Bioactivity of gallic acid–conjugated silica nanoparticles against <i>Paenibacillus larvae</i> and their host, <i>Apis mellifera</i> honeybee

Autores
Domínguez, Enzo; Moliné, María P.; Churio, María Sandra; Arce, Valeria Beatriz; Mártire, Daniel Osvaldo; Álvarez, Brenda S.; Gende, Liesel Brenda; Damiani, Natalia
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this work was to evaluate antimicrobial activity against Paenibacillus larvae and oral toxicity against workers and larvae of Apis mellifera of gallic acid (GA) and two nanohybrids of GA and silica. Also, the physicochemical, structural, and energetic properties of GA and the nanohybrids were determined through structure–activity relationship (SAR). The minimum inhibitory concentration (MIC) against P. larvae was determined. GA showed MIC values between 62.5 and 125 μg/ml, whereas the nanoparticle functionalized through the GA carboxylic moiety (NP2) showed the best antimicrobial activity with a MIC value of 23 μg GA/ml for four of the five isolates used. SAR analysis showed that electronegativity, chemical hardness, and dipolar moment are reliable estimators of the antimicrobial activity. NP2 showed the lowest toxicity against workers and was innocuous for bee larvae. Therefore, the nanohybrid NP2 was the best antibacterial and resulted in non-toxic against workers and larvae of honeybees, becoming a potentially effective and safe agent for the treatment of American Foulbrood disease.
Facultad de Ingeniería
Centro de Investigaciones Ópticas
Facultad de Ciencias Exactas
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
Materia
Ciencias Exactas
Ingeniería
Apis mellifera
Paenibacillus larvae
gallic acid
silica nanohybrid
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/124801
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/124801
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Bioactivity of gallic acid–conjugated silica nanoparticles against <i>Paenibacillus larvae</i> and their host, <i>Apis mellifera</i> honeybeeDomínguez, EnzoMoliné, María P.Churio, María SandraArce, Valeria BeatrizMártire, Daniel OsvaldoÁlvarez, Brenda S.Gende, Liesel BrendaDamiani, NataliaCiencias ExactasIngenieríaApis melliferaPaenibacillus larvaegallic acidsilica nanohybridThe aim of this work was to evaluate antimicrobial activity against <i>Paenibacillus larvae</i> and oral toxicity against workers and larvae of <i>Apis mellifera</i> of gallic acid (GA) and two nanohybrids of GA and silica. Also, the physicochemical, structural, and energetic properties of GA and the nanohybrids were determined through structure–activity relationship (SAR). The minimum inhibitory concentration (MIC) against <i>P. larvae</i> was determined. GA showed MIC values between 62.5 and 125 μg/ml, whereas the nanoparticle functionalized through the GA carboxylic moiety (NP2) showed the best antimicrobial activity with a MIC value of 23 μg GA/ml for four of the five isolates used. SAR analysis showed that electronegativity, chemical hardness, and dipolar moment are reliable estimators of the antimicrobial activity. NP2 showed the lowest toxicity against workers and was innocuous for bee larvae. Therefore, the nanohybrid NP2 was the best antibacterial and resulted in non-toxic against workers and larvae of honeybees, becoming a potentially effective and safe agent for the treatment of American Foulbrood disease.Facultad de IngenieríaCentro de Investigaciones ÓpticasFacultad de Ciencias ExactasInstituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas2019-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf616-631http://sedici.unlp.edu.ar/handle/10915/124801enginfo:eu-repo/semantics/altIdentifier/issn/0044-8435info:eu-repo/semantics/altIdentifier/issn/1297-9678info:eu-repo/semantics/altIdentifier/doi/10.1007/s13592-019-00675-yinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T11:01:53Zoai:sedici.unlp.edu.ar:10915/124801Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 11:01:53.936SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Bioactivity of gallic acid–conjugated silica nanoparticles against <i>Paenibacillus larvae</i> and their host, <i>Apis mellifera</i> honeybee
title Bioactivity of gallic acid–conjugated silica nanoparticles against <i>Paenibacillus larvae</i> and their host, <i>Apis mellifera</i> honeybee
spellingShingle Bioactivity of gallic acid–conjugated silica nanoparticles against <i>Paenibacillus larvae</i> and their host, <i>Apis mellifera</i> honeybee
Domínguez, Enzo
Ciencias Exactas
Ingeniería
Apis mellifera
Paenibacillus larvae
gallic acid
silica nanohybrid
title_short Bioactivity of gallic acid–conjugated silica nanoparticles against <i>Paenibacillus larvae</i> and their host, <i>Apis mellifera</i> honeybee
title_full Bioactivity of gallic acid–conjugated silica nanoparticles against <i>Paenibacillus larvae</i> and their host, <i>Apis mellifera</i> honeybee
title_fullStr Bioactivity of gallic acid–conjugated silica nanoparticles against <i>Paenibacillus larvae</i> and their host, <i>Apis mellifera</i> honeybee
title_full_unstemmed Bioactivity of gallic acid–conjugated silica nanoparticles against <i>Paenibacillus larvae</i> and their host, <i>Apis mellifera</i> honeybee
title_sort Bioactivity of gallic acid–conjugated silica nanoparticles against <i>Paenibacillus larvae</i> and their host, <i>Apis mellifera</i> honeybee
dc.creator.none.fl_str_mv Domínguez, Enzo
Moliné, María P.
