Pulmonary lesions in guinea pigs experimentally infected with Actinobacillus pleuropneumoniae (A.p.) serovar 1.
- Autores
- Perfumo, Carlos Juan; Petruccelli, Miguel Ángel; Itagaki, Shin-ichi
- Año de publicación
- 1999
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Pathological studies were carried out on the lungs of guinea pigs intratracheally inoculated with 4.6 × 106-8 colony forming units (CFU)/head of Actinobacillus pleuropneumoniae serovar 1. All animals in the highest dose group died within 24 hr post inoculation (hpi) and showed pulmonary lesions being hemorrhagic in nature while all animals in the lowest dose group were killed as scheduled at 11 days post inoculation (dpi) and showed only hyperplasia of peribronchial lymphoid tissues. In the middle dose group, two died within 24 hpi, two died at 9 dpi, and the remaining one was killed at 11 dpi. Two guinea pigs which died at 9 dpi showed fibrinonecrotic pleuropneumonia which is the most characteristic acute pulmonary lesion in swine, and has not yet been reproduced in laboratory animals up to the present time. This suggests that guinea pigs may be a useful laboratory animal for studying the pathogenesis of Actinobacillus pleuropneumoniae infection in swine.
Facultad de Ciencias Veterinarias - Materia
-
Veterinaria
Biología
Actinobacillus pleuropneumoniae serovar 1
fibrinonecrotic pleuropneumonia
guinea pig - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
.jpg)
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/137823
Ver los metadatos del registro completo
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Pulmonary lesions in guinea pigs experimentally infected with Actinobacillus pleuropneumoniae (A.p.) serovar 1.Perfumo, Carlos JuanPetruccelli, Miguel ÁngelItagaki, Shin-ichiVeterinariaBiologíaActinobacillus pleuropneumoniae serovar 1fibrinonecrotic pleuropneumoniaguinea pigPathological studies were carried out on the lungs of guinea pigs intratracheally inoculated with 4.6 × 106-8 colony forming units (CFU)/head of Actinobacillus pleuropneumoniae serovar 1. All animals in the highest dose group died within 24 hr post inoculation (hpi) and showed pulmonary lesions being hemorrhagic in nature while all animals in the lowest dose group were killed as scheduled at 11 days post inoculation (dpi) and showed only hyperplasia of peribronchial lymphoid tissues. In the middle dose group, two died within 24 hpi, two died at 9 dpi, and the remaining one was killed at 11 dpi. Two guinea pigs which died at 9 dpi showed fibrinonecrotic pleuropneumonia which is the most characteristic acute pulmonary lesion in swine, and has not yet been reproduced in laboratory animals up to the present time. This suggests that guinea pigs may be a useful laboratory animal for studying the pathogenesis of Actinobacillus pleuropneumoniae infection in swine.Facultad de Ciencias Veterinarias1999info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf163-165http://sedici.unlp.edu.ar/handle/10915/137823enginfo:eu-repo/semantics/altIdentifier/issn/0916-7250info:eu-repo/semantics/altIdentifier/issn/1347-7439info:eu-repo/semantics/altIdentifier/doi/10.1292/jvms.61.163info:eu-repo/semantics/altIdentifier/pmid/10081756info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:23:43Zoai:sedici.unlp.edu.ar:10915/137823Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:23:43.983SEDICI (UNLP) - Universidad Nacional de La Platafalse |
| dc.title.none.fl_str_mv |
Pulmonary lesions in guinea pigs experimentally infected with Actinobacillus pleuropneumoniae (A.p.) serovar 1. |
| title |
Pulmonary lesions in guinea pigs experimentally infected with Actinobacillus pleuropneumoniae (A.p.) serovar 1. |
| spellingShingle |
Pulmonary lesions in guinea pigs experimentally infected with Actinobacillus pleuropneumoniae (A.p.) serovar 1. Perfumo, Carlos Juan Veterinaria Biología Actinobacillus pleuropneumoniae serovar 1 fibrinonecrotic pleuropneumonia guinea pig |
| title_short |
Pulmonary lesions in guinea pigs experimentally infected with Actinobacillus pleuropneumoniae (A.p.) serovar 1. |
| title_full |
Pulmonary lesions in guinea pigs experimentally infected with Actinobacillus pleuropneumoniae (A.p.) serovar 1. |
| title_fullStr |
Pulmonary lesions in guinea pigs experimentally infected with Actinobacillus pleuropneumoniae (A.p.) serovar 1. |
| title_full_unstemmed |
Pulmonary lesions in guinea pigs experimentally infected with Actinobacillus pleuropneumoniae (A.p.) serovar 1. |
| title_sort |
Pulmonary lesions in guinea pigs experimentally infected with Actinobacillus pleuropneumoniae (A.p.) serovar 1. |
| dc.creator.none.fl_str_mv |
Perfumo, Carlos Juan Petruccelli, Miguel Ángel Itagaki, Shin-ichi |
| author |
Perfumo, Carlos Juan |
| author_facet |
Perfumo, Carlos Juan Petruccelli, Miguel Ángel Itagaki, Shin-ichi |
| author_role |
author |
| author2 |
Petruccelli, Miguel Ángel Itagaki, Shin-ichi |
| author2_role |
author author |
| dc.subject.none.fl_str_mv |
Veterinaria Biología Actinobacillus pleuropneumoniae serovar 1 fibrinonecrotic pleuropneumonia guinea pig |
| topic |
Veterinaria Biología Actinobacillus pleuropneumoniae serovar 1 fibrinonecrotic pleuropneumonia guinea pig |
| dc.description.none.fl_txt_mv |
Pathological studies were carried out on the lungs of guinea pigs intratracheally inoculated with 4.6 × 106-8 colony forming units (CFU)/head of Actinobacillus pleuropneumoniae serovar 1. All animals in the highest dose group died within 24 hr post inoculation (hpi) and showed pulmonary lesions being hemorrhagic in nature while all animals in the lowest dose group were killed as scheduled at 11 days post inoculation (dpi) and showed only hyperplasia of peribronchial lymphoid tissues. In the middle dose group, two died within 24 hpi, two died at 9 dpi, and the remaining one was killed at 11 dpi. Two guinea pigs which died at 9 dpi showed fibrinonecrotic pleuropneumonia which is the most characteristic acute pulmonary lesion in swine, and has not yet been reproduced in laboratory animals up to the present time. This suggests that guinea pigs may be a useful laboratory animal for studying the pathogenesis of Actinobacillus pleuropneumoniae infection in swine. Facultad de Ciencias Veterinarias |
| description |
Pathological studies were carried out on the lungs of guinea pigs intratracheally inoculated with 4.6 × 106-8 colony forming units (CFU)/head of Actinobacillus pleuropneumoniae serovar 1. All animals in the highest dose group died within 24 hr post inoculation (hpi) and showed pulmonary lesions being hemorrhagic in nature while all animals in the lowest dose group were killed as scheduled at 11 days post inoculation (dpi) and showed only hyperplasia of peribronchial lymphoid tissues. In the middle dose group, two died within 24 hpi, two died at 9 dpi, and the remaining one was killed at 11 dpi. Two guinea pigs which died at 9 dpi showed fibrinonecrotic pleuropneumonia which is the most characteristic acute pulmonary lesion in swine, and has not yet been reproduced in laboratory animals up to the present time. This suggests that guinea pigs may be a useful laboratory animal for studying the pathogenesis of Actinobacillus pleuropneumoniae infection in swine. |
| publishDate |
1999 |
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1999 |
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http://sedici.unlp.edu.ar/handle/10915/137823 |
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eng |
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eng |
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