Recent progress and recommendations on celiac disease from the working group on prolamin analysis and toxicity
- Autores
- Scherf, Katharina A.; Catassi, Carlo; Chirdo, Fernando Gabriel; Ciclitira, Paul J.; Feighery, Conleth; Gianfrani, Carmen; Koning, Frits; Lundin, Knut E. A.; Schuppan, Detlef; Smulders, Marinus J. M.; Tranquet, Olivier; Troncone, Riccardo; Koehler, Peter
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Celiac disease (CD) affects a growing number of individuals worldwide. To elucidate the causes for this increase, future multidisciplinary collaboration is key to understanding the interactions between immunoreactive components in gluten-containing cereals and the human gastrointestinal tract and immune system and to devise strategies for CD prevention and treatment beyond the gluten-free diet. During the last meetings, the Working Group on Prolamin Analysis and Toxicity (Prolamin Working Group, PWG) discussed recent progress in the field together with key stakeholders from celiac disease societies, academia, industry and regulatory bodies. Based on the current state of knowledge, this perspective from the PWG members provides recommendations regarding clinical, analytical and legal aspects of CD. The selected key topics that require future multidisciplinary collaborative efforts in the clinical field are to collect robust data on the increasing prevalence of CD, to evaluate what is special about gluten-specific T cells, to study their kinetics and transcriptomics and to put some attention to the identification of the environmental agents that facilitate the breaking of tolerance to gluten. In the field of gluten analysis, the key topics are the precise assessment of gluten immunoreactive components in wheat, rye and barley to understand how these are affected by genetic and environmental factors, the comparison of different methods for compliance monitoring of gluten-free products and the development of improved reference materials for gluten analysis.
Fil: Scherf, Katharina A.. Karlsruher Institut für Technologie; Alemania
Fil: Catassi, Carlo. Polytechnic University of Marche; Italia
Fil: Chirdo, Fernando Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina
Fil: Ciclitira, Paul J.. University of East Anglia; Reino Unido
Fil: Feighery, Conleth. Universidad de Dublin; Irlanda
Fil: Gianfrani, Carmen. Italian National Council of Research; Italia
Fil: Koning, Frits. Leiden University. Leiden University Medical Center; Países Bajos
Fil: Lundin, Knut E. A.. University of Oslo; Noruega
Fil: Schuppan, Detlef. Johannes Gutenberg Universitat Mainz; Alemania
Fil: Smulders, Marinus J. M.. Wageningen University & Research; Países Bajos
Fil: Tranquet, Olivier. National Research Institute for Agriculture, Food and the Environment; Francia
Fil: Troncone, Riccardo. Università degli Studi di Napoli Federico II; Italia
Fil: Koehler, Peter. Biotask AG; Alemania - Materia
-
CELIAC DISEASE
GLUTEN
GLUTEN FREE DIET
PROLAMIN WORKING GROUP
BARLEY
RYE
WHEAT - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/154321
Ver los metadatos del registro completo
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Recent progress and recommendations on celiac disease from the working group on prolamin analysis and toxicityScherf, Katharina A.Catassi, CarloChirdo, Fernando GabrielCiclitira, Paul J.Feighery, ConlethGianfrani, CarmenKoning, FritsLundin, Knut E. A.Schuppan, DetlefSmulders, Marinus J. M.Tranquet, OlivierTroncone, RiccardoKoehler, PeterCELIAC DISEASEGLUTENGLUTEN FREE DIETPROLAMIN WORKING GROUPBARLEYRYEWHEAThttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Celiac disease (CD) affects a growing number of individuals worldwide. To elucidate the causes for this increase, future multidisciplinary collaboration is key to understanding the interactions between immunoreactive components in gluten-containing cereals and the human gastrointestinal tract and immune system and to devise strategies for CD prevention and treatment beyond the gluten-free diet. During the last meetings, the Working Group on Prolamin Analysis and Toxicity (Prolamin Working Group, PWG) discussed recent progress in the field together with key stakeholders from celiac disease societies, academia, industry and regulatory bodies. Based on the current state of knowledge, this perspective from the PWG members provides recommendations regarding clinical, analytical and legal aspects of CD. The selected key topics that require future multidisciplinary collaborative efforts in the clinical field are to collect robust data on the increasing prevalence of CD, to evaluate what is special about gluten-specific T cells, to study their kinetics and transcriptomics and to put some attention to the identification of the environmental agents that facilitate the