Effect of ethanol administration on fatty acid desaturation

Autores
Nervi, Aníbal M.; Peluffo, Raúl Omar; Brenner, Rodolfo Roberto; Leikin, Alicia Isabel
Año de publicación
1980
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The effect of ethanol on the fatty acid desaturation by rat liver has been studied using liquid diets of different composition. Acute ethanol administration increased triacylglycerols of total liver lipids, but did not modify significantly the lipidic composition of microsomes. The Δ6 and Δ5 desaturases were inhibited by ethanol whereas the Δ9 desaturase and fatty acid synthetase were apparently modified only by diet composition. NADH-cytochrome (cyt.) c reductase was partially inhibited, whereas NADH-cyt. b5 reductase remained practically unaltered and NADPH-cyt. c reductase activity was enhanced. Decreased electrons supplied by the microsomal cyt. b5 electron transport chain would not be the reason for the inhibition of Δ6 and Δ5 desaturases by ethanol.
Facultad de Ciencias Médicas
Materia
Bioquímica
Ethanol
Fatty acid
Lipidic
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/136621
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/136621
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Effect of ethanol administration on fatty acid desaturationNervi, Aníbal M.Peluffo, Raúl OmarBrenner, Rodolfo RobertoLeikin, Alicia IsabelBioquímicaEthanolFatty acidLipidicThe effect of ethanol on the fatty acid desaturation by rat liver has been studied using liquid diets of different composition. Acute ethanol administration increased triacylglycerols of total liver lipids, but did not modify significantly the lipidic composition of microsomes. The Δ6 and Δ5 desaturases were inhibited by ethanol whereas the Δ9 desaturase and fatty acid synthetase were apparently modified only by diet composition. NADH-cytochrome (cyt.) c reductase was partially inhibited, whereas NADH-cyt. b5 reductase remained practically unaltered and NADPH-cyt. c reductase activity was enhanced. Decreased electrons supplied by the microsomal cyt. b5 electron transport chain would not be the reason for the inhibition of Δ6 and Δ5 desaturases by ethanol.Facultad de Ciencias Médicas1980info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf263-268http://sedici.unlp.edu.ar/handle/10915/136621enginfo:eu-repo/semantics/altIdentifier/issn/0024-4201info:eu-repo/semantics/altIdentifier/issn/1558-9307info:eu-repo/semantics/altIdentifier/doi/10.1007/bf02535837info:eu-repo/semantics/altIdentifier/pmid/7374380info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-17T10:14:56Zoai:sedici.unlp.edu.ar:10915/136621Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-17 10:14:56.613SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Effect of ethanol administration on fatty acid desaturation
title Effect of ethanol administration on fatty acid desaturation
spellingShingle Effect of ethanol administration on fatty acid desaturation
Nervi, Aníbal M.
Bioquímica
Ethanol
Fatty acid
Lipidic
title_short Effect of ethanol administration on fatty acid desaturation
title_full Effect of ethanol administration on fatty acid desaturation
title_fullStr Effect of ethanol administration on fatty acid desaturation
title_full_unstemmed Effect of ethanol administration on fatty acid desaturation
title_sort Effect of ethanol administration on fatty acid desaturation
dc.creator.none.fl_str_mv Nervi, Aníbal M.
Peluffo, Raúl Omar
Brenner, Rodolfo Roberto
Leikin, Alicia Isabel
author Nervi, Aníbal M.
author_facet Nervi, Aníbal M.
Peluffo, Raúl Omar
Brenner, Rodolfo Roberto
Leikin, Alicia Isabel
author_role author
author2 Peluffo, Raúl Omar
Brenner, Rodolfo Roberto
Leikin, Alicia Isabel
author2_role author
author
author
dc.subject.none.fl_str_mv Bioquímica
Ethanol
Fatty acid
Lipidic
topic Bioquímica
Ethanol
Fatty acid
Lipidic
dc.description.none.fl_txt_mv The effect of ethanol on the fatty acid desaturation by rat liver has been studied using liquid diets of different composition. Acute ethanol administration increased triacylglycerols of total liver lipids, but did not modify significantly the lipidic composition of microsomes. The Δ6 and Δ5 desaturases were inhibited by ethanol whereas the Δ9 desaturase and fatty acid synthetase were apparently modified only by diet composition. NADH-cytochrome (cyt.) c reductase was partially inhibited, whereas NADH-cyt. b5 reductase remained practically unaltered and NADPH-cyt. c reductase activity was enhanced. Decreased electrons supplied by the microsomal cyt. b5 electron transport chain would not be the reason for the inhibition of Δ6 and Δ5 desaturases by ethanol.
Facultad de Ciencias Médicas
description The effect of ethanol on the fatty acid desaturation by rat liver has been studied using liquid diets of different composition. Acute ethanol administration increased triacylglycerols of total liver lipids, but did not modify significantly the lipidic composition of microsomes. The Δ6 and Δ5 desaturases were inhibited by ethanol whereas the Δ9 desaturase and fatty acid synthetase were apparently modified only by diet composition. NADH-cytochrome (cyt.) c reductase was partially inhibited, whereas NADH-cyt. b5 reductase remained practically unaltered and NADPH-cyt. c reductase activity was enhanced. Decreased electrons supplied by the microsomal cyt. b5 electron transport chain would not be the reason for the inhibition of Δ6 and Δ5 desaturases by ethanol.
publishDate 1980
dc.date.none.fl_str_mv 1980
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/136621
url http://sedici.unlp.edu.ar/handle/10915/136621
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0024-4201
info:eu-repo/semantics/altIdentifier/issn/1558-9307
info:eu-repo/semantics/altIdentifier/doi/10.1007/bf02535837
info:eu-repo/semantics/altIdentifier/pmid/7374380
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
263-268
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.000565

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