Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity

Autores
Scherf, Katharina A; Catassi, Carlo; Chirdo, Fernando Gabriel; Ciclitira, Paul J.; Feighery, Conleth; Gianfrani, Carmen; Koning, Frits; Lundin, Knut E. A.; Schuppan, Detlef; Smulders, Marinus J. M.; Tranquet, Olivier; Troncone, Riccardo; Koehler, Peter
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Celiac disease (CD) affects a growing number of individuals worldwide. To elucidate the causes for this increase, future multidisciplinary collaboration is key to understanding the interactions between immunoreactive components in gluten-containing cereals and the human gastrointestinal tract and immune system and to devise strategies for CD prevention and treatment beyond the gluten-free diet. During the last meetings, the Working Group on Prolamin Analysis and Toxicity (Prolamin Working Group, PWG) discussed recent progress in the field together with key stakeholders from celiac disease societies, academia, industry and regulatory bodies. Based on the current state of knowledge, this perspective from the PWG members provides recommendations regarding clinical, analytical and legal aspects of CD. The selected key topics that require future multidisciplinary collaborative efforts in the clinical field are to collect robust data on the increasing prevalence of CD, to evaluate what is special about gluten-specific T cells, to study their kinetics and transcriptomics and to put some attention to the identification of the environmental agents that facilitate the breaking of tolerance to gluten. In the field of gluten analysis, the key topics are the precise assessment of gluten immunoreactive components in wheat, rye and barley to understand how these are affected by genetic and environmental factors, the comparison of different methods for compliance monitoring of gluten-free products and the development of improved reference materials for gluten analysis.
Instituto de Estudios Inmunológicos y Fisiopatológicos
Materia
Biología
Ciencias Médicas
Barley
Celiac disease
Gluten
Gluten-free diet
Prolamin working group
Rye
Wheat
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/107438

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spelling Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and ToxicityScherf, Katharina ACatassi, CarloChirdo, Fernando GabrielCiclitira, Paul J.Feighery, ConlethGianfrani, CarmenKoning, FritsLundin, Knut E. A.Schuppan, DetlefSmulders, Marinus J. M.Tranquet, OlivierTroncone, RiccardoKoehler, PeterBiologíaCiencias MédicasBarleyCeliac diseaseGlutenGluten-free dietProlamin working groupRyeWheatCeliac disease (CD) affects a growing number of individuals worldwide. To elucidate the causes for this increase, future multidisciplinary collaboration is key to understanding the interactions between immunoreactive components in gluten-containing cereals and the human gastrointestinal tract and immune system and to devise strategies for CD prevention and treatment beyond the gluten-free diet. During the last meetings, the Working Group on Prolamin Analysis and Toxicity (Prolamin Working Group, PWG) discussed recent progress in the field together with key stakeholders from celiac disease societies, academia, industry and regulatory bodies. Based on the current state of knowledge, this perspective from the PWG members provides recommendations regarding clinical, analytical and legal aspects of CD. The selected key topics that require future multidisciplinary collaborative efforts in the clinical field are to collect robust data on the increasing prevalence of CD, to evaluate what is special about gluten-specific T cells, to study their kinetics and transcriptomics and to put some attention to the identification of the environmental agents that facilitate the breaking of tolerance to gluten. In the field of gluten analysis, the key topics are the precise assessment of gluten immunoreactive components in wheat, rye and barley to understand how these are affected by genetic and environmental factors, the comparison of different methods for compliance monitoring of gluten-free products and the development of improved reference materials for gluten analysis.Instituto de Estudios Inmunológicos y Fisiopatológicos2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/107438enginfo:eu-repo/semantics/altIdentifier/url/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7090026&blobtype=pdfinfo:eu-repo/semantics/altIdentifier/issn/2296-861Xinfo:eu-repo/semantics/altIdentifier/pmid/32258047info:eu-repo/semantics/altIdentifier/doi/10.3389/fnut.2020.00029info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:23:52Zoai:sedici.unlp.edu.ar:10915/107438Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:23:52.941SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity
title Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity
spellingShingle Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity
Scherf, Katharina A
Biología
Ciencias Médicas
Barley
Celiac disease
Gluten
Gluten-free diet
Prolamin working group
Rye
Wheat
title_short Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity
title_full Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity
title_fullStr Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity
title_full_unstemmed Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity
title_sort Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity
dc.creator.none.fl_str_mv Scherf, Katharina A
Catassi, Carlo
Chirdo, Fernando Gabriel
Ciclitira, Paul J.
