Lewis x Antigen is Associated to Head and Neck Squamous Cell Carcinoma Survival

Autores
Rabassa, Martín Enrique; Pereyra, Adrián; Pereyra, Liliana; Segal-Eiras, Amada; Abba, Martín Carlos; Croce, María Virginia
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Head and neck squamous cell carcinoma (HNSCC) is an aggressive disease with poor prognosis without appropriate prognostic markers. Previous research shows that Lewis antigens have been involved in carcinoma dissemination and patients´ survival. Fucosyl and sialyltransferases are the enzymes implicated in the Lewis antigens synthesis. The purpose of this study was to evaluate the prognostic utility of Lewis antigens in HNSCC. We conducted a prospective research including histological samples from 79 patients with primary HNSCC. Lewis x and sialyl Lewis x expression were detected by immunohistochemistry; patient's data, progression free, and overall survival were documented. A statistical correlation study of antigenic expression and patients´ histopathological variables was performed. Cox regression models with internal validation procedures were employed to analyze survival data. By immunohistochemistry, Lewis x was detected in 34/79 (43%) tumor samples, while sialyl Lewis x only in 11/79 (14%). Lewis x expression showed a positive correlation with tumor differentiation and a better overall survival for Lewis x + patients was detected. Moreover, multivariate Cox's regression analysis showed that Lewis x is an independent predictor of better overall survival. The in silico analysis supported the presence of deregulated fucosyl (FUT4) and sialyltransferase (ST3GAL4) in the Lewis synthetic pathway related to patient survival. These results suggest that Lewis x expression is associated with a better outcome in patients with HNSCC.
Centro de Investigaciones Inmunológicas Básicas y Aplicadas
Materia
Medicina
Antigenic expression
Head and neck squamous cell carcinoma
Risk and prognostic factors
Survival
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/144463
Acceder
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network_name_str SEDICI (UNLP)
spelling Lewis x Antigen is Associated to Head and Neck Squamous Cell Carcinoma SurvivalRabassa, Martín EnriquePereyra, AdriánPereyra, LilianaSegal-Eiras, AmadaAbba, Martín CarlosCroce, María VirginiaMedicinaAntigenic expressionHead and neck squamous cell carcinomaRisk and prognostic factorsSurvivalHead and neck squamous cell carcinoma (HNSCC) is an aggressive disease with poor prognosis without appropriate prognostic markers. Previous research shows that Lewis antigens have been involved in carcinoma dissemination and patients´ survival. Fucosyl and sialyltransferases are the enzymes implicated in the Lewis antigens synthesis. The purpose of this study was to evaluate the prognostic utility of Lewis antigens in HNSCC. We conducted a prospective research including histological samples from 79 patients with primary HNSCC. Lewis x and sialyl Lewis x expression were detected by immunohistochemistry; patient's data, progression free, and overall survival were documented. A statistical correlation study of antigenic expression and patients´ histopathological variables was performed. Cox regression models with internal validation procedures were employed to analyze survival data. By immunohistochemistry, Lewis x was detected in 34/79 (43%) tumor samples, while sialyl Lewis x only in 11/79 (14%). Lewis x expression showed a positive correlation with tumor differentiation and a better overall survival for Lewis x + patients was detected. Moreover, multivariate Cox's regression analysis showed that Lewis x is an independent predictor of better overall survival. The in silico analysis supported the presence of deregulated fucosyl (FUT4) and sialyltransferase (ST3GAL4) in the Lewis synthetic pathway related to patient survival. These results suggest that Lewis x expression is associated with a better outcome in patients with HNSCC.Centro de Investigaciones Inmunológicas Básicas y Aplicadas2018-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf525-531http://sedici.unlp.edu.ar/handle/10915/144463enginfo:eu-repo/semantics/altIdentifier/issn/1532-2807info:eu-repo/semantics/altIdentifier/issn/1219-4956info:eu-repo/semantics/altIdentifier/doi/10.1007/s12253-017-0269-4info:eu-repo/semantics/altIdentifier/pmid/28681122info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:24:10Zoai:sedici.unlp.edu.ar:10915/144463Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:24:10.968SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Lewis x Antigen is Associated to Head and Neck Squamous Cell Carcinoma Survival
title Lewis x Antigen is Associated to Head and Neck Squamous Cell Carcinoma Survival
spellingShingle Lewis x Antigen is Associated to Head and Neck Squamous Cell Carcinoma Survival
Rabassa, Martín Enrique
Medicina
Antigenic expression
Head and neck squamous cell carcinoma
