Recent progress and recommendations on celiac disease from the working group on prolamin analysis and toxicity

Autores
Scherf, Katharina A.; Catassi, Carlo; Chirdo, Fernando Gabriel; Ciclitira, Paul J.; Feighery, Conleth; Gianfrani, Carmen; Koning, Frits; Lundin, Knut E. A.; Schuppan, Detlef; Smulders, Marinus J. M.; Tranquet, Olivier; Troncone, Riccardo; Koehler, Peter
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Celiac disease (CD) affects a growing number of individuals worldwide. To elucidate the causes for this increase, future multidisciplinary collaboration is key to understanding the interactions between immunoreactive components in gluten-containing cereals and the human gastrointestinal tract and immune system and to devise strategies for CD prevention and treatment beyond the gluten-free diet. During the last meetings, the Working Group on Prolamin Analysis and Toxicity (Prolamin Working Group, PWG) discussed recent progress in the field together with key stakeholders from celiac disease societies, academia, industry and regulatory bodies. Based on the current state of knowledge, this perspective from the PWG members provides recommendations regarding clinical, analytical and legal aspects of CD. The selected key topics that require future multidisciplinary collaborative efforts in the clinical field are to collect robust data on the increasing prevalence of CD, to evaluate what is special about gluten-specific T cells, to study their kinetics and transcriptomics and to put some attention to the identification of the environmental agents that facilitate the breaking of tolerance to gluten. In the field of gluten analysis, the key topics are the precise assessment of gluten immunoreactive components in wheat, rye and barley to understand how these are affected by genetic and environmental factors, the comparison of different methods for compliance monitoring of gluten-free products and the development of improved reference materials for gluten analysis.
Fil: Scherf, Katharina A.. Karlsruher Institut für Technologie; Alemania
Fil: Catassi, Carlo. Polytechnic University of Marche; Italia
Fil: Chirdo, Fernando Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina
Fil: Ciclitira, Paul J.. University of East Anglia; Reino Unido
Fil: Feighery, Conleth. Universidad de Dublin; Irlanda
Fil: Gianfrani, Carmen. Italian National Council of Research; Italia
Fil: Koning, Frits. Leiden University. Leiden University Medical Center; Países Bajos
Fil: Lundin, Knut E. A.. University of Oslo; Noruega
Fil: Schuppan, Detlef. Johannes Gutenberg Universitat Mainz; Alemania
Fil: Smulders, Marinus J. M.. Wageningen University & Research; Países Bajos
Fil: Tranquet, Olivier. National Research Institute for Agriculture, Food and the Environment; Francia
Fil: Troncone, Riccardo. Università degli Studi di Napoli Federico II; Italia
Fil: Koehler, Peter. Biotask AG; Alemania
Materia
CELIAC DISEASE
GLUTEN
GLUTEN FREE DIET
PROLAMIN WORKING GROUP
BARLEY
RYE
WHEAT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/154321
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/154321
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Recent progress and recommendations on celiac disease from the working group on prolamin analysis and toxicityScherf, Katharina A.Catassi, CarloChirdo, Fernando GabrielCiclitira, Paul J.Feighery, ConlethGianfrani, CarmenKoning, FritsLundin, Knut E. A.Schuppan, DetlefSmulders, Marinus J. M.Tranquet, OlivierTroncone, RiccardoKoehler, PeterCELIAC DISEASEGLUTENGLUTEN FREE DIETPROLAMIN WORKING GROUPBARLEYRYEWHEAThttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Celiac disease (CD) affects a growing number of individuals worldwide. To elucidate the causes for this increase, future multidisciplinary collaboration is key to understanding the interactions between immunoreactive components in gluten-containing cereals and the human gastrointestinal tract and immune system and to devise strategies for CD prevention and treatment beyond the gluten-free diet. During the last meetings, the Working Group on Prolamin Analysis and Toxicity (Prolamin Working Group, PWG) discussed recent progress in the field together with key stakeholders from celiac disease societies, academia, industry and regulatory bodies. Based on the current state of knowledge, this perspective