Safety of Chemotherapy for Hematologic Malignancies as Regards Testicular Endocrine Function in Children and Teenagers
- Autores
- Grinspon, Romina; Arozarena, María; Prada, Silvina; Bargman, Graciela; Sanzone, María; Morales Bazurto, Marjorie; Gutiérrez, Marcela; Bedecarras, Patricia Gladys; Kannemann, Ana; Elena, Graciela O.; Gottlieb, Silvia Elisa; Berenstein, Ariel José; Ropelato, Maria Gabriela; Bergadá, Ignacio; Aversa, Luis; Rey, Rodolfo Alberto
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- Effective treatments have increasedlife expectancy in children with hematologic malignancies, but loss offertility has become a concern. However, the effects of chemotherapy on Sertoliand Leydig cell function in boys and adolescents has received little attention.Objective: To determine whethertreatments used in boys with hematologic malignancies affect endocrine function of the developing testes.Methods: In an observational study of 97 boys (83 acute lymphocytic leukaemia, 5acute myeloid leukemia and 9 non-Hodgkin lymphoma) we assessed serum levels ofAMH and FSH and testosterone and LH as biomarkers respectively of Sertoli andLeydig cell function.Results: Sixty-one patients, with at least 1 year of follow-up after the end ofchemotherapy were included in the cross-sectional analysis. Serum AMH were within normal levels in all 37patients treated before the age of 10 years (Group A). FSH was also normal inthe vast majority, and only slightly elevated in 3. Serum levels oftestosterone and LH were within the normal levels in all of them. In the 24 patients in whom treatment ended after 10 years(Group B), AMH was also within the reference range but FSH was elevated in 8cases, suggesting a compensated primary Sertoli cell insufficiency. Similarly,testosterone levels were normal in all cases, but LH were slightly elevated in5 patients, probably indicating a compensated Leydig cell dysfunction. All 97 patients were included in the longitudinalanalysis, 58 patients completed treatment before 10 years (Group A) and 39 after10 years of age (Group B). Serum AMH was never <2 SDS in any of the patientsduring follow-up. Testosterone remained below the reference range in only onecase. In Group A, 9 patients (15.5 %) had at least one FSH value>2 SDS during follow-up. In 3 of them (7.7 %) was also >2 SDS. In GroupB, 14 patients (35.9%) had at least one FSH value >2 SDS. Eight of them(20.5 %) also had LH >2 SDS. Three (7.7 %) had only LH elevation. The proportionof patients with FSH and LH >2 SDS was higher (P=0.008 and 0.03, respectively) in Group B than in Group A. Conclusion: Therapy ofhematologic malignancies did not significantly affect Sertoli and Leydig cell functions inboys treated <10 years. Conversely, when treatment ended after pubertalonset, a compensated Sertoli and Leydig cell dysfunction was more frequentlyobserved. No risk factor could be identified in association with thecompensated endocrine dysfunction.
Fil: Grinspon, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Arozarena, María. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Prada, Silvina. Departamento de Urgencias ; Hospital General de Niños Ricardo Gutierrez ; Gobierno de la Ciudad Autonoma de Buenos Aires;
Fil: Bargman, Graciela. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Fil: Sanzone, María. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Morales Bazurto, Marjorie. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Gutiérrez, Marcela. Departamento de Urgencias ; Hospital General de Niños Ricardo Gutierrez ; Gobierno de la Ciudad Autonoma de Buenos Aires;
Fil: Bedecarras, Patricia Gladys. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Kannemann, Ana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Fil: Elena, Graciela O.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Fil: Gottlieb, Silvia Elisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Berenstein, Ariel José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Ropelato, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Bergadá, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Aversa, Luis. Departamento de Urgencias ; Hospital General de Niños Ricardo Gutierrez ; Gobierno de la Ciudad Autonoma de Buenos Aires;
Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
XVIII Latin American Congress of Pediatric Endocrinology; 2019 Annual Meeting of the Latin American Society for Pediatric Endocrinology
Florianopolis
Brasil
Latin American Pediatric Endocrinology Society - Materia
-
Hematologic malignancies
Sertoli cell
Anti-müllerian hormone - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/239410