Churio, María Sandra
Arce, Valeria Beatriz
Mártire, Daniel Osvaldo
Álvarez, Brenda S.
Gende, Liesel Brenda
Damiani, Natalia
author Domínguez, Enzo
author_facet Domínguez, Enzo
Moliné, María P.
Churio, María Sandra
Arce, Valeria Beatriz
Mártire, Daniel Osvaldo
Álvarez, Brenda S.
Gende, Liesel Brenda
Damiani, Natalia
author_role author
author2 Moliné, María P.
Churio, María Sandra
Arce, Valeria Beatriz
Mártire, Daniel Osvaldo
Álvarez, Brenda S.
Gende, Liesel Brenda
Damiani, Natalia
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Ingeniería
Apis mellifera
Paenibacillus larvae
gallic acid
silica nanohybrid
topic Ciencias Exactas
Ingeniería
Apis mellifera
Paenibacillus larvae
gallic acid
silica nanohybrid
dc.description.none.fl_txt_mv The aim of this work was to evaluate antimicrobial activity against <i>Paenibacillus larvae</i> and oral toxicity against workers and larvae of <i>Apis mellifera</i> of gallic acid (GA) and two nanohybrids of GA and silica. Also, the physicochemical, structural, and energetic properties of GA and the nanohybrids were determined through structure–activity relationship (SAR). The minimum inhibitory concentration (MIC) against <i>P. larvae</i> was determined. GA showed MIC values between 62.5 and 125 μg/ml, whereas the nanoparticle functionalized through the GA carboxylic moiety (NP2) showed the best antimicrobial activity with a MIC value of 23 μg GA/ml for four of the five isolates used. SAR analysis showed that electronegativity, chemical hardness, and dipolar moment are reliable estimators of the antimicrobial activity. NP2 showed the lowest toxicity against workers and was innocuous for bee larvae. Therefore, the nanohybrid NP2 was the best antibacterial and resulted in non-toxic against workers and larvae of honeybees, becoming a potentially effective and safe agent for the treatment of American Foulbrood disease.
Facultad de Ingeniería
Centro de Investigaciones Ópticas
Facultad de Ciencias Exactas
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
description The aim of this work was to evaluate antimicrobial activity against <i>Paenibacillus larvae</i> and oral toxicity against workers and larvae of <i>Apis mellifera</i> of gallic acid (GA) and two nanohybrids of GA and silica. Also, the physicochemical, structural, and energetic properties of GA and the nanohybrids were determined through structure–activity relationship (SAR). The minimum inhibitory concentration (MIC) against <i>P. larvae</i> was determined. GA showed MIC values between 62.5 and 125 μg/ml, whereas the nanoparticle functionalized through the GA carboxylic moiety (NP2) showed the best antimicrobial activity with a MIC value of 23 μg GA/ml for four of the five isolates used. SAR analysis showed that electronegativity, chemical hardness, and dipolar moment are reliable estimators of the antimicrobial activity. NP2 showed the lowest toxicity against workers and was innocuous for bee larvae. Therefore, the nanohybrid NP2 was the best antibacterial and resulted in non-toxic against workers and larvae of honeybees, becoming a potentially effective and safe agent for the treatment of American Foulbrood disease.
publishDate 2019
dc.date.none.fl_str_mv 2019-08-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/124801
url http://sedici.unlp.edu.ar/handle/10915/124801
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0044-8435
info:eu-repo/semantics/altIdentifier/issn/1297-9678
info:eu-repo/semantics/altIdentifier/doi/10.1007/s13592-019-00675-y
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
616-631
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.13397

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