from the PWG members provides recommendations regarding clinical, analytical and legal aspects of CD. The selected key topics that require future multidisciplinary collaborative efforts in the clinical field are to collect robust data on the increasing prevalence of CD, to evaluate what is special about gluten-specific T cells, to study their kinetics and transcriptomics and to put some attention to the identification of the environmental agents that facilitate the breaking of tolerance to gluten. In the field of gluten analysis, the key topics are the precise assessment of gluten immunoreactive components in wheat, rye and barley to understand how these are affected by genetic and environmental factors, the comparison of different methods for compliance monitoring of gluten-free products and the development of improved reference materials for gluten analysis.Fil: Scherf, Katharina A.. Karlsruher Institut für Technologie; AlemaniaFil: Catassi, Carlo. Polytechnic University of Marche; ItaliaFil: Chirdo, Fernando Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; ArgentinaFil: Ciclitira, Paul J.. University of East Anglia; Reino UnidoFil: Feighery, Conleth. Universidad de Dublin; IrlandaFil: Gianfrani, Carmen. Italian National Council of Research; ItaliaFil: Koning, Frits. Leiden University. Leiden University Medical Center; Países BajosFil: Lundin, Knut E. A.. University of Oslo; NoruegaFil: Schuppan, Detlef. Johannes Gutenberg Universitat Mainz; AlemaniaFil: Smulders, Marinus J. M.. Wageningen University & Research; Países BajosFil: Tranquet, Olivier. National Research Institute for Agriculture, Food and the Environment; FranciaFil: Troncone, Riccardo. Università degli Studi di Napoli Federico II; ItaliaFil: Koehler, Peter. Biotask AG; AlemaniaFrontiers Media2020-03-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/154321Scherf, Katharina A.; Catassi, Carlo; Chirdo, Fernando Gabriel; Ciclitira, Paul J.; Feighery, Conleth; et al.; Recent progress and recommendations on celiac disease from the working group on prolamin analysis and toxicity; Frontiers Media; Frontiers in Nutrition; 7; 29; 17-3-2020; 1-142296-861XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/article/10.3389/fnut.2020.00029/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fnut.2020.00029info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:07:28Zoai:ri.conicet.gov.ar:11336/154321instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:07:29.074CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Recent progress and recommendations on celiac disease from the working group on prolamin analysis and toxicity
title Recent progress and recommendations on celiac disease from the working group on prolamin analysis and toxicity
spellingShingle Recent progress and recommendations on celiac disease from the working group on prolamin analysis and toxicity
Scherf, Katharina A.
CELIAC DISEASE
GLUTEN
GLUTEN FREE DIET
PROLAMIN WORKING GROUP
BARLEY
RYE
WHEAT
title_short Recent progress and recommendations on celiac disease from the working group on prolamin analysis and toxicity
title_full Recent progress and recommendations on celiac disease from the working group on prolamin analysis and toxicity
title_fullStr Recent progress and recommendations on celiac disease from the working group on prolamin analysis and toxicity
title_full_unstemmed Recent progress and recommendations on celiac disease from the working group on prolamin analysis and toxicity
title_sort Recent progress and recommendations on celiac disease from the working group on prolamin analysis and toxicity
dc.creator.none.fl_str_mv Scherf, Katharina A.
Catassi, Carlo
Chirdo, Fernando Gabriel
Ciclitira, Paul J.
Feighery, Conleth
Gianfrani, Carmen
Koning, Frits
Lundin, Knut E. A.
Schuppan, Detlef
Smulders, Marinus J. M.
Tranquet, Olivier
Troncone, Riccardo
Koehler, Peter
author Scherf, Katharina A.
author_facet Scherf, Katharina A.
Catassi, Carlo
Chirdo, Fernando Gabriel
Ciclitira, Paul J.
Feighery, Conleth
Gianfrani, Carmen
Koning, Frits
Lundin, Knut E. A.
Schuppan, Detlef
Smulders, Marinus J. M.
Tranquet, Olivier
Troncone, Riccardo
Koehler, Peter
author_role author
author2 Catassi, Carlo
Chirdo, Fernando Gabriel
Ciclitira, Paul J.
Feighery, Conleth
Gianfrani, Carmen
Koning, Frits
Lundin, Knut E. A.
Schuppan, Detlef
Smulders, Marinus J. M.