breaking of tolerance to gluten. In the field of gluten analysis, the key topics are the precise assessment of gluten immunoreactive components in wheat, rye and barley to understand how these are affected by genetic and environmental factors, the comparison of different methods for compliance monitoring of gluten-free products and the development of improved reference materials for gluten analysis.Fil: Scherf, Katharina A.. Karlsruher Institut für Technologie; AlemaniaFil: Catassi, Carlo. Polytechnic University of Marche; ItaliaFil: Chirdo, Fernando Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; ArgentinaFil: Ciclitira, Paul J.. University of East Anglia; Reino UnidoFil: Feighery, Conleth. Universidad de Dublin; IrlandaFil: Gianfrani, Carmen. Italian National Council of Research; ItaliaFil: Koning, Frits. Leiden University. Leiden University Medical Center; Países BajosFil: Lundin, Knut E. A.. University of Oslo; NoruegaFil: Schuppan, Detlef. Johannes Gutenberg Universitat Mainz; AlemaniaFil: Smulders, Marinus J. M.. Wageningen University & Research; Países BajosFil: Tranquet, Olivier. National Research Institute for Agriculture, Food and the Environment; FranciaFil: Troncone, Riccardo. Università degli Studi di Napoli Federico II; ItaliaFil: Koehler, Peter. Biotask AG; AlemaniaFrontiers Media2020-03-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/154321Scherf, Katharina A.; Catassi, Carlo; Chirdo, Fernando Gabriel; Ciclitira, Paul J.; Feighery, Conleth; et al.; Recent progress and recommendations on celiac disease from the working group on prolamin analysis and toxicity; Frontiers Media; Frontiers in Nutrition; 7; 29; 17-3-2020; 1-142296-861XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/article/10.3389/fnut.2020.00029/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fnut.2020.00029info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:39:08Zoai:ri.conicet.gov.ar:11336/154321instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:39:09.003CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Recent progress and recommendations on celiac disease from the working group on prolamin analysis and toxicity |
title |
Recent progress and recommendations on celiac disease from the working group on prolamin analysis and toxicity |
spellingShingle |
Recent progress and recommendations on celiac disease from the working group on prolamin analysis and toxicity Scherf, Katharina A. CELIAC DISEASE GLUTEN GLUTEN FREE DIET PROLAMIN WORKING GROUP BARLEY RYE WHEAT |
title_short |
Recent progress and recommendations on celiac disease from the working group on prolamin analysis and toxicity |
title_full |
Recent progress and recommendations on celiac disease from the working group on prolamin analysis and toxicity |
title_fullStr |
Recent progress and recommendations on celiac disease from the working group on prolamin analysis and toxicity |
title_full_unstemmed |
Recent progress and recommendations on celiac disease from the working group on prolamin analysis and toxicity |
title_sort |
Recent progress and recommendations on celiac disease from the working group on prolamin analysis and toxicity |
dc.creator.none.fl_str_mv |
Scherf, Katharina A. Catassi, Carlo Chirdo, Fernando Gabriel Ciclitira, Paul J. Feighery, Conleth Gianfrani, Carmen Koning, Frits Lundin, Knut E. A. Schuppan, Detlef Smulders, Marinus J. M. Tranquet, Olivier Troncone, Riccardo Koehler, Peter |
author |
Scherf, Katharina A. |
author_facet |
Scherf, Katharina A. Catassi, Carlo Chirdo, Fernando Gabriel Ciclitira, Paul J. Feighery, Conleth Gianfrani, Carmen Koning, Frits Lundin, Knut E. A. Schuppan, Detlef Smulders, Marinus J. M. Tranquet, Olivier Troncone, Riccardo Koehler, Peter |
author_role |
author |
author2 |
Catassi, Carlo Chirdo, Fernando Gabriel Ciclitira, Paul J. Feighery, Conleth Gianfrani, Carmen Koning, Frits Lundin, Knut E. A. Schuppan, Detlef Smulders, Marinus J. M. Tranquet, Olivier Troncone, Riccardo Koehler, Peter |
author2_role |
author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
CELIAC DISEASE GLUTEN GLUTEN FREE DIET PROLAMIN WORKING GROUP BARLEY RYE WHEAT |
topic |
