Inhalation of marijuana affects <i>Drosophila</i> heart function

Autores
Gómez, Ivana María; Rodríguez, Maia Abigail; Santalla, Manuela; Kassis, George; Colman Lerner, Jorge Esteban; Aranda Mosquera, Jorge Oswaldo; Sedan, Daniela Yazmine; Andrinolo, Darío; Valverde, Carlos Alfredo; Ferrero, Paola Viviana
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We investigated the effect of inhalation of vaporized marijuana on cardiac function in Drosophila melanogaster, a suitable genetic model for studying human diseases. Adult flies were exposed to marijuana for variable time periods and the effects on cardiac function were studied. Short treatment protocol incremented heart-rate variability. Contractility was augmented only under prolonged exposure to cannabis and itwas associated with incremented calcium transient within cardiomyocytes. Neither the activity of the major proteins responsible for calcium handling nor the calcium load of the sarcoplasmic reticulum were affected by the cannabis treatment. The observed changes manifested in the cardiomyocytes even in the absence of the canonical cannabinoid receptors described in mammals. Our results are the first evidence of the in vivo impact of phytocannabinoids in D. melanogaster. By providing a simple and affordable platformprior to mammalian models, this characterization of cardiac function under marijuana exposure opens new paths for conducting genetic screenings using vaporized compounds.
Centro de Investigaciones Cardiovasculares
Centro de Investigación y Desarrollo en Ciencias Aplicadas
Centro de Investigaciones del Medioambiente
Materia
Ciencias Exactas
Ciencias Médicas
Drosophila melanogaster
Cannabis
Cardiac
THC
CBD
Calcium
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/106330
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/106330
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Inhalation of marijuana affects <i>Drosophila</i> heart functionGómez, Ivana MaríaRodríguez, Maia AbigailSantalla, ManuelaKassis, GeorgeColman Lerner, Jorge EstebanAranda Mosquera, Jorge OswaldoSedan, Daniela YazmineAndrinolo, DaríoValverde, Carlos AlfredoFerrero, Paola VivianaCiencias ExactasCiencias MédicasDrosophila melanogasterCannabisCardiacTHCCBDCalciumWe investigated the effect of inhalation of vaporized marijuana on cardiac function in Drosophila melanogaster, a suitable genetic model for studying human diseases. Adult flies were exposed to marijuana for variable time periods and the effects on cardiac function were studied. Short treatment protocol incremented heart-rate variability. Contractility was augmented only under prolonged exposure to cannabis and itwas associated with incremented calcium transient within cardiomyocytes. Neither the activity of the major proteins responsible for calcium handling nor the calcium load of the sarcoplasmic reticulum were affected by the cannabis treatment. The observed changes manifested in the cardiomyocytes even in the absence of the canonical cannabinoid receptors described in mammals. Our results are the first evidence of the in vivo impact of phytocannabinoids in D. melanogaster. By providing a simple and affordable platformprior to mammalian models, this characterization of cardiac function under marijuana exposure opens new paths for conducting genetic screenings using vaporized compounds.Centro de Investigaciones CardiovascularesCentro de Investigación y Desarrollo en Ciencias AplicadasCentro de Investigaciones del Medioambiente2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/106330enginfo:eu-repo/semantics/altIdentifier/issn/2046-6390info:eu-repo/semantics/altIdentifier/doi/10.1242/bio.044081info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-10T12:26:31Zoai:sedici.unlp.edu.ar:10915/106330Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-10 12:26:31.786SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Inhalation of marijuana affects <i>Drosophila</i> heart function
title Inhalation of marijuana affects <i>Drosophila</i> heart function
spellingShingle Inhalation of marijuana affects <i>Drosophila</i> heart function
Gómez, Ivana María
Ciencias Exactas
Ciencias Médicas
