Flavonoid silybin improves the response to radiotherapy in invasive bladder cancer

Autores
Prack Mc Cormick, Bárbara Patricia; Langle, Yanina Verónica; Belgorosky, Denise; Vanzulli, Silvia; Balarino, Natalia Patricia; Sandes, Eduardo Omar; Eijan, Ana Maria
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Conservative treatment for invasive bladder cancer (BC) involves a complete transurethral tumor resection combined with chemotherapy (CT) and radiotherapy (RT). The major obstacles of chemo-radiotherapy are the addition of the toxicities of RT and CT, and the recurrence due to RT and CT resistances. The flavonoid Silybin (Sb) inhibits pathways involved in cell survival and resistance mechanisms, therefore the purpose of this paper was to study in vitro and in vivo, the ability of Sb to improve the response to RT, in two murine BC cell lines, with different levels of invasiveness, placing emphasis on radio-sensitivity, and pathways involved in radio-resistance and survival. In vitro, Sb radio-sensitized murine invasive cells through the inhibition of RT-induced NF-κB and PI3K pathways, and the increase of oxidative stress, while non-invasive cells did not show to be sensitized. In vivo, Sb improved RT-response and overall survival in invasive murine tumors. As Sb is already being tested in clinical trials for other urological cancers and it improves RT-response in invasive BC, these results could have translational relevance, supporting further research.
Fil: Prack Mc Cormick, Bárbara Patricia. Universidad Nacional de Lomas de Zamora. Facultad de Cs.agrarias. Laboratorio de Suelos; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Langle, Yanina Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina
Fil: Belgorosky, Denise. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina
Fil: Vanzulli, Silvia. Academia Nacional de Medicina de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina
Fil: Balarino, Natalia Patricia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sandes, Eduardo Omar. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina
Fil: Eijan, Ana Maria. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
BLADDER CANCER
BLADDER PRESERVATION
SILYBIN
RADIOTHERAPY
RADIOSENSITIZER
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/93289
Acceder
id CONICETDig_894bdd73f745ab2050292d4f7ea437c5
oai_identifier_str oai:ri.conicet.gov.ar:11336/93289
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Flavonoid silybin improves the response to radiotherapy in invasive bladder cancerPrack Mc Cormick, Bárbara PatriciaLangle, Yanina VerónicaBelgorosky, DeniseVanzulli, SilviaBalarino, Natalia PatriciaSandes, Eduardo OmarEijan, Ana MariaBLADDER CANCERBLADDER PRESERVATIONSILYBINRADIOTHERAPYRADIOSENSITIZERhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Conservative treatment for invasive bladder cancer (BC) involves a complete transurethral tumor resection combined with chemotherapy (CT) and radiotherapy (RT). The major obstacles of chemo-radiotherapy are the addition of the toxicities of RT and CT, and the recurrence due to RT and CT resistances. The flavonoid Silybin (Sb) inhibits pathways involved in cell survival and resistance mechanisms, therefore the purpose of this paper was to study in vitro and in vivo, the ability of Sb to improve the response to RT, in two murine BC cell lines, with different levels of invasiveness, placing emphasis on radio-sensitivity, and pathways involved in radio-resistance and survival. In vitro, Sb radio-sensitized murine invasive cells through the inhibition of RT-induced NF-κB and PI3K pathways, and the increase of oxidative stress, while non-invasive cells did not show to be sensitized. In vivo, Sb improved RT-response and overall survival in invasive murine tumors. As Sb is already being tested in clinical trials for other urological cancers and it improves RT-response in invasive BC, these results could have translational relevance, supporting further research.Fil: Prack Mc Cormick, Bárbara Patricia. Universidad Nacional de Lomas de Zamora. Facultad de Cs.agrarias. Laboratorio de Suelos; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Langle, Yanina Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; ArgentinaFil: Belgorosky, Denise. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; ArgentinaFil: Vanzulli, Silvia. Academia Nacional de Medicina de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; ArgentinaFil: Balarino, Natalia Patricia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sandes, Eduardo Omar. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; ArgentinaFil: Eijan, Ana Maria. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaWiley-liss, Div John Wiley & Sons Inc2018-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/93289Prack Mc Cormick, Bárbara Patricia; Langle, Yanina Verónica; Belgorosky, Denise; Vanzulli, Silvia; Balarino, Natalia Patricia; et al.; Flavonoid silybin improves the response to radiotherapy in invasive bladder cancer; Wiley-liss, Div John Wiley & Sons Inc; Journal of Cellular Biochemistry; 119; 7; 1-2018; 5402-54120730-2312CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcb.26693info:eu-repo/semantics/altIdentifier/doi/10.1002/jcb.26693info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:23:05Zoai:ri.conicet.gov.ar:11336/93289instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:23:06.132CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Flavonoid silybin improves the response to radiotherapy in invasive bladder cancer
title Flavonoid silybin improves the response to radiotherapy in invasive bladder cancer
