MiR-17-92 cluster dysregulation in lymphoid malignancies: Its role in lymphomagenesis

Autores
Roisman, Alejandro; Slavutsky, Irma Rosa
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
MicroRNAs (miRNAs) are short, endogenous singled-stranded noncoding RNAs whose dysregulation has been implicated in important biologic processes, including cancer development. The principal mechanism of action of these master regulators is to control gene expression by suppressing mRNA translation and reducing mRNA stability. In particular, the miR-17-92 cluster is the most frequently miRNA expressed in different subtypes of non-Hodgkin lymphomas. Its widespread dysregulation in these pathologies suggests this cluster as a new biomarker that may supplement lymphoma diagnosis and prognosis, and also as an attractive target to design novel strategies for cancer therapy.
Fil: Roisman, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Materia
miRNAS
LYMPHOID MALIGNANCIES
PROGNOSTIC FACTORS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/210547
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling MiR-17-92 cluster dysregulation in lymphoid malignancies: Its role in lymphomagenesisRoisman, AlejandroSlavutsky, Irma RosamiRNASLYMPHOID MALIGNANCIESPROGNOSTIC FACTORShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3MicroRNAs (miRNAs) are short, endogenous singled-stranded noncoding RNAs whose dysregulation has been implicated in important biologic processes, including cancer development. The principal mechanism of action of these master regulators is to control gene expression by suppressing mRNA translation and reducing mRNA stability. In particular, the miR-17-92 cluster is the most frequently miRNA expressed in different subtypes of non-Hodgkin lymphomas. Its widespread dysregulation in these pathologies suggests this cluster as a new biomarker that may supplement lymphoma diagnosis and prognosis, and also as an attractive target to design novel strategies for cancer therapy.Fil: Roisman, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaUniversity of Texas2017-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/210547Roisman, Alejandro; Slavutsky, Irma Rosa; MiR-17-92 cluster dysregulation in lymphoid malignancies: Its role in lymphomagenesis; University of Texas; Clinics in Oncology; 2; 1210; 4-2017; 1-32474-1663CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.clinicsinoncology.com/open-access/mir-17-92-cluster-dysregulation-in-lymphoid-malignancies-its-role-in-limphomagenesis-1377.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:01:30Zoai:ri.conicet.gov.ar:11336/210547instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:01:30.685CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv MiR-17-92 cluster dysregulation in lymphoid malignancies: Its role in lymphomagenesis
title MiR-17-92 cluster dysregulation in lymphoid malignancies: Its role in lymphomagenesis
spellingShingle MiR-17-92 cluster dysregulation in lymphoid malignancies: Its role in lymphomagenesis
Roisman, Alejandro
miRNAS
LYMPHOID MALIGNANCIES
PROGNOSTIC FACTORS
title_short MiR-17-92 cluster dysregulation in lymphoid malignancies: Its role in lymphomagenesis
title_full MiR-17-92 cluster dysregulation in lymphoid malignancies: Its role in lymphomagenesis
title_fullStr MiR-17-92 cluster dysregulation in lymphoid malignancies: Its role in lymphomagenesis
title_full_unstemmed MiR-17-92 cluster dysregulation in lymphoid malignancies: Its role in lymphomagenesis
title_sort MiR-17-92 cluster dysregulation in lymphoid malignancies: Its role in lymphomagenesis
dc.creator.none.fl_str_mv Roisman, Alejandro
Slavutsky, Irma Rosa
author Roisman, Alejandro
author_facet Roisman, Alejandro
Slavutsky, Irma Rosa
author_role author
author2 Slavutsky, Irma Rosa
author2_role author
dc.subject.none.fl_str_mv miRNAS
LYMPHOID MALIGNANCIES
PROGNOSTIC FACTORS
topic miRNAS
LYMPHOID MALIGNANCIES
PROGNOSTIC FACTORS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv MicroRNAs (miRNAs) are short, endogenous singled-stranded noncoding RNAs whose dysregulation has been implicated in important biologic processes, including cancer development. The principal mechanism of action of these master regulators is to control gene expression by suppressing mRNA translation and reducing mRNA stability. In particular, the miR-17-92 cluster is the most frequently miRNA expressed in different subtypes of non-Hodgkin lymphomas. Its widespread dysregulation in these pathologies suggests this cluster as a new biomarker that may supplement lymphoma diagnosis and prognosis, and also as an attractive target to design novel strategies for cancer therapy.
Fil: Roisman, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
description MicroRNAs (miRNAs) are short, endogenous singled-stranded noncoding RNAs whose dysregulation has been implicated in important biologic processes, including cancer development. The principal mechanism of action of these master regulators is to control gene expression by suppressing mRNA translation and reducing mRNA stability. In particular, the miR-17-92 cluster is the most frequently miRNA expressed in different subtypes of non-Hodgkin lymphomas. Its widespread dysregulation in these pathologies suggests this cluster as a new biomarker that may supplement lymphoma diagnosis and prognosis, and also as an attractive target to design novel strategies for cancer therapy.
publishDate 2017
dc.date.none.fl_str_mv 2017-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/210547
Roisman, Alejandro; Slavutsky, Irma Rosa; MiR-17-92 cluster dysregulation in lymphoid malignancies: Its role in lymphomagenesis; University of Texas; Clinics in Oncology; 2; 1210; 4-2017; 1-3
2474-1663
CONICET Digital
CONICET
url http://hdl.handle.net/11336/210547
identifier_str_mv Roisman, Alejandro; Slavutsky, Irma Rosa; MiR-17-92 cluster dysregulation in lymphoid malignancies: Its role in lymphomagenesis; University of Texas; Clinics in Oncology; 2; 1210; 4-2017; 1-3
2474-1663
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.clinicsinoncology.com/open-access/mir-17-92-cluster-dysregulation-in-lymphoid-malignancies-its-role-in-limphomagenesis-1377.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv University of Texas
publisher.none.fl_str_mv University of Texas
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269700012113920
score 13.13397

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