Calcium deficiency modifies polyunsaturated fatty acid metabolism in growing rats

Autores
Marra, Carlos Alberto; Tacconi de Alaniz, María Josefa
Año de publicación
2000
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fatty acid desaturase activities were determined in liver microsomes from calcium-deficient rats and compared to calcium-sufficient ones. The calcium-deprived diet (0.5 g/kg) administered for 60 d caused a 30% inhibition in the Δ5 desaturase activity and a 45–55% decrease in Δ6 and Δ9, respectively, facts that cannot be attributed to a reduction in food intake. In vitro addition of calcium, ethyleneglycol-bis(β-aminoethyl ether)N,N-tetraacetic acid, and/or cytosol fractions from control or calcium-deficient rats to microsomes from both groups of animals indicates that the reduced desaturase capacities would be the consequence of an indirect effect of calcium deprivation. The present work shows that the reduced unsaturated fatty acid biosynthesis might be the result of modifications in the physicochemical properties of microsomal membranes. Such changes could also be derived from the inhibition of phospholipase A2 activity induced by calcium deficiency.
Instituto de Investigaciones Bioquímicas de La Plata
Materia
Bioquímica
Calcium
Unsaturated fatty acid
Phospholipase A2
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/132519
Acceder
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network_name_str SEDICI (UNLP)
spelling Calcium deficiency modifies polyunsaturated fatty acid metabolism in growing ratsMarra, Carlos AlbertoTacconi de Alaniz, María JosefaBioquímicaCalciumUnsaturated fatty acidPhospholipase A2Fatty acid desaturase activities were determined in liver microsomes from calcium-deficient rats and compared to calcium-sufficient ones. The calcium-deprived diet (0.5 g/kg) administered for 60 d caused a 30% inhibition in the Δ5 desaturase activity and a 45–55% decrease in Δ6 and Δ9, respectively, facts that cannot be attributed to a reduction in food intake. In vitro addition of calcium, ethyleneglycol-bis(β-aminoethyl ether)N,N-tetraacetic acid, and/or cytosol fractions from control or calcium-deficient rats to microsomes from both groups of animals indicates that the reduced desaturase capacities would be the consequence of an indirect effect of calcium deprivation. The present work shows that the reduced unsaturated fatty acid biosynthesis might be the result of modifications in the physicochemical properties of microsomal membranes. Such changes could also be derived from the inhibition of phospholipase A2 activity induced by calcium deficiency.Instituto de Investigaciones Bioquímicas de La Plata2000info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf983-990http://sedici.unlp.edu.ar/handle/10915/132519enginfo:eu-repo/semantics/altIdentifier/issn/0024-4201info:eu-repo/semantics/altIdentifier/issn/1558-9307info:eu-repo/semantics/altIdentifier/doi/10.1007/s11745-000-0609-8info:eu-repo/semantics/altIdentifier/pmid/11026619info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:24:04Zoai:sedici.unlp.edu.ar:10915/132519Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:24:04.572SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Calcium deficiency modifies polyunsaturated fatty acid metabolism in growing rats
title Calcium deficiency modifies polyunsaturated fatty acid metabolism in growing rats
spellingShingle Calcium deficiency modifies polyunsaturated fatty acid metabolism in growing rats
Marra, Carlos Alberto
Bioquímica
Calcium
Unsaturated fatty acid
Phospholipase A2
title_short Calcium deficiency modifies polyunsaturated fatty acid metabolism in growing rats
title_full Calcium deficiency modifies polyunsaturated fatty acid metabolism in growing rats
title_fullStr Calcium deficiency modifies polyunsaturated fatty acid metabolism in growing rats
title_full_unstemmed Calcium deficiency modifies polyunsaturated fatty acid metabolism in growing rats
title_sort Calcium deficiency modifies polyunsaturated fatty acid metabolism in growing rats
dc.creator.none.fl_str_mv Marra, Carlos Alberto
Tacconi de Alaniz, María Josefa
author Marra, Carlos Alberto
author_facet Marra, Carlos Alberto
Tacconi de Alaniz, María Josefa
author_role author
author2 Tacconi de Alaniz, María Josefa
author2_role author
dc.subject.none.fl_str_mv Bioquímica
Calcium
Unsaturated fatty acid
Phospholipase A2
topic Bioquímica
Calcium
Unsaturated fatty acid
Phospholipase A2
dc.description.none.fl_txt_mv Fatty acid desaturase activities were determined in liver microsomes from calcium-deficient rats and compared to calcium-sufficient ones. The calcium-deprived diet (0.5 g/kg) administered for 60 d caused a 30% inhibition in the Δ5 desaturase activity and a 45–55% decrease in Δ6 and Δ9, respectively, facts that cannot be attributed to a reduction in food intake. In vitro addition of calcium, ethyleneglycol-bis(β-aminoethyl ether)N,N-tetraacetic acid, and/or cytosol fractions from control or calcium-deficient rats to microsomes from both groups of animals indicates that the reduced desaturase capacities would be the consequence of an indirect effect of calcium deprivation. The present work shows that the reduced unsaturated fatty acid biosynthesis might be the result of modifications in the physicochemical properties of microsomal membranes. Such changes could also be derived from the inhibition of phospholipase A2 activity induced by calcium deficiency.
Instituto de Investigaciones Bioquímicas de La Plata
description Fatty acid desaturase activities were determined in liver microsomes from calcium-deficient rats and compared to calcium-sufficient ones. The calcium-deprived diet (0.5 g/kg) administered for 60 d caused a 30% inhibition in the Δ5 desaturase activity and a 45–55% decrease in Δ6 and Δ9, respectively, facts that cannot be attributed to a reduction in food intake. In vitro addition of calcium, ethyleneglycol-bis(β-aminoethyl ether)N,N-tetraacetic acid, and/or cytosol fractions from control or calcium-deficient rats to microsomes from both groups of animals indicates that the reduced desaturase capacities would be the consequence of an indirect effect of calcium deprivation. The present work shows that the reduced unsaturated fatty acid biosynthesis might be the result of modifications in the physicochemical properties of microsomal membranes. Such changes could also be derived from the inhibition of phospholipase A2 activity induced by calcium deficiency.
publishDate 2000
dc.date.none.fl_str_mv 2000
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/132519
url http://sedici.unlp.edu.ar/handle/10915/132519
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0024-4201
info:eu-repo/semantics/altIdentifier/issn/1558-9307
info:eu-repo/semantics/altIdentifier/doi/10.1007/s11745-000-0609-8
info:eu-repo/semantics/altIdentifier/pmid/11026619
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
983-990
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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