spellingShingle Flavonoid silybin improves the response to radiotherapy in invasive bladder cancer
Prack Mc Cormick, Bárbara Patricia
BLADDER CANCER
BLADDER PRESERVATION
SILYBIN
RADIOTHERAPY
RADIOSENSITIZER
title_short Flavonoid silybin improves the response to radiotherapy in invasive bladder cancer
title_full Flavonoid silybin improves the response to radiotherapy in invasive bladder cancer
title_fullStr Flavonoid silybin improves the response to radiotherapy in invasive bladder cancer
title_full_unstemmed Flavonoid silybin improves the response to radiotherapy in invasive bladder cancer
title_sort Flavonoid silybin improves the response to radiotherapy in invasive bladder cancer
dc.creator.none.fl_str_mv Prack Mc Cormick, Bárbara Patricia
Langle, Yanina Verónica
Belgorosky, Denise
Vanzulli, Silvia
Balarino, Natalia Patricia
Sandes, Eduardo Omar
Eijan, Ana Maria
author Prack Mc Cormick, Bárbara Patricia
author_facet Prack Mc Cormick, Bárbara Patricia
Langle, Yanina Verónica
Belgorosky, Denise
Vanzulli, Silvia
Balarino, Natalia Patricia
Sandes, Eduardo Omar
Eijan, Ana Maria
author_role author
author2 Langle, Yanina Verónica
Belgorosky, Denise
Vanzulli, Silvia
Balarino, Natalia Patricia
Sandes, Eduardo Omar
Eijan, Ana Maria
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv BLADDER CANCER
BLADDER PRESERVATION
SILYBIN
RADIOTHERAPY
RADIOSENSITIZER
topic BLADDER CANCER
BLADDER PRESERVATION
SILYBIN
RADIOTHERAPY
RADIOSENSITIZER
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Conservative treatment for invasive bladder cancer (BC) involves a complete transurethral tumor resection combined with chemotherapy (CT) and radiotherapy (RT). The major obstacles of chemo-radiotherapy are the addition of the toxicities of RT and CT, and the recurrence due to RT and CT resistances. The flavonoid Silybin (Sb) inhibits pathways involved in cell survival and resistance mechanisms, therefore the purpose of this paper was to study in vitro and in vivo, the ability of Sb to improve the response to RT, in two murine BC cell lines, with different levels of invasiveness, placing emphasis on radio-sensitivity, and pathways involved in radio-resistance and survival. In vitro, Sb radio-sensitized murine invasive cells through the inhibition of RT-induced NF-κB and PI3K pathways, and the increase of oxidative stress, while non-invasive cells did not show to be sensitized. In vivo, Sb improved RT-response and overall survival in invasive murine tumors. As Sb is already being tested in clinical trials for other urological cancers and it improves RT-response in invasive BC, these results could have translational relevance, supporting further research.
Fil: Prack Mc Cormick, Bárbara Patricia. Universidad Nacional de Lomas de Zamora. Facultad de Cs.agrarias. Laboratorio de Suelos; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Langle, Yanina Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina
Fil: Belgorosky, Denise. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina
Fil: Vanzulli, Silvia. Academia Nacional de Medicina de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina
Fil: Balarino, Natalia Patricia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sandes, Eduardo Omar. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina
Fil: Eijan, Ana Maria. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Conservative treatment for invasive bladder cancer (BC) involves a complete transurethral tumor resection combined with chemotherapy (CT) and radiotherapy (RT). The major obstacles of chemo-radiotherapy are the addition of the toxicities of RT and CT, and the recurrence due to RT and CT resistances. The flavonoid Silybin (Sb) inhibits pathways involved in cell survival and resistance mechanisms, therefore the purpose of this paper was to study in vitro and in vivo, the ability of Sb to improve the response to RT, in two murine BC cell lines, with different levels of invasiveness, placing emphasis on radio-sensitivity, and pathways involved in radio-resistance and survival. In vitro, Sb radio-sensitized murine invasive cells through the inhibition of RT-induced NF-κB and PI3K pathways, and the increase of oxidative stress, while non-invasive cells did not show to be sensitized. In vivo, Sb improved RT-response and overall survival in invasive murine tumors. As Sb is already being tested in clinical trials for other urological cancers and it improves RT-response in invasive BC, these results could have translational relevance, supporting further research.
publishDate 2018
dc.date.none.fl_str_mv 2018-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/93289
Prack Mc Cormick, Bárbara Patricia; Langle, Yanina Verónica; Belgorosky, Denise; Vanzulli, Silvia; Balarino, Natalia Patricia; et al.; Flavonoid silybin improves the response to radiotherapy in invasive bladder cancer; Wiley-liss, Div John Wiley & Sons Inc; Journal of Cellular Biochemistry; 119; 7; 1-2018; 5402-5412
0730-2312
CONICET Digital
CONICET
url http://hdl.handle.net/11336/93289
identifier_str_mv Prack Mc Cormick, Bárbara Patricia; Langle, Yanina Verónica; Belgorosky, Denise; Vanzulli, Silvia; Balarino, Natalia Patricia; et al.; Flavonoid silybin improves the response to radiotherapy in invasive bladder cancer; Wiley-liss, Div John Wiley & Sons Inc; Journal of Cellular Biochemistry; 119; 7; 1-2018; 5402-5412
0730-2312
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcb.26693
info:eu-repo/semantics/altIdentifier/doi/10.1002/jcb.26693
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842981273727926272
score 12.493442

Publicaciones similares