Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity
- Autores
- Scherf, Katharina A; Catassi, Carlo; Chirdo, Fernando Gabriel; Ciclitira, Paul J.; Feighery, Conleth; Gianfrani, Carmen; Koning, Frits; Lundin, Knut E. A.; Schuppan, Detlef; Smulders, Marinus J. M.; Tranquet, Olivier; Troncone, Riccardo; Koehler, Peter
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Celiac disease (CD) affects a growing number of individuals worldwide. To elucidate the causes for this increase, future multidisciplinary collaboration is key to understanding the interactions between immunoreactive components in gluten-containing cereals and the human gastrointestinal tract and immune system and to devise strategies for CD prevention and treatment beyond the gluten-free diet. During the last meetings, the Working Group on Prolamin Analysis and Toxicity (Prolamin Working Group, PWG) discussed recent progress in the field together with key stakeholders from celiac disease societies, academia, industry and regulatory bodies. Based on the current state of knowledge, this perspective from the PWG members provides recommendations regarding clinical, analytical and legal aspects of CD. The selected key topics that require future multidisciplinary collaborative efforts in the clinical field are to collect robust data on the increasing prevalence of CD, to evaluate what is special about gluten-specific T cells, to study their kinetics and transcriptomics and to put some attention to the identification of the environmental agents that facilitate the breaking of tolerance to gluten. In the field of gluten analysis, the key topics are the precise assessment of gluten immunoreactive components in wheat, rye and barley to understand how these are affected by genetic and environmental factors, the comparison of different methods for compliance monitoring of gluten-free products and the development of improved reference materials for gluten analysis.
Instituto de Estudios Inmunológicos y Fisiopatológicos - Materia
-
Biología
Ciencias Médicas
Barley
Celiac disease
Gluten
Gluten-free diet
Prolamin working group
Rye
Wheat - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/107438
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Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and ToxicityScherf, Katharina ACatassi, CarloChirdo, Fernando GabrielCiclitira, Paul J.Feighery, ConlethGianfrani, CarmenKoning, FritsLundin, Knut E. A.Schuppan, DetlefSmulders, Marinus J. M.Tranquet, OlivierTroncone, RiccardoKoehler, PeterBiologíaCiencias MédicasBarleyCeliac diseaseGlutenGluten-free dietProlamin working groupRyeWheatCeliac disease (CD) affects a growing number of individuals worldwide. To elucidate the causes for this increase, future multidisciplinary collaboration is key to understanding the interactions between immunoreactive components in gluten-containing cereals and the human gastrointestinal tract and immune system and to devise strategies for CD prevention and treatment beyond the gluten-free diet. During the last meetings, the Working Group on Prolamin Analysis and Toxicity (Prolamin Working Group, PWG) discussed recent progress in the field together with key stakeholders from celiac disease societies, academia, industry and regulatory bodies. Based on the current state of knowledge, this perspective from the PWG members provides recommendations regarding clinical, analytical and legal aspects of CD. The selected key topics that require future multidisciplinary collaborative efforts in the clinical field are to collect robust data on the increasing prevalence of CD, to evaluate what is special about gluten-specific T cells, to study their kinetics and transcriptomics and to put some attention to the identification of the environmental agents that facilitate the breaking of tolerance to gluten. In the field of gluten analysis, the key topics are the precise assessment of gluten immunoreactive components in wheat, rye and barley to understand how these are affected by genetic and environmental factors, the comparison of different methods for compliance monitoring of gluten-free products and the development of improved reference materials for gluten analysis.Instituto de Estudios Inmunológicos y Fisiopatológicos2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/107438enginfo:eu-repo/semantics/altIdentifier/url/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7090026&blobtype=pdfinfo:eu-repo/semantics/altIdentifier/issn/2296-861Xinfo:eu-repo/semantics/altIdentifier/pmid/32258047info:eu-repo/semantics/altIdentifier/doi/10.3389/fnut.2020.00029info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:23:52Zoai:sedici.unlp.edu.ar:10915/107438Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:23:52.941SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity |
title |
Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity |
spellingShingle |
Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity Scherf, Katharina A Biología Ciencias Médicas Barley Celiac disease Gluten Gluten-free diet Prolamin working group Rye Wheat |
title_short |
Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity |
title_full |
Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity |
title_fullStr |
Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity |
title_full_unstemmed |
Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity |
title_sort |
Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity |
dc.creator.none.fl_str_mv |
Scherf, Katharina A Catassi, Carlo Chirdo, Fernando Gabriel Ciclitira, Paul J. Feighery, Conleth Gianfrani, Carmen Koning, Frits Lundin, Knut E. A. Schuppan, Detlef Smulders, Marinus J. M. Tranquet, Olivier Troncone, Riccardo Koehler, Peter |
author |
Scherf, Katharina A |
author_facet |
Scherf, Katharina A Catassi, Carlo Chirdo, Fernando Gabriel Ciclitira, Paul J. Feighery, Conleth Gianfrani, Carmen Koning, Frits Lundin, Knut E. A. Schuppan, Detlef Smulders, Marinus J. M. Tranquet, Olivier Troncone, Riccardo Koehler, Peter |
author_role |
author |
author2 |
Catassi, Carlo Chirdo, Fernando Gabriel Ciclitira, Paul J. Feighery, Conleth Gianfrani, Carmen Koning, Frits Lundin, Knut E. A. Schuppan, Detlef Smulders, Marinus J. M. Tranquet, Olivier Troncone, Riccardo Koehler, Peter |
author2_role |
author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Biología Ciencias Médicas Barley Celiac disease Gluten Gluten-free diet Prolamin working group Rye Wheat |
topic |
Biología Ciencias Médicas Barley Celiac disease Gluten Gluten-free diet Prolamin working group Rye Wheat |
dc.description.none.fl_txt_mv |
Celiac disease (CD) affects a growing number of individuals worldwide. To elucidate the causes for this increase, future multidisciplinary collaboration is key to understanding the interactions between immunoreactive components in gluten-containing cereals and the human gastrointestinal tract and immune system and to devise strategies for CD prevention and treatment beyond the gluten-free diet. During the last meetings, the Working Group on Prolamin Analysis and Toxicity (Prolamin Working Group, PWG) discussed recent progress in the field together with key stakeholders from celiac disease societies, academia, industry and regulatory bodies. Based on the current state of knowledge, this perspective from the PWG members provides recommendations regarding clinical, analytical and legal aspects of CD. The selected key topics that require future multidisciplinary collaborative efforts in the clinical field are to collect robust data on the increasing prevalence of CD, to evaluate what is special about gluten-specific T cells, to study their kinetics and transcriptomics and to put some attention to the identification of the environmental agents that facilitate the breaking of tolerance to gluten. In the field of gluten analysis, the key topics are the precise assessment of gluten immunoreactive components in wheat, rye and barley to understand how these are affected by genetic and environmental factors, the comparison of different methods for compliance monitoring of gluten-free products and the development of improved reference materials for gluten analysis. Instituto de Estudios Inmunológicos y Fisiopatológicos |
description |
Celiac disease (CD) affects a growing number of individuals worldwide. To elucidate the causes for this increase, future multidisciplinary collaboration is key to understanding the interactions between immunoreactive components in gluten-containing cereals and the human gastrointestinal tract and immune system and to devise strategies for CD prevention and treatment beyond the gluten-free diet. During the last meetings, the Working Group on Prolamin Analysis and Toxicity (Prolamin Working Group, PWG) discussed recent progress in the field together with key stakeholders from celiac disease societies, academia, industry and regulatory bodies. Based on the current state of knowledge, this perspective from the PWG members provides recommendations regarding clinical, analytical and legal aspects of CD. The selected key topics that require future multidisciplinary collaborative efforts in the clinical field are to collect robust data on the increasing prevalence of CD, to evaluate what is special about gluten-specific T cells, to study their kinetics and transcriptomics and to put some attention to the identification of the environmental agents that facilitate the breaking of tolerance to gluten. In the field of gluten analysis, the key topics are the precise assessment of gluten immunoreactive components in wheat, rye and barley to understand how these are affected by genetic and environmental factors, the comparison of different methods for compliance monitoring of gluten-free products and the development of improved reference materials for gluten analysis. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020 |
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