Risk and prognostic factors
Survival
title_short Lewis x Antigen is Associated to Head and Neck Squamous Cell Carcinoma Survival
title_full Lewis x Antigen is Associated to Head and Neck Squamous Cell Carcinoma Survival
title_fullStr Lewis x Antigen is Associated to Head and Neck Squamous Cell Carcinoma Survival
title_full_unstemmed Lewis x Antigen is Associated to Head and Neck Squamous Cell Carcinoma Survival
title_sort Lewis x Antigen is Associated to Head and Neck Squamous Cell Carcinoma Survival
dc.creator.none.fl_str_mv Rabassa, Martín Enrique
Pereyra, Adrián
Pereyra, Liliana
Segal-Eiras, Amada
Abba, Martín Carlos
Croce, María Virginia
author Rabassa, Martín Enrique
author_facet Rabassa, Martín Enrique
Pereyra, Adrián
Pereyra, Liliana
Segal-Eiras, Amada
Abba, Martín Carlos
Croce, María Virginia
author_role author
author2 Pereyra, Adrián
Pereyra, Liliana
Segal-Eiras, Amada
Abba, Martín Carlos
Croce, María Virginia
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Medicina
Antigenic expression
Head and neck squamous cell carcinoma
Risk and prognostic factors
Survival
topic Medicina
Antigenic expression
Head and neck squamous cell carcinoma
Risk and prognostic factors
Survival
dc.description.none.fl_txt_mv Head and neck squamous cell carcinoma (HNSCC) is an aggressive disease with poor prognosis without appropriate prognostic markers. Previous research shows that Lewis antigens have been involved in carcinoma dissemination and patients´ survival. Fucosyl and sialyltransferases are the enzymes implicated in the Lewis antigens synthesis. The purpose of this study was to evaluate the prognostic utility of Lewis antigens in HNSCC. We conducted a prospective research including histological samples from 79 patients with primary HNSCC. Lewis x and sialyl Lewis x expression were detected by immunohistochemistry; patient's data, progression free, and overall survival were documented. A statistical correlation study of antigenic expression and patients´ histopathological variables was performed. Cox regression models with internal validation procedures were employed to analyze survival data. By immunohistochemistry, Lewis x was detected in 34/79 (43%) tumor samples, while sialyl Lewis x only in 11/79 (14%). Lewis x expression showed a positive correlation with tumor differentiation and a better overall survival for Lewis x + patients was detected. Moreover, multivariate Cox's regression analysis showed that Lewis x is an independent predictor of better overall survival. The in silico analysis supported the presence of deregulated fucosyl (FUT4) and sialyltransferase (ST3GAL4) in the Lewis synthetic pathway related to patient survival. These results suggest that Lewis x expression is associated with a better outcome in patients with HNSCC.
Centro de Investigaciones Inmunológicas Básicas y Aplicadas
description Head and neck squamous cell carcinoma (HNSCC) is an aggressive disease with poor prognosis without appropriate prognostic markers. Previous research shows that Lewis antigens have been involved in carcinoma dissemination and patients´ survival. Fucosyl and sialyltransferases are the enzymes implicated in the Lewis antigens synthesis. The purpose of this study was to evaluate the prognostic utility of Lewis antigens in HNSCC. We conducted a prospective research including histological samples from 79 patients with primary HNSCC. Lewis x and sialyl Lewis x expression were detected by immunohistochemistry; patient's data, progression free, and overall survival were documented. A statistical correlation study of antigenic expression and patients´ histopathological variables was performed. Cox regression models with internal validation procedures were employed to analyze survival data. By immunohistochemistry, Lewis x was detected in 34/79 (43%) tumor samples, while sialyl Lewis x only in 11/79 (14%). Lewis x expression showed a positive correlation with tumor differentiation and a better overall survival for Lewis x + patients was detected. Moreover, multivariate Cox's regression analysis showed that Lewis x is an independent predictor of better overall survival. The in silico analysis supported the presence of deregulated fucosyl (FUT4) and sialyltransferase (ST3GAL4) in the Lewis synthetic pathway related to patient survival. These results suggest that Lewis x expression is associated with a better outcome in patients with HNSCC.
publishDate 2018
dc.date.none.fl_str_mv 2018-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/144463
url http://sedici.unlp.edu.ar/handle/10915/144463
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1532-2807
info:eu-repo/semantics/altIdentifier/issn/1219-4956
info:eu-repo/semantics/altIdentifier/doi/10.1007/s12253-017-0269-4
info:eu-repo/semantics/altIdentifier/pmid/28681122
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
525-531
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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