Feighery, Conleth
Gianfrani, Carmen
Koning, Frits
Lundin, Knut E. A.
Schuppan, Detlef
Smulders, Marinus J. M.
Tranquet, Olivier
Troncone, Riccardo
Koehler, Peter
author Scherf, Katharina A
author_facet Scherf, Katharina A
Catassi, Carlo
Chirdo, Fernando Gabriel
Ciclitira, Paul J.
Feighery, Conleth
Gianfrani, Carmen
Koning, Frits
Lundin, Knut E. A.
Schuppan, Detlef
Smulders, Marinus J. M.
Tranquet, Olivier
Troncone, Riccardo
Koehler, Peter
author_role author
author2 Catassi, Carlo
Chirdo, Fernando Gabriel
Ciclitira, Paul J.
Feighery, Conleth
Gianfrani, Carmen
Koning, Frits
Lundin, Knut E. A.
Schuppan, Detlef
Smulders, Marinus J. M.
Tranquet, Olivier
Troncone, Riccardo
Koehler, Peter
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Biología
Ciencias Médicas
Barley
Celiac disease
Gluten
Gluten-free diet
Prolamin working group
Rye
Wheat
topic Biología
Ciencias Médicas
Barley
Celiac disease
Gluten
Gluten-free diet
Prolamin working group
Rye
Wheat
dc.description.none.fl_txt_mv Celiac disease (CD) affects a growing number of individuals worldwide. To elucidate the causes for this increase, future multidisciplinary collaboration is key to understanding the interactions between immunoreactive components in gluten-containing cereals and the human gastrointestinal tract and immune system and to devise strategies for CD prevention and treatment beyond the gluten-free diet. During the last meetings, the Working Group on Prolamin Analysis and Toxicity (Prolamin Working Group, PWG) discussed recent progress in the field together with key stakeholders from celiac disease societies, academia, industry and regulatory bodies. Based on the current state of knowledge, this perspective from the PWG members provides recommendations regarding clinical, analytical and legal aspects of CD. The selected key topics that require future multidisciplinary collaborative efforts in the clinical field are to collect robust data on the increasing prevalence of CD, to evaluate what is special about gluten-specific T cells, to study their kinetics and transcriptomics and to put some attention to the identification of the environmental agents that facilitate the breaking of tolerance to gluten. In the field of gluten analysis, the key topics are the precise assessment of gluten immunoreactive components in wheat, rye and barley to understand how these are affected by genetic and environmental factors, the comparison of different methods for compliance monitoring of gluten-free products and the development of improved reference materials for gluten analysis.
Instituto de Estudios Inmunológicos y Fisiopatológicos
description Celiac disease (CD) affects a growing number of individuals worldwide. To elucidate the causes for this increase, future multidisciplinary collaboration is key to understanding the interactions between immunoreactive components in gluten-containing cereals and the human gastrointestinal tract and immune system and to devise strategies for CD prevention and treatment beyond the gluten-free diet. During the last meetings, the Working Group on Prolamin Analysis and Toxicity (Prolamin Working Group, PWG) discussed recent progress in the field together with key stakeholders from celiac disease societies, academia, industry and regulatory bodies. Based on the current state of knowledge, this perspective from the PWG members provides recommendations regarding clinical, analytical and legal aspects of CD. The selected key topics that require future multidisciplinary collaborative efforts in the clinical field are to collect robust data on the increasing prevalence of CD, to evaluate what is special about gluten-specific T cells, to study their kinetics and transcriptomics and to put some attention to the identification of the environmental agents that facilitate the breaking of tolerance to gluten. In the field of gluten analysis, the key topics are the precise assessment of gluten immunoreactive components in wheat, rye and barley to understand how these are affected by genetic and environmental factors, the comparison of different methods for compliance monitoring of gluten-free products and the development of improved reference materials for gluten analysis.
publishDate 2020
dc.date.none.fl_str_mv 2020
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info:eu-repo/semantics/altIdentifier/pmid/32258047
info:eu-repo/semantics/altIdentifier/doi/10.3389/fnut.2020.00029
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Creative Commons Attribution 4.0 International (CC BY 4.0)
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