Mucosal interplay among commensal and pathogenic bacteria : Lessons from flagellin and Toll-like receptor 5

Autores
Rumbo, Martín; Nempont, Clément; Kraehenbuhl, Jean-Pierre; Sirard, Jean-Claude
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Toll-like receptors (TLR) detect pathogen-associated molecular patterns (PAMP) and play a crucial role in triggering immunity. Due to their large surfaces in direct contact with the environment, mucosal tissues are the major sites of PAMP-TLR signalling. How innate and adaptive immunity are triggered through flagellin-TLR5 interaction is the main focus of the review. In view of recent reports on genetic polymorphism, we will summarize the impact of TLR5 on the susceptibility to mucosal infections and on various immuno-pathologies. Finally, the contribution of TLRs in the induction and maintenance of mucosal homeostasis and commensal discrimination is discussed.
Facultad de Ciencias Exactas
Materia
Ciencias Exactas
Toll-like receptor
Flagellin
Innate immunity
Epithelium
Pathogenic bacteria
Commensal flora
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-nd/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/127275
Acceder
id SEDICI_0bf74669d5fb8fdc66ca221eedc92864
oai_identifier_str oai:sedici.unlp.edu.ar:10915/127275
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Mucosal interplay among commensal and pathogenic bacteria : Lessons from flagellin and Toll-like receptor 5Rumbo, MartínNempont, ClémentKraehenbuhl, Jean-PierreSirard, Jean-ClaudeCiencias ExactasToll-like receptorFlagellinInnate immunityEpitheliumPathogenic bacteriaCommensal floraToll-like receptors (TLR) detect pathogen-associated molecular patterns (PAMP) and play a crucial role in triggering immunity. Due to their large surfaces in direct contact with the environment, mucosal tissues are the major sites of PAMP-TLR signalling. How innate and adaptive immunity are triggered through flagellin-TLR5 interaction is the main focus of the review. In view of recent reports on genetic polymorphism, we will summarize the impact of TLR5 on the susceptibility to mucosal infections and on various immuno-pathologies. Finally, the contribution of TLRs in the induction and maintenance of mucosal homeostasis and commensal discrimination is discussed.Facultad de Ciencias Exactas2006-04-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf2976-2984http://sedici.unlp.edu.ar/handle/10915/127275enginfo:eu-repo/semantics/altIdentifier/url/https://febs.onlinelibrary.wiley.com/doi/abs/10.1016/j.febslet.2006.04.036info:eu-repo/semantics/altIdentifier/issn/0014-5793info:eu-repo/semantics/altIdentifier/pmid/16650409info:eu-repo/semantics/altIdentifier/doi/10.1016/j.febslet.2006.04.036info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T11:02:44Zoai:sedici.unlp.edu.ar:10915/127275Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 11:02:44.802SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Mucosal interplay among commensal and pathogenic bacteria : Lessons from flagellin and Toll-like receptor 5
title Mucosal interplay among commensal and pathogenic bacteria : Lessons from flagellin and Toll-like receptor 5
spellingShingle Mucosal interplay among commensal and pathogenic bacteria : Lessons from flagellin and Toll-like receptor 5
Rumbo, Martín
Ciencias Exactas
Toll-like receptor
Flagellin
Innate immunity
Epithelium
Pathogenic bacteria
Commensal flora
title_short Mucosal interplay among commensal and pathogenic bacteria : Lessons from flagellin and Toll-like receptor 5
title_full Mucosal interplay among commensal and pathogenic bacteria : Lessons from flagellin and Toll-like receptor 5
title_fullStr Mucosal interplay among commensal and pathogenic bacteria : Lessons from flagellin and Toll-like receptor 5
title_full_unstemmed Mucosal interplay among commensal and pathogenic bacteria : Lessons from flagellin and Toll-like receptor 5
title_sort Mucosal interplay among commensal and pathogenic bacteria : Lessons from flagellin and Toll-like receptor 5
dc.creator.none.fl_str_mv Rumbo, Martín
Nempont, Clément
Kraehenbuhl, Jean-Pierre
Sirard, Jean-Claude
author Rumbo, Martín
author_facet Rumbo, Martín
Nempont, Clément
Kraehenbuhl, Jean-Pierre
Sirard, Jean-Claude
author_role author
author2 Nempont, Clément
Kraehenbuhl, Jean-Pierre
Sirard, Jean-Claude
author2_role author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Toll-like receptor
Flagellin
Innate immunity
Epithelium
Pathogenic bacteria
Commensal flora
topic Ciencias Exactas
Toll-like receptor
Flagellin
Innate immunity
Epithelium
Pathogenic bacteria
Commensal flora
dc.description.none.fl_txt_mv Toll-like receptors (TLR) detect pathogen-associated molecular patterns (PAMP) and play a crucial role in triggering immunity. Due to their large surfaces in direct contact with the environment, mucosal tissues are the major sites of PAMP-TLR signalling. How innate and adaptive immunity are triggered through flagellin-TLR5 interaction is the main focus of the review. In view of recent reports on genetic polymorphism, we will summarize the impact of TLR5 on the susceptibility to mucosal infections and on various immuno-pathologies. Finally, the contribution of TLRs in the induction and maintenance of mucosal homeostasis and commensal discrimination is discussed.
Facultad de Ciencias Exactas
description Toll-like receptors (TLR) detect pathogen-associated molecular patterns (PAMP) and play a crucial role in triggering immunity. Due to their large surfaces in direct contact with the environment, mucosal tissues are the major sites of PAMP-TLR signalling. How innate and adaptive immunity are triggered through flagellin-TLR5 interaction is the main focus of the review. In view of recent reports on genetic polymorphism, we will summarize the impact of TLR5 on the susceptibility to mucosal infections and on various immuno-pathologies. Finally, the contribution of TLRs in the induction and maintenance of mucosal homeostasis and commensal discrimination is discussed.
publishDate 2006
dc.date.none.fl_str_mv 2006-04-21
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/127275
url http://sedici.unlp.edu.ar/handle/10915/127275
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://febs.onlinelibrary.wiley.com/doi/abs/10.1016/j.febslet.2006.04.036
info:eu-repo/semantics/altIdentifier/issn/0014-5793
info:eu-repo/semantics/altIdentifier/pmid/16650409
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.febslet.2006.04.036
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.format.none.fl_str_mv application/pdf
2976-2984
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.13397

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