Drosophila melanogaster
Cannabis
Cardiac
THC
CBD
Calcium
title_short Inhalation of marijuana affects <i>Drosophila</i> heart function
title_full Inhalation of marijuana affects <i>Drosophila</i> heart function
title_fullStr Inhalation of marijuana affects <i>Drosophila</i> heart function
title_full_unstemmed Inhalation of marijuana affects <i>Drosophila</i> heart function
title_sort Inhalation of marijuana affects <i>Drosophila</i> heart function
dc.creator.none.fl_str_mv Gómez, Ivana María
Rodríguez, Maia Abigail
Santalla, Manuela
Kassis, George
Colman Lerner, Jorge Esteban
Aranda Mosquera, Jorge Oswaldo
Sedan, Daniela Yazmine
Andrinolo, Darío
Valverde, Carlos Alfredo
Ferrero, Paola Viviana
author Gómez, Ivana María
author_facet Gómez, Ivana María
Rodríguez, Maia Abigail
Santalla, Manuela
Kassis, George
Colman Lerner, Jorge Esteban
Aranda Mosquera, Jorge Oswaldo
Sedan, Daniela Yazmine
Andrinolo, Darío
Valverde, Carlos Alfredo
Ferrero, Paola Viviana
author_role author
author2 Rodríguez, Maia Abigail
Santalla, Manuela
Kassis, George
Colman Lerner, Jorge Esteban
Aranda Mosquera, Jorge Oswaldo
Sedan, Daniela Yazmine
Andrinolo, Darío
Valverde, Carlos Alfredo
Ferrero, Paola Viviana
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Ciencias Médicas
Drosophila melanogaster
Cannabis
Cardiac
THC
CBD
Calcium
topic Ciencias Exactas
Ciencias Médicas
Drosophila melanogaster
Cannabis
Cardiac
THC
CBD
Calcium
dc.description.none.fl_txt_mv We investigated the effect of inhalation of vaporized marijuana on cardiac function in Drosophila melanogaster, a suitable genetic model for studying human diseases. Adult flies were exposed to marijuana for variable time periods and the effects on cardiac function were studied. Short treatment protocol incremented heart-rate variability. Contractility was augmented only under prolonged exposure to cannabis and itwas associated with incremented calcium transient within cardiomyocytes. Neither the activity of the major proteins responsible for calcium handling nor the calcium load of the sarcoplasmic reticulum were affected by the cannabis treatment. The observed changes manifested in the cardiomyocytes even in the absence of the canonical cannabinoid receptors described in mammals. Our results are the first evidence of the in vivo impact of phytocannabinoids in D. melanogaster. By providing a simple and affordable platformprior to mammalian models, this characterization of cardiac function under marijuana exposure opens new paths for conducting genetic screenings using vaporized compounds.
Centro de Investigaciones Cardiovasculares
Centro de Investigación y Desarrollo en Ciencias Aplicadas
Centro de Investigaciones del Medioambiente
description We investigated the effect of inhalation of vaporized marijuana on cardiac function in Drosophila melanogaster, a suitable genetic model for studying human diseases. Adult flies were exposed to marijuana for variable time periods and the effects on cardiac function were studied. Short treatment protocol incremented heart-rate variability. Contractility was augmented only under prolonged exposure to cannabis and itwas associated with incremented calcium transient within cardiomyocytes. Neither the activity of the major proteins responsible for calcium handling nor the calcium load of the sarcoplasmic reticulum were affected by the cannabis treatment. The observed changes manifested in the cardiomyocytes even in the absence of the canonical cannabinoid receptors described in mammals. Our results are the first evidence of the in vivo impact of phytocannabinoids in D. melanogaster. By providing a simple and affordable platformprior to mammalian models, this characterization of cardiac function under marijuana exposure opens new paths for conducting genetic screenings using vaporized compounds.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/106330
url http://sedici.unlp.edu.ar/handle/10915/106330
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/2046-6390
info:eu-repo/semantics/altIdentifier/doi/10.1242/bio.044081
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 12.993085

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