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Safety of Chemotherapy for Hematologic Malignancies as Regards Testicular Endocrine Function in Children and TeenagersGrinspon, RominaArozarena, MaríaPrada, SilvinaBargman, GracielaSanzone, MaríaMorales Bazurto, MarjorieGutiérrez, MarcelaBedecarras, Patricia GladysKannemann, AnaElena, Graciela O.Gottlieb, Silvia ElisaBerenstein, Ariel JoséRopelato, Maria GabrielaBergadá, IgnacioAversa, LuisRey, Rodolfo AlbertoHematologic malignanciesSertoli cellAnti-müllerian hormonehttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Effective treatments have increasedlife expectancy in children with hematologic malignancies, but loss offertility has become a concern. However, the effects of chemotherapy on Sertoliand Leydig cell function in boys and adolescents has received little attention.Objective: To determine whethertreatments used in boys with hematologic malignancies affect endocrine function of the developing testes.Methods: In an observational study of 97 boys (83 acute lymphocytic leukaemia, 5acute myeloid leukemia and 9 non-Hodgkin lymphoma) we assessed serum levels ofAMH and FSH and testosterone and LH as biomarkers respectively of Sertoli andLeydig cell function.Results: Sixty-one patients, with at least 1 year of follow-up after the end ofchemotherapy were included in the cross-sectional analysis. Serum AMH were within normal levels in all 37patients treated before the age of 10 years (Group A). FSH was also normal inthe vast majority, and only slightly elevated in 3. Serum levels oftestosterone and LH were within the normal levels in all of them. In the 24 patients in whom treatment ended after 10 years(Group B), AMH was also within the reference range but FSH was elevated in 8cases, suggesting a compensated primary Sertoli cell insufficiency. Similarly,testosterone levels were normal in all cases, but LH were slightly elevated in5 patients, probably indicating a compensated Leydig cell dysfunction. All 97 patients were included in the longitudinalanalysis, 58 patients completed treatment before 10 years (Group A) and 39 after10 years of age (Group B). Serum AMH was never <2 SDS in any of the patientsduring follow-up. Testosterone remained below the reference range in only onecase. In Group A, 9 patients (15.5 %) had at least one FSH value>2 SDS during follow-up. In 3 of them (7.7 %) was also >2 SDS. In GroupB, 14 patients (35.9%) had at least one FSH value >2 SDS. Eight of them(20.5 %) also had LH >2 SDS. Three (7.7 %) had only LH elevation. The proportionof patients with FSH and LH >2 SDS was higher (P=0.008 and 0.03, respectively) in Group B than in Group A. Conclusion: Therapy ofhematologic malignancies did not significantly affect Sertoli and Leydig cell functions inboys treated <10 years. Conversely, when treatment ended after pubertalonset, a compensated Sertoli and Leydig cell dysfunction was more frequentlyobserved. No risk factor could be identified in association with thecompensated endocrine dysfunction.Fil: Grinspon, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; ArgentinaFil: Arozarena, María. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; ArgentinaFil: Prada, Silvina. Departamento de Urgencias ; Hospital General de Niños Ricardo Gutierrez ; Gobierno de la Ciudad Autonoma de Buenos Aires;Fil: Bargman, Graciela. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); ArgentinaFil: Sanzone, María. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; ArgentinaFil: Morales Bazurto, Marjorie. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; ArgentinaFil: Gutiérrez, Marcela. Departamento de Urgencias ; Hospital General de Niños Ricardo Gutierrez ; Gobierno de la Ciudad Autonoma de Buenos Aires;Fil: Bedecarras, Patricia Gladys. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; ArgentinaFil: Kannemann, Ana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); ArgentinaFil: Elena, Graciela O.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); ArgentinaFil: Gottlieb, Silvia Elisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; ArgentinaFil: Berenstein, Ariel José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; ArgentinaFil: Ropelato, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; ArgentinaFil: Bergadá, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; ArgentinaFil: Aversa, Luis. Departamento de Urgencias ; Hospital General de Niños Ricardo Gutierrez ; Gobierno de la Ciudad Autonoma de Buenos Aires;Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; ArgentinaXVIII Latin American Congress of Pediatric Endocrinology; 2019 Annual Meeting of the Latin American Society for Pediatric EndocrinologyFlorianopolisBrasilLatin American Pediatric Endocrinology SocietyKarger2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/239410Safety of Chemotherapy for Hematologic Malignancies as Regards Testicular Endocrine Function in Children and Teenagers; XVIII Latin American Congress of Pediatric Endocrinology; 2019 Annual Meeting of the Latin American Society for Pediatric Endocrinology; Florianopolis; Brasil; 2019; 31-311663-2818CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Journal/Issue/278982info:eu-repo/semantics/altIdentifier/doi/10.1159/000504400Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:55Zoai:ri.conicet.gov.ar:11336/239410instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:56.266CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Safety of Chemotherapy for Hematologic Malignancies as Regards Testicular Endocrine Function in Children and Teenagers |
| title |
Safety of Chemotherapy for Hematologic Malignancies as Regards Testicular Endocrine Function in Children and Teenagers |