CELIAC DISEASE GLUTEN GLUTEN FREE DIET PROLAMIN WORKING GROUP BARLEY RYE WHEAT |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Celiac disease (CD) affects a growing number of individuals worldwide. To elucidate the causes for this increase, future multidisciplinary collaboration is key to understanding the interactions between immunoreactive components in gluten-containing cereals and the human gastrointestinal tract and immune system and to devise strategies for CD prevention and treatment beyond the gluten-free diet. During the last meetings, the Working Group on Prolamin Analysis and Toxicity (Prolamin Working Group, PWG) discussed recent progress in the field together with key stakeholders from celiac disease societies, academia, industry and regulatory bodies. Based on the current state of knowledge, this perspective from the PWG members provides recommendations regarding clinical, analytical and legal aspects of CD. The selected key topics that require future multidisciplinary collaborative efforts in the clinical field are to collect robust data on the increasing prevalence of CD, to evaluate what is special about gluten-specific T cells, to study their kinetics and transcriptomics and to put some attention to the identification of the environmental agents that facilitate the breaking of tolerance to gluten. In the field of gluten analysis, the key topics are the precise assessment of gluten immunoreactive components in wheat, rye and barley to understand how these are affected by genetic and environmental factors, the comparison of different methods for compliance monitoring of gluten-free products and the development of improved reference materials for gluten analysis. Fil: Scherf, Katharina A.. Karlsruher Institut für Technologie; Alemania Fil: Catassi, Carlo. Polytechnic University of Marche; Italia Fil: Chirdo, Fernando Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina Fil: Ciclitira, Paul J.. University of East Anglia; Reino Unido Fil: Feighery, Conleth. Universidad de Dublin; Irlanda Fil: Gianfrani, Carmen. Italian National Council of Research; Italia Fil: Koning, Frits. Leiden University. Leiden University Medical Center; Países Bajos Fil: Lundin, Knut E. A.. University of Oslo; Noruega Fil: Schuppan, Detlef. Johannes Gutenberg Universitat Mainz; Alemania Fil: Smulders, Marinus J. M.. Wageningen University & Research; Países Bajos Fil: Tranquet, Olivier. National Research Institute for Agriculture, Food and the Environment; Francia Fil: Troncone, Riccardo. Università degli Studi di Napoli Federico II; Italia Fil: Koehler, Peter. Biotask AG; Alemania |
description |
Celiac disease (CD) affects a growing number of individuals worldwide. To elucidate the causes for this increase, future multidisciplinary collaboration is key to understanding the interactions between immunoreactive components in gluten-containing cereals and the human gastrointestinal tract and immune system and to devise strategies for CD prevention and treatment beyond the gluten-free diet. During the last meetings, the Working Group on Prolamin Analysis and Toxicity (Prolamin Working Group, PWG) discussed recent progress in the field together with key stakeholders from celiac disease societies, academia, industry and regulatory bodies. Based on the current state of knowledge, this perspective from the PWG members provides recommendations regarding clinical, analytical and legal aspects of CD. The selected key topics that require future multidisciplinary collaborative efforts in the clinical field are to collect robust data on the increasing prevalence of CD, to evaluate what is special about gluten-specific T cells, to study their kinetics and transcriptomics and to put some attention to the identification of the environmental agents that facilitate the breaking of tolerance to gluten. In the field of gluten analysis, the key topics are the precise assessment of gluten immunoreactive components in wheat, rye and barley to understand how these are affected by genetic and environmental factors, the comparison of different methods for compliance monitoring of gluten-free products and the development of improved reference materials for gluten analysis. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-03-17 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/154321 Scherf, Katharina A.; Catassi, Carlo; Chirdo, Fernando Gabriel; Ciclitira, Paul J.; Feighery, Conleth; et al.; Recent progress and recommendations on celiac disease from the working group on prolamin analysis and toxicity; Frontiers Media; Frontiers in Nutrition; 7; 29; 17-3-2020; 1-14 2296-861X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/154321 |
identifier_str_mv |
Scherf, Katharina A.; Catassi, Carlo; Chirdo, Fernando Gabriel; Ciclitira, Paul J.; Feighery, Conleth; et al.; Recent progress and recommendations on celiac disease from the working group on prolamin analysis and toxicity; Frontiers Media; Frontiers in Nutrition; 7; 29; 17-3-2020; 1-14 2296-861X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/article/10.3389/fnut.2020.00029/full info:eu-repo/semantics/altIdentifier/doi/10.3389/fnut.2020.00029 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
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openAccess |
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https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613237377597440 |
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13.070432 |