Tranquet, Olivier
Troncone, Riccardo
Koehler, Peter
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CELIAC DISEASE
GLUTEN
GLUTEN FREE DIET
PROLAMIN WORKING GROUP
BARLEY
RYE
WHEAT
topic CELIAC DISEASE
GLUTEN
GLUTEN FREE DIET
PROLAMIN WORKING GROUP
BARLEY
RYE
WHEAT
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Celiac disease (CD) affects a growing number of individuals worldwide. To elucidate the causes for this increase, future multidisciplinary collaboration is key to understanding the interactions between immunoreactive components in gluten-containing cereals and the human gastrointestinal tract and immune system and to devise strategies for CD prevention and treatment beyond the gluten-free diet. During the last meetings, the Working Group on Prolamin Analysis and Toxicity (Prolamin Working Group, PWG) discussed recent progress in the field together with key stakeholders from celiac disease societies, academia, industry and regulatory bodies. Based on the current state of knowledge, this perspective from the PWG members provides recommendations regarding clinical, analytical and legal aspects of CD. The selected key topics that require future multidisciplinary collaborative efforts in the clinical field are to collect robust data on the increasing prevalence of CD, to evaluate what is special about gluten-specific T cells, to study their kinetics and transcriptomics and to put some attention to the identification of the environmental agents that facilitate the breaking of tolerance to gluten. In the field of gluten analysis, the key topics are the precise assessment of gluten immunoreactive components in wheat, rye and barley to understand how these are affected by genetic and environmental factors, the comparison of different methods for compliance monitoring of gluten-free products and the development of improved reference materials for gluten analysis.
Fil: Scherf, Katharina A.. Karlsruher Institut für Technologie; Alemania
Fil: Catassi, Carlo. Polytechnic University of Marche; Italia
Fil: Chirdo, Fernando Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina
Fil: Ciclitira, Paul J.. University of East Anglia; Reino Unido
Fil: Feighery, Conleth. Universidad de Dublin; Irlanda
Fil: Gianfrani, Carmen. Italian National Council of Research; Italia
Fil: Koning, Frits. Leiden University. Leiden University Medical Center; Países Bajos
Fil: Lundin, Knut E. A.. University of Oslo; Noruega
Fil: Schuppan, Detlef. Johannes Gutenberg Universitat Mainz; Alemania
Fil: Smulders, Marinus J. M.. Wageningen University & Research; Países Bajos
Fil: Tranquet, Olivier. National Research Institute for Agriculture, Food and the Environment; Francia
Fil: Troncone, Riccardo. Università degli Studi di Napoli Federico II; Italia
Fil: Koehler, Peter. Biotask AG; Alemania
description Celiac disease (CD) affects a growing number of individuals worldwide. To elucidate the causes for this increase, future multidisciplinary collaboration is key to understanding the interactions between immunoreactive components in gluten-containing cereals and the human gastrointestinal tract and immune system and to devise strategies for CD prevention and treatment beyond the gluten-free diet. During the last meetings, the Working Group on Prolamin Analysis and Toxicity (Prolamin Working Group, PWG) discussed recent progress in the field together with key stakeholders from celiac disease societies, academia, industry and regulatory bodies. Based on the current state of knowledge, this perspective from the PWG members provides recommendations regarding clinical, analytical and legal aspects of CD. The selected key topics that require future multidisciplinary collaborative efforts in the clinical field are to collect robust data on the increasing prevalence of CD, to evaluate what is special about gluten-specific T cells, to study their kinetics and transcriptomics and to put some attention to the identification of the environmental agents that facilitate the breaking of tolerance to gluten. In the field of gluten analysis, the key topics are the precise assessment of gluten immunoreactive components in wheat, rye and barley to understand how these are affected by genetic and environmental factors, the comparison of different methods for compliance monitoring of gluten-free products and the development of improved reference materials for gluten analysis.
publishDate 2020
dc.date.none.fl_str_mv 2020-03-17
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/154321
Scherf, Katharina A.; Catassi, Carlo; Chirdo, Fernando Gabriel; Ciclitira, Paul J.; Feighery, Conleth; et al.; Recent progress and recommendations on celiac disease from the working group on prolamin analysis and toxicity; Frontiers Media; Frontiers in Nutrition; 7; 29; 17-3-2020; 1-14
2296-861X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/154321
identifier_str_mv Scherf, Katharina A.; Catassi, Carlo; Chirdo, Fernando Gabriel; Ciclitira, Paul J.; Feighery, Conleth; et al.; Recent progress and recommendations on celiac disease from the working group on prolamin analysis and toxicity; Frontiers Media; Frontiers in Nutrition; 7; 29; 17-3-2020; 1-14
2296-861X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/article/10.3389/fnut.2020.00029/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fnut.2020.00029
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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