Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications

Autores
Echeverría, María Gabriela; Pardini, Oscar Ricardo; Debandi, María Valeria; François, Nora Judit; Daraio, Marta Edith; Amalvy, Javier Ignacio
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A pH-sensitive blend of polyurethane (PU) and poly(2-(diethyl amino)ethyl methacrylate (PDEA) with good film‑forming capacity was prepared from the corresponding aqueous dispersions. The polymer matrix was first characterized by using FTIR, DSC, water vapor transmission and water swelling capacity at different pHs. The drug release profile of films was evaluated using a vertical Franz Cell and theophylline as model drug. The water swelling degree increases from 54 to 180% when the pH of the medium is changed from 6 to 2, demonstrating the pH-responsive behavior of the film. The in-vitro release studies indicate that an anomalous transport mechanism governs the theophylline release.
Facultad de Ingeniería
Materia
Ingeniería Química
poliuretanos, sistemas de liberación de medicamentos, teofilina
polyurethanes, drug delivery systems, stimuli-sensitive polymers, swelling, theophylline
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/75587

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network_name_str SEDICI (UNLP)
spelling Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applicationsEcheverría, María GabrielaPardini, Oscar RicardoDebandi, María ValeriaFrançois, Nora JuditDaraio, Marta EdithAmalvy, Javier IgnacioIngeniería Químicapoliuretanos, sistemas de liberación de medicamentos, teofilinapolyurethanes, drug delivery systems, stimuli-sensitive polymers, swelling, theophyllineA pH-sensitive blend of polyurethane (PU) and poly(2-(diethyl amino)ethyl methacrylate (PDEA) with good film‑forming capacity was prepared from the corresponding aqueous dispersions. The polymer matrix was first characterized by using FTIR, DSC, water vapor transmission and water swelling capacity at different pHs. The drug release profile of films was evaluated using a vertical Franz Cell and theophylline as model drug. The water swelling degree increases from 54 to 180% when the pH of the medium is changed from 6 to 2, demonstrating the pH-responsive behavior of the film. The in-vitro release studies indicate that an anomalous transport mechanism governs the theophylline release.Facultad de Ingeniería2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf336-343http://sedici.unlp.edu.ar/handle/10915/75587enginfo:eu-repo/semantics/altIdentifier/hdl/11746/5757info:eu-repo/semantics/altIdentifier/doi/10.1590/0104-1428.1716info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc/4.0/Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:05:06Zoai:sedici.unlp.edu.ar:10915/75587Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:05:06.98SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
title Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
spellingShingle Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
Echeverría, María Gabriela
Ingeniería Química
poliuretanos, sistemas de liberación de medicamentos, teofilina
polyurethanes, drug delivery systems, stimuli-sensitive polymers, swelling, theophylline
title_short Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
title_full Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
title_fullStr Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
title_full_unstemmed Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
title_sort Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
dc.creator.none.fl_str_mv Echeverría, María Gabriela
Pardini, Oscar Ricardo
Debandi, María Valeria
François, Nora Judit
Daraio, Marta Edith
Amalvy, Javier Ignacio
author Echeverría, María Gabriela
author_facet Echeverría, María Gabriela
Pardini, Oscar Ricardo
Debandi, María Valeria
François, Nora Judit
Daraio, Marta Edith
Amalvy, Javier Ignacio
author_role author
author2 Pardini, Oscar Ricardo
Debandi, María Valeria
François, Nora Judit
Daraio, Marta Edith
Amalvy, Javier Ignacio
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Ingeniería Química
poliuretanos, sistemas de liberación de medicamentos, teofilina
polyurethanes, drug delivery systems, stimuli-sensitive polymers, swelling, theophylline
topic Ingeniería Química
poliuretanos, sistemas de liberación de medicamentos, teofilina
polyurethanes, drug delivery systems, stimuli-sensitive polymers, swelling, theophylline
dc.description.none.fl_txt_mv A pH-sensitive blend of polyurethane (PU) and poly(2-(diethyl amino)ethyl methacrylate (PDEA) with good film‑forming capacity was prepared from the corresponding aqueous dispersions. The polymer matrix was first characterized by using FTIR, DSC, water vapor transmission and water swelling capacity at different pHs. The drug release profile of films was evaluated using a vertical Franz Cell and theophylline as model drug. The water swelling degree increases from 54 to 180% when the pH of the medium is changed from 6 to 2, demonstrating the pH-responsive behavior of the film. The in-vitro release studies indicate that an anomalous transport mechanism governs the theophylline release.
Facultad de Ingeniería
description A pH-sensitive blend of polyurethane (PU) and poly(2-(diethyl amino)ethyl methacrylate (PDEA) with good film‑forming capacity was prepared from the corresponding aqueous dispersions. The polymer matrix was first characterized by using FTIR, DSC, water vapor transmission and water swelling capacity at different pHs. The drug release profile of films was evaluated using a vertical Franz Cell and theophylline as model drug. The water swelling degree increases from 54 to 180% when the pH of the medium is changed from 6 to 2, demonstrating the pH-responsive behavior of the film. The in-vitro release studies indicate that an anomalous transport mechanism governs the theophylline release.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/75587
url http://sedici.unlp.edu.ar/handle/10915/75587
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/hdl/11746/5757
info:eu-repo/semantics/altIdentifier/doi/10.1590/0104-1428.1716
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc/4.0/
Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/4.0/
Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
dc.format.none.fl_str_mv application/pdf
336-343
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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