| spellingShingle |
Safety of Chemotherapy for Hematologic Malignancies as Regards Testicular Endocrine Function in Children and Teenagers Grinspon, Romina Hematologic malignancies Sertoli cell Anti-müllerian hormone |
| title_short |
Safety of Chemotherapy for Hematologic Malignancies as Regards Testicular Endocrine Function in Children and Teenagers |
| title_full |
Safety of Chemotherapy for Hematologic Malignancies as Regards Testicular Endocrine Function in Children and Teenagers |
| title_fullStr |
Safety of Chemotherapy for Hematologic Malignancies as Regards Testicular Endocrine Function in Children and Teenagers |
| title_full_unstemmed |
Safety of Chemotherapy for Hematologic Malignancies as Regards Testicular Endocrine Function in Children and Teenagers |
| title_sort |
Safety of Chemotherapy for Hematologic Malignancies as Regards Testicular Endocrine Function in Children and Teenagers |
| dc.creator.none.fl_str_mv |
Grinspon, Romina Arozarena, María Prada, Silvina Bargman, Graciela Sanzone, María Morales Bazurto, Marjorie Gutiérrez, Marcela Bedecarras, Patricia Gladys Kannemann, Ana Elena, Graciela O. Gottlieb, Silvia Elisa Berenstein, Ariel José Ropelato, Maria Gabriela Bergadá, Ignacio Aversa, Luis Rey, Rodolfo Alberto |
| author |
Grinspon, Romina |
| author_facet |
Grinspon, Romina Arozarena, María Prada, Silvina Bargman, Graciela Sanzone, María Morales Bazurto, Marjorie Gutiérrez, Marcela Bedecarras, Patricia Gladys Kannemann, Ana Elena, Graciela O. Gottlieb, Silvia Elisa Berenstein, Ariel José Ropelato, Maria Gabriela Bergadá, Ignacio Aversa, Luis Rey, Rodolfo Alberto |
| author_role |
author |
| author2 |
Arozarena, María Prada, Silvina Bargman, Graciela Sanzone, María Morales Bazurto, Marjorie Gutiérrez, Marcela Bedecarras, Patricia Gladys Kannemann, Ana Elena, Graciela O. Gottlieb, Silvia Elisa Berenstein, Ariel José Ropelato, Maria Gabriela Bergadá, Ignacio Aversa, Luis Rey, Rodolfo Alberto |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Hematologic malignancies Sertoli cell Anti-müllerian hormone |
| topic |
Hematologic malignancies Sertoli cell Anti-müllerian hormone |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Effective treatments have increasedlife expectancy in children with hematologic malignancies, but loss offertility has become a concern. However, the effects of chemotherapy on Sertoliand Leydig cell function in boys and adolescents has received little attention.Objective: To determine whethertreatments used in boys with hematologic malignancies affect endocrine function of the developing testes.Methods: In an observational study of 97 boys (83 acute lymphocytic leukaemia, 5acute myeloid leukemia and 9 non-Hodgkin lymphoma) we assessed serum levels ofAMH and FSH and testosterone and LH as biomarkers respectively of Sertoli andLeydig cell function.Results: Sixty-one patients, with at least 1 year of follow-up after the end ofchemotherapy were included in the cross-sectional analysis. Serum AMH were within normal levels in all 37patients treated before the age of 10 years (Group A). FSH was also normal inthe vast majority, and only slightly elevated in 3. Serum levels oftestosterone and LH were within the normal levels in all of them. In the 24 patients in whom treatment ended after 10 years(Group B), AMH was also within the reference range but FSH was elevated in 8cases, suggesting a compensated primary Sertoli cell insufficiency. Similarly,testosterone levels were normal in all cases, but LH were slightly elevated in5 patients, probably indicating a compensated Leydig cell dysfunction. All 97 patients were included in the longitudinalanalysis, 58 patients completed treatment before 10 years (Group A) and 39 after10 years of age (Group B). Serum AMH was never <2 SDS in any of the patientsduring follow-up. Testosterone remained below the reference range in only onecase. In Group A, 9 patients (15.5 %) had at least one FSH value>2 SDS during follow-up. In 3 of them (7.7 %) was also >2 SDS. In GroupB, 14 patients (35.9%) had at least one FSH value >2 SDS. Eight of them(20.5 %) also had LH >2 SDS. Three (7.7 %) had only LH elevation. The proportionof patients with FSH and LH >2 SDS was higher (P=0.008 and 0.03, respectively) in Group B than in Group A. Conclusion: Therapy ofhematologic malignancies did not significantly affect Sertoli and Leydig cell functions inboys treated <10 years. Conversely, when treatment ended after pubertalonset, a compensated Sertoli and Leydig cell dysfunction was more frequentlyobserved. No risk factor could be identified in association with thecompensated endocrine dysfunction. Fil: Grinspon, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina Fil: Arozarena, María. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina Fil: Prada, Silvina. Departamento de Urgencias ; Hospital General de Niños Ricardo Gutierrez ; Gobierno de la Ciudad Autonoma de Buenos Aires; Fil: Bargman, Graciela. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina Fil: Sanzone, María. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina Fil: Morales Bazurto, Marjorie. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina Fil: Gutiérrez, Marcela. Departamento de Urgencias ; Hospital General de Niños Ricardo Gutierrez ; Gobierno de la Ciudad Autonoma de Buenos Aires; Fil: Bedecarras, Patricia Gladys. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina Fil: Kannemann, Ana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina Fil: Elena, Graciela O.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina Fil: Gottlieb, Silvia Elisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina Fil: Berenstein, Ariel José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina Fil: Ropelato, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina Fil: Bergadá, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina Fil: Aversa, Luis. Departamento de Urgencias ; Hospital General de Niños Ricardo Gutierrez ; Gobierno de la Ciudad Autonoma de Buenos Aires; Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina XVIII Latin American Congress of Pediatric Endocrinology; 2019 Annual Meeting of the Latin American Society for Pediatric Endocrinology Florianopolis Brasil Latin American Pediatric Endocrinology Society |
| description |
Effective treatments have increasedlife expectancy in children with hematologic malignancies, but loss offertility has become a concern. However, the effects of chemotherapy on Sertoliand Leydig cell function in boys and adolescents has received little attention.Objective: To determine whethertreatments used in boys with hematologic malignancies affect endocrine function of the developing testes.Methods: In an observational study of 97 boys (83 acute lymphocytic leukaemia, 5acute myeloid leukemia and 9 non-Hodgkin lymphoma) we assessed serum levels ofAMH and FSH and testosterone and LH as biomarkers respectively of Sertoli andLeydig cell function.Results: Sixty-one patients, with at least 1 year of follow-up after the end ofchemotherapy were included in the cross-sectional analysis. Serum AMH were within normal levels in all 37patients treated before the age of 10 years (Group A). FSH was also normal inthe vast majority, and only slightly elevated in 3. Serum levels oftestosterone and LH were within the normal levels in all of them. In the 24 patients in whom treatment ended after 10 years(Group B), AMH was also within the reference range but FSH was elevated in 8cases, suggesting a compensated primary Sertoli cell insufficiency. Similarly,testosterone levels were normal in all cases, but LH were slightly elevated in5 patients, probably indicating a compensated Leydig cell dysfunction. All 97 patients were included in the longitudinalanalysis, 58 patients completed treatment before 10 years (Group A) and 39 after10 years of age (Group B). Serum AMH was never <2 SDS in any of the patientsduring follow-up. Testosterone remained below the reference range in only onecase. In Group A, 9 patients (15.5 %) had at least one FSH value>2 SDS during follow-up. In 3 of them (7.7 %) was also >2 SDS. In GroupB, 14 patients (35.9%) had at least one FSH value >2 SDS. Eight of them(20.5 %) also had LH >2 SDS. Three (7.7 %) had only LH elevation. The proportionof patients with FSH and LH >2 SDS was higher (P=0.008 and 0.03, respectively) in Group B than in Group A. Conclusion: Therapy ofhematologic malignancies did not significantly affect Sertoli and Leydig cell functions inboys treated <10 years. Conversely, when treatment ended after pubertalonset, a compensated Sertoli and Leydig cell dysfunction was more frequentlyobserved. No risk factor could be identified in association with thecompensated endocrine dysfunction. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/conferenceObject Reunión Journal http://purl.org/coar/resource_type/c_5794 info:ar-repo/semantics/documentoDeConferencia |
| status_str |
publishedVersion |
| format |
conferenceObject |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/239410 Safety of Chemotherapy for Hematologic Malignancies as Regards Testicular Endocrine Function in Children and Teenagers; XVIII Latin American Congress of Pediatric Endocrinology; 2019 Annual Meeting of the Latin American Society for Pediatric Endocrinology; Florianopolis; Brasil; 2019; 31-31 1663-2818 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/239410 |
| identifier_str_mv |
Safety of Chemotherapy for Hematologic Malignancies as Regards Testicular Endocrine Function in Children and Teenagers; XVIII Latin American Congress of Pediatric Endocrinology; 2019 Annual Meeting of the Latin American Society for Pediatric Endocrinology; Florianopolis; Brasil; 2019; 31-31 1663-2818 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Journal/Issue/278982 info:eu-repo/semantics/altIdentifier/doi/10.1159/000504400 |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
| dc.coverage.none.fl_str_mv |
Internacional |
| dc.publisher.none.fl_str_mv |
Karger |
| publisher.none.fl_str_mv |
Karger |
| dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
| reponame_str |
CONICET Digital (CONICET) |
| collection |
CONICET Digital (CONICET) |
| instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
| _version_ |
1842269934989606912 |
| score |
13.13397 |