Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
- Autores
- Echeverría, María Gabriela; Pardini, Oscar Ricardo; Debandi, María Valeria; François, Nora Judit; Daraio, Marta Edith; Amalvy, Javier Ignacio
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- A pH-sensitive blend of polyurethane (PU) and poly(2-(diethyl amino)ethyl methacrylate (PDEA) with good film‑forming capacity was prepared from the corresponding aqueous dispersions. The polymer matrix was first characterized by using FTIR, DSC, water vapor transmission and water swelling capacity at different pHs. The drug release profile of films was evaluated using a vertical Franz Cell and theophylline as model drug. The water swelling degree increases from 54 to 180% when the pH of the medium is changed from 6 to 2, demonstrating the pH-responsive behavior of the film. The in-vitro release studies indicate that an anomalous transport mechanism governs the theophylline release.
Facultad de Ingeniería - Materia
-
Ingeniería Química
poliuretanos, sistemas de liberación de medicamentos, teofilina
polyurethanes, drug delivery systems, stimuli-sensitive polymers, swelling, theophylline - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/75587
Ver los metadatos del registro completo
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Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applicationsEcheverría, María GabrielaPardini, Oscar RicardoDebandi, María ValeriaFrançois, Nora JuditDaraio, Marta EdithAmalvy, Javier IgnacioIngeniería Químicapoliuretanos, sistemas de liberación de medicamentos, teofilinapolyurethanes, drug delivery systems, stimuli-sensitive polymers, swelling, theophyllineA pH-sensitive blend of polyurethane (PU) and poly(2-(diethyl amino)ethyl methacrylate (PDEA) with good film‑forming capacity was prepared from the corresponding aqueous dispersions. The polymer matrix was first characterized by using FTIR, DSC, water vapor transmission and water swelling capacity at different pHs. The drug release profile of films was evaluated using a vertical Franz Cell and theophylline as model drug. The water swelling degree increases from 54 to 180% when the pH of the medium is changed from 6 to 2, demonstrating the pH-responsive behavior of the film. The in-vitro release studies indicate that an anomalous transport mechanism governs the theophylline release.Facultad de Ingeniería2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf336-343http://sedici.unlp.edu.ar/handle/10915/75587enginfo:eu-repo/semantics/altIdentifier/hdl/11746/5757info:eu-repo/semantics/altIdentifier/doi/10.1590/0104-1428.1716info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc/4.0/Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:05:06Zoai:sedici.unlp.edu.ar:10915/75587Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:05:06.98SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications |
title |
Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications |
spellingShingle |
Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications Echeverría, María Gabriela Ingeniería Química poliuretanos, sistemas de liberación de medicamentos, teofilina polyurethanes, drug delivery systems, stimuli-sensitive polymers, swelling, theophylline |
title_short |
Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications |
title_full |
Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications |
title_fullStr |
Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications |
title_full_unstemmed |
Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications |
title_sort |
Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications |
dc.creator.none.fl_str_mv |
Echeverría, María Gabriela Pardini, Oscar Ricardo Debandi, María Valeria François, Nora Judit Daraio, Marta Edith Amalvy, Javier Ignacio |
author |
Echeverría, María Gabriela |
author_facet |
Echeverría, María Gabriela Pardini, Oscar Ricardo Debandi, María Valeria François, Nora Judit Daraio, Marta Edith Amalvy, Javier Ignacio |
author_role |
author |
author2 |
Pardini, Oscar Ricardo Debandi, María Valeria François, Nora Judit Daraio, Marta Edith Amalvy, Javier Ignacio |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Ingeniería Química poliuretanos, sistemas de liberación de medicamentos, teofilina polyurethanes, drug delivery systems, stimuli-sensitive polymers, swelling, theophylline |
topic |
Ingeniería Química poliuretanos, sistemas de liberación de medicamentos, teofilina polyurethanes, drug delivery systems, stimuli-sensitive polymers, swelling, theophylline |
dc.description.none.fl_txt_mv |
A pH-sensitive blend of polyurethane (PU) and poly(2-(diethyl amino)ethyl methacrylate (PDEA) with good film‑forming capacity was prepared from the corresponding aqueous dispersions. The polymer matrix was first characterized by using FTIR, DSC, water vapor transmission and water swelling capacity at different pHs. The drug release profile of films was evaluated using a vertical Franz Cell and theophylline as model drug. The water swelling degree increases from 54 to 180% when the pH of the medium is changed from 6 to 2, demonstrating the pH-responsive behavior of the film. The in-vitro release studies indicate that an anomalous transport mechanism governs the theophylline release. Facultad de Ingeniería |
description |
A pH-sensitive blend of polyurethane (PU) and poly(2-(diethyl amino)ethyl methacrylate (PDEA) with good film‑forming capacity was prepared from the corresponding aqueous dispersions. The polymer matrix was first characterized by using FTIR, DSC, water vapor transmission and water swelling capacity at different pHs. The drug release profile of films was evaluated using a vertical Franz Cell and theophylline as model drug. The water swelling degree increases from 54 to 180% when the pH of the medium is changed from 6 to 2, demonstrating the pH-responsive behavior of the film. The in-vitro release studies indicate that an anomalous transport mechanism governs the theophylline release. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/75587 |
url |
http://sedici.unlp.edu.ar/handle/10915/75587 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/hdl/11746/5757 info:eu-repo/semantics/altIdentifier/doi/10.1590/0104-1428.1716 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) |
dc.format.none.fl_str_mv |
application/pdf 336-343 |
dc.source.none.fl_str_mv |
reponame:SEDICI (UNLP) instname:Universidad Nacional de La Plata instacron:UNLP |
reponame_str |
SEDICI (UNLP) |
collection |
SEDICI (UNLP) |
instname_str |
Universidad Nacional de La Plata |
instacron_str |
UNLP |
institution |
UNLP |
repository.name.fl_str_mv |
SEDICI (UNLP) - Universidad Nacional de La Plata |
repository.mail.fl_str_mv |
alira@sedici.unlp.edu.ar |
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1846064105598746624 |
score |
13.22299 |