Abnormal expression of apoptosis-related genes in haematological malignancies: Overexpression of MYC is poor prognostic sign in mantle cell lymphoma

Autores
Nagy, Bálint; Lundán, Tuija; Larramendy, Marcelo Luis; Aalto, Yan; Zhu, Ying; Niini, Tarja; Edgren, Henrik; Ferrer, Anna; Vilpo, Juhani; Elonen, Erkki; Vettenranta, Kim; Franssila, Kaarle; Knuutila, Sakari
Año de publicación
2003
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The expression of apoptosis-related genes BCL2, BAX, BCL2L1, BCL2A1, MCL1, DAPK1 and MYC was studied by quantitative real-time polymerase chain reaction on total RNA samples from patients with acute lymphoblastic leukaemia (ALL, n = 16), acute myeloid leukaemia (AML, n = 27). chronic myeloid leukaemia (CML, n = 12), mantle cell lymphoma (MCL, n = 19) and chronic lymphoid leukaemia (CLL. n = 32). BCL2, BAX, BCL2A1, MCL1, DAPK1 and MYC were overexpressed in all patient groups. BCL2L1 was underexpressed in CLL and CML, but not in AML, ALL and MCL. MCL1 levels were significantly higher in CD13 and CD33-positive ALL, and in CD56-positive AML samples. BCL2, BCL2L1, BCL2A1 and MCL1 were overexpressed and DAPK1 was underexpressed in CLL samples with a 11q23 deletion. MYC overexpression was significantly associated with shorter overall survival in MCL (P ≤ 0.01). AML patients with a normal karyotype showed a higher frequency of BCL2A1 overexpression (P ≤ 0.001) than those with an abnormal karyotype.
Facultad de Ciencias Naturales y Museo
Materia
Ciencias Naturales
Apoptotic genes
Gene expression
Haematological malignancies
Prognosis
Quantitative real-time PCR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/84918
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/84918
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Abnormal expression of apoptosis-related genes in haematological malignancies: Overexpression of MYC is poor prognostic sign in mantle cell lymphomaNagy, BálintLundán, TuijaLarramendy, Marcelo LuisAalto, YanZhu, YingNiini, TarjaEdgren, HenrikFerrer, AnnaVilpo, JuhaniElonen, ErkkiVettenranta, KimFranssila, KaarleKnuutila, SakariCiencias NaturalesApoptotic genesGene expressionHaematological malignanciesPrognosisQuantitative real-time PCRThe expression of apoptosis-related genes BCL2, BAX, BCL2L1, BCL2A1, MCL1, DAPK1 and MYC was studied by quantitative real-time polymerase chain reaction on total RNA samples from patients with acute lymphoblastic leukaemia (ALL, n = 16), acute myeloid leukaemia (AML, n = 27). chronic myeloid leukaemia (CML, n = 12), mantle cell lymphoma (MCL, n = 19) and chronic lymphoid leukaemia (CLL. n = 32). BCL2, BAX, BCL2A1, MCL1, DAPK1 and MYC were overexpressed in all patient groups. BCL2L1 was underexpressed in CLL and CML, but not in AML, ALL and MCL. MCL1 levels were significantly higher in CD13 and CD33-positive ALL, and in CD56-positive AML samples. BCL2, BCL2L1, BCL2A1 and MCL1 were overexpressed and DAPK1 was underexpressed in CLL samples with a 11q23 deletion. MYC overexpression was significantly associated with shorter overall survival in MCL (P ≤ 0.01). AML patients with a normal karyotype showed a higher frequency of BCL2A1 overexpression (P ≤ 0.001) than those with an abnormal karyotype.Facultad de Ciencias Naturales y Museo2003info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf434-441http://sedici.unlp.edu.ar/handle/10915/84918enginfo:eu-repo/semantics/altIdentifier/issn/0007-1048info:eu-repo/semantics/altIdentifier/doi/10.1046/j.1365-2141.2003.04121.xinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-12-23T11:18:28Zoai:sedici.unlp.edu.ar:10915/84918Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-12-23 11:18:28.925SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Abnormal expression of apoptosis-related genes in haematological malignancies: Overexpression of MYC is poor prognostic sign in mantle cell lymphoma
title Abnormal expression of apoptosis-related genes in haematological malignancies: Overexpression of MYC is poor prognostic sign in mantle cell lymphoma
spellingShingle Abnormal expression of apoptosis-related genes in haematological malignancies: Overexpression of MYC is poor prognostic sign in mantle cell lymphoma
Nagy, Bálint
Ciencias Naturales
Apoptotic genes
Gene expression
Haematological malignancies
Prognosis
Quantitative real-time PCR
