Effect of different immunosuppressive therapies on the lipid pattern in kidney-transplanted rats

Autores
Lausada, Natalia Raquel; Tacconi de Gómez Dumm, Irma Nelva; Luna, Georgina Cecilia; Camihort, Gisela; Raimondi, J. Clemente
Año de publicación
2005
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We analyzed the effect of oral administration of cyclosporine- methylprednisone (CsA-MP) and sirolimus (SRL) on the lipid pattern of kidney-transplanted rats after a 7-day survival. A significant increase in plasma cholesterol in CsA-MP group (control: 26 ± 3 mg/dl vs. 59 ± 8 mg/dl, P < 0.05) and in triglyceride levels in SRL group (control: 53 ± 4 mg/dl vs. 114 ± 3 mg/dl, P < 0.05), was shown. Kidney microsomal membranes from both treated groups showed that cholesterol and triglyceride values and the relative percentage of arachidonic acid in the total amount of n-6 fatty acids decreased. A diminution of linoleic acid occurred in testis (control: 9.4 ± 0.1 mg/dl vs. CsA-MP: 6.0 ± 0.3 mg/dl and vs. SRL: 6.8 ± 0.2 mg/dl, P < 0.05), liver (control: 17.7 ± 0.6 mg/dl vs. CsA-MP: 15.1 ± 0.6 mg/dl and SRL: 13.5 ± 0.8 mg/dl, P < 0.05) and erythrocyte membranes (control:11.7 ± 0.1% vs. CsA-MP: 10.6 ± 0.2% and SRL: 10.0 ± 0.4%, P < 0.01). The immunosuppressive therapies improved the rejection rate of the graft, fact that was remarkable in the SRL-treated group. However, lipid abnormalities still remain in spite of immunosuppressive therapies. (150).
Facultad de Ciencias Médicas
Materia
Ciencias Médicas
Cholesterol
Cydosporine
Polyunsaturated fatty acids
Prednisone
Sirolimus
Triglycerides
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/83413
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/83413
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Effect of different immunosuppressive therapies on the lipid pattern in kidney-transplanted ratsLausada, Natalia RaquelTacconi de Gómez Dumm, Irma NelvaLuna, Georgina CeciliaCamihort, GiselaRaimondi, J. ClementeCiencias MédicasCholesterolCydosporinePolyunsaturated fatty acidsPrednisoneSirolimusTriglyceridesWe analyzed the effect of oral administration of cyclosporine- methylprednisone (CsA-MP) and sirolimus (SRL) on the lipid pattern of kidney-transplanted rats after a 7-day survival. A significant increase in plasma cholesterol in CsA-MP group (control: 26 ± 3 mg/dl vs. 59 ± 8 mg/dl, P < 0.05) and in triglyceride levels in SRL group (control: 53 ± 4 mg/dl vs. 114 ± 3 mg/dl, P < 0.05), was shown. Kidney microsomal membranes from both treated groups showed that cholesterol and triglyceride values and the relative percentage of arachidonic acid in the total amount of n-6 fatty acids decreased. A diminution of linoleic acid occurred in testis (control: 9.4 ± 0.1 mg/dl vs. CsA-MP: 6.0 ± 0.3 mg/dl and vs. SRL: 6.8 ± 0.2 mg/dl, P < 0.05), liver (control: 17.7 ± 0.6 mg/dl vs. CsA-MP: 15.1 ± 0.6 mg/dl and SRL: 13.5 ± 0.8 mg/dl, P < 0.05) and erythrocyte membranes (control:11.7 ± 0.1% vs. CsA-MP: 10.6 ± 0.2% and SRL: 10.0 ± 0.4%, P < 0.01). The immunosuppressive therapies improved the rejection rate of the graft, fact that was remarkable in the SRL-treated group. However, lipid abnormalities still remain in spite of immunosuppressive therapies. (150).Facultad de Ciencias Médicas2005info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf524-531http://sedici.unlp.edu.ar/handle/10915/83413enginfo:eu-repo/semantics/altIdentifier/issn/0934-0874info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1432-2277.2005.00084.xinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:15:46Zoai:sedici.unlp.edu.ar:10915/83413Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:15:46.977SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Effect of different immunosuppressive therapies on the lipid pattern in kidney-transplanted rats
title Effect of different immunosuppressive therapies on the lipid pattern in kidney-transplanted rats
spellingShingle Effect of different immunosuppressive therapies on the lipid pattern in kidney-transplanted rats
Lausada, Natalia Raquel
Ciencias Médicas
Cholesterol
Cydosporine
Polyunsaturated fatty acids
Prednisone
Sirolimus
Triglycerides
title_short Effect of different immunosuppressive therapies on the lipid pattern in kidney-transplanted rats
title_full Effect of different immunosuppressive therapies on the lipid pattern in kidney-transplanted rats
title_fullStr Effect of different immunosuppressive therapies on the lipid pattern in kidney-transplanted rats
title_full_unstemmed Effect of different immunosuppressive therapies on the lipid pattern in kidney-transplanted rats
title_sort Effect of different immunosuppressive therapies on the lipid pattern in kidney-transplanted rats
dc.creator.none.fl_str_mv Lausada, Natalia Raquel
Tacconi de Gómez Dumm, Irma Nelva
Luna, Georgina Cecilia
Camihort, Gisela
Raimondi, J. Clemente
author Lausada, Natalia Raquel
author_facet Lausada, Natalia Raquel
Tacconi de Gómez Dumm, Irma Nelva
Luna, Georgina Cecilia
Camihort, Gisela
Raimondi, J. Clemente
author_role author
author2 Tacconi de Gómez Dumm, Irma Nelva
Luna, Georgina Cecilia
Camihort, Gisela
Raimondi, J. Clemente
author2_role author
author
author
author
dc.subject.none.fl_str_mv Ciencias Médicas
Cholesterol
Cydosporine
Polyunsaturated fatty acids
Prednisone
Sirolimus
Triglycerides
topic Ciencias Médicas
Cholesterol
Cydosporine
Polyunsaturated fatty acids
Prednisone
Sirolimus
Triglycerides
dc.description.none.fl_txt_mv We analyzed the effect of oral administration of cyclosporine- methylprednisone (CsA-MP) and sirolimus (SRL) on the lipid pattern of kidney-transplanted rats after a 7-day survival. A significant increase in plasma cholesterol in CsA-MP group (control: 26 ± 3 mg/dl vs. 59 ± 8 mg/dl, P < 0.05) and in triglyceride levels in SRL group (control: 53 ± 4 mg/dl vs. 114 ± 3 mg/dl, P < 0.05), was shown. Kidney microsomal membranes from both treated groups showed that cholesterol and triglyceride values and the relative percentage of arachidonic acid in the total amount of n-6 fatty acids decreased. A diminution of linoleic acid occurred in testis (control: 9.4 ± 0.1 mg/dl vs. CsA-MP: 6.0 ± 0.3 mg/dl and vs. SRL: 6.8 ± 0.2 mg/dl, P < 0.05), liver (control: 17.7 ± 0.6 mg/dl vs. CsA-MP: 15.1 ± 0.6 mg/dl and SRL: 13.5 ± 0.8 mg/dl, P < 0.05) and erythrocyte membranes (control:11.7 ± 0.1% vs. CsA-MP: 10.6 ± 0.2% and SRL: 10.0 ± 0.4%, P < 0.01). The immunosuppressive therapies improved the rejection rate of the graft, fact that was remarkable in the SRL-treated group. However, lipid abnormalities still remain in spite of immunosuppressive therapies. (150).
Facultad de Ciencias Médicas
description We analyzed the effect of oral administration of cyclosporine- methylprednisone (CsA-MP) and sirolimus (SRL) on the lipid pattern of kidney-transplanted rats after a 7-day survival. A significant increase in plasma cholesterol in CsA-MP group (control: 26 ± 3 mg/dl vs. 59 ± 8 mg/dl, P < 0.05) and in triglyceride levels in SRL group (control: 53 ± 4 mg/dl vs. 114 ± 3 mg/dl, P < 0.05), was shown. Kidney microsomal membranes from both treated groups showed that cholesterol and triglyceride values and the relative percentage of arachidonic acid in the total amount of n-6 fatty acids decreased. A diminution of linoleic acid occurred in testis (control: 9.4 ± 0.1 mg/dl vs. CsA-MP: 6.0 ± 0.3 mg/dl and vs. SRL: 6.8 ± 0.2 mg/dl, P < 0.05), liver (control: 17.7 ± 0.6 mg/dl vs. CsA-MP: 15.1 ± 0.6 mg/dl and SRL: 13.5 ± 0.8 mg/dl, P < 0.05) and erythrocyte membranes (control:11.7 ± 0.1% vs. CsA-MP: 10.6 ± 0.2% and SRL: 10.0 ± 0.4%, P < 0.01). The immunosuppressive therapies improved the rejection rate of the graft, fact that was remarkable in the SRL-treated group. However, lipid abnormalities still remain in spite of immunosuppressive therapies. (150).
publishDate 2005
dc.date.none.fl_str_mv 2005
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/83413
url http://sedici.unlp.edu.ar/handle/10915/83413
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0934-0874
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1432-2277.2005.00084.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
524-531
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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