdentifier/issn/0198-8859info:eu-repo/semantics/altIdentifier/doi/10.1016/j.humimm.2023.03.008info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:42:40Zoai:sedici.unlp.edu.ar:10915/162467Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:42:41.198SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in Argentina |
title |
HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in Argentina |
spellingShingle |
HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in Argentina Moavro, Damián Ezequiel Ciencias Médicas Transitional bladder carcinoma Human leukocyte antigen G Immunohistochemistry Prognostic factor |
title_short |
HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in Argentina |
title_full |
HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in Argentina |
title_fullStr |
HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in Argentina |
title_full_unstemmed |
HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in Argentina |
title_sort |
HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in Argentina |
dc.creator.none.fl_str_mv |
Moavro, Damián Ezequiel Andrini, Laura Beatriz Iribarne, Ailén Colaci, Pablo Francisco García, Marcela Nilda |
author |
Moavro, Damián Ezequiel |
author_facet |
Moavro, Damián Ezequiel Andrini, Laura Beatriz Iribarne, Ailén Colaci, Pablo Francisco García, Marcela Nilda |
author_role |
author |
author2 |
Andrini, Laura Beatriz Iribarne, Ailén Colaci, Pablo Francisco García, Marcela Nilda |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Ciencias Médicas Transitional bladder carcinoma Human leukocyte antigen G Immunohistochemistry Prognostic factor |
topic |
Ciencias Médicas Transitional bladder carcinoma Human leukocyte antigen G Immunohistochemistry Prognostic factor |
dc.description.none.fl_txt_mv |
Transitional carcinoma (TC) is the most common neoplasm of the bladder (80%). The immune checkpoint (IC) Human leukocyte antigen G (HLA‐G) expression has been demonstrated within numerous types of cancer and correlates with the degree of malignancy. This study aims for HLA‐G expression in the bladder TC in a public hospital in Argentina linking its malignancy grade with the survival of the patients. We study thirty TC samples, in which we determine the invasion level and the HLA‐G expression by immunohistochemistry. From all analyzed cases, 23 correspond to high‐grade TC, of whom 91% presented HLA‐G immunostaining and 83% compromised the muscularis propria layer of the bladder. Four patients in this group have not exceeded 5 years of survival. This data confirms that HLA‐G expression in the bladder TC is associated with greater aggressiveness. Therefore, adding this immunostaining to the immunohistochemical panel used in the routine diagnosis of this neoplasm would be very useful. Facultad de Ciencias Médicas |
description |
Transitional carcinoma (TC) is the most common neoplasm of the bladder (80%). The immune checkpoint (IC) Human leukocyte antigen G (HLA‐G) expression has been demonstrated within numerous types of cancer and correlates with the degree of malignancy. This study aims for HLA‐G expression in the bladder TC in a public hospital in Argentina linking its malignancy grade with the survival of the patients. We study thirty TC samples, in which we determine the invasion level and the HLA‐G expression by immunohistochemistry. From all analyzed cases, 23 correspond to high‐grade TC, of whom 91% presented HLA‐G immunostaining and 83% compromised the muscularis propria layer of the bladder. Four patients in this group have not exceeded 5 years of survival. This data confirms that HLA‐G expression in the bladder TC is associated with greater aggressiveness. Therefore, adding this immunostaining to the immunohistochemical panel used in the routine diagnosis of this neoplasm would be very useful. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-04-15 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/162467 |
url |
http://sedici.unlp.edu.ar/handle/10915/162467 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/issn/0198-8859 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.humimm.2023.03.008 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
eu_rights_str_mv |
openAccess |
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http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
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application/pdf 423-427 |
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reponame:SEDICI (UNLP) instname:Universidad Nacional de La Plata instacron:UNLP |
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SEDICI (UNLP) - Universidad Nacional de La Plata |
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alira@sedici.unlp.edu.ar |
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