title_short Abnormal expression of apoptosis-related genes in haematological malignancies: Overexpression of MYC is poor prognostic sign in mantle cell lymphoma
title_full Abnormal expression of apoptosis-related genes in haematological malignancies: Overexpression of MYC is poor prognostic sign in mantle cell lymphoma
title_fullStr Abnormal expression of apoptosis-related genes in haematological malignancies: Overexpression of MYC is poor prognostic sign in mantle cell lymphoma
title_full_unstemmed Abnormal expression of apoptosis-related genes in haematological malignancies: Overexpression of MYC is poor prognostic sign in mantle cell lymphoma
title_sort Abnormal expression of apoptosis-related genes in haematological malignancies: Overexpression of MYC is poor prognostic sign in mantle cell lymphoma
dc.creator.none.fl_str_mv Nagy, Bálint
Lundán, Tuija
Larramendy, Marcelo Luis
Aalto, Yan
Zhu, Ying
Niini, Tarja
Edgren, Henrik
Ferrer, Anna
Vilpo, Juhani
Elonen, Erkki
Vettenranta, Kim
Franssila, Kaarle
Knuutila, Sakari
author Nagy, Bálint
author_facet Nagy, Bálint
Lundán, Tuija
Larramendy, Marcelo Luis
Aalto, Yan
Zhu, Ying
Niini, Tarja
Edgren, Henrik
Ferrer, Anna
Vilpo, Juhani
Elonen, Erkki
Vettenranta, Kim
Franssila, Kaarle
Knuutila, Sakari
author_role author
author2 Lundán, Tuija
Larramendy, Marcelo Luis
Aalto, Yan
Zhu, Ying
Niini, Tarja
Edgren, Henrik
Ferrer, Anna
Vilpo, Juhani
Elonen, Erkki
Vettenranta, Kim
Franssila, Kaarle
Knuutila, Sakari
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Naturales
Apoptotic genes
Gene expression
Haematological malignancies
Prognosis
Quantitative real-time PCR
topic Ciencias Naturales
Apoptotic genes
Gene expression
Haematological malignancies
Prognosis
Quantitative real-time PCR
dc.description.none.fl_txt_mv The expression of apoptosis-related genes BCL2, BAX, BCL2L1, BCL2A1, MCL1, DAPK1 and MYC was studied by quantitative real-time polymerase chain reaction on total RNA samples from patients with acute lymphoblastic leukaemia (ALL, n = 16), acute myeloid leukaemia (AML, n = 27). chronic myeloid leukaemia (CML, n = 12), mantle cell lymphoma (MCL, n = 19) and chronic lymphoid leukaemia (CLL. n = 32). BCL2, BAX, BCL2A1, MCL1, DAPK1 and MYC were overexpressed in all patient groups. BCL2L1 was underexpressed in CLL and CML, but not in AML, ALL and MCL. MCL1 levels were significantly higher in CD13 and CD33-positive ALL, and in CD56-positive AML samples. BCL2, BCL2L1, BCL2A1 and MCL1 were overexpressed and DAPK1 was underexpressed in CLL samples with a 11q23 deletion. MYC overexpression was significantly associated with shorter overall survival in MCL (P ≤ 0.01). AML patients with a normal karyotype showed a higher frequency of BCL2A1 overexpression (P ≤ 0.001) than those with an abnormal karyotype.
Facultad de Ciencias Naturales y Museo
description The expression of apoptosis-related genes BCL2, BAX, BCL2L1, BCL2A1, MCL1, DAPK1 and MYC was studied by quantitative real-time polymerase chain reaction on total RNA samples from patients with acute lymphoblastic leukaemia (ALL, n = 16), acute myeloid leukaemia (AML, n = 27). chronic myeloid leukaemia (CML, n = 12), mantle cell lymphoma (MCL, n = 19) and chronic lymphoid leukaemia (CLL. n = 32). BCL2, BAX, BCL2A1, MCL1, DAPK1 and MYC were overexpressed in all patient groups. BCL2L1 was underexpressed in CLL and CML, but not in AML, ALL and MCL. MCL1 levels were significantly higher in CD13 and CD33-positive ALL, and in CD56-positive AML samples. BCL2, BCL2L1, BCL2A1 and MCL1 were overexpressed and DAPK1 was underexpressed in CLL samples with a 11q23 deletion. MYC overexpression was significantly associated with shorter overall survival in MCL (P ≤ 0.01). AML patients with a normal karyotype showed a higher frequency of BCL2A1 overexpression (P ≤ 0.001) than those with an abnormal karyotype.
publishDate 2003
dc.date.none.fl_str_mv 2003
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/84918
url http://sedici.unlp.edu.ar/handle/10915/84918
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0007-1048
info:eu-repo/semantics/altIdentifier/doi/10.1046/j.1365-2141.2003.04121.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
434-441